Semiautomatic Growth Analysis of Multicellular Tumor Spheroids

SLAS Discovery - Tập 16 - Trang 1119-1124 - 2011
Bjoern Rodday1, Franziska Hirschhaeuser1, Stefan Walenta1, Wolfgang Mueller-Klieser1
1Institute of Physiology and Pathophysiology, University Medical Center of the Johannes Gutenberg University of Mainz, 55128 Mainz, Germany.

Tài liệu tham khảo

Sutherland, 1988, Cell and Environment Interactions in Tumor Microregions: The Multicell Spheroid Model, Science., 240, 177, 10.1126/science.2451290 Mueller-Klieser, 1997, Three-Dimensional Cell Cultures: From Molecular Mechanisms to Clinical Applications, Am. J. Physiol., 273, C1109, 10.1152/ajpcell.1997.273.4.C1109 Kunz-Schughart, 1998, Multicellular Spheroids: A Three-Dimensional in Vitro Culture System to Study Tumour Biology, Int. J. Exp. Pathol., 79, 1, 10.1046/j.1365-2613.1998.00051.x Mueller-Klieser, 2000, Tumor Biology and Experimental Therapeutics, Crit. Rev. Oncol. Hematol., 36, 123, 10.1016/S1040-8428(00)00082-2 Kunz-Schughart, 2004, The Use of 3-D Cultures for High-Throughput Screening: The Multicellular Spheroid Model, J. Biomol. Screen., 9, 273, 10.1177/1087057104265040 Friedrich, 2007, Experimental Anti-Tumor Therapy in 3-D: Spheroids—Old Hat or New Challenge?, Int. J. Radiat. Biol., 83, 849, 10.1080/09553000701727531 Friedrich, 2009, Spheroid-Based Drug Screen: Considerations and Practical Approach, Nat. Protoc., 4, 309, 10.1038/nprot.2008.226 Hirschhaeuser, 2010, Efficacy of Catumaxomab in Tumor Spheroid Killing Is Mediated by Its Trifunctional Mode of Action, Cancer Immunol. Immunother., 59, 1675, 10.1007/s00262-010-0894-1 Hirschhaeuser, 2010, Multicellular Tumor Spheroids: An Underestimated Tool Is Catching up Again, J. Biotechnol., 148, 3, 10.1016/j.jbiotec.2010.01.012 Hirschhaeuser, 2009, Test System for Trifunctional Antibodies in 3D MCTS Culture, J. Biomol. Screen., 14, 980, 10.1177/1087057109341766 Sasaki, 1984, Development of Multicellular Spheroids of HeLa Cells Cocultured with Fibroblasts and Their Response to X-Irradiation, Cancer Res., 44, 345 Freyer, 1986, Regulation of Growth Saturation and Development of Necrosis in EMT6/Ro Multicellular Spheroids by the Glucose and Oxygen Supply, Cancer Res., 46, 3504 Kunz-Schughart, 2000, Proliferative Activity and Tumorigenic Conversion: Impact on Cellular Metabolism in 3-D Culture, Am. J. Physiol. Cell Physiol., 278, C765, 10.1152/ajpcell.2000.278.4.C765 Ivascu, 2006, Rapid Generation of Single-Tumor Spheroids for High-Throughput Cell Function and Toxicity Analysis, J. Biomol. Screen., 11, 922, 10.1177/1087057106292763 Wang, 2006, Control of Prostate Cancer Spheroid Growth Using 213Bi-labeled Multiple Targeted Alpha Radioimmunoconjugates, Prostate., 66, 1753, 10.1002/pros.20502 Santini, 2006, A 50 Hz Sinusoidal Magnetic Field Does Not Damage MG-63 Three-Dimensional Tumor Spheroids but Induces Changes in Their Invasive Properties, Bioelectromagnetics., 27, 132, 10.1002/bem.20184 Freyer, 1987, Viable Sorting of Intact Multicellular Spheroids by Flow Cytometry, Cytometry., 8, 427, 10.1002/cyto.990080413 Freyer, 1989, Use of Xantham Gum to Suspend Large Particles during Flow Cytometric Analysis and Sorting, Cytometry., 10, 803, 10.1002/cyto.990100620 Hung, T. Baran, A. Ware, C. Pulak, R. Multicellular Cytometric Analyses and Sorting on Embryoid Bodies and Embryonic Stem Cell Clusters. 3rd Annual ISSCR Meeting 2005, June 23–25 [last update August 6, 2010]. http://www.unionbio.com/documents/ISSCR05PosterHandout.pdf. Thielecke, 2001, A Multicellular Spheroid-Based Sensor for Anti-Cancer Therapeutics, Biosens. Bioelectron., 16, 261, 10.1016/S0956-5663(01)00140-3 Thielecke, H. Robitzki, A. Device and Method for Characterizing Spheroids. World Intellectual Property Organization, CH-1211 Geneva 20, Switzerland [last update August 6, 2010]. http://www.wipo.int/pctdb/en/wo.jsp?wo=2001023865.