Semi‐automated primary tumor volume measurements by dynamic contrast‐enhanced MRI in patients with head and neck cancer

Head and Neck - Tập 35 Số 4 - Trang 521-526 - 2013
Wouter L. Lodder1, Kenneth G. A. Gilhuijs2, Charlotte A.H. Lange3, Frank A. Pameijer4, Alfons J. M. Balm1,5, Michiel W. M. van den Brekel1,5
1Department of Head and Neck Oncology and Surgery, The Netherlands Cancer Institute—Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands
2Department of Radiology, Image Sciences Institute, University Medical Centre Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands
3Department of Radiology, The Netherlands Cancer Institute—Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands
4Department of Radiology, University Medical Centre Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands
5Department of Otorhinolaryngology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands

Tóm tắt

AbstractBackgroundTumor volume is a significant prognostic factor in the treatment of malignant head and neck tumors. Unfortunately, it is not routinely measured because of the workload involved.MethodsTwenty‐one patients, between 2009 and 2010, were studied. Dynamic contrast‐enhanced MRI (DCE‐MRI) at 3.0T was performed. A workstation previously developed for semi‐automated segmentation of breast cancers on DCE‐MRI was used to segment the head and neck cancers. The Pearson correlation analysis was used to assess the agreement between volumetric measurements and the manually derived gross tumor volume (GTV).ResultsIn 90.5% of the patients (19 of 21) correlation could be made between DCE‐MRI and the manually derived GTV. The Pearson correlation coefficient between the automatically derived tumor volume at DCE‐MRI and the manually derived GTVs was R2 = 0.95 (p < .001).ConclusionSemi‐automated tumor volumes on DCE‐MRI were representative of those derived from the manually derived GTV (R2 = 0.95; p < .001). © 2012 Wiley Periodicals, Inc. Head Neck, 2013

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Head and Neck

Tập 35 Số 4

521-526

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