Semi-Targeted Metabolomics to Validate Biomarkers of Grape Downy Mildew Infection Under Field Conditions

Gessler, 2011, Plasmopara viticola: A review of knowledge on downy mildew of grapevine and effective disease management, Phytopathol. Mediterr., 50, 3

Runkle, 2017, A systematic review of Mancozeb as a reproductive and developmental hazard, Environ. Int., 99, 29, 10.1016/j.envint.2016.11.006

Juang, 2012, Copper accumulation, translocation, and toxic effects in grapevine cuttings, Environ. Sci. Pollut. Res., 19, 1315, 10.1007/s11356-011-0657-3

Bordas, 2010, Contamination of vineyard soils with fungicides: A review of environmental and toxicological aspects, Environ. Int., 36, 138, 10.1016/j.envint.2009.10.005

Dagostin, 2011, Are there alternatives to copper for controlling grapevine downy mildew in organic viticulture?, Crop Prot., 30, 776, 10.1016/j.cropro.2011.02.031

Jacometti, 2010, Review: Alternatives to synthetic fungicides for Botrytis cinerea management in vineyards, Aust. J. Grape Wine Res., 16, 154, 10.1111/j.1755-0238.2009.0067.x

Watt, 2020, Phenotyping: New windows into the plant for breeders, Annu. Rev. Plant Biol., 71, 689, 10.1146/annurev-arplant-042916-041124

Kennelly, 2007, Primary infection, lesion productivity, and survival of sporangia in the grapevine downy mildew pathogen Plasmopara viticola, Phytopathology, 97, 512, 10.1094/PHYTO-97-4-0512

Polesani, 2008, cDNA-AFLP analysis of plant and pathogen genes expressed in grapevine infected with Plasmopara viticola, Bmc Genom., 9, 1, 10.1186/1471-2164-9-142

Gamm, 2011, Changes in carbohydrate metabolism in Plasmopara viticola-infected grapevine leaves, Mol. Plant-Microbe Interact., 24, 1061, 10.1094/MPMI-02-11-0040

Mattivi, 2011, Profiling of resveratrol oligomers, important stress metabolites, accumulating in the leaves of hybrid Vitis vinifera (Merzling × Teroldego) genotypes infected with Plasmopara viticola, J. Agric. Food Chem., 59, 5364, 10.1021/jf200771y

Chitarrini, 2017, Identification of biomarkers for defense response to Plasmopara viticola in a resistant grape variety, Front. Plant Sci., 8, 1524, 10.3389/fpls.2017.01524

Pezet, 2004, Glycosylation and oxidative dimerization of resveratrol are respectively associated to sensitivity and resistance of grapevine cultivars to downy mildew, Physiol. Mol. Plant Pathol., 65, 297, 10.1016/j.pmpp.2005.03.002

Pezet, 2003, δ-viniferin, a resveratrol dehydrodimer: One of the major stilbenes synthesized by stressed grapevine leaves, J. Agric. Food Chem., 51, 5488, 10.1021/jf030227o

Dai, 1995, Histochemical responses of leaves of in vitro plantlets of Vitis spp. to infection with Plasmopara viticola, Phytopathology, 85, 149, 10.1094/Phyto-85-149

Gindro, 2006, Histological and biochemical criteria for objective and early selection of grapevine cultivars resistant to Plasmopara viticola, Vitis–J. Grapevine Res., 45, 191

Pawlus, 2012, Stilbenoid chemistry from wine and the genus Vitis, a review, OENO One, 46, 57, 10.20870/oeno-one.2012.46.2.1512

Pawlus, 2012, Natural stilbenoids: Distribution in the plant kingdom and chemotaxonomic interest in Vitaceae, Nat. Prod. Rep., 29, 1317, 10.1039/c2np20049j

Pezet, 2004, Effects of resveratrol, viniferins and pterostilbene on Plasmopara viticola zoospore mobility and disease development, Vitis–J. Grapevine Res., 43, 145

Schnee, 2013, Vitis vinifera canes, a new source of antifungal compounds against Plasmopara viticola, Erysiphe necator and Botrytis cinerea, J. Agric. Food Chem., 61, 5459, 10.1021/jf4010252

Fiehn, 2002, Metabolomics–The link between genotypes and phenotypes, Plant Mol. Biol., 48, 155, 10.1023/A:1013713905833

Zhou, 2016, Strategies for large-scale targeted metabolomics quantification by Liquid Chromatography-Mass Spectrometry, Analyst, 141, 6362, 10.1039/C6AN01753C

Krauss, 2010, LC-high resolution MS in environmental analysis: From target screening to the identification of unknowns, Anal. Bioanal. Chem., 397, 943, 10.1007/s00216-010-3608-9

Flamini, 2013, An innovative approach to grape metabolomics: Stilbene profiling by suspect screening analysis, Metabolomics, 9, 1243, 10.1007/s11306-013-0530-0

Billet, K., Houillé, B., De Bernonville, T.D., Besseau, S., Oudin, A., Courdavault, V., Delanoue, G., Guérin, L., Clastre, M., and Giglioli-Guivarc’h, N. (2018). Field-based metabolomics of Vitis vinifera L. stems provides new insights for genotype discrimination and polyphenol metabolism structuring. Front. Plant Sci., 9.

Mayr, 2018, High-resolution mass spectrometry metabolomics of grape chemical markers to reveal use of not-allowed varieties in the production of Amarone and Recioto wines, Metabolomics, 14, 124, 10.1007/s11306-018-1415-z

Anesi, A., Stocchero, M., Dal Santo, S., Commisso, M., Zenoni, S., Ceoldo, S., Tornielli, G.B., Siebert, T.E., Herderich, M., and Pezzotti, M. (2015). Towards a scientific interpretation of the terroir concept: Plasticity of the grape berry metabolome. Bmc Plant Biol., 15.

Sumner, 2007, Proposed minimum reporting standards for chemical analysis, Metabolomics, 3, 211, 10.1007/s11306-007-0082-2

Moss, 2013, Investigation of monomeric and oligomeric wine stilbenoids in red wines by ultra-high-performance liquid chromatography/electrospray ionization quadrupole time-of-flight mass spectrometry, Rapid Commun. Mass Spectrom., 27, 1815, 10.1002/rcm.6636

Vrhovsek, 2012, A versatile targeted metabolomics method for the rapid quantification of multiple classes of phenolics in fruits and beverages, J. Agric. Food Chem., 60, 8831, 10.1021/jf2051569

Floren, 2006, Survey of grapevine Vitis vinifera stem polyphenols by Liquid Chromatography-Diode Array Detection-Tandem Mass Spectrometry, J. Agric. Food Chem., 54, 7488, 10.1021/jf061155e

Santiago, 2012, Pattern recognition of three Vitis vinifera L. red grapes varieties based on anthocyanin and flavonol profiles, with correlations between their biosynthesis pathways, Food Chem., 130, 9, 10.1016/j.foodchem.2011.06.006

Ehrhardt, 2014, Analysis of the phenolic composition of fungus-resistant grape varieties cultivated in Italy and Germany using UHPLC-MS/MS, J. Mass Spectrom., 49, 860, 10.1002/jms.3440

Monagas, 2006, Chemical characterization of commercial dietary ingredients from Vitis vinifera L., Anal. Chim. Acta, 563, 401, 10.1016/j.aca.2005.10.065

Teixeira, 2016, Proanthocyanidin screening by LC–ESI-MS of Portuguese red wines made with teinturier grapes, Food Chem., 190, 300, 10.1016/j.foodchem.2015.05.065

Franceschi, 2012, A benchmark spike-in data set for biomarker identification in metabolomics, J. Chemom., 26, 16, 10.1002/cem.1420

Malacarne, 2011, Resistance to Plasmopara viticola is associated with a complex pattern of stilbenoids and with specific host transcriptional responses, Bmc Plant Biol., 11, 1, 10.1186/1471-2229-11-114

Vezzulli, 2019, The Rpv3-3 haplotype and stilbenoid induction mediate downy mildew resistance in a grapevine interspecific population, Front. Plant Sci., 10, 1, 10.3389/fpls.2019.00234

Gabaston, 2017, Stilbenes from Vitis vinifera L. waste: A sustainable tool for controlling Plasmopara viticola, J. Agric. Food Chem., 65, 2711, 10.1021/acs.jafc.7b00241

Laskin, 2005, The biotrophic stages of oomycete–plant interactions, Advances in Applied Microbiology, 57, 217, 10.1016/S0065-2164(05)57007-2

Ciaffi, 2019, Transcriptional regulation of stilbene synthases in grapevine germplasm differentially susceptible to downy mildew, Bmc Plant Biol., 19, 1, 10.1186/s12870-019-2014-5

Maes, 2019, Perspectives for remote sensing with Unmanned Aerial Vehicles in precision agriculture, Trends Plant Sci., 24, 152, 10.1016/j.tplants.2018.11.007

Latouche, 2013, Influence of constitutive phenolic compounds on the response of grapevine (Vitis vinifera L.) leaves to infection by Plasmopara viticola, Planta, 237, 351, 10.1007/s00425-012-1776-x

Bellow, 2012, In vivo localization at the cellular level of stilbene fluorescence induced by Plasmopara viticola in grapevine leaves, J. Exp. Bot., 63, 3697, 10.1093/jxb/ers060

Diago, 2019, Assessment of amino acids and total soluble solids in intact grape berries using contactless Vis and NIR spectroscopy during ripening, Talanta, 199, 244, 10.1016/j.talanta.2019.02.037

Gago, 2017, Integrative field scale phenotyping for investigating metabolic components of water stress within a vineyard, Plant Methods, 13, 1, 10.1186/s13007-017-0241-z

Kerkech, 2020, Vine disease detection in UAV multispectral images using optimized image registration and deep learning segmentation approach, Comput. Electron. Agric., 174, 105446, 10.1016/j.compag.2020.105446

Steimetz, 2012, Influence of leaf age on induced resistance in grapevine against Plasmopara viticola, Physiol. Mol. Plant Pathol., 79, 89, 10.1016/j.pmpp.2012.05.004

R Core Team (2017). R: A Language and Environment for Statistical Computing, R Foundation for Statistical Computing.

Nepusz, 2006, The igraph software package for complex network research, Interjournal Complex Syst., 1695, 1

Fruchterman, 1991, Graph drawing by force-directed placement, Softw. Pract. Exp., 21, 1129, 10.1002/spe.4380211102