Self-assembled pH-responsive DNA nanosponges for targeted co-delivery of doxorubicin and capsaicin for colorectal cancer therapy

Brar, 2021, Nanotechnology in colorectal cancer for precision diagnosis and therapy, Front. Nanotechnol., 3, 66, 10.3389/fnano.2021.699266 Xie, 2020, Comprehensive review of targeted therapy for colorectal cancer, Signal Transduct. Target. Ther., 5, 1 Asakiya, 2022, Current progress of miRNA-derivative nucleotide drugs: modifications, delivery systems, applications, Https://Doi. Org. /10. 1080/17425247. 2022. 2063835, 19, 435 Gulbake, 2016, Insight to drug delivery aspects for colorectal cancer, World J. Gastroenterol., 22, 582, 10.3748/wjg.v22.i2.582 Chemotherapy - Mayo Clinic, (n.d.). 〈https://www.mayoclinic.org/tests-procedures/chemotherapy/about/pac-20385033〉 (accessed March 3, 2023). Su, 2021, Novel nanomedicines to overcome canmulti-drugdrug resistance, Drug Resist. Updates, 58, 10.1016/j.drup.2021.100777 Pan, 2019, Polymeric co-delivery systems in cancer treatment: an overview on component drugs’ dosage ratio effect, Molecules, 24, 1035, 10.3390/molecules24061035 Ma, 2019, Fabrication of redox-responsive doxorubicin and paclitaxel prodrug nanoparticles with microfluidics for selective cancer therapy, Biomater. Sci., 7, 634, 10.1039/C8BM01333K Hayman, 2008, Capsaicin: a review of its pharmacology and clinical applications, Curr. Anaesth. Crit. Care, 19, 338, 10.1016/j.cacc.2008.07.003 Friedman, 2017, Capsaicin synergizes with camptothecin to induce increased apoptosis in human small cell lung cancers via the calpain pathway, Biochem Pharm., 129, 54, 10.1016/j.bcp.2017.01.004 Vendrely, 2017, Resveratrol and capsaicin used together as food complements reduce tumor growth and rescue full efficiency of low dose gemcitabine in a pancreatic cancer model, Cancer Lett., 390, 91, 10.1016/j.canlet.2017.01.002 Li, 2018, Capsaicin and piperine can overcome multi-drug resistance in cancer cells to doxorubicin, Molecules, 23 Lan, 2019, Co-delivery of paclitaxel by a capsaicin prodrug micelle facilitating for combination therapy on breast cancer, Mol. Pharm., 16, 3430, 10.1021/acs.molpharmaceut.9b00209 Al-Samydai, 2021, Preparation, characterization, and anti-cancer effects of capsaicin-loaded nanoliposomes, Nutrients, 13, 10.3390/nu13113995 Peng, 2014, Oral delivery of capsaicin using MPEG-PCL nanoparticles, Acta Pharmacol. Sin., 36, 139, 10.1038/aps.2014.113 Gao, 2011, Controlled intracellular release of doxorubicin in multidrug-resistant cancer cells by tuning the shell-pore sizes of mesoporous silica nanoparticles, ACS Nano, 5, 9788, 10.1021/nn2033105 Zhao, 2012, DNA origami delivery system for cancer therapy with tunable release properties, ACS Nano, 6, 8684, 10.1021/nn3022662 Keller, 2020, Challenges and perspectives of DNA nanostructures in biomedicine, Angew. Chem. Int. Ed., 59, 15818, 10.1002/anie.201916390 Zhu, 2013, Noncanonical self-assembly of multifunctional DNA nanoflowers for biomedical applications, J. Am. Chem. Soc., 135, 16438, 10.1021/ja406115e Zhao, 2018, Magnesium-stabilized multifunctional DNA nanoparticles for tumor-targeted and pH-responsive drug delivery, ACS Appl. Mater. Interfaces, 10, 15418, 10.1021/acsami.8b01932 Huang, 2017, A pure DNA hydrogel with stable catalytic ability produced by one-step rolling circle amplification, Chem. Commun., 53, 3038, 10.1039/C7CC00636E Yuhan, 2022, Cell-specific aptamers as potential drugs in therapeutic applications: a review of current progress, J. Control. Release, 346, 405, 10.1016/j.jconrel.2022.04.039 Bates, 2009, Discovery and development of the G-rich oligonucleotide AS1411 as a novel treatment for cancer, Exp. Mol. Pathol., 86, 151, 10.1016/j.yexmp.2009.01.004 Yazdian-Robati, 2020, Therapeutic applications of AS1411 aptamer, an updated review, Int J. Biol. Macromol., 155, 1420, 10.1016/j.ijbiomac.2019.11.118 Li, 2015, Targeted delivery of anti-cancer drugs by aptamer AS1411 mediated Pluronic F127/cyclodextrin-linked polymer composite micelles, Nanomedicine, 11, 175, 10.1016/j.nano.2014.08.013 Liao, 2015, An AS1411 aptamer-conjugated liposomal system containing a bubble-generating agent for tumor-specific chemotherapy that overcomulti-drugdrug resistance, J. Control Release, 208, 42, 10.1016/j.jconrel.2015.01.032 Y. Wu, R. Guo, S. Wen, M. Shen, … M.Z.-J. of M., undefined 2014, Folic acid-modified laponite nanodisks for targeted anti-cancer drug delivery, Pubs.Rsc.Org. (n.d.). 〈https://pubs.rsc.org/en/content/articlehtml/2014/tb/c4tb01162g〉 (accessed March 11, 2023). Kiaee, 2022, Laponite-based nanomaterials for drug delivery, Adv. Health Mater., 11, 10.1002/adhm.202102054 Zhao, 2018, Magnesium-stabilized multifunctional DNA nanoparticles for tumor-targeted and pH-responsive drug delivery, ACS Appl. Mater. Interfaces, 10, 15418, 10.1021/acsami.8b01932 Cheng, 2018, Self-assembled RNAi nanoflowers via rolling circle transcription for aptamer-targeted siRNA delivery, J. Mater. Chem. B, 6, 4638, 10.1039/C8TB00758F Lohlamoh, 2021, Anti-proliferative effect of doxorubicin-loaded AS1411 aptamer on colorectal cancer cell, Asian Pac. J. Cancer Prev., 22, 2209, 10.31557/APJCP.2021.22.7.2209 Li, 2018, Capsaicin and piperine can overcome multi-drug resistance in cancer cells to doxorubicin, Molecules, 23, 557, 10.3390/molecules23030557 Zhu, 2021, Exosomes mediated the delivery of ochratoxin A-induced cytotoxicity in HEK293 cells, Toxicology, 461, 10.1016/j.tox.2021.152926 Lee, 2012, Self-assembled RNA interference microsponges for efficient siRNA delivery, Nat. Mater., 11, 316, 10.1038/nmat3253 Mosafer, 2018, Cell surface nucleolin as a promising receptor for effective AS1411 aptamer-mediated targeted drug delivery into cancer cells, Curr. Drug Deliv., 15, 1323, 10.2174/1567201815666180724104451 Rosenberg, 2013, A phase II trial of AS1411 (a novel nucleolin-targeted DNA aptamer) in metastatic renal cell carcinoma, Investig. N. Drugs, 32, 178, 10.1007/s10637-013-0045-6 Krstin, 2015, Combining alkaloids affecting different molecular targets with the saponin digitonin can synergistically enhance trypanocidal activity against Trypanosoma brucei brucei, Antimicrob. Agents Chemother., 59, 7011, 10.1128/AAC.01315-15 Chen, 2021, p capsaicin inhibits proliferation and induces apoptosis in breast cancer by down-regulating fbi-1-mediated NF-κB pathway /p, Drug Des. Dev. Ther., 15, 125, 10.2147/DDDT.S269901 Arumugam, 2021, Synergistic effect of anethole and doxorubicin alleviates cell proliferation, cell cycle arrest, ER stress and promotes ROS-mediated apoptosis in triple-negative breast cancer cells, J. Biochem Mol. Toxicol., 35, 10.1002/jbt.22928 Su, 2019, Reactive oxygen species-induced lipid peroxidation in apoptosis, autophagy, and ferroptosis, Oxid. Med. Cell Longev., 2019, 10.1155/2019/5080843 Cieślar-Pobuda, 2017, ROS and oxidative stress in stem cells, Oxid. Med Cell Longev., 2017, 10.1155/2017/5047168 Liao, 2016, Dietary lipid concentration affects liver mitochondrial DNA copy number, gene expression and DNA methylation in large yellow croaker (Larimichthys crocea, Comp. Biochem. Physiol. B Biochem Mol. Biol., 193, 25, 10.1016/j.cbpb.2015.11.012 Dijk, 2020, Mitochondria as target to inhibit proliferation and induce apoptosis of cancer cells: the effects of doxycycline and gemcitabine, Sci. Rep., 10, 1, 10.1038/s41598-020-61381-9