Self-Assembled Multivalent Aptamer Nanoparticles with Potential CAR-like Characteristics Could Activate T Cells and Inhibit Melanoma Growth

Molecular Therapy - Oncolytics - Tập 17 - Trang 9-20 - 2020
Chenjun Bai1,2, Shanshan Gao2, Sai Hu2, Xuemei Liu1, Hui Li1, Jie Dong1, Aixue Huang1, Lingling Zhu1, Pingkun Zhou2, Shaohua Li1,3, Ningsheng Shao1
1Institute of Military Cognition and Brain Sciences, Beijing 100850, China
2Institute of Radiation Medicine, Beijing 100850, China
3The Fifth Medical Center of PLA General Hospital, Beijing, 100039, China

Tài liệu tham khảo

Sharma, 2011, Novel cancer immunotherapy agents with survival benefit: recent successes and next steps, Nat. Rev. Cancer, 11, 805, 10.1038/nrc3153 Chen, 2013, Molecular mechanisms of T cell co-stimulation and co-inhibition, Nat. Rev. Immunol., 13, 227, 10.1038/nri3405 Sharma, 2015, Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential, Cell, 161, 205, 10.1016/j.cell.2015.03.030 Kochenderfer, 2010, Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19, Blood, 116, 4099, 10.1182/blood-2010-04-281931 Porter, 2011, Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia, N. Engl. J. Med., 365, 725, 10.1056/NEJMoa1103849 Weijtens, 1996, Single chain Ig/gamma gene-redirected human T lymphocytes produce cytokines, specifically lyse tumor cells, and recycle lytic capacity, J. Immunol., 157, 836, 10.4049/jimmunol.157.2.836 Carpenito, 2009, Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains, Proc. Natl. Acad. Sci. USA, 106, 3360, 10.1073/pnas.0813101106 Pegram, 2012, Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning, Blood, 119, 4133, 10.1182/blood-2011-12-400044 June, 2015, Adoptive cellular therapy: a race to the finish line, Sci. Transl. Med., 7, 280ps7, 10.1126/scitranslmed.aaa3643 Kochenderfer, 2013, Treating B-cell cancer with T cells expressing anti-CD19 chimeric antigen receptors, Nat. Rev. Clin. Oncol., 10, 267, 10.1038/nrclinonc.2013.46 Mazzarella, 2014, Tales from the Jazz ASH: highlights from the 2013 American Society of Haematology meeting, Ecancermedicalscience, 8, 390 Grupp, 2013, Chimeric antigen receptor-modified T cells for acute lymphoid leukemia, N. Engl. J. Med., 368, 1509, 10.1056/NEJMoa1215134 Ellington, 1990, In vitro selection of RNA molecules that bind specific ligands, Nature, 346, 818, 10.1038/346818a0 Tuerk, 1990, Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase, Science, 249, 505, 10.1126/science.2200121 Groher, 2016, In vitro selection of antibiotic-binding aptamers, Methods, 106, 42, 10.1016/j.ymeth.2016.05.008 Bock, 1992, Selection of single-stranded DNA molecules that bind and inhibit human thrombin, Nature, 355, 564, 10.1038/355564a0 Lou, 2009, Micromagnetic selection of aptamers in microfluidic channels, Proc. Natl. Acad. Sci. USA, 106, 2989, 10.1073/pnas.0813135106 Shangguan, 2006, Aptamers evolved from live cells as effective molecular probes for cancer study, Proc. Natl. Acad. Sci. USA, 103, 11838, 10.1073/pnas.0602615103 Wang, 2003, Single-stranded DNA aptamers that bind differentiated but not parental cells: subtractive systematic evolution of ligands by exponential enrichment, J. Biotechnol., 102, 15, 10.1016/S0168-1656(02)00360-7 Li, 2009, Identification of an aptamer targeting hnRNP A1 by tissue slide-based SELEX, J. Pathol., 218, 327, 10.1002/path.2543 Röthlisberger, 2018, Aptamer chemistry, Adv. Drug Deliv. Rev., 134, 3, 10.1016/j.addr.2018.04.007 Han, 2013, In vitro selection of RNA aptamer specific to Salmonella typhimurium, J. Microbiol. Biotechnol., 23, 878, 10.4014/jmb.1212.12033 Liu, 2004, Screening of functional antidotes of RNA aptamers against bovine thrombin, FEBS Lett., 562, 125, 10.1016/S0014-5793(04)00197-8 Kaiser, 2006, Antivascular endothelial growth factor agents and their development: therapeutic implications in ocular diseases, Am. J. Ophthalmol., 142, 660, 10.1016/j.ajo.2006.05.061 Kraus, 1998, Cutting edge: novel RNA ligands able to bind CD4 antigen and inhibit CD4+ T lymphocyte function, J. Immunol., 160, 5209, 10.4049/jimmunol.160.11.5209 Wheeler, 2013, Durable knockdown and protection from HIV transmission in humanized mice treated with gel-formulated CD4 aptamer-siRNA chimeras, Mol. Ther., 21, 1378, 10.1038/mt.2013.77 Santulli-Marotto, 2003, Multivalent RNA aptamers that inhibit CTLA-4 and enhance tumor immunity, Cancer Res., 63, 7483 Pastor, 2013, CD28 aptamers as powerful immune response modulators, Mol. Ther. Nucleic Acids, 2, e98, 10.1038/mtna.2013.26 Dollins, 2008, Assembling OX40 aptamers on a molecular scaffold to create a receptor-activating aptamer, Chem. Biol., 15, 675, 10.1016/j.chembiol.2008.05.016 Prodeus, 2015, Targeting the PD-1/PD-L1 Immune Evasion Axis With DNA Aptamers as a Novel Therapeutic Strategy for the Treatment of Disseminated Cancers, Mol. Ther. Nucleic Acids, 4, e237, 10.1038/mtna.2015.11 Chauveau, 2007, Binding of an aptamer to the N-terminal fragment of VCAM-1, Bioorg. Med. Chem. Lett., 17, 6119, 10.1016/j.bmcl.2007.09.046 Jenison, 1998, Oligonucleotide inhibitors of P-selectin-dependent neutrophil-platelet adhesion, Antisense Nucleic Acid Drug Dev., 8, 265, 10.1089/oli.1.1998.8.265 Liu, 2010, Aptamer-based electrochemical biosensor for interferon gamma detection, Anal. Chem., 82, 8131, 10.1021/ac101409t Kang, 2008, Combinatorial selection of a single stranded DNA thioaptamer targeting TGF-beta1 protein, Bioorg. Med. Chem. Lett., 18, 1835, 10.1016/j.bmcl.2008.02.023 Boomer, 2005, Conjugation to polyethylene glycol polymer promotes aptamer biodistribution to healthy and inflamed tissues, Oligonucleotides, 15, 183, 10.1089/oli.2005.15.183 Shu, 2011, Thermodynamically stable RNA three-way junction for constructing multifunctional nanoparticles for delivery of therapeutics, Nat. Nanotechnol., 6, 658, 10.1038/nnano.2011.105 Levine, 2016, Global Manufacturing of CAR T Cell Therapy, Mol. Ther. Methods Clin. Dev., 4, 92, 10.1016/j.omtm.2016.12.006 Brentjens, 2010, Treatment of chronic lymphocytic leukemia with genetically targeted autologous T cells: case report of an unforeseen adverse event in a phase I clinical trial, Mol. Ther., 18, 666, 10.1038/mt.2010.31 Maude, 2018, Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia, N. Engl. J. Med., 378, 439, 10.1056/NEJMoa1709866 Morgan, 2010, Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2, Mol. Ther., 18, 843, 10.1038/mt.2010.24 Shimabukuro-Vornhagen, 2018, Cytokine release syndrome, J. Immunother. Cancer, 6, 56, 10.1186/s40425-018-0343-9 Rusconi, 2002, RNA aptamers as reversible antagonists of coagulation factor IXa, Nature, 419, 90, 10.1038/nature00963 Pastor, 2011, Targeting 4-1BB costimulation to disseminated tumor lesions with bi-specific oligonucleotide aptamers, Mol. Ther., 19, 1878, 10.1038/mt.2011.145 Boltz, 2011, Bi-specific aptamers mediating tumor cell lysis, J. Biol. Chem., 286, 21896, 10.1074/jbc.M111.238261 Im, 2016, Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy, Nature, 537, 417, 10.1038/nature19330 Kamphorst, 2017, Rescue of exhausted CD8 T cells by PD-1-targeted therapies is CD28-dependent, Science, 355, 1423, 10.1126/science.aaf0683 Gross, 2016, Therapeutic Potential of T Cell Chimeric Antigen Receptors (CARs) in Cancer Treatment: Counteracting Off-Tumor Toxicities for Safe CAR T Cell Therapy, Annu. Rev. Pharmacol. Toxicol., 56, 59, 10.1146/annurev-pharmtox-010814-124844 Mercier, 2017, Selection of Nucleic Acid Aptamers Targeting Tumor Cell-Surface Protein Biomarkers, Cancers (Basel), 9, E69, 10.3390/cancers9060069