Selective targeting of ASIC3 using artificial miRNAs inhibits primary and secondary hyperalgesia after muscle inflammation

Pain - Tập 152 - Trang 2348-2356 - 2011
Roxanne Y. Walder1,2, Mamta Gautam1,2, Steven P. Wilson3, Christopher J. Benson4, Kathleen A. Sluka1,2
1Physical Therapy and Rehabilitation Sciences Graduate Program, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, IA, USA
2Neuroscience Graduate Program, Pain Research Program, The University of Iowa, Iowa City, IA, USA
3Department of Pharmacology, Physiology, and Neuroscience, University of South Carolina School of Medicine, Columbia, SC, USA
4Department of Internal Medicine, Pain Research Program, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, IA, USA

Tài liệu tham khảo

Alvarez de la Rosa, 2003, Distribution, subcellular localization and ontogeny of ASIC1 in the mammalian central nervous system., J Physiol, 546, 77, 10.1113/jphysiol.2002.030692 Anesti, 2010, Delivery of RNA interference to peripheral neurons in vivo using herpes simplex virus., Methods Mol Biol, 617, 347, 10.1007/978-1-60327-323-7_26 Anesti, 2008, Efficient delivery of RNA interference to peripheral neurons in vivo using herpes simplex virus., Nucleic Acids Res, 36, e86, 10.1093/nar/gkn371 Benson, 2002, Heteromultimers of DEGENaC subunits form H-gated channels in mouse sensory neurons., Proc Natl Acad Sci USA, 99, 2338, 10.1073/pnas.032678399 Carnally, 2008, Direct visualization of the trimeric structure of the ASIC1a channel, using AFM imaging., Biochem Biophys Res Commun, 372, 752, 10.1016/j.bbrc.2008.05.100 Chen, 2002, A role for ASIC3 in the modulation of high-intensity pain stimuli., Proc Natl Acad Sci USA, 99, 8992, 10.1073/pnas.122245999 Deval, 2008, ASIC3, a sensor of acidic and primary inflammatory pain., EMBO J, 27, 3047, 10.1038/emboj.2008.213 Dube, 2009, Acid sensing ion channels and acid nociception., Curr Pharm Des, 15, 1750, 10.2174/138161209788186263 Dube, 2005, Electrophysiological and in vivo characterization of A-317567, a novel blocker of acid sensing ion channels., Pain, 117, 88, 10.1016/j.pain.2005.05.021 Elbashir, 2001, Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells., Nature, 411, 494, 10.1038/35078107 Eshcol, 2008, Acid-sensing ion channel 3 (ASIC3) cell surface expression is modulated by PSD-95 within lipid rafts., Am J Physiol Cell Physiol, 295, C732, 10.1152/ajpcell.00514.2007 Frey Law, 2008, Acidic buffer induced muscle pain evokes referred pain and mechanical hyperalgesia in humans., Pain, 140, 254, 10.1016/j.pain.2008.08.014 Geborek, 1989, Synovial fluid acidosis correlates with radiological joint destruction in rheumatoid arthritis knee joints., J Rheumatol, 16, 468 Gonzales, 2009, Pore architecture and ion sites in acid-sensing ion channels and P2X receptors., Nature, 460, 599, 10.1038/nature08218 Goss, 2009, HSV vector-mediated modification of primary nociceptor afferents: an approach to inhibit chronic pain., Gene Ther, 16, 493, 10.1038/gt.2009.24 Hattori, 2009, ASIC2a and ASIC3 heteromultimerize to form pH-sensitive channels in mouse cardiac dorsal root ganglia neurons., Circ Res, 105, 279, 10.1161/CIRCRESAHA.109.202036 Hesselager, 2004, PH Dependency and desensitization kinetics of heterologously expressed combinations of acid-sensing ion channel subunits., J Biol Chem, 279, 11006, 10.1074/jbc.M313507200 Hong, 2006, Herpes simplex virus RNAi and neprilysin gene transfer vectors reduce accumulation of Alzheimers disease-related amyloid-beta peptide in vivo., Gene Ther, 13, 1068, 10.1038/sj.gt.3302719 Hood, 1988, Effect of systemic pH on pHi and lactic acid generation in exhaustive forearm exercise., Am J Physiol, 255, F479 Ikeuchi, 2008, Role of ASIC3 in the primary and secondary hyperalgesia produced by joint inflammation in mice., Pain, 137, 662, 10.1016/j.pain.2008.01.020 Ikeuchi, 2009, Acid-sensing ion channel 3 expression in mouse knee joint afferents and effects of carrageenan-induced arthritis., J Pain, 10, 336, 10.1016/j.jpain.2008.10.010 Issberner, 1996, Pain due to tissue acidosis: a mechanism for inflammatory and ischemic myalgia?, Neurosci Lett, 208, 191, 10.1016/0304-3940(96)12576-3 Jasti, 2007, Structure of acid-sensing ion channel 1 at 1.9 A resolution and low pH., Nature, 449, 316, 10.1038/nature06163 Jones, 2004, Acid-induced pain and its modulation in humans., J Neurosci, 24, 10974, 10.1523/JNEUROSCI.2619-04.2004 Karczewski, 2010, Reversal of acid-induced and inflammatory pain by the selective ASIC3 inhibitor, APETx2., Br J Pharmacol, 161, 950, 10.1111/j.1476-5381.2010.00918.x Kolker, 2010, ASIC3 expressed in type B synoviocytes and chondrocytes modulates hyaluronan expression and release., Ann Rheum Dis, 69, 903, 10.1136/ard.2009.117168 Lingueglia, 2007, Acid-sensing ion channels in sensory perception., J Biol Chem, 282, 17325, 10.1074/jbc.R700011200 Lingueglia, 1997, A modulatory subunit of acid sensing ion channels in brain and dorsal root ganglion cells., J Biol Chem, 272, 29778, 10.1074/jbc.272.47.29778 Mense, 1993, Nociception from skeletal muscle in relation to clinical muscle pain., Pain, 54, 241, 10.1016/0304-3959(93)90027-M Mense, 1988, Spinal and supraspinal terminations of primary afferent fibers from the gastrocnemius-soleus muscle in the cat., Neuroscience, 26, 1023, 10.1016/0306-4522(88)90117-0 Mogil, 2005, Transgenic expression of a dominant-negative ASIC3 subunit leads to increased sensitivity to mechanical and inflammatory stimuli., J Neurosci, 25, 9893, 10.1523/JNEUROSCI.2019-05.2005 Molliver, 2005, ASIC3, an acid-sensing ion channel, is expressed in metaboreceptive sensory neurons., Mol Pain, 1, 35, 10.1186/1744-8069-1-35 Napoli, 1990, Introduction of a chimeric chalcone synthase gene into petunia results in reversible co-suppression of homologous genes in trans., Plant Cell, 2, 279, 10.2307/3869076 Nielsen, 2009, Neuron-specific RNA interference using lentiviral vectors., J Gene Med, 11, 559, 10.1002/jgm.1333 OBrien, 1989, Differences in the chemical expression of rat primary afferent neurons which innervate skin, muscle or joint., Neuroscience, 32, 493, 10.1016/0306-4522(89)90096-1 Ohtori, 2000, Fos expression in the rat brain and spinal cord evoked by noxious stimulation to low back muscle and skin., Spine, 25, 2425, 10.1097/00007632-200010010-00002 Olson, 1998, An acid sensing ion channel (ASIC) localizes to small primary afferent neurons in rats., Neuroreport, 9, 1109, 10.1097/00001756-199804200-00028 Pan, 1988, Intracellular pH in human skeletal muscle by 1H NMR., Proc Natl Acad Sci USA, 85, 7836, 10.1073/pnas.85.21.7836 Plenderleith, 1993, The plant lectin Bandeiraea simplicifolia I-B4 identifies a subpopulation of small diameter primary sensory neurones which innervate the skin in the rat., Neurosci Lett, 159, 17, 10.1016/0304-3940(93)90787-L Price, 2001, The DRASIC cation channel contributes to the detection of cutaneous touch and acid stimuli in mice., Neuron, 32, 1071, 10.1016/S0896-6273(01)00547-5 Reeh, 1996, Tissue acidosis in nociception and pain., Prog Brain Res, 113, 143, 10.1016/S0079-6123(08)61085-7 Schaible, 1993, Afferent and spinal mechanisms of joint pain., Pain, 55, 5, 10.1016/0304-3959(93)90183-P Shah, 2005, An in vivo microanalytical technique for measuring the local biochemical milieu of human skeletal muscle., J Appl Physiol, 99, 1977, 10.1152/japplphysiol.00419.2005 Skyba, 2002, Effects of NMDA and non-NMDA ionotropic glutamate receptor antagonists on the development and maintenance of hyperalgesia induced by repeated intramuscular injection of acidic saline., Pain, 98, 69, 10.1016/S0304-3959(01)00471-7 Skyba, 2005, Excitatory amino acid concentrations increase in the spinal cord dorsal horn after repeated intramuscular injection of acidic saline., Pain, 119, 142, 10.1016/j.pain.2005.09.025 Sluka, 2002, Stimulation of deep somatic tissue with capsaicin produces long-lasting mechanical allodynia and heat hypoalgesia that depends on early activation of the cAMP pathway., J Neurosci, 22, 5687, 10.1523/JNEUROSCI.22-13-05687.2002 Sluka, 2001, Unilateral intramuscular injections of acidic saline produce a bilateral, long-lasting hyperalgesia., Muscle Nerve, 24, 37, 10.1002/1097-4598(200101)24:1<37::AID-MUS4>3.0.CO;2-8 Sluka, 2003, Chronic hyperalgesia induced by repeated acid injections in muscle is abolished by the loss of ASIC3, but not ASIC1., Pain, 106, 229, 10.1016/S0304-3959(03)00269-0 Sluka, 2007, ASIC3 in muscle mediates mechanical, but not heat, hyperalgesia associated with muscle inflammation., Pain, 129, 102, 10.1016/j.pain.2006.09.038 Sluka, 2009, Acid-sensing ion channels: a new target for pain and CNS diseases., Curr Opin Drug Discov Dev, 12, 693 Staniland, 2009, Mice lacking acid-sensing ion channels (ASIC) 1 or 2, but not ASIC3, show increased pain behaviour in the formalin test., Eur J Pain, 13, 554, 10.1016/j.ejpain.2008.07.001 Steen, 1993, Sustained graded pain and hyperalgesia from harmless experimental tissue acidosis in human skin., Neurosci Lett, 154, 113, 10.1016/0304-3940(93)90184-M Stegmeier, 2005, A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells., Proc Natl Acad Sci USA, 102, 13212, 10.1073/pnas.0506306102 Sutherland, 2001, Acid-sensing ion channel 3 matches the acid-gated current in cardiac ischemia-sensing neurons., Proc Natl Acad Sci USA, 98, 711, 10.1073/pnas.98.2.711 Sutherland, 2000, Chemical mediators of pain due to tissue damage and ischemia., Prog Brain Res, 129, 21, 10.1016/S0079-6123(00)29003-1 Ugawa, 2002, Amiloride-blockable acid-sensing ion channels are leading acid sensors expressed in human nociceptors., J Clin Invest, 110, 1185, 10.1172/JCI0215709 van der Krol, 1990, Flavonoid genes in petunia: addition of a limited number of gene copies may lead to a suppression of gene expression., Plant Cell, 2, 291 Walder, 2010, ASIC1 and ASIC3 play different roles in the development of hyperalgesia after inflammatory muscle injury., J Pain, 11, 210, 10.1016/j.jpain.2009.07.004 Waldmann, 1997, Molecular cloning of a non-inactivating proton-gated Na channel specific for sensory neurons., J Biol Chem, 272, 20975, 10.1074/jbc.272.34.20975 Waldmann, 1997, A proton-gated cation channel involved in acid-sensing., Nature, 386, 173, 10.1038/386173a0 Wall, 1984, Muscle but not cutaneous C-afferent input produces prolonged increases in the excitability of the flexion reflex in the rat., J Physiol, 356, 443, 10.1113/jphysiol.1984.sp015475 Wemmie, 2006, Acid-sensing ion channels: advances, questions and therapeutic opportunities., Trends Neurosci, 29, 578, 10.1016/j.tins.2006.06.014 Woolf, 1986, Relative effectiveness of C primary afferent fibers of different origins in evoking a prolonged facilitation of the flexor reflex in the rat., J Neurosci, 6, 1433, 10.1523/JNEUROSCI.06-05-01433.1986 Xie, 2002, DRASIC contributes to pH-gated currents in large dorsal root ganglion sensory neurons by forming heteromultimeric channels., J Neurophysiol, 87, 2835, 10.1152/jn.2002.87.6.2835 Yen, 2009, Role of acid-sensing ion channel 3 in sub-acute-phase inflammation., Mol Pain, 5, 1, 10.1186/1744-8069-5-1 Zhang, 2008, Enhanced peripheral analgesia using virally mediated gene transfer of the mu-opioid receptor in mice., Anesthesiology, 108, 305, 10.1097/01.anes.0000299836.61785.79