Selective glucocorticoid receptor agonists (SEGRAs): Novel ligands with an improved therapeutic index
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Adams, 2003, Homodimerization of the glucocorticoid receptor is not essential for response element binding: activation of the phenylethanolamine N-methyltransferase gene by dimerization-defective mutants, Mol. Endocrinol., 17, 2583, 10.1210/me.2002-0305
Barker, 2006, Dissociated nonsteroidal glucocorticoid receptor modulators; discovery of the agonist trigger in a tetrahydronaphthalene-benzoxazine series, J. Med. Chem., 49, 4216, 10.1021/jm060302x
Belvisi, 2001, Therapeutic benefit of a dissociated glucocorticoid and the relevance of in vitro separation of transrepression from transactivation activity, J. Immunol., 166, 1975, 10.4049/jimmunol.166.3.1975
Berrebi, 2003, Synthesis of glucocorticoid-induced leucine zipper (GILZ) by macrophages: an anti-inflammatory and immunosuppressive mechanism shared by glucocorticoids and IL-10, Blood, 101, 729, 10.1182/blood-2002-02-0538
Bladh, 2005, Identification of endogenous glucocorticoid repressed genes differentially regulated by a glucocorticoid receptor mutant able to separate between nuclear factor-kappaB and activator protein-1 repression, Mol. Pharmacol., 67, 815, 10.1124/mol.104.005801
Bodor, 2006, Corticosteroid design for the treatment of asthma: structural insights and the therapeutic potential of soft corticosteroids, Curr. Pharm. Des., 12, 3241, 10.2174/138161206778194132
Braddock, 2007, Advances in anti-inflammatory therapeutics: 20–21 November 2006, London, UK, Expert Opin. Investig. Drugs, 16, 257, 10.1517/13543784.16.2.257
Bruna, 2003, Glucocorticoid receptor-JNK interaction mediates inhibition of the JNK pathway by glucocorticoids, EMBO J., 22, 6035, 10.1093/emboj/cdg590
Caelles, 1997, Nuclear hormone receptor antagonism with AP-1 by inhibition of the JNK pathway, Genes Dev., 11, 3351, 10.1101/gad.11.24.3351
Calandra, 1995, MIF as a glucocorticoid-induced modulator of cytokine production, Nature, 377, 68, 10.1038/377068a0
Cato, 2004, The glucocorticoid receptor as target for classic and novel anti-inflammatory therapy, Curr. Drug Target Inflamm. Allergy, 3, 347, 10.2174/1568010042634479
Chono, 2005, Efficient drug delivery to atherosclerotic lesions and the antiatherosclerotic effect by dexamethasone incorporated into liposomes in atherogenic mice, J. Drug Target, 13, 267, 10.1080/10611860500159030
Clark, 2003, MAP kinase phosphatase 1: a novel mediator of biological effects of glucocorticoids?, J. Endocrinol., 178, 5, 10.1677/joe.0.1780005
Coghlan, 2003, The pursuit of differentiated ligands for the glucocorticoid receptor, Curr. Top. Med. Chem., 3, 1617, 10.2174/1568026033451718
Coghlan, 2003, A novel anti-inflammatory maintains glucocorticoid efficacy with reduced side effects, Mol. Endocrinol., 17, 860, 10.1210/me.2002-0355
De Bosscher, 2005, A fully dissociated compound of plant origin for inflammatory gene repression, Proc. Natl. Acad. Sci. U.S.A., 102, 15827, 10.1073/pnas.0505554102
Doggrell, 2005, The nitrosterols—a step forward from the steroid anti-inflammatory drugs?, Expert Opin. Invest. Drugs, 14, 823, 10.1517/13543784.14.7.823
Dostert, 2004, Negative glucocorticoid receptor response elements and their role in glucocorticoid action, Curr. Pharm. Des., 10, 2807, 10.2174/1381612043383601
Elmore, 2004, Differentiation of in vitro transcriptional repression and activation profiles of selective glucocorticoid receptor modulators, Bioorg. Med. Chem. Lett., 14, 1721, 10.1016/j.bmcl.2004.01.044
Feige, J.N., Auwerx, J., 2007. Transcriptional coregulators in the control of energy homeostasis. Trends in Cell Biol. [Epub ahead of print].
Günther, 1998, Percutaneous absorption of methylprednisolone aceponate following topical application of Advantan® lotion on intact, inflamed and stripped skin of male volunteers, Skin Pharmacol. Appl. Skin Physiol., 11, 35, 10.1159/000029806
Hamdi, 2007, Induction of antigen-specific regulatory T lymphocytes by human dendritic cells expressing the glucocorticoid-induced leucine zipper, Blood, 110, 211, 10.1182/blood-2006-10-052506
Heck, 1994, A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription of AP-1, EMBO J., 13, 4087, 10.1002/j.1460-2075.1994.tb06726.x
Hench, 1949, Effect of hormone of adrenal cortex (17-hydroxy-11-dehydrocorticosterone: compound E) and of pituitary adrenocorticotropic hormone on rheumatoid arthritis: preliminary report, Proc. Staff Meet., Mayo Clin., 24, 181
Hench, 1950, Effects of cortisone acetate and pituitary ACTH on rheumatoid arthritis, rheumatic fever and certain other conditions, Arch. Med. Interna, 85, 545, 10.1001/archinte.1950.00230100002001
Hengge, 2006, Adverse effects of topical glucocorticosteroids, J. Am. Acad. Dermatol., 54, 1, 10.1016/j.jaad.2005.01.010
Högger, 2003, Current concepts for optimizing the therapeutic index of glucocorticoid receptor ligands for oral inhalative use: basic considerations and clinical reality, Curr. Med. Chem., 2, 395
Humphrey, 2006, Effects of dissociated glucocorticoids on OPG and RANKL in osteoblastic cells, Bone, 38, 652, 10.1016/j.bone.2005.10.004
Hyun, 2004, Anti-inflammatory effects of nitric oxide-releasing hydrocortisone NCX 1022, in a murine model of contact dermatis, Br. J. Pharmacol., 143, 618, 10.1038/sj.bjp.0705854
Ito, 2000, Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1β-induced histone H4 acetylation on lysines 8 and 12, Mol. Cell. Biol., 20, 6891, 10.1128/MCB.20.18.6891-6903.2000
Ito, 2001, p65-Activated histone acetyltransferase activity is repressed by glucocorticoids: mifepristone fails to recruit HDAC2 to the p65-HAT complex, J. Biol. Chem., 276, 30208, 10.1074/jbc.M103604200
Kassel, 2001, Glucocorticoids inhibit MAP kinase via increased expression and decreased degradation of MKP-1, EMBO J., 20, 7108, 10.1093/emboj/20.24.7108
Lasa, 2002, Dexamethasone causes sustained expression of mitogen-activated protein kinase (MAPK) phosphatase 1 and phosphatase-mediated inhibition of MAPK p38, Mol. Cell. Biol., 22, 7802, 10.1128/MCB.22.22.7802-7811.2002
Lefstin, 1998, Allosteric effects of DNA on transcriptional regulators, Nature, 392, 885, 10.1038/31860
Marshall, 2007, Alpha-methyltryptamin sulphonamide derivatives as novel glucocorticoid receptor ligands, Bioorg. Med. Chem. Lett., 17, 315, 10.1016/j.bmcl.2006.10.058
Mason, 1936, The chemistry of crystalline substances isolated from the suprarenal gland, J. Biol. Chem., 114, 613, 10.1016/S0021-9258(18)74790-X
Mason, 1936, Chemical studies of the suprarenal cortex. II. The definition of a substance which possesses the qualitative action of cortin; its conversion into a diketone closely related to androstenedione, J. Biol. Chem., 116, 267, 10.1016/S0021-9258(18)74681-4
Metselaar, 2004, Liposomal targeting of glucocorticoids to synovial linig cells strongly increases therapeutic benefit in collagen type II induced arthritis, Ann. Rheum. Dis., 63, 348, 10.1136/ard.2003.009944
Meyer, 1997, Glucocorticoid-dependent transcriptional repression of the osteocalcin gene by competitive binding at the TATA box, DNA Cell. Biol., 16, 919, 10.1089/dna.1997.16.919
Mills, 1993, Side effects of topical glucocorticoids, Curr. Probl. Dermatol., 21, 122, 10.1159/000422371
Miner, 2005, New and improved glucocorticoid receptor ligands, Expert Opin. Invest. Drugs, 14, 1527, 10.1517/13543784.14.12.1527
Mizuno, 1997, Glucocorticoid induced the expression of mRNA and the secretion of lipocortin 1 in rat astrocytoma cells, Brain Res., 764, 256, 10.1016/S0006-8993(96)01259-0
Mohler, 2007, Dissociated non-steroidal glucocorticoids: tuning out untoward effects, Expert Opin. Ther. Patents, 17, 37, 10.1517/13543776.17.1.37
Morimoto, 2002, Dynamic remodeling of transcription complexes by molecular chaperones, Cell, 110, 281, 10.1016/S0092-8674(02)00860-7
Nissen, 2000, The glucocorticoid receptor inhibits NF-kappaB by interfering with serine-2 phosphorylation of RNA polymerase II carboxy-terminal domain, Genes Dev., 18, 2314, 10.1101/gad.827900
O’Connell, 2003, Review of the unique properties of budesonide, Clin. Ther., 25, C42, 10.1016/S0149-2918(03)80305-3
Ogawa, 2005, Molecular determinants of crosstalk between nuclear receptors and toll-like receptors, Cell, 122, 707, 10.1016/j.cell.2005.06.029
Owen, 2007, The growth plate sparing effects of the selective glucocorticoid receptor modulator AL-438, Mol. Cell. Endocrinol., 264, 164, 10.1016/j.mce.2006.11.006
Philips, 1997, Antagonism between Nurr77 and glucocorticoid receptor for control of transcription, Mol. Cell. Biol., 17, 5952, 10.1128/MCB.17.10.5952
Reichardt, 1998, DNA binding of the glucocorticoid receptor is not essential for survival, Cell, 93, 531, 10.1016/S0092-8674(00)81183-6
Reichardt, 2001, Repression of inflammatory responses in the absence of DNA binding by the glucocorticoid receptor, EMBO J., 20, 7168, 10.1093/emboj/20.24.7168
Reily, 2006, The GRIP1:IRF3 interaction as a target for glucocorticoid receptor-mediated immunosuppression, EMBO J., 25, 108, 10.1038/sj.emboj.7600919
Rogatsky, 2001, Factor recruitment and TIF2/GRIP1 corepressor activity at a collagenase-3 response element that mediates regulation by phorbol esters and hormones, EMBO J., 20, 6071, 10.1093/emboj/20.21.6071
Rogatsky, 2003, Drug discovery for inflammatory diseases, Expert Opin. Biol. Ther., 3, 1001, 10.1517/14712598.3.6.1001
Rogatsky, 2003, Target-specific utilization of transcriptional regulatory surfaces by the glucocorticoid receptor, Proc. Natl. Acad. Sci., 100, 13845, 10.1073/pnas.2336092100
Rogatsky, 2006, Glucocorticoid modulation of cytokine signalling, Tissue Antigens, 68, 1, 10.1111/j.1399-0039.2006.00599.x
Schäcke, 2002, Mechanisms involved in the side effects of glucocorticoids, Pharmacol. Ther., 96, 23, 10.1016/S0163-7258(02)00297-8
Schäcke, 2004, Dissociation of transactivation from transrepression by a selective glucocorticoid receptor agonist leads to separation of therapeutic effects from side effects, Proc. Natl. Acad. Sci. U.S.A., 101, 227, 10.1073/pnas.0300372101
Schäcke, 2005, Dissociated glucocorticoid receptor ligands: compounds with an improved therapeutic index, Curr. Opin. Invest. Drugs, 6, 503
Schulz, 2004, Novel ligands: fine tuning the transcriptional activity of the glucocorticoid receptor, Curr. Pharm. Des., 10, 2826, 10.2174/1381612043383610
Shah, 2004, Design and evaluation of novel nonsteroidal dissociating glucocorticoid receptor ligands, Bioorg. Med. Chem. Lett., 14, 5199, 10.1016/j.bmcl.2004.07.052
Stocklin, 1996, Functional interactions between Stat5 and the glucocorticoid receptor, Nature, 383, 726, 10.1038/383726a0
Teshima, 2006, Prolonged blood concentration of prednisolone after intravenous injection of liposomal palimtoyl prednisolone, J. Control. Release, 112, 320, 10.1016/j.jconrel.2006.03.004
Thompson, 2005, Novel heterocyclic glucocorticoids: in vitro profile and in vivo efficacy, Bioorg. Med. Chem. Lett., 15, 2163, 10.1016/j.bmcl.2005.02.009
Tronche, 2004, Glucocorticoid receptor function in hepatocytes is essential to promote postnatal body growth, Genes Dev., 18, 492, 10.1101/gad.284704
Tuckermann, 1999, The DNA binding-independent function of the glucocorticoid receptor mediates repression of AP-1-dependent genes in skin, J. Cell. Biol., 147, 1365, 10.1083/jcb.147.7.1365
Tuckermann, J., Schilling, A.F., Kleyman, A., Priemel, M., Stride, B., Kirilov, M., Amling, M, Schütz, G., 2006. Glucocorticoid induced osteoporosis requires the glucocorticoid receptor in osteoblasts and does not depend on DNA binding of the receptor. Abstract Keystone Symposium Nuclear Receptors: Steroids Sisters.
Vanden Berghe, 2002, 233
Wärnmark, 2003, Activation functions 1 and 2 of nuclear receptors: molecular strategies for transcriptional activation, Mol. Endocrinol., 17, 1901, 10.1210/me.2002-0384
Welker, 1996, Glucocorticoid-induced modulation of cytokine secretion from normal and leukemic human myelomonocytic cells, Int. Arch. Allergy Immunol., 109, 110, 10.1159/000237208
Xu, 2002, Molecular and cellular biology of steroid receptor coactivator (SRC) family in steroid receptor function, Rev. Endocr. Metab. Disord., 3, 185, 10.1023/A:1020016208071
Young, 1999, Thymosin beta 4 sulfoxide is an anti-inflammatory agent generated by monocytes in the presence of glucocorticoids, Nat. Med., 5, 1424, 10.1038/71002