Selective and Specific Inhibition of the Plasmodium falciparum Lysyl-tRNA Synthetase by the Fungal Secondary Metabolite Cladosporin

Anke, 1979, Metabolic products of microorganisms. 184. On the mode of action of cladosporin, J. Antibiot. (Tokyo), 32, 952, 10.7164/antibiotics.32.952

Burrows, 2011, The state of the art in anti-malarial drug discovery and development, Curr. Top. Med. Chem., 11, 1226, 10.2174/156802611795429194

Dharia, 2009, Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum, Genome Biol., 10, R21, 10.1186/gb-2009-10-2-r21

Eastman, 2009, Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria, Nat. Rev. Microbiol., 7, 864, 10.1038/nrmicro2239

Gamo, 2010, Thousands of chemical starting points for antimalarial lead identification, Nature, 465, 305, 10.1038/nature09107

Gelperin, 2005, Biochemical and genetic analysis of the yeast proteome with a movable ORF collection, Genes Dev., 19, 2816, 10.1101/gad.1362105

Giaever, 1999, Genomic profiling of drug sensitivities via induced haploinsufficiency, Nat. Genet., 21, 278, 10.1038/6791

Giaever, 2002, Functional profiling of the Saccharomyces cerevisiae genome, Nature, 418, 387, 10.1038/nature00935

Goodman, 2007, The effects of anti-bacterials on the malaria parasite Plasmodium falciparum, Mol. Biochem. Parasitol., 152, 181, 10.1016/j.molbiopara.2007.01.005

Grove, 1981, The insecticidal activity of some fungal dihydroisocoumarins, Mycopathologia, 76, 65, 10.1007/BF00443751

Guiguemde, 2010, Chemical genetics of Plasmodium falciparum, Nature, 465, 311, 10.1038/nature09099

Guo, 2008, Crystal structure of tetrameric form of human lysyl-tRNA synthetase: implications for multisynthetase complex formation, Proc. Natl. Acad. Sci. USA, 105, 2331, 10.1073/pnas.0712072105

Hughes, 1980, Interaction of pseudomonic acid A with Escherichia coli B isoleucyl-tRNA synthetase, Biochem. J., 191, 209, 10.1042/bj1910209

Hurdle, 2005, Prospects for aminoacyl-tRNA synthetase inhibitors as new antimicrobial agents, Antimicrob. Agents Chemother., 49, 4821, 10.1128/AAC.49.12.4821-4833.2005

Istvan, 2011, Validation of isoleucine utilization targets in Plasmodium falciparum, Proc. Natl. Acad. Sci. USA, 108, 1627, 10.1073/pnas.1011560108

Kato, 2008, Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility, Nat. Chem. Biol., 4, 347, 10.1038/nchembio.87

Knockaert, 2000, Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilised inhibitors, Chem. Biol., 7, 411, 10.1016/S1074-5521(00)00124-1

McNamara, 2011, Target identification and validation of novel antimalarials, Future Microbiol., 6, 693, 10.2217/fmb.11.45

Meister, 2011, Exploring Plasmodium hepatic stages to find next-generation antimalarial drugs, Science, 334, 1372, 10.1126/science.1211936

Miller, 2010, Inflammation-associated gene transcription and expression in mouse lungs induced by low molecular weight compounds from fungi from the built environment, Chem. Biol. Interact., 183, 113, 10.1016/j.cbi.2009.09.023

Mirande, 1988, The yeast lysyl-tRNA synthetase gene. Evidence for general amino acid control of its expression and domain structure of the encoded protein, J. Biol. Chem., 263, 18443, 10.1016/S0021-9258(19)81378-9

Nam, 2011, A chemical genomic analysis of decoquinate, a plasmodium falciparum cytochrome b inhibitor, ACS Chem. Biol., 6, 1214, 10.1021/cb200105d

Park, 2005, Human lysyl-tRNA synthetase is secreted to trigger proinflammatory response, Proc. Natl. Acad. Sci. USA, 102, 6356, 10.1073/pnas.0500226102

Park, 2010, Aminoacyl-tRNA synthetase-interacting multifunctional proteins (AIMPs): a triad for cellular homeostasis, IUBMB Life, 62, 296, 10.1002/iub.324

Pierce, 2007, Genome-wide analysis of barcoded Saccharomyces cerevisiae gene-deletion mutants in pooled cultures, Nat. Protoc., 2, 2958, 10.1038/nprot.2007.427

Plouffe, 2008, In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen, Proc. Natl. Acad. Sci. USA, 105, 9059, 10.1073/pnas.0802982105

Rock, 2007, An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site, Science, 316, 1759, 10.1126/science.1142189

Rottmann, 2010, Spiroindolones, a potent compound class for the treatment of malaria, Science, 329, 1175, 10.1126/science.1193225

Sakurama, 2009, Two crystal structures of lysyl-tRNA synthetase from Bacillus stearothermophilus in complex with lysyladenylate-like compounds: insights into the irreversible formation of the enzyme-bound adenylate of L-lysine hydroxamate, J. Biochem., 145, 555, 10.1093/jb/mvp014

Scott, 1971, Cladosporin, a new antifungal metabolite from Cladosporium cladosporioides, J. Antibiot. (Tokyo), 24, 747, 10.7164/antibiotics.24.747

Sheng, 2011, New lead structures in antifungal drug discovery, Curr. Med. Chem., 18, 733, 10.2174/092986711794480113

Shibata, 2011, Selective inhibitors of methionyl-tRNA synthetase have potent activity against Trypanosoma brucei infection in mice, Antimicrob. Agents Chemother., 55, 1982, 10.1128/AAC.01796-10

Sidhu, 2007, In vitro efficacy, resistance selection, and structural modeling studies implicate the malarial parasite apicoplast as the target of azithromycin, J. Biol. Chem., 282, 2494, 10.1074/jbc.M608615200

Springer, 1981, Plant growth regulatory effects and stereochemistry of cladosporin, J. Agric. Food Chem., 29, 853, 10.1021/jf00106a044

2010

Winzeler, 1999, Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis, Science, 285, 901, 10.1126/science.285.5429.901