Selective Stimulation of VEGFR2 Accelerates Progressive Renal Disease

The American Journal of Pathology - Tập 179 - Trang 155-166 - 2011
Waichi Sato1, Katsuyuki Tanabe2, Tomoki Kosugi1,2, Kelly Hudkins3, Miguel A. Lanaspa1, Li Zhang4, Martha Campbell-Thompson4, Qiuhong Li5, David A. Long6, Charles E. Alpers3, Takahiko Nakagawa1,2
1Division of Nephrology, University of Florida, Gainesville, Florida
2Division of Renal Disease and Hypertension, University of Colorado, Denver, Aurora, Colorado
3Department of Pathology, University of Washington, Seattle, Washington
4Molecular Pathology and Immunology Core Laboratory, University of Florida, Gainesville, Florida
5Department of Ophthalmology, University of Florida, Gainesville, Florida
6Nephro-Urology Unit, University College London Institute of Child Health, University College London, London, United Kingdom

Tài liệu tham khảo

Kang, 2001, Impaired angiogenesis in the aging kidney: vascular endothelial growth factor and thrombospondin-1 in renal disease, Am J Kidney Dis, 37, 601, 10.1053/ajkd.2001.22087 Kang, 2001, Impaired angiogenesis in the remnant kidney model: I, J Am Soc Nephrol, 12, 1434, 10.1681/ASN.V1271434 Suga, 2001, Vascular endothelial growth factor (VEGF121) protects rats from renal infarction in thrombotic microangiopathy, Kidney Int, 60, 1297, 10.1046/j.1523-1755.2001.00935.x Kang, 2001, Impaired angiogenesis in the remnant kidney model: II, J Am Soc Nephrol, 12, 1448, 10.1681/ASN.V1271448 Yuan, 2003, Peritubular capillary loss after mouse acute nephrotoxicity correlates with down-regulation of vascular endothelial growth factor-A and hypoxia-inducible factor-1 alpha, Am J Pathol, 163, 2289, 10.1016/S0002-9440(10)63586-9 Kim, 2000, Vascular endothelial growth factor accelerates renal recovery in experimental thrombotic microangiopathy, Kidney Int, 58, 2390, 10.1046/j.1523-1755.2000.00422.x Shimizu, 2004, Vascular endothelial growth factor165 resolves glomerular inflammation and accelerates glomerular capillary repair in rat anti-glomerular basement membrane glomerulonephritis, J Am Soc Nephrol, 15, 2655, 10.1097/01.ASN.0000141038.28733.F2 de Vriese, 2001, Antibodies against vascular endothelial growth factor improve early renal dysfunction in experimental diabetes, J Am Soc Nephrol, 12, 993, 10.1681/ASN.V125993 Flyvbjerg, 2002, Amelioration of long-term renal changes in obese type 2 diabetic mice by a neutralizing vascular endothelial growth factor antibody, Diabetes, 51, 3090, 10.2337/diabetes.51.10.3090 Nakagawa, 2006, Uncoupling of vascular endothelial growth factor with nitric oxide as a mechanism for diabetic vasculopathy, J Am Soc Nephrol, 17, 736, 10.1681/ASN.2005070759 Sato, 2008, The pivotal role of VEGF on glomerular macrophage infiltration in advanced diabetic nephropathy, Lab Invest, 88, 949, 10.1038/labinvest.2008.60 Barleon, 1996, Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1, Blood, 87, 3336, 10.1182/blood.V87.8.3336.bloodjournal8783336 Shih, 2003, Selective stimulation of VEGFR-1 prevents oxygen-induced retinal vascular degeneration in retinopathy of prematurity, J Clin Invest, 112, 50, 10.1172/JCI17808 Fong, 1995, Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium, Nature, 376, 66, 10.1038/376066a0 Kiba, 2003, VEGFR-2-specific ligand VEGF-E induces non-edematous hyper-vascularization in mice, Biochem Biophys Res Commun, 301, 371, 10.1016/S0006-291X(02)03033-4 Li, 2002, KDR (VEGF receptor 2) is the major mediator for the hypotensive effect of VEGF, Hypertension, 39, 1095, 10.1161/01.HYP.0000018588.56950.7A Cooper, 1999, Increased renal expression of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 in experimental diabetes, Diabetes, 48, 2229, 10.2337/diabetes.48.11.2229 Nakagawa, 2007, Uncoupling of the VEGF-endothelial nitric oxide axis in diabetic nephropathy: an explanation for the paradoxical effects of VEGF in renal disease, Am J Physiol Renal Physiol, 292, F1665, 10.1152/ajprenal.00495.2006 Nakagawa, 2009, Abnormal angiogenesis in diabetic nephropathy, Diabetes, 58, 1471, 10.2337/db09-0119 Li, 2000, Receptor-selective variants of human vascular endothelial growth factor, J Biol Chem, 275, 29823, 10.1074/jbc.M002015200 Gerber, 1998, Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway, J Biol Chem, 273, 30336, 10.1074/jbc.273.46.30336 Gille, 2001, Analysis of biological effects and signaling properties of Flt-1 (VEGFR-1) and KDR (VEGFR-2), J Biol Chem, 276, 3222, 10.1074/jbc.M002016200 Mu, 2009, Angiostatin overexpression is associated with an improvement in chronic kidney injury by an anti-inflammatory mechanism, Am J Physiol Renal Physiol, 296, F145, 10.1152/ajprenal.90430.2008 Nakagawa, 2007, Diabetic eNOS knockout mice develop advanced diabetic nephropathy, J Am Soc Nephrol, 18, 539, 10.1681/ASN.2006050459 Masaki, 2003, Heterogeneity of antigen expression explains controversy over glomerular macrophage accumulation in mouse glomerulonephritis, Nephrol Dial Transplant, 18, 178, 10.1093/ndt/18.1.178 Yuzawa, 1993, Antibody-mediated redistribution and shedding of endothelial antigens in the rabbit, J Immunol, 150, 5633, 10.4049/jimmunol.150.12.5633 Roberts, 2009, The Oxford classification of IgA nephropathy: pathology definitions, correlations, and reproducibility, Kidney Int, 76, 546, 10.1038/ki.2009.168 Nakayama, 2010, Endothelial von Willebrand factor release due to eNOS deficiency predisposes to thrombotic microangiopathy in mouse aging kidney, Am J Pathol, 176, 2198, 10.2353/ajpath.2010.090316 Wu, 2000, Utilization of distinct signaling pathways by receptors for vascular endothelial cell growth factor and other mitogens in the induction of endothelial cell proliferation, J Biol Chem, 275, 5096, 10.1074/jbc.275.7.5096 Flyvbjerg, 2002, Compensatory glomerular growth after unilateral nephrectomy is VEGF dependent, Am J Physiol Endocrinol Metab, 283, E362, 10.1152/ajpendo.00007.2002 Senthil, 2003, Vascular endothelial growth factor induces protein synthesis in renal epithelial cells: a potential role in diabetic nephropathy, Kidney Int, 64, 468, 10.1046/j.1523-1755.2003.00135.x Facemire, 2009, Vascular endothelial growth factor receptor 2 controls blood pressure by regulating nitric oxide synthase expression, Hypertension, 54, 652, 10.1161/HYPERTENSIONAHA.109.129973 Iatropoulos, 1996, Proliferation markers, Exp Toxicol Pathol, 48, 175, 10.1016/S0940-2993(96)80039-X Ohashi, 2002, Peritubular capillary regression during the progression of experimental obstructive nephropathy, J Am Soc Nephrol, 13, 1795, 10.1097/01.ASN.0000018408.51388.57 Floege, 2008, A new look at platelet-derived growth factor in renal disease, J Am Soc Nephrol, 19, 12, 10.1681/ASN.2007050532 Eremina, 2006, Vascular endothelial growth factor a signaling in the podocyte-endothelial compartment is required for mesangial cell migration and survival, J Am Soc Nephrol, 17, 724, 10.1681/ASN.2005080810 Thomas, 2000, Vascular endothelial growth factor receptors in human mesangium in vitro and in glomerular disease, J Am Soc Nephrol, 11, 1236, 10.1681/ASN.V1171236 Pettersson, 2000, Heterogeneity of the angiogenic response induced in different normal adult tissues by vascular permeability factor/vascular endothelial growth factor, Lab Invest, 80, 99, 10.1038/labinvest.3780013 Kremer, 1997, Up-regulation of flk-1/vascular endothelial growth factor receptor 2 by its ligand in a cerebral slice culture system, Cancer Res, 57, 3852 Hudkins, 2004, Exogenous PDGF-D is a potent mesangial cell mitogen and causes a severe mesangial proliferative glomerulopathy, J Am Soc Nephrol, 15, 286, 10.1097/01.ASN.0000108522.79652.63 Hakroush, 2009, Effects of increased renal tubular vascular endothelial growth factor (VEGF) on fibrosis, cyst formation, and glomerular disease, Am J Pathol, 175, 1883, 10.2353/ajpath.2009.080792 Ball, 2007, Vascular endothelial growth factor can signal through platelet-derived growth factor receptors, J Cell Biol, 177, 489, 10.1083/jcb.200608093 Veron, 2010, Overexpression of VEGF-A in podocytes of adult mice causes glomerular disease, Kidney Int, 77, 989, 10.1038/ki.2010.64 Sison, 2010, Glomerular structure and function require paracrine, not autocrine, VEGF-VEGFR-2 signaling, J Am Soc Nephrol, 21, 1691, 10.1681/ASN.2010030295 Vitalone, 2008, Epithelial-to-mesenchymal transition in early transplant tubulointerstitial damage, J Am Soc Nephrol, 19, 1571, 10.1681/ASN.2007050580 Mann, 2008, Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): a multicentre, randomised, double-blind, controlled trial, Lancet, 372, 547, 10.1016/S0140-6736(08)61236-2 Brandes, 2000, An endothelium-derived hyperpolarizing factor distinct from NO and prostacyclin is a major endothelium-dependent vasodilator in resistance vessels of wild-type and endothelial NO synthase knockout mice, Proc Natl Acad Sci USA, 97, 9747, 10.1073/pnas.97.17.9747 Iwakiri, 2002, Mice with targeted deletion of eNOS develop hyperdynamic circulation associated with portal hypertension, Am J Physiol Gastrointest Liver Physiol, 283, G1074, 10.1152/ajpgi.00145.2002 Yang, 2009, The arachidonic acid epoxygenase is a component of the signaling mechanisms responsible for VEGF-stimulated angiogenesis, Arch Biochem Biophys, 489, 82, 10.1016/j.abb.2009.05.006 Webler, 2008, Epoxyeicosatrienoic acids are part of the VEGF-activated signaling cascade leading to angiogenesis, Am J Physiol Cell Physiol, 295, C1292, 10.1152/ajpcell.00230.2008 Nishimura, 2007, Adipogenesis in obesity requires close interplay between differentiating adipocytes, stromal cells, and blood vessels, Diabetes, 56, 1517, 10.2337/db06-1749 Tam, 2009, Blockade of VEGFR2 and not VEGFR1 can limit diet-induced fat tissue expansion: role of local versus bone marrow-derived endothelial cells, PLoS One, 4, e4974, 10.1371/journal.pone.0004974 Pruna, 1997, Thrombomodulin is synthesized by human mesangial cells, Kidney Int, 51, 687, 10.1038/ki.1997.99