Các chất chẹn α1-adrenergic chọn lọc trong điều trị tăng huyết áp: Liệu chúng ta nên sử dụng nhiều hơn?

M. Ligueros1, R. Unwin1, M. Wilkins1
1Department of Clinical Pharmacology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK

Tóm tắt

Gần đây, rõ ràng rằng trong điều trị tăng huyết áp nguyên phát, việc giảm huyết áp đơn thuần không đủ để giảm đáng kể tỷ lệ mắc bệnh và tử vong do bệnh tim thiếu máu cục bộ. Kể từ khi phương pháp tiếp cận đa yếu tố đối với việc phòng ngừa bệnh tim mạch xuất hiện, mối tương tác tiềm năng giữa liệu pháp huyết áp và các yếu tố chuyển hóa, chẳng hạn như kiểm soát mức đường huyết và lipid, đã trở thành một vấn đề quan trọng. Chức năng bất thường của hệ thần kinh giao cảm có thể góp phần vào cả việc khởi phát và duy trì tình trạng tăng huyết áp cùng với các rối loạn chuyển hóa liên quan. Thế hệ mới của các chất chẹn α1-adrenergic chọn lọc, bên cạnh việc hạ huyết áp, dường như có tác động tích cực đến chuyển hóa lipid và glucose. Việc sử dụng các loại thuốc này và vị trí của chúng trong điều trị tăng huyết áp được thảo luận.

Từ khóa

#tăng huyết áp #chất chẹn α1-adrenergic #bệnh tim mạch #rối loạn chuyển hóa #đường huyết #lipid

Tài liệu tham khảo

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