Searching for new therapeutic options for the uncommon pathogen Mycobacterium chimaera: an open drug discovery approach

Kohler, 2015, Healthcare-associated prosthetic heart valve, aortic vascular graft, and disseminated Mycobacterium chimaera infections subsequent to open heart surgery, Eur Heart J, 36, 2745, 10.1093/eurheartj/ehv342 van Ingen, 2017, Global outbreak of severe Mycobacterium chimaera disease after cardiac surgery: a molecular epidemiological study, Lancet Infect Dis, 17, 1033, 10.1016/S1473-3099(17)30324-9 Scriven, 2018, Mycobacterium chimaera infection following cardiac surgery in the UK: clinical features and outcome of the first 30 cases, Clin Microbiol Infect, 24, 1164, 10.1016/j.cmi.2018.04.027 Larcher, 2019, Mycobacterium chimaera pulmonary disease in cystic fibrosis patients, France, 2010–17, Emerg Infect Dis, 25, 611, 10.3201/eid2503.181590 Schweickert, 2008, Occurrence and clinical relevance of Mycobacterium chimaera sp nov, Germany, Emerg Infect Dis, 14, 1443, 10.3201/eid1409.071032 Tan, 2016, Disseminated Mycobacterium chimaera infection after cardiothoracic surgery, Open Forum Infect Dis, 3, 10.1093/ofid/ofw131 Daley, 2020, Treatment of nontuberculous mycobacterial pulmonary disease: an official ATS/ERS/ESCMID/IDSA clinical practice guideline, Eur Respir J, 56, 10.1183/13993003.00535-2020 Maurer, 2019, Differential drug susceptibility patterns of Mycobacterium chimaera and other members of the Mycobacterium avium-intracellulare complex, Clin Microbiol Infect, 25, 379e1, 10.1016/j.cmi.2018.06.010 Schulthess, 2021, Drug susceptibility distributions of Mycobacterium chimaera and other non-tuberculous mycobacteria, Antimicrob Agents Chemother, 65, e02132, 10.1128/AAC.02131-20 Palomino, 2002, Resazurin microtiter assay plate: simple and inexpensive method for detection of drug resistance in Mycobacterium tuberculosis, Antimicrob Agents Chemother, 46, 2720, 10.1128/AAC.46.8.2720-2722.2002 Woods, 2018 Zhang, 1999, A simple statistical parameter for use in evaluation and validation of high throughput screening assays, J Biomol Screen, 4, 67, 10.1177/108705719900400206 Yan Ling Haworth, 2017, British Thoracic Society guidelines for the management of non-tuberculous mycobacterial pulmonary disease (NTM-PD), Thorax, 72, ii1, 10.1136/thoraxjnl-2017-210927 Songsungthong, 2019, Diaminoquinazoline MMV675968 from pathogen box inhibits Acinetobacter baumannii growth through targeting of dihydrofolate reductase, Sci Rep, 9, 10.1038/s41598-019-52176-8 Zheng, 2013, Para-aminosalicylic acid is a prodrug targeting dihydrofolate reductase in Mycobacterium tuberculosis, J Biol Chem, 288, 23447, 10.1074/jbc.M113.475798 Duffy, 2017, Screening the medicines for malaria venture pathogen box across multiple pathogens reclassifies starting points for open-source drug discovery, Antimicrob Agents Chemother, 61, 1, 10.1128/AAC.00379-17 Gatto, 2013, NADPH oxidase-dependent and oxidase-independent mechanisms of reported inhibitors of reactive oxygen generation, J Enzyme Inhib Med Chem, 28, 95, 10.3109/14756366.2011.636360 Low, 2017, Screening of TB actives for activity against nontuberculous mycobacteria delivers high hit rates, Front Microbiol, 8, 10.3389/fmicb.2017.01539 Martin, 2019, In vitro activity of bedaquiline against slow-growing nontuberculous mycobacteria, J Med Microbiol, 68, 1137, 10.1099/jmm.0.001025 Ruth, 2019, A bedaquiline-clofazimine combination regimen might add activity to the treatment of clinically relevant non-tuberculous mycobacteria, J Antimicrob Chemother, 74, 935, 10.1093/jac/dky526 Philley, 2015, Preliminary results of bedaquiline as salvage therapy for patients with nontuberculous mycobacterial lung disease, Chest, 148, 499, 10.1378/chest.14-2764 Griffith, 2021, You gotta make me see, what does it mean to have an MIC?, Chest, 159, 462, 10.1016/j.chest.2020.11.007 Mok, 2019, Antimicrobial susceptibility of clinical and environmental Mycobacterium chimaera isolates, Antimicrob Agents Chemother, 63, 1, 10.1128/AAC.00755-19 Lee, 2019, New drugs to treat difficult tuberculous and nontuberculous mycobacterial pulmonary disease, Curr Opin Pulm Med, 25, 271, 10.1097/MCP.0000000000000570