Screening and Detection of Apoptosis

Kerr, 1972, Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics, Br J Cancer, 26, 239, 10.1038/bjc.1972.33

Cummings, 1997, Apoptosis, Am J Surg Pathol, 21, 88, 10.1097/00000478-199701000-00010

Ziegler, 2004, Morphological features of apoptosis, News Physiol Sci, 19, 124

Krammer, 2000, CD95’s deadly mission in the immune system, Nature, 407, 789, 10.1038/35037728

Walczak, 2000, The CD95 (APO-1/Fas) and the TRAIL (APO-2L) apoptosis systems, Exp Cell Res, 256, 58, 10.1006/excr.2000.4840

Adrain, 2001, The mitochondrial apoptosome: A killer unleashed by the cytochrome seas, Trends Biochem Sci, 26, 390, 10.1016/S0968-0004(01)01844-8

Chauhan, 2001, Apaf-1/cytochrome c-independent and Smac-dependent induction of apoptosis in multiple myeloma (MM) cells, J Biol Chem, 276, 24453, 10.1074/jbc.C100074200

Sperandio, 2000, An alternative, nonapoptotic form of programmed cell death, Proc Natl Acad Sci USA, 97, 14376, 10.1073/pnas.97.26.14376

Hengartner, 2000, The biochemistry of apoptosis, Nature, 407, 770, 10.1038/35037710

Du, 2000, Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition, Cell, 102, 33, 10.1016/S0092-8674(00)00008-8

Mayo, 2000, The transcription factor NF-kappaB: Control of oncogenesis and cancer therapy resistance, Biochim Biophys Acta, 1470, M55

Roy, 2000, Cross-talk in cell death signaling, J Exp Med, 192, 21, 10.1084/jem.192.8.F21

Slee, 1999, Serial killers: Ordering caspase activation events in apoptosis, Cell Death Differ, 6, 1067, 10.1038/sj.cdd.4400601

Broker, 2005, Cell death independent of caspases: A review, Clin Cancer Res, 11, 3155, 10.1158/1078-0432.CCR-04-2223

Gavrieli, 1992, Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation, J Cell Biol, 119, 493, 10.1083/jcb.119.3.493

Takemura, 2001, Characterization of ultrastructure and its relation with DNA fragmentation in Fas-induced apoptosis of cultured cardiac myocytes, J Pathol, 193, 546, 10.1002/1096-9896(2000)9999:9999<::AID-PATH794>3.0.CO;2-L

Hoffman Le Roche Inc. http://www.roche-diagnostics.com/researchers/cellbiology_immunochemistry.html#apoptosis. 2006.

Chemicon International. http://www.chemicon.com/resource/litlibrary/2005Catalog/2005TOC.asp. 2006.

White, 2004, A morphologic approach to detect apoptosis based on electron microscopy, Methods Mol Biol, 285, 105

Charriaut-Marlangue, 1995, A cautionary note on the use of the TUNEL stain to determine apoptosis, Neuroreport, 7, 61, 10.1097/00001756-199512000-00014

Ichimura, 1995, Formalin fixation by boiling: is it suitable for the TUNEL staining?, Pathol Int, 45, 971, 10.1111/j.1440-1827.1995.tb03424.x

Lucassen, 1995, Microwave-enhanced in situ end-labeling of fragmented DNA: Parametric studies in relation to postmortem delay and fixation of rat and human brain, J Histochem Cytochem, 43, 1163, 10.1177/43.11.7560899

Davison, 1995, The effects of formalin fixation on the detection of apoptosis in human brain by in situ end-labelling of DNA, Histochem J, 27, 983

Grasl-Kraupp, 1995, In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: A cautionary note, Hepatology, 21, 1465

Wijsman, 1993, A new method to detect apoptosis in paraffin sections: In situ end-labeling of fragmented DNA, J Histochem Cytochem, 41, 7, 10.1177/41.1.7678025

Oberhammer, 1993, Apoptotic death in epithelial cells: Cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation, EMBO J, 12, 3679, 10.1002/j.1460-2075.1993.tb06042.x

Zunino, 1996, Immunodetection of histone epitopes correlates with early stages of apoptosis in activated human peripheral T lymphocytes, Am J Pathol, 149, 653

Dimmeler, 1997, Suppression of apoptosis by nitric oxide via inhibition of interleukin-1beta-converting enzyme (ICE)-like and cysteine protease protein (CPP)-32-like proteases, J Exp Med, 185, 601, 10.1084/jem.185.4.601

Fadok, 1992, Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages, J Immunol, 148, 2207, 10.4049/jimmunol.148.7.2207

Martin, 1995, Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: Inhibition by overexpression of Bcl-2 and Abl, J Exp Med, 182, 1545, 10.1084/jem.182.5.1545

Dobrowsky, 1992, Ceramide stimulates a cytosolic protein phosphatase, J Biol Chem, 267, 5048, 10.1016/S0021-9258(18)42727-5

Mathias, 1991, Characterization of a ceramide-activated protein kinase: Stimulation by tumor necrosis factor alpha, Proc Natl Acad Sci USA, 88, 10009, 10.1073/pnas.88.22.10009

Jarvis, 1994, Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway, Proc Natl Acad Sci USA, 91, 73, 10.1073/pnas.91.1.73

Dressler, 1992, Tumor necrosis factor-alpha activates the sphingomyelin signal transduction pathway in a cell-free system, Science, 255, 1715, 10.1126/science.1313189

Macho, 1996, Chloromethyl-X-Rosamine is an aldehyde-fixable potential-sensitive fluorochrome for the detection of early apoptosis, Cytometry, 25, 333, 10.1002/(SICI)1097-0320(19961201)25:4<333::AID-CYTO4>3.0.CO;2-E

Verhagen, 2002, Cell death regulation by the mammalian IAP antagonist Diablo/Smac, Apoptosis, 7, 163, 10.1023/A:1014318615955

Burri, 2005, Mature DIABLO/Smac is produced by the IMP protease complex on the mitochondrial inner membrane, Mol Biol Cell, 16, 2926, 10.1091/mbc.E04-12-1086

Siskind, 2005, Mitochondrial ceramide and the induction of apoptosis, J Bioenerg Biomembr, 37, 143, 10.1007/s10863-005-6567-7

Adams, 1998, The Bcl-2 protein family: Arbiters of cell survival, Science, 281, 1322, 10.1126/science.281.5381.1322

Antonsson, 2000, The Bcl-2 protein family, Exp Cell Res, 256, 50, 10.1006/excr.2000.4839

Urbano, 2005, AIF suppresses chemical stress-induced apoptosis and maintains the transformed state of tumor cells, EMBO J, 24, 2815, 10.1038/sj.emboj.7600746

LaCasse, 1998, The inhibitors of apoptosis (IAPs) and their emerging role in cancer, Oncogene, 17, 3247, 10.1038/sj.onc.1202569

Jaattela, 1999, Escaping cell death: Survival proteins in cancer, Exp Cell Res, 248, 30, 10.1006/excr.1999.4455

Zhivotovsky, 2003, Defects in the apoptotic machinery of cancer cells: Role in drug resistance, Semin Cancer Biol, 13, 125, 10.1016/S1044-579X(02)00130-X

Sevilla, 2001, Transcriptional regulation of the bcl-x gene encoding the anti-apoptotic Bcl-xL protein by Ets, Rel/NFkappaB, STAT and AP1 transcription factor families, Histol Histopathol, 16, 595

Hongo, 2005, Inhibition of the transcription factor Yin Yang 1 activity by S-nitrosation, Biochem Biophys Res Commun, 336, 692, 10.1016/j.bbrc.2005.08.150

Huerta-Yepez, 2004, Nitric oxide sensitizes prostate carcinoma cell lines to TRAIL-mediated apoptosis via inactivation of NF-kappa B and inhibition of Bcl-xl expression, Oncogene, 23, 4993, 10.1038/sj.onc.1207655

Jazirehi, 2005, Rituximab (chimeric anti-CD20 monoclonal antibody) inhibits the constitutive nuclear factor-{kappa}B signaling pathway in non-Hodgkin’s lymphoma B-cell lines: Role in sensitization to chemotherapeutic drug-induced apoptosis, Cancer Res, 65, 264, 10.1158/0008-5472.264.65.1

Vega, 2005, Rituximab-induced inhibition of YY1 and Bcl-xL expression in Ramos non-Hodgkin’s lymphoma cell line via inhibition of NF-kappa B activity: Role of YY1 and Bcl-xL in Fas resistance and chemoresistance, respectively, J Immunol, 175, 2174, 10.4049/jimmunol.175.4.2174

MacFarlane, 2002, Proteasome-mediated degradation of Smac during apoptosis: XIAP promotes Smac ubiquitination in vitro, J Biol Chem, 277, 36611, 10.1074/jbc.M200317200

Sun, 2004, Caspase activation inhibits proteasome function during apoptosis, Mol Cell, 14, 81, 10.1016/S1097-2765(04)00156-X

Zhang, 2004, Regulation of apoptosis proteins in cancer cells by ubiquitin, Oncogene, 23, 2009, 10.1038/sj.onc.1207373

Hideshima, 2001, The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells, Cancer Res, 61, 3071

Lockhart, 1996, Expression monitoring by hybridization to high-density oligonucleotide arrays, Nat Biotechnol, 14, 1675, 10.1038/nbt1296-1675

GeneSpring. http://www.chem.agilent.com/scripts/pds.asp?lpage=27881. 2006.

Li, 2001, Model-based analysis of oligonucleotide arrays: Expression index computation and outlier detection, Proc Natl Acad Sci USA, 98, 31, 10.1073/pnas.011404098

Huerta, 2003, Gene expression profile of metastatic colon cancer cells resistant to cisplatin-induced apoptosis, Int J Oncol, 22, 663

Bhattacharjee, 2005, Microarray analysis identifies apoptosis regulatory gene expression in HCT116 cells infected with thermostable direct hemolysin-deletion mutant of Vibrio parahaemolyticus, Biochem Biophys Res Commun, 335, 328, 10.1016/j.bbrc.2005.07.080

Krajewska, 2005, Analysis of apoptosis protein expression in early-stage colorectal cancer suggests opportunities for new prognostic biomarkers, Clin Cancer Res, 11, 5451, 10.1158/1078-0432.CCR-05-0094

Williams, 2003, Identification and validation of genes involved in the pathogenesis of colorectal cancer using cDNA microarrays and RNA interference, Clin Cancer Res, 9, 931

Jackson, 2004, Noise amidst the silence: Off-target effects of siRNAs?, Trends Genet, 20, 521, 10.1016/j.tig.2004.08.006

Pai, 2005, Prospects of RNA interference therapy for cancer, Gene Ther, 13, 464, 10.1038/sj.gt.3302694

Abedini, 2004, Possible role of FLICE-like inhibitory protein (FLIP) in chemoresistant ovarian cancer cells in vitro, Oncogene, 23, 6997, 10.1038/sj.onc.1207925

Holle, 2004, Bcl-2 targeting siRNA expressed by a T7 vector system inhibits human tumor cell growth in vitro, Int J Oncol, 24, 615

Lima, 2004, Specific downregulation of bcl-2 and xIAP by RNAi enhances the effects of chemotherapeutic agents in MCF-7 human breast cancer cells, Cancer Gene Ther, 11, 309, 10.1038/sj.cgt.7700706

Yano, 2004, Antitumor activity of small interfering RNA/cationic liposome complex in mouse models of cancer, Clin Cancer Res, 10, 7721, 10.1158/1078-0432.CCR-04-1049

Zangemeister-Wittke, 2003, Antisense to apoptosis inhibitors facilitates chemotherapy and TRAIL-induced death signaling, Ann N Y Acad Sci, 1002, 90, 10.1196/annals.1281.019

Tran, 2005, The tumor necrosis factor-like weak inducer of apoptosis (TWEAK)-fibroblast growth factor-inducible 14 (Fn14) signaling system regulates glioma cell survival via NFkappaB pathway activation and BCL-XL/BCL-W expression, J Biol Chem, 280, 3483, 10.1074/jbc.M409906200

Zhu, 2005, Bcl-XL small interfering RNA suppresses the proliferation of 5-fluorouracil-resistant human colon cancer cells, Mol Cancer Ther, 4, 451, 10.1158/1535-7163.MCT-04-0162

Caldas, 2005, Survivin splice variants regulate the balance between proliferation and cell death, Oncogene, 24, 1994, 10.1038/sj.onc.1208350

Cheng, 2005, Knockdown of survivin gene expression by RNAi induces apoptosis in human hepatocellular carcinoma cell line SMMC-7721, World J Gastroenterol, 11, 756, 10.3748/wjg.v11.i5.756

Kappler, 2004, Knockdown of survivin expression by small interfering RNA reduces the clonogenic survival of human sarcoma cell lines independently of p53, Cancer Gene Ther, 11, 186, 10.1038/sj.cgt.7700677

Kappler, 2005, Radiosensitization, after a combined treatment of survivin siRNA and irradiation, is correlated with the activation of caspases 3 and 7 in a wt-p53 sarcoma cell line, but not in a mt-p53 sarcoma cell line, Oncol Rep, 13, 167

Ning, 2004, siRNA-mediated down-regulation of survivin inhibits bladder cancer cell growth, Int J Oncol, 25, 1065

Uchida, 2004, Adenovirus-mediated transfer of siRNA against survivin induced apoptosis and attenuated tumor cell growth in vitro and in vivo, Mol Ther, 10, 162, 10.1016/j.ymthe.2004.05.006

Hatano, 2004, Enhancement of C2-ceramide antitumor activity by small interfering RNA on X chromosome-linked inhibitor of apoptosis protein in resistant human glioma cells, J Neurosurg, 101, 119, 10.3171/jns.2004.101.1.0119

Ravi, 2002, Requirement of BAX for TRAIL/Apo2L-induced apoptosis of colorectal cancers: Synergism with sulindac-mediated inhibition of Bcl-x(L), Cancer Res, 62, 1583