Schizophrenia—An Overview

JAMA Psychiatry - Tập 77 Số 2 - Trang 201 - 2020
Robert A. McCutcheon1,2,3, Tiago Reis Marques1,2,3, Oliver Howes1,2,3
1Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, Kings College London, London, United Kingdom
2Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, United Kingdom
3Psychiatric Imaging Group, Medical Research Council, London Institute of Medical Sciences, Hammersmith Hospital, London, United Kingdom

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McCutcheon, Treatment of first-episode schizophrenia in a young woman, JAMA Psychiatry

Provencher, 1997, Positive and negative symptom behaviors and caregiver burden in the relatives of persons with schizophrenia., Schizophr Res, 26, 71, 10.1016/S0920-9964(97)00043-1

Saha, 2005, A systematic review of the prevalence of schizophrenia., PLoS Med, 2, 10.1371/journal.pmed.0020141

Cloutier, 2016, The economic burden of schizophrenia in the United States in 2013., J Clin Psychiatry, 77, 764, 10.4088/JCP.15m10278

Andreasen, 2010, The lifetime trajectory of schizophrenia and the concept of neurodevelopment., Dialogues Clin Neurosci, 12, 409, 10.31887/DCNS.2010.12.3/nandreasen

Hjorthøj, 2017, Years of potential life lost and life expectancy in schizophrenia: a systematic review and meta-analysis., Lancet Psychiatry, 4, 295, 10.1016/S2215-0366(17)30078-0

Murray, 1988, Is schizophrenia a neurodevelopmental disorder?, BMJ (Clin Res Ed), 296, 63, 10.1136/bmj.296.6614.63

Bramon, 2005, Dermatoglyphics and schizophrenia: a meta-analysis and investigation of the impact of obstetric complications upon a-b ridge count., Schizophr Res, 75, 399, 10.1016/j.schres.2004.08.022

Hulshoff Pol, 2000, Prenatal exposure to famine and brain morphology in schizophrenia., Am J Psychiatry, 157, 1170, 10.1176/appi.ajp.157.7.1170

Xu, 2009, Prenatal malnutrition and adult schizophrenia: further evidence from the 1959-1961 Chinese famine., Schizophr Bull, 35, 568, 10.1093/schbul/sbn168

Erlenmeyer-Kimling, 2000, Attention, memory, and motor skills as childhood predictors of schizophrenia-related psychoses: the New York High-Risk Project., Am J Psychiatry, 157, 1416, 10.1176/appi.ajp.157.9.1416

Sullivan, 2003, Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies., Arch Gen Psychiatry, 60, 1187, 10.1001/archpsyc.60.12.1187

Ripke, 2014, Biological insights from 108 schizophrenia-associated genetic loci., Nature, 511, 421, 10.1038/nature13595

Bassett, 2008, Schizophrenia and 22q11.2 deletion syndrome., Curr Psychiatry Rep, 10, 148, 10.1007/s11920-008-0026-1

Schneider, 2014, Psychiatric disorders from childhood to adulthood in 22q11.2 deletion syndrome: results from the International Consortium on Brain and Behavior in 22q11.2 Deletion Syndrome., Am J Psychiatry, 171, 627, 10.1176/appi.ajp.2013.13070864

Hilker, 2018, Heritability of schizophrenia and schizophrenia spectrum based on the nationwide Danish Twin Register., Biol Psychiatry, 83, 492, 10.1016/j.biopsych.2017.08.017

Ursini, 2018, Convergence of placenta biology and genetic risk for schizophrenia., Nat Med, 24, 792, 10.1038/s41591-018-0021-y

Aleman, 2003, Sex differences in the risk of schizophrenia: evidence from meta-analysis., Arch Gen Psychiatry, 60, 565, 10.1001/archpsyc.60.6.565

Fromer, 2016, Gene expression elucidates functional impact of polygenic risk for schizophrenia., Nat Neurosci, 19, 1442, 10.1038/nn.4399

Skene, 2018, Genetic identification of brain cell types underlying schizophrenia., Nat Genet, 50, 825, 10.1038/s41588-018-0129-5

Sekar, 2016, Schizophrenia risk from complex variation of complement component 4., Nature, 530, 177, 10.1038/nature16549

Sellgren, 2019, Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning., Nat Neurosci, 22, 374, 10.1038/s41593-018-0334-7

Osimo, 2019, Synaptic loss in schizophrenia: a meta-analysis and systematic review of synaptic protein and mRNA measures., Mol Psychiatry, 24, 549, 10.1038/s41380-018-0041-5

Lewis, 2005, Cortical inhibitory neurons and schizophrenia., Nat Rev Neurosci, 6, 312, 10.1038/nrn1648

Keefe, 2007, How should DSM-V criteria for schizophrenia include cognitive impairment?, Schizophr Bull, 33, 912, 10.1093/schbul/sbm046

Piskulic, 2012, Negative symptoms in individuals at clinical high risk of psychosis., Psychiatry Res, 196, 220, 10.1016/j.psychres.2012.02.018

Fusar-Poli, 2012, Cognitive functioning in prodromal psychosis: a meta-analysis., Arch Gen Psychiatry, 69, 562, 10.1001/archgenpsychiatry.2011.1592

Huttenlocher, 1979, Synaptic density in human frontal cortex - developmental changes and effects of aging., Brain Res, 163, 195, 10.1016/0006-8993(79)90349-4

Blakemore, 2006, Development of the adolescent brain: implications for executive function and social cognition., J Child Psychol Psychiatry, 47, 296, 10.1111/jcpp.2006.47.issue-3-4

Feinberg, 1982-1983, Schizophrenia: caused by a fault in programmed synaptic elimination during adolescence?, J Psychiatr Res, 17, 319, 10.1016/0022-3956(82)90038-3

Fusar-Poli, 2012, Neuroanatomical maps of psychosis onset: voxel-wise meta-analysis of antipsychotic-naive VBM studies., Schizophr Bull, 38, 1297, 10.1093/schbul/sbr134

Kambeitz, 2016, Aberrant functional whole-brain network architecture in patients with schizophrenia: a meta-analysis., Schizophr Bull, 42, S13, 10.1093/schbul/sbv174

Sui, 2015, In search of multimodal neuroimaging biomarkers of cognitive deficits in schizophrenia., Biol Psychiatry, 78, 794, 10.1016/j.biopsych.2015.02.017

Barch, 2012, Cognition in schizophrenia: core psychological and neural mechanisms., Trends Cogn Sci, 16, 27, 10.1016/j.tics.2011.11.015

Alekseichuk, 2016, Spatial working memory in humans depends on theta and high gamma synchronization in the prefrontal cortex., Curr Biol, 26, 1513, 10.1016/j.cub.2016.04.035

Schirner, 2018, Inferring multi-scale neural mechanisms with brain network modelling., Elife, 7, 1, 10.7554/eLife.28927

Niessing, 2005, Hemodynamic signals correlate tightly with synchronized gamma oscillations., Science, 309, 948, 10.1126/science.1110948

Van Den Heuvel, 2011, Exploring the brain network: a review on resting-state fMRI functional connectivity., Psiquiatr Biol, 18, 28, 10.1016/j.psiq.2011.05.001

Uhlhaas, 2010, Abnormal neural oscillations and synchrony in schizophrenia., Nat Rev Neurosci, 11, 100, 10.1038/nrn2774

Sheffield, 2016, Cognition and resting-state functional connectivity in schizophrenia., Neurosci Biobehav Rev, 61, 108, 10.1016/j.neubiorev.2015.12.007

Cardin, 2009, Driving fast-spiking cells induces gamma rhythm and controls sensory responses., Nature, 459, 663, 10.1038/nature08002

Lewis, 2012, Cortical parvalbumin interneurons and cognitive dysfunction in schizophrenia., Trends Neurosci, 35, 57, 10.1016/j.tins.2011.10.004

Marín, 2012, Interneuron dysfunction in psychiatric disorders., Nat Rev Neurosci, 13, 107, 10.1038/nrn3155

Howes, 2017, Inflammation and the neural diathesis-stress hypothesis of schizophrenia: a reconceptualization., Transl Psychiatry, 7, 10.1038/tp.2016.278

Marques, 2019, Neuroinflammation in schizophrenia: meta-analysis of in vivo microglial imaging studies., Psychol Med, 49, 2186, 10.1017/S0033291718003057

Selvaraj, 2018, Brain TSPO imaging and gray matter volume in schizophrenia patients and in people at ultra high risk of psychosis: an [11C]PBR28 study., Schizophr Res, 195, 206, 10.1016/j.schres.2017.08.063

Yang, 2016, Functional hierarchy underlies preferential connectivity disturbances in schizophrenia., Proc Natl Acad Sci U S A, 113, E219, 10.1073/pnas.1508436113

Radua, 2018, What causes psychosis? an umbrella review of risk and protective factors., World Psychiatry, 17, 49, 10.1002/wps.v17.1

Morgan, 2010, Migration, ethnicity, and psychosis: toward a sociodevelopmental model., Schizophr Bull, 36, 655, 10.1093/schbul/sbq051

Egerton, 2016, Adversity in childhood linked to elevated striatal dopamine function in adulthood., Schizophr Res, 176, 171, 10.1016/j.schres.2016.06.005

Egerton, 2017, Elevated striatal dopamine function in immigrants and their children: a risk mechanism for psychosis., Schizophr Bull, 43, 293

Akdeniz, 2014, Neuroimaging evidence for a role of neural social stress processing in ethnic minority-associated environmental risk., JAMA Psychiatry, 71, 672, 10.1001/jamapsychiatry.2014.35

McCutcheon, 2018, Amygdala reactivity in ethnic minorities and its relationship to the social environment: an fMRI study., Psychol Med, 48, 1985, 10.1017/S0033291717003506

Lederbogen, 2011, City living and urban upbringing affect neural social stress processing in humans., Nature, 474, 498, 10.1038/nature10190

McCutcheon, 2018, Chronic psychosocial stressors are associated with alterations in salience processing and corticostriatal connectivity., Schizophr Res, pii

Beards, 2013, Life events and psychosis: a review and meta-analysis., Schizophr Bull, 39, 740, 10.1093/schbul/sbt065

Connell, 1957, Amphetamine psychosis., BMJ, 5018, 582, 10.1136/bmj.1.5018.582

Abi-Dargham, 1998, Increased striatal dopamine transmission in schizophrenia: confirmation in a second cohort., Am J Psychiatry, 155, 761

McCutcheon, 2018, Defining the locus of dopaminergic dysfunction in schizophrenia: a meta-analysis and test of the mesolimbic hypothesis., Schizophr Bull, 44, 1301, 10.1093/schbul/sbx180

Howes, 2012, The nature of dopamine dysfunction in schizophrenia and what this means for treatment., Arch Gen Psychiatry, 69, 776, 10.1001/archgenpsychiatry.2012.169

Laruelle, 1999, Increased dopamine transmission in schizophrenia: relationship to illness phases., Biol Psychiatry, 46, 56, 10.1016/S0006-3223(99)00067-0

Howes, 2009, Elevated striatal dopamine function linked to prodromal signs of schizophrenia., Arch Gen Psychiatry, 66, 13, 10.1001/archgenpsychiatry.2008.514

Mizrahi, 2014, Stress-induced dopamine response in subjects at clinical high risk for schizophrenia with and without concurrent cannabis use., Neuropsychopharmacology, 39, 1479, 10.1038/npp.2013.347

Howes, 2011, Dopamine synthesis capacity before onset of psychosis: a prospective [18F]-DOPA PET imaging study., Am J Psychiatry, 168, 1311, 10.1176/appi.ajp.2011.11010160

Howes, 2011, Progressive increase in striatal dopamine synthesis capacity as patients develop psychosis: a PET study., Mol Psychiatry, 16, 885, 10.1038/mp.2011.20

Abi-Dargham, 2009, Baseline and amphetamine-stimulated dopamine activity are related in drug-naïve schizophrenic subjects., Biol Psychiatry, 65, 1091, 10.1016/j.biopsych.2008.12.007

Schultz, 1997, A neural substrate of prediction and reward., Science, 275, 1593, 10.1126/science.275.5306.1593

Menegas, 2018, Dopamine neurons projecting to the posterior striatum reinforce avoidance of threatening stimuli., Nat Neurosci, 21, 1421, 10.1038/s41593-018-0222-1

Menegas, 2017, Opposite initialization to novel cues in dopamine signaling in ventral and posterior striatum in mice., Elife, 6, 1, 10.7554/eLife.21886

Nour, 2018, Dopaminergic basis for signaling belief updates, but not surprise, and the link to paranoia., Proc Natl Acad Sci U S A, 115, E10167, 10.1073/pnas.1809298115

McCutcheon, 2019, Schizophrenia, dopamine and the striatum: from biology to symptoms., Trends Neurosci, 42, 205, 10.1016/j.tins.2018.12.004

Kapur, 2003, Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia., Am J Psychiatry, 160, 13, 10.1176/appi.ajp.160.1.13

Kinderman, 1997, Causal attributions in paranoia and depression: internal, personal, and situational attributions for negative events., J Abnorm Psychol, 106, 341, 10.1037/0021-843X.106.2.341

Garety, 2007, Implications for neurobiological research of cognitive models of psychosis: a theoretical paper., Psychol Med, 37, 1377, 10.1017/S003329170700013X

Kapur, 2000, Relationship between dopamine D(2) occupancy, clinical response, and side effects: a double-blind PET study of first-episode schizophrenia., Am J Psychiatry, 157, 514, 10.1176/appi.ajp.157.4.514

Kapur, 2003, Half a century of antipsychotics and still a central role for dopamine D2 receptors., Prog Neuropsychopharmacol Biol Psychiatry, 27, 1081, 10.1016/j.pnpbp.2003.09.004

Silvestri, 2000, Increased dopamine D2 receptor binding after long-term treatment with antipsychotics in humans: a clinical PET study., Psychopharmacology (Berl), 152, 174, 10.1007/s002130000532

Jauhar, 2019, The effects of antipsychotic treatment on presynaptic dopamine synthesis capacity in first-episode psychosis: a positron emission tomography study., Biol Psychiatry, 85, 79, 10.1016/j.biopsych.2018.07.003

Samaha, 2007, “Breakthrough” dopamine supersensitivity during ongoing antipsychotic treatment leads to treatment failure over time., J Neurosci, 27, 2979, 10.1523/JNEUROSCI.5416-06.2007

Butzlaff, 1998, Expressed emotion and psychiatric relapse: a meta-analysis., Arch Gen Psychiatry, 55, 547, 10.1001/archpsyc.55.6.547

Jauhar, 2014, Cognitive-behavioural therapy for the symptoms of schizophrenia: systematic review and meta-analysis with examination of potential bias., Br J Psychiatry, 204, 20, 10.1192/bjp.bp.112.116285

Alameda, 2018, Redox dysregulation as a link between childhood trauma and psychopathological and neurocognitive profile in patients with early psychosis., Proc Natl Acad Sci U S A, 115, 12495, 10.1073/pnas.1812821115

Thompson, 2013, Striatal dopamine release in schizophrenia comorbid with substance dependence., Mol Psychiatry, 18, 909, 10.1038/mp.2012.109

Selvaraj, 2014, Alterations in the serotonin system in schizophrenia: a systematic review and meta-analysis of postmortem and molecular imaging studies., Neurosci Biobehav Rev, 45, 233, 10.1016/j.neubiorev.2014.06.005

Erickson, 2016, A meta-analysis of mismatch negativity in schizophrenia: from clinical risk to disease specificity and progression., Biol Psychiatry, 79, 980, 10.1016/j.biopsych.2015.08.025

Kim, 2015, Spine pruning drives antipsychotic-sensitive locomotion via circuit control of striatal dopamine., Nat Neurosci, 18, 883, 10.1038/nn.4015

McCutcheon, 2019, Mesolimbic dopamine function is related to salience network connectivity: an integrative positron emission tomography and magnetic resonance study., Biol Psychiatry, 85, 368, 10.1016/j.biopsych.2018.09.010

Mouchlianitis, 2016, Brain-imaging studies of treatment-resistant schizophrenia: a systematic review., Lancet Psychiatry, 3, 451, 10.1016/S2215-0366(15)00540-4

Zhang, 2019, Schizophrenia polygenic risk score as a predictor of antipsychotic efficacy in first-episode psychosis., Am J Psychiatry, 176, 21, 10.1176/appi.ajp.2018.17121363

Wimberley, 2017, Polygenic risk score for schizophrenia and treatment-resistant schizophrenia., Schizophr Bull, 43, 1064, 10.1093/schbul/sbx007

Wimberley, 2016, Predictors of treatment resistance in patients with schizophrenia: a population-based cohort study., Lancet Psychiatry, 3, 358, 10.1016/S2215-0366(15)00575-1

McCutcheon, The efficacy and heterogeneity of antipsychotic response in schizophrenia: a meta-analysis, Mol Psychiatry

Galderisi, 2018, Negative symptoms of schizophrenia: new developments and unanswered research questions., Lancet Psychiatry, 5, 664, 10.1016/S2215-0366(18)30050-6

Brugger, 2017, Heterogeneity and homogeneity of regional brain structure in schizophrenia: a meta-analysis., JAMA Psychiatry, 74, 1104, 10.1001/jamapsychiatry.2017.2663

Insel, 2010, Research domain criteria (RDoC): toward a new classification framework for research on mental disorders., Am J Psychiatry, 167, 748, 10.1176/appi.ajp.2010.09091379

Kaar, 2019, Antipsychotics: mechanisms underlying clinical response and side-effects and novel treatment approaches based on pathophysiology., Neuropharmacology, 107704

Bleuler, 1950, Dementia Praecox or the Group of Schizophrenias

National Institute For Clinical Excellence. Psychosis and schizophrenia in adults: prevention and management: clinical guideline [CG178]. https://www.nice.org.uk/guidance/cg178. Published 2014. Accessed September 23, 2019.