Sarcopenia: revised European consensus on definition and diagnosis

Age and Ageing - Tập 48 Số 1 - Trang 16-31 - 2019
Alfonso J. Cruz‐Jentoft1, Gülistan Bahat2, Jürgen M. Bauer3, Yves Boirie‌4, Olivier Bruyère5, Tommy Cederholm6, Cyrus Cooper7,8,9, Francesco Landi10, Yves Rolland11, Avan Aihie Sayer12, S. Schneider13, Cornel Sieber14, Eva Topinková15, Maurits Vandewoude16, Marjolein Visser17,18,19, Mauro Zamboni20, Ivan Bautmans21,22, Jean‐Pierre Baeyens23,24,25,26, Matteo Cesari27, Antonio Cherubini28, John А. Kanis29,30,31, Marcello Maggio32, Finbarr C. Martin33, Jean‐Pierre Michel34,35, Kaisu Pitkälä36,37, Jean‐Yves Reginster38, René Rizzoli39,35, Dolores Sánchez‐Rodríguez40, Jos M. G. A. Schols41,42
1Servicio de Geriatría, Hospital Universitario Ramón y Cajal (IRYCIS), Madrid, Spain
2Department of Internal Medicine, Division of Geriatrics, Istanbul Medical School, Istanbul University, Istanbul, Turkey
3Center for Geriatric Medicine, University Heidelberg, Agaplesion Bethanien Krankenhaus, Heidelberg, Germany
4Research Department, Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand, France
5Department of Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium
6Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, and Theme Ageing, Karolinska University Hospital, Stockholm, Sweden
7MRC Lifecourse Epidemiology Unit, University of Southampton
8MRC Lifecourse Epidemiology Unit, University of Southampton; Southampton, UK; and Department of Epidemiology, University of Oxford, OX, UK
9Southampton, UK
10Instituto di Medicina Interna e Geriatria, Università Cattolica del Sacro Cuore, Roma, Italy
11Department of Geriatrics, Hospital and University of Toulouse, Toulouse, France
12NIHR Newcastle Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust and Faculty of Medical Sciences, Newcastle University, Newcastle, UK
13Department of Gastroenterology and Clinical Nutrition, Centre Hospitalier Universitaire de Nice, Université Côte d’Azur, Nice, France
14Department of Internal Medicine-Geriatrics, Institute for Biomedicine and Ageing, Friedrich-Alexander-University, Erlangen-Nürnberg, Germany
15Department of Geriatrics, First Faculty of Medicine, Charles University, and General Faculty Hospital, Prague, Czech Republic
16Department Geriatrics, University of Antwerp, Ziekenhuisnetwerk Antwerpen (ZNA), Antwerp, Belgium
17Amsterdam, The Netherlands
18Department of Health Sciences, Faculty of Science, Vrije Universiteit Amsterdam and the Amsterdam Public Health Research Institute, Amsterdam, The Netherlands
19the Amsterdam Public Health Research Institute
20Department of Medicine, Geriatric Section, University of Verona, Verona, Italy
21Brussels, Belgium
22Department of Gerontology and Department of Frailty in Ageing, Vrije University Brussel; Brussels, Belgium
23Eeklo, Belgium
24Geriatrician at the Teaching Hospital AZ Alma; Eeklo, Belgium; and University of Luxembourg; Luxembourg City, Luxenbourg
25Luxembourg City, Luxenbourg
26University of Luxembourg
27Geriatric Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Università di Milano; Milan, Italy
28Geriatria, Accettazione geriatrica e Centro di Ricerca Per l'invecchiamento, IRCCS INRCA, Ancona, Italy
29Center for Metabolic Bone Diseases, University of Sheffield Medical School; Sheffield, UK and Institute for Health and Ageing, Australian Catholic University; Melbourne, Australia
30Melbourne, Australia
31Sheffield, UK and Institute for Health and Ageing, Australian Catholic University
32Geriatric Clinic Unit, Geriatric Rehabilitation Department, University-Hospital of Parma, Department of Medicine and Surgery
33Department of Ageing and Health, Guys and St Thomas’ NHS Foundation Trust; London, UK
34Department of Rehabilitation and Geriatrics, University of Geneva; Geneva, Switzerland
35Geneva, Switzerland
36Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Central Hospital, Unit of Primary Health Care; Helsinki, Finland
37Helsinki, Finland
38Bone and Cartilage Metabolism Unit, University of Liège, Liège, Belgium
39Department of Bone Disease, University of Geneva; Geneva, Switzerland
40Geriatrics Department, Parc Salut Mar. Rehabilitation Research Group, Institut Hospital del Mar d’Investigacions Mèdiques (IMIM). Universitat Autònoma de Barcelona, Universitat Pompeu Fabra; Barcelona, Spain
41Department of Health Services Research, Maastricht University, Maastricht, The Netherlands
42Maastricht, The Netherlands

Tóm tắt

Từ khóa


Tài liệu tham khảo

Cruz-Jentoft, 2010, Sarcopenia: European consensus on definition and diagnosis: report of the European working group on sarcopenia in older people, Age Ageing, 39, 412, 10.1093/ageing/afq034

Morley, 2011, Sarcopenia with limited mobility: an international consensus, J Am Med Dir Assoc, 12, 403, 10.1016/j.jamda.2011.04.014

Studenski, 2014, The FNIH sarcopenia project: rationale, study description, conference recommendations, and final estimates, J Gerontol A Biol Sci Med Sci, 69, 547, 10.1093/gerona/glu010

Chen, 2014, Sarcopenia in Asia: consensus report of the Asian working group for sarcopenia, J Am Med Dir Assoc, 15, 95, 10.1016/j.jamda.2013.11.025

Argiles, 2016, Skeletal muscle regulates metabolism via interorgan crosstalk: roles in health and disease, J Am Med Dir Assoc, 17, 789, 10.1016/j.jamda.2016.04.019

Frontera, 2015, Skeletal muscle: a brief review of structure and function, Calcif Tissue Int, 96, 183, 10.1007/s00223-014-9915-y

Vellas, 2018, Implications of ICD-10 for sarcopenia clinical practice and clinical trials: report by the International Conference on Frailty and Sarcopenia Research Task Force, J Frailty Aging, 7, 2

Mijnarends, 2018, Muscle, health and costs: a glance at their relationship, J Nutr Health Aging, 22, 766, 10.1007/s12603-018-1058-9

Bischoff-Ferrari, 2015, Comparative performance of current definitions of sarcopenia against the prospective incidence of falls among community-dwelling seniors age 65 and older, Osteoporos Int, 26, 2793, 10.1007/s00198-015-3194-y

Schaap, 2018, Associations of sarcopenia definitions, and their components, with the incidence of recurrent falling and fractures: the longitudinal aging study Amsterdam, J Gerontol A Biol Sci Med Sci, 73, 1199, 10.1093/gerona/glx245

Malmstrom, 2016, SARC-F: a symptom score to predict persons with sarcopenia at risk for poor functional outcomes, J Cachexia Sarcopenia Muscle, 7, 28, 10.1002/jcsm.12048

Bahat, 2016, Sarcopenia and the cardiometabolic syndrome: a narrative review, Eur Geriatr Med, 6, 220, 10.1016/j.eurger.2015.12.012

Bone, 2017, Sarcopenia and frailty in chronic respiratory disease, Chron Respir Dis, 14, 85, 10.1177/1479972316679664

Chang, 2016, Association between sarcopenia and cognitive impairment: a systematic review and meta-analysis, J Am Med Dir Assoc, 17, 1164.e7, 10.1016/j.jamda.2016.09.013

Beaudart, 2017, Validation of the SarQoL(R), a specific health-related quality of life questionnaire for Sarcopenia, J Cachexia Sarcopenia Muscle, 8, 238, 10.1002/jcsm.12149

Dos Santos, 2017, Sarcopenia and physical independence in older adults: the independent and synergic role of muscle mass and muscle function, J Cachexia Sarcopenia Muscle, 8, 245, 10.1002/jcsm.12160

Akune, 2014, Incidence of certified need of care in the long-term care insurance system and its risk factors in the elderly of Japanese population-based cohorts: the ROAD study, Geriatr Gerontol Int, 14, 695, 10.1111/ggi.12155

Steffl, 2017, Relationship between sarcopenia and physical activity in older people: a systematic review and meta-analysis, Clin Interv Aging, 12, 835, 10.2147/CIA.S132940

De Buyser, 2016, Validation of the FNIH sarcopenia criteria and SOF frailty index as predictors of long-term mortality in ambulatory older men, Age Ageing, 45, 602, 10.1093/ageing/afw071

Cawthon, 2017, Clinical definitions of sarcopenia and risk of hospitalization in community-dwelling older men: the osteoporotic fractures in men study, J Gerontol A Biol Sci Med Sci, 72, 1383, 10.1093/gerona/glw327

Antunes, 2017, Sarcopenia and hospitalisation costs in older adults: a cross-sectional study, Nutr Diet, 74, 46, 10.1111/1747-0080.12287

Steffl, 2017, The increase in health care costs associated with muscle weakness in older people without long-term illnesses in the Czech Republic: results from the Survey of Health, Ageing and Retirement in Europe (SHARE), Clin Interv Aging, 12, 2003, 10.2147/CIA.S150826

Sousa, 2016, Financial impact of sarcopenia on hospitalization costs, Eur J Clin Nutr, 70, 1046, 10.1038/ejcn.2016.73

Sayer, 2008, The developmental origins of sarcopenia, J Nutr Health Aging, 12, 427, 10.1007/BF02982703

Dodds, 2014, Grip strength across the life course: normative data from twelve British studies, PLoS One, 9, e113637, 10.1371/journal.pone.0113637

Sayer, 2004, Does sarcopenia originate in early life? Findings from the Hertfordshire cohort study, J Gerontol A Biol Sci Med Sci, 59, M930, 10.1093/gerona/59.9.M930

Ibrahim, 2016, A feasibility study of implementing grip strength measurement into routine hospital practice (GRImP): study protocol, Pilot Feasibility Stud, 2, 27, 10.1186/s40814-016-0067-x

Leong, 2015, Prognostic value of grip strength: findings from the Prospective Urban Rural Epidemiology (PURE) study, Lancet, 386, 266, 10.1016/S0140-6736(14)62000-6

Alley, 2014, Grip strength cutpoints for the identification of clinically relevant weakness, J Gerontol A Biol Sci Med Sci, 69, 559, 10.1093/gerona/glu011

Buckinx, 2018, Pitfalls in the measurement of muscle mass: a need for a reference standard, J Cachexia Sarcopenia Muscle, 9, 269, 10.1002/jcsm.12268

Masanes, 2017, Cut-off points for muscle mass—not grip strength or gait speed—determine variations in sarcopenia prevalence, J Nutr Health Aging, 21, 825, 10.1007/s12603-016-0844-5

McGregor, 2014, It is not just muscle mass: a review of muscle quality, composition and metabolism during ageing as determinants of muscle function and mobility in later life, Longev Healthspan, 3, 9, 10.1186/2046-2395-3-9

Trevino-Aguirre, 2014, Availability and use of dual energy X-ray absorptiometry (DXA) and bio-impedance analysis (BIA) for the evaluation of sarcopenia by Belgian and Latin American geriatricians, J Cachexia Sarcopenia Muscle, 5, 79, 10.1007/s13539-013-0126-6

Keller, 2018, Sarcopenia, Wien Med Wochenschr

Han, 2018, Diagnostic criteria and clinical outcomes in sarcopenia research: a literature review, J Clin Med, 7, 10.3390/jcm7040070

Schaap, 2013, Adiposity, muscle mass, and muscle strength in relation to functional decline in older persons, Epidemiol Rev, 35, 51, 10.1093/epirev/mxs006

Reginster, 2016, Recommendations for the conduct of clinical trials for drugs to treat or prevent sarcopenia, Aging Clin Exp Res, 28, 47, 10.1007/s40520-015-0517-y

Mijnarends, 2013, Validity and reliability of tools to measure muscle mass, strength, and physical performance in community-dwelling older people: a systematic review, J Am Med Dir Assoc, 14, 170, 10.1016/j.jamda.2012.10.009

Ishii, 2014, Development of a simple screening test for sarcopenia in older adults, Geriatr Gerontol Int, 14, 93, 10.1111/ggi.12197

Roberts, 2011, A review of the measurement of grip strength in clinical and epidemiological studies: towards a standardised approach, Age Ageing, 40, 423, 10.1093/ageing/afr051

Schweitzer, 2015, What is the best reference site for a single MRI slice to assess whole-body skeletal muscle and adipose tissue volumes in healthy adults?, Am J Clin Nutr, 102, 58, 10.3945/ajcn.115.111203

Mitsiopoulos, 1998, Cadaver validation of skeletal muscle measurement by magnetic resonance imaging and computerized tomography, J Appl Physiol (1985), 85, 115, 10.1152/jappl.1998.85.1.115

Shen, 2004, Total body skeletal muscle and adipose tissue volumes: estimation from a single abdominal cross-sectional image, J Appl Physiol (1985), 97, 2333, 10.1152/japplphysiol.00744.2004

Sergi, 2017, Measurement of lean body mass using bioelectrical impedance analysis: a consideration of the pros and cons, Aging Clin Exp Res, 29, 591, 10.1007/s40520-016-0622-6

Maden-Wilkinson, 2013, Comparison of MRI and DXA to measure muscle size and age-related atrophy in thigh muscles, J Musculoskelet Neuronal Interact, 13, 320

Heymsfield, 1990, Appendicular skeletal muscle mass: measurement by dual-photon absorptiometry, Am J Clin Nutr, 52, 214, 10.1093/ajcn/52.2.214

Kim, 2002, Total-body skeletal muscle mass: estimation by a new dual-energy X-ray absorptiometry method, Am J Clin Nutr, 76, 378, 10.1093/ajcn/76.2.378

Yamada, 2017, Developing and validating an age-independent equation using multi-frequency bioelectrical impedance analysis for estimation of appendicular skeletal muscle mass and establishing a cutoff for sarcopenia, Int J Environ Res Public Health, 14, 10.3390/ijerph14070809

Lee, 2004, Relation between whole-body and regional measures of human skeletal muscle, Am J Clin Nutr, 80, 1215, 10.1093/ajcn/80.5.1215

van der Werf, 2018, Percentiles for skeletal muscle index, area and radiation attenuation based on computed tomography imaging in a healthy Caucasian population, Eur J Clin Nutr, 72, 288, 10.1038/s41430-017-0034-5

Derstine, 2018, Skeletal muscle cutoff values for sarcopenia diagnosis using T10 to L5 measurements in a healthy US population, Sci Rep, 8, 11369, 10.1038/s41598-018-29825-5

Goodpaster, 2000, Skeletal muscle attenuation determined by computed tomography is associated with skeletal muscle lipid content, J Appl Physiol (1985), 89, 104, 10.1152/jappl.2000.89.1.104

Reinders, 2016, Muscle quality and myosteatosis: novel associations with mortality risk: the Age, Gene/Environment Susceptibility (AGES)-Reykjavik study, Am J Epidemiol, 183, 53, 10.1093/aje/kwv153

Grimm, 2018, Evaluation of 2-point, 3-point, and 6-point Dixon magnetic resonance imaging with flexible echo timing for muscle fat quantification, Eur J Radiol, 103, 57, 10.1016/j.ejrad.2018.04.011

Distefano, 2018, Physical activity unveils the relationship between mitochondrial energetics, muscle quality, and physical function in older adults, J Cachexia Sarcopenia Muscle, 9, 279, 10.1002/jcsm.12272

Ruan, 2007, Estimating whole body intermuscular adipose tissue from single cross-sectional magnetic resonance images, J Appl Physiol (1985), 102, 748, 10.1152/japplphysiol.00304.2006

Woo, 2015, Defining sarcopenia in terms of incident adverse outcomes, J Am Med Dir Assoc, 16, 247, 10.1016/j.jamda.2014.11.013

Bahat, 2018, Performance of SARC-F in regard to sarcopenia definitions, muscle mass and functional measures, J Nutr Health Aging, 10.1007/s12603-018-1067-8

Bahat, 2018, Cross-cultural adaptation and validation of the SARC-F to assess sarcopenia: methodological report from European Union Geriatric Medicine Society Sarcopenia Special Interest Group, Eur Geriatr Med, 9, 23, 10.1007/s41999-017-0003-5

Locquet, 2018, Comparison of the performance of five screening methods for sarcopenia, Clin Epidemiol, 10, 71, 10.2147/CLEP.S148638

Rossi, 2014, Identifying sarcopenia in acute care setting patients, J Am Med Dir Assoc, 15, 303.e7, 10.1016/j.jamda.2013.11.018

Steiber, 2016, Strong or weak handgrip? Normative reference values for the German population across the life course stratified by sex, age, and body height, PLoS One, 11, e0163917, 10.1371/journal.pone.0163917

Beaudart, 2016, Sarcopenia in daily practice: assessment and management, BMC Geriatr, 16, 170, 10.1186/s12877-016-0349-4

Sipers, 2016, The Martin vigorimeter represents a reliable and more practical tool than the Jamar dynamometer to assess handgrip strength in the geriatric patient, J Am Med Dir Assoc, 17, 466.e1, 10.1016/j.jamda.2016.02.026

Francis, 2017, Measurement of maximal isometric torque and muscle quality of the knee extensors and flexors in healthy 50- to 70-year-old women, Clin Physiol Funct Imaging, 37, 448, 10.1111/cpf.12332

Cesari, 2009, Added value of physical performance measures in predicting adverse health-related events: results from the Health, Aging And Body Composition Study, J Am Geriatr Soc, 57, 251, 10.1111/j.1532-5415.2008.02126.x

Jones, 1999, A 30-s chair-stand test as a measure of lower body strength in community-residing older adults, Res Q Exerc Sport, 70, 113, 10.1080/02701367.1999.10608028

Cooper, 2013, Tools in the assessment of sarcopenia, Calcif Tissue Int, 93, 201, 10.1007/s00223-013-9757-z

Cawthon, 2014, Cutpoints for low appendicular lean mass that identify older adults with clinically significant weakness, J Gerontol A Biol Sci Med Sci, 69, 567, 10.1093/gerona/glu023

Hull, 2009, iDXA, Prodigy, and DPXL dual-energy X-ray absorptiometry whole-body scans: a cross-calibration study, J Clin Densitom, 12, 95, 10.1016/j.jocd.2008.09.004

Kim, 2016, Differences among skeletal muscle mass indices derived from height-, weight-, and body mass index-adjusted models in assessing sarcopenia, Korean J Intern Med, 31, 643, 10.3904/kjim.2016.015

Kyle, 2003, Validation of a bioelectrical impedance analysis equation to predict appendicular skeletal muscle mass (ASMM), Clin Nutr, 22, 537, 10.1016/S0261-5614(03)00048-7

Sergi, 2015, Assessing appendicular skeletal muscle mass with bioelectrical impedance analysis in free-living Caucasian older adults, Clin Nutr, 34, 667, 10.1016/j.clnu.2014.07.010

Gonzalez, 2017, Bioelectrical impedance analysis for diagnosing sarcopenia and cachexia: what are we really estimating?, J Cachexia Sarcopenia Muscle, 8, 187, 10.1002/jcsm.12159

Yu, 2016, The performance of five bioelectrical impedance analysis prediction equations against dual X-ray absorptiometry in estimating appendicular skeletal muscle mass in an Adult Australian Population, Nutrients, 8, 189, 10.3390/nu8040189

Reiss, 2016, Case finding for sarcopenia in geriatric inpatients: performance of bioimpedance analysis in comparison to dual X-ray absorptiometry, BMC Geriatr, 16, 52, 10.1186/s12877-016-0228-z

Tosato, 2017, Measurement of muscle mass in sarcopenia: from imaging to biochemical markers, Aging Clin Exp Res, 29, 19, 10.1007/s40520-016-0717-0

Landi, 2014, Calf circumference, frailty and physical performance among older adults living in the community, Clin Nutr, 33, 539, 10.1016/j.clnu.2013.07.013

Beaudart, Assessment of muscle function and physical performance in daily clinical practice, 10.1007/s00223-019-00545-w

Bruyere, 2016, Assessment of muscle mass, muscle strength and physical performance in clinical practice: an international survey, Eur Geriatr Med, 7, 243, 10.1016/j.eurger.2015.12.009

Abellan van Kan, 2009, Gait speed at usual pace as a predictor of adverse outcomes in community-dwelling older people an International Academy on Nutrition and Aging (IANA) Task Force, J Nutr Health Aging, 13, 881, 10.1007/s12603-009-0246-z

Peel, 2013, Gait speed as a measure in geriatric assessment in clinical settings: a systematic review, J Gerontol A Biol Sci Med Sci, 68, 39, 10.1093/gerona/gls174

Studenski, 2011, Gait speed and survival in older adults, JAMA, 305, 50, 10.1001/jama.2010.1923

Guralnik, 2000, Lower extremity function and subsequent disability: consistency across studies, predictive models, and value of gait speed alone compared with the short physical performance battery, J Gerontol A Biol Sci Med Sci, 55, M221, 10.1093/gerona/55.4.M221

Maggio, 2016, Instrumental and non-instrumental evaluation of 4-meter walking speed in older individuals, PLoS One, 11, e0153583, 10.1371/journal.pone.0153583

Rydwik, 2012, Investigation into the reliability and validity of the measurement of elderly people’s clinical walking speed: a systematic review, Physiother Theory Pract, 28, 238, 10.3109/09593985.2011.601804

Podsiadlo, 1991, The timed ‘Up & Go’: a test of basic functional mobility for frail elderly persons, J Am Geriatr Soc, 39, 142, 10.1111/j.1532-5415.1991.tb01616.x

Pavasini, 2016, Short physical performance battery and all-cause mortality: systematic review and meta-analysis, BMC Med, 14, 215, 10.1186/s12916-016-0763-7

Vestergaard, 2009, Characteristics of 400-meter walk test performance and subsequent mortality in older adults, Rejuvenation Res, 12, 177, 10.1089/rej.2009.0853

Bergland, 2017, Mobility as a predictor of all-cause mortality in older men and women: 11.8 year follow-up in the Tromso study, BMC Health Serv Res, 17, 22, 10.1186/s12913-016-1950-0

Heymsfield, 2015, Skeletal muscle mass and quality: evolution of modern measurement concepts in the context of sarcopenia, Proc Nutr Soc, 74, 355, 10.1017/S0029665115000129

Mourtzakis, 2008, A practical and precise approach to quantification of body composition in cancer patients using computed tomography images acquired during routine care, Appl Physiol Nutr Metab, 33, 997, 10.1139/H08-075

Fearon, 2011, Definition and classification of cancer cachexia: an international consensus, Lancet Oncol, 12, 489, 10.1016/S1470-2045(10)70218-7

Kim, 2015, Prognostic significance of CT-determined sarcopenia in patients with small-cell lung cancer, J Thorac Oncol, 10, 1795, 10.1097/JTO.0000000000000690

Baracos, 2013, Clinical outcomes related to muscle mass in humans with cancer and catabolic illnesses, Int J Biochem Cell Biol, 45, 2302, 10.1016/j.biocel.2013.06.016

Moisey, 2013, Skeletal muscle predicts ventilator-free days, ICU-free days, and mortality in elderly ICU patients, Crit Care, 17, R206, 10.1186/cc12901

Montano-Loza, 2014, Severe muscle depletion predicts postoperative length of stay but is not associated with survival after liver transplantation, Liver Transpl, 20, 640, 10.1002/lt.23863

Baracos, 2010, Body composition in patients with non-small cell lung cancer: a contemporary view of cancer cachexia with the use of computed tomography image analysis, Am J Clin Nutr, 91, 1133S, 10.3945/ajcn.2010.28608C

Gu, 2018, Clinical usefulness of psoas muscle thickness for the diagnosis of sarcopenia in patients with liver cirrhosis, Clin Mol Hepatol, 24, 319, 10.3350/cmh.2017.0077

Hanaoka, 2017, Morphologic change of the psoas muscle as a surrogate marker of sarcopenia and predictor of complications after colorectal cancer surgery, Int J Colorectal Dis, 32, 847, 10.1007/s00384-017-2773-0

Baracos, 2017, Psoas as a sentinel muscle for sarcopenia: a flawed premise, J Cachexia Sarcopenia Muscle, 8, 527, 10.1002/jcsm.12221

Rutten, 2017, Psoas muscle area is not representative of total skeletal muscle area in the assessment of sarcopenia in ovarian cancer, J Cachexia Sarcopenia Muscle, 8, 630, 10.1002/jcsm.12180

Hamaguchi, 2017, Impact of skeletal muscle mass index, intramuscular adipose tissue content, and visceral to subcutaneous adipose tissue area ratio on early mortality of living donor liver transplantation, Transplantation, 101, 565, 10.1097/TP.0000000000001587

Lynch, 1999, Muscle quality. I. Age-associated differences between arm and leg muscle groups, J Appl Physiol (1985), 86, 188, 10.1152/jappl.1999.86.1.188

Rolland, 2004, Muscle strength in obese elderly women: effect of recreational physical activity in a cross-sectional study, Am J Clin Nutr, 79, 552, 10.1093/ajcn/79.4.552

Tracy, 1999, Muscle quality. II. Effects Of strength training in 65- to 75-yr-old men and women, J Appl Physiol (1985), 86, 195, 10.1152/jappl.1999.86.1.195

Shankaran, 2018, Dilution of oral D3-creatine to measure creatine pool size and estimate skeletal muscle mass: development of a correction algorithm, J Cachexia Sarcopenia Muscle, 9, 540, 10.1002/jcsm.12278

Clark, 2018, Creatine ( methyl-d3) dilution in urine for estimation of total body skeletal muscle mass: accuracy and variability vs. MRI and DXA, J Appl Physiol, 124, 1, 10.1152/japplphysiol.00455.2016

Buehring, 2018, Comparison of muscle/lean mass measurement methods: correlation with functional and biochemical testing, Osteoporos Int, 29, 675, 10.1007/s00198-017-4315-6

Galindo Martin, 2017, Bedside ultrasound measurement of rectus femoris: a tutorial for the nutrition support clinician, J Nutr Metab, 2017, 2767232, 10.1155/2017/2767232

Ticinesi, 2018, Assessing sarcopenia with vastus lateralis muscle ultrasound: an operative protocol, Aging Clin Exp Res, 10.1007/s40520-018-0958-1

SARCUS working group on behalf of the Sarcopenia Special Interest Group of the European Geriatric Medicine Society, 2018, Application of ultrasound for muscle assessment in sarcopenia: towards standardized measurements, Eur J Med

Sipila, 1993, Muscle ultrasonography and computed tomography in elderly trained and untrained women, Muscle Nerve, 16, 294, 10.1002/mus.880160309

Ismail, 2015, Diagnostic ultrasound estimates of muscle mass and muscle quality discriminate between women with and without sarcopenia, Front Physiol, 6, 302, 10.3389/fphys.2015.00302

Nijholt, 2017, The reliability and validity of ultrasound to quantify muscles in older adults: a systematic review, J Cachexia Sarcopenia Muscle, 8, 702, 10.1002/jcsm.12210

Ticinesi, 2017, Muscle ultrasound and sarcopenia in older individuals: a clinical perspective, J Am Med Dir Assoc, 18, 290, 10.1016/j.jamda.2016.11.013

Abe, 2015, Validity of ultrasound prediction equations for total and regional muscularity in middle-aged and older men and women, Ultrasound Med Biol, 41, 557, 10.1016/j.ultrasmedbio.2014.09.007

Curcio, 2016, Biomarkers in sarcopenia: a multifactorial approach, Exp Gerontol, 85, 1, 10.1016/j.exger.2016.09.007

Calvani, 2017, Biomarkers for physical frailty and sarcopenia, Aging Clin Exp Res, 29, 29, 10.1007/s40520-016-0708-1

Beaudart, 2015, Development of a self-administrated quality of life questionnaire for sarcopenia in elderly subjects: the SarQoL, Age Ageing, 44, 960, 10.1093/ageing/afv133

Beaudart, 2017, Current review of the SarQoL(R): a health-related quality of life questionnaire specific to sarcopenia, Expert Rev Pharmacoecon Outcomes Res, 17, 335, 10.1080/14737167.2017.1360768

Beaudart, 2018, Quality of life in sarcopenia measured with the SarQoL(R): impact of the use of different diagnosis definitions, Aging Clin Exp Res, 30, 307, 10.1007/s40520-017-0866-9

Gould, 2014, Total and appendicular lean mass reference ranges for Australian men and women: the Geelong osteoporosis study, Calcif Tissue Int, 94, 363, 10.1007/s00223-013-9830-7

Guralnik, 1995, Lower-extremity function in persons over the age of 70 years as a predictor of subsequent disability, N Engl J Med, 332, 556, 10.1056/NEJM199503023320902

Bischoff, 2003, Identifying a cut-off point for normal mobility: a comparison of the timed ‘up and go’ test in community-dwelling and institutionalised elderly women, Age Ageing, 32, 315, 10.1093/ageing/32.3.315

Newman, 2006, Association of long-distance corridor walk performance with mortality, cardiovascular disease, mobility limitation, and disability, JAMA, 295, 2018, 10.1001/jama.295.17.2018

Keller, 2013, Strength and muscle mass loss with aging process. Age and strength loss, Muscles Ligaments Tendons J, 3, 346, 10.32098/mltj.04.2013.17

Dodds, 2012, Birth weight and muscle strength: a systematic review and meta-analysis, J Nutr Health Aging, 16, 609, 10.1007/s12603-012-0053-9

Bloom, 2018, Diet quality and sarcopenia in older adults: a systematic review, Nutrients, 10, 10.3390/nu10030308

Mijnarends, 2016, Physical activity and incidence of sarcopenia: the population-based AGES-Reykjavik Study, Age Ageing, 45, 614, 10.1093/ageing/afw090

Prado, 2012, Sarcopenic obesity: a critical appraisal of the current evidence, Clin Nutr, 31, 583, 10.1016/j.clnu.2012.06.010

Johnson Stoklossa, 2017, Prevalence of sarcopenic obesity in adults with class II/III obesity using different diagnostic criteria, J Nutr Metab, 2017, 7307618, 10.1155/2017/7307618

Kalinkovich, 2017, Sarcopenic obesity or obese sarcopenia: A cross talk between age-associated adipose tissue and skeletal muscle inflammation as a main mechanism of the pathogenesis, Ageing Res Rev, 35, 200, 10.1016/j.arr.2016.09.008

Barbat-Artigas, 2014, Exploring the role of muscle mass, obesity, and age in the relationship between muscle quality and physical function, J Am Med Dir Assoc, 15, 303.e13, 10.1016/j.jamda.2013.12.008

Tian, 2016, Association of sarcopenic obesity with the risk of all-cause mortality: A meta-analysis of prospective cohort studies, Geriatr Gerontol Int, 16, 155, 10.1111/ggi.12579

Newman, 2003, Strength and muscle quality in a well-functioning cohort of older adults: the Health, Aging and Body Composition Study, J Am Geriatr Soc, 51, 323, 10.1046/j.1532-5415.2003.51105.x

Morley, 2013, Frailty consensus: a call to action, J Am Med Dir Assoc, 14, 392, 10.1016/j.jamda.2013.03.022

Clegg, 2013, Frailty in elderly people, Lancet, 381, 752, 10.1016/S0140-6736(12)62167-9

Langlois, 2012, The multiple dimensions of frailty: physical capacity, cognition, and quality of life, Int Psychogeriatr, 24, 1429, 10.1017/S1041610212000634

Sieber, 2017, Frailty - From concept to clinical practice, Exp Gerontol, 87, 160, 10.1016/j.exger.2016.05.004

Fried, 2001, Frailty in older adults: evidence for a phenotype, J Gerontol A Biol Sci Med Sci, 56, M146, 10.1093/gerona/56.3.M146

Dodds, 2015, Sarcopenia and frailty: new challenges for clinical practice, Clin Med (Lond), 15, s88, 10.7861/clinmedicine.15-6-s88

Cederholm, 2015, Overlaps between frailty and sarcopenia definitions, Nestle Nutr Inst Workshop Ser, 83, 65, 10.1159/000382063

Steverink, 2001, Measuring frailty: developing and testing the Groningen Frailty Indicator (GFI), Gerontologist, 41, 236

Rockwood, 2005, A global clinical measure of fitness and frailty in elderly people, CMAJ, 173, 489, 10.1503/cmaj.050051

Dent, 2016, Frailty measurement in research and clinical practice: A review, Eur J Intern Med, 31, 3, 10.1016/j.ejim.2016.03.007

Roppolo, 2015, A comparison between uni- and multidimensional frailty measures: prevalence, functional status, and relationships with disability, Clin Interv Aging, 10, 1669

Muscaritoli, 2010, Consensus definition of sarcopenia, cachexia and pre-cachexia: joint document elaborated by Special Interest Groups (SIG) ‘cachexia-anorexia in chronic wasting diseases’ and ‘nutrition in geriatrics’, Clin Nutr, 29, 154, 10.1016/j.clnu.2009.12.004

Cederholm, 2017, ESPEN guidelines on definitions and terminology of clinical nutrition, Clin Nutr, 36, 49, 10.1016/j.clnu.2016.09.004

Cederholm, 2018, GLIM criteria for the diagnosis of malnutrition - A consensus report from the global clinical nutrition community, Clin Nutr