Sarcopenia-related gut microbial changes are associated with the risk of complications in people with cirrhosis

Dasarathy, 2016, Sarcopenia from mechanism to diagnosis and treatment in liver disease, J Hepatol, 65, 1232, 10.1016/j.jhep.2016.07.040 Merli, 2019, EASL Clinical Practice Guidelines on nutrition in chronic liver disease, J Hepatol, 70, 172, 10.1016/j.jhep.2018.06.024 Montano-Loza, 2012, Muscle wasting is associated with mortality in patients with cirrhosis, Clin Gastroenterol Hepatol, 10, 166, 10.1016/j.cgh.2011.08.028 Huguet, 2018, The psoas muscle transversal diameter predicts mortality in patients with cirrhosis on a waiting list for liver transplantation: a retrospective cohort study, Nutrition, 51–52, 73, 10.1016/j.nut.2018.01.008 Kang, 2018, Impact of sarcopenia on prognostic value of cirrhosis: going beyond the hepatic venous pressure gradient and MELD score, J Cachexia Sarcopenia Muscle, 9, 860, 10.1002/jcsm.12333 Praktiknjo, 2018, Fat-free muscle mass in magnetic resonance imaging predicts acute-on-chronic liver failure and survival in decompensated cirrhosis, Hepatology, 67, 1014, 10.1002/hep.29602 Ren, 2021, Alterations of intestinal microbiota in liver cirrhosis with muscle wasting, Nutrition, 83, 10.1016/j.nut.2020.111081 Chu, 2019, Small metabolites, possible big changes: a microbiota-centered view of non-alcoholic fatty liver disease, Gut, 68, 359, 10.1136/gutjnl-2018-316307 Schnabl, 2014, Interactions between the intestinal microbiome and liver diseases, Gastroenterology, 146, 1513, 10.1053/j.gastro.2014.01.020 Bajaj, 2014, Altered profile of human gut microbiome is associated with cirrhosis and its complications, J Hepatol, 60, 940, 10.1016/j.jhep.2013.12.019 Trebicka, 2021, The microbiota in cirrhosis and its role in hepatic decompensation, J Hepatol, 75, S67, 10.1016/j.jhep.2020.11.013 Bindels, 2013, Muscle wasting: the gut microbiota as a new therapeutic target?, Int J Biochem Cel Biol, 45, 2186, 10.1016/j.biocel.2013.06.021 Ponziani, 2021, Characterization of the gut-liver-muscle axis in cirrhotic patients with sarcopenia, Liver Int, 41, 1320, 10.1111/liv.14876 Tsochatzis, 2014, Liver cirrhosis, Lancet, 383, 1749, 10.1016/S0140-6736(14)60121-5 Chen, 2020, Asian working group for sarcopenia: 2019 consensus update on sarcopenia diagnosis and treatment, J Am Med Dir Assoc, 21, 300, 10.1016/j.jamda.2019.12.012 Belarmino, 2018, Diagnosing sarcopenia in male patients with cirrhosis by dual-energy X-ray absorptiometry estimates of appendicular skeletal muscle mass, JPEN J Parenter Enteral Nutr, 42, 24, 10.1177/0148607117701400 Carey, 2010, Six-minute walk distance predicts mortality in liver transplant candidates, Liver Transpl, 16, 1373, 10.1002/lt.22167 Angeli, 2018, EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis, J Hepatol, 69, 406, 10.1016/j.jhep.2018.03.024 Tandon, 2017, A practical approach to nutritional screening and assessment in cirrhosis, Hepatology, 65, 1044, 10.1002/hep.29003 Bassett, 2003, International physical activity questionnaire: 12-country reliability and validity, Med Sci Sports Exerc, 35, 1396, 10.1249/01.MSS.0000078923.96621.1D Tsai, 2018, A lipidomics study reveals lipid signatures associated with early allograft dysfunction in living donor liver transplantation, J Clin Med, 8, 30 Nossa, 2010, Design of 16S rRNA gene primers for 454 pyrosequencing of the human foregut microbiome, World J Gastroenterol, 16, 4135, 10.3748/wjg.v16.i33.4135 Callahan, 2016, DADA2: high-resolution sample inference from Illumina amplicon data, Nat Methods, 13, 581, 10.1038/nmeth.3869 Bolyen, 2019, Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2, Nat Biotechnol, 37, 852, 10.1038/s41587-019-0209-9 Douglas, 2020, PICRUSt2 for prediction of metagenome functions, Nat Biotechnol, 38, 685, 10.1038/s41587-020-0548-6 Fluss, 2005, Estimation of the Youden Index and its associated cutoff point, Biom J, 47, 458, 10.1002/bimj.200410135 Grosicki, 2018, Gut microbiota contribute to age-related changes in skeletal muscle size, composition, and function: biological basis for a gut-muscle Axis, Calcif Tissue Int, 102, 433, 10.1007/s00223-017-0345-5 Ticinesi, 2017, Aging gut microbiota at the cross-road between nutrition, physical frailty, and sarcopenia: is there a gut-muscle Axis?, Nutrients, 9, 1303, 10.3390/nu9121303 Bajaj, 2018, Diet affects gut microbiota and modulates hospitalization risk differentially in an international cirrhosis cohort, Hepatology, 68, 234, 10.1002/hep.29791 Belzer, 2017, Microbial metabolic networks at the mucus layer lead to diet-independent butyrate and vitamin B(12) production by intestinal symbionts, mBio, 8, 10.1128/mBio.00770-17 Ticinesi, 2019, Gut microbiota, muscle mass and function in aging: a focus on physical frailty and sarcopenia, Nutrients, 11, 1633, 10.3390/nu11071633 Bloom, 2021, Deep stool microbiome analysis in cirrhosis reveals an association between short-chain fatty acids and hepatic encephalopathy, Ann Hepatol, 25, 10.1016/j.aohep.2021.100333 Lang, 2020, Changes in the fecal bacterial microbiota associated with disease severity in alcoholic hepatitis patients, Gut Microbes, 12, 10.1080/19490976.2020.1785251 Liu, 2021, Understanding the gut microbiota and sarcopenia: a systematic review, J Cachexia Sarcopenia Muscle, 12, 1393, 10.1002/jcsm.12784 Chen, 2011, Characterization of fecal microbial communities in patients with liver cirrhosis, Hepatology, 54, 562, 10.1002/hep.24423 Bajaj, 2012, Linkage of gut microbiome with cognition in hepatic encephalopathy, Am J Physiol Gastrointest Liver Physiol, 302, G168, 10.1152/ajpgi.00190.2011 Bajaj, 2017, Fecal microbiota transplant from a rational stool donor improves hepatic encephalopathy: a randomized clinical trial, Hepatology, 66, 1727, 10.1002/hep.29306 Lahiri, 2019, The gut microbiota influences skeletal muscle mass and function in mice, Sci Transl Med, 11, 10.1126/scitranslmed.aan5662 Metges, 2000, Contribution of microbial amino acids to amino acid homeostasis of the host, J Nutr, 130, 1857s Beaumont, 2017, Quantity and source of dietary protein influence metabolite production by gut microbiota and rectal mucosa gene expression: a randomized, parallel, double-blind trial in overweight humans, Am J Clin Nutr, 106, 1005, 10.3945/ajcn.117.158816 Lynch, 2014, Branched-chain amino acids in metabolic signalling and insulin resistance, Nat Rev Endocrinol, 10, 723, 10.1038/nrendo.2014.171 Wu, 2013, Functional amino acids in nutrition and health, Amino Acids, 45, 407, 10.1007/s00726-013-1500-6 Trommelen, 2021, Gut amino acid absorption in humans: concepts and relevance for postprandial metabolism, Clinical Nutrition Open Science, 36, 43, 10.1016/j.nutos.2020.12.006