Salivary C‐reactive protein and mean platelet volume in diagnosis of late‐onset neonatal pneumonia
Tóm tắt
Neonatal pneumonia is an important and major cause of neonatal morbidity and mortality worldwide therefore; its early detection plays a crucial role in successful therapy. Analysis of saliva as a non‐invasive method for detection of neonatal diseases holds great promise for improving health care. Till now, salivary C‐reactive protein (CRP), mean platelet volume (MPV), neutrophil/lymphocyte ratio (NLR) and platelets/lymphocytes ratio (PLR) have not been studied as markers of diagnosis in neonatal pneumonia.
To assess the applicability of salivary CRP, MPV, NLR and PLR as diagnostic markers in late‐onset neonatal pneumonia.
A prospective case control study of 70 full‐term neonates, 35 with late‐onset neonatal pneumonia and 35 healthy controls, was enrolled. Serum and salivary CRP concentrations were measured by ELISA, while MPV, NLR and PLR were measured by automated blood cell counter.
This study showed a statistically significant difference between salivary CRP means in neonates with late‐onset neonatal pneumonia vs control neonates (6.2 ± 4.6 and 2.8 ± 1.9 ng/L) respectively. At the cutoff point of 3.8 ng/L, salivary CRP showed 91.4% sensitivity and 80.9% specificity. Salivary CRP also showed accuracy in predicting elevated serum CRP in neonates with pneumonia. MPV showed a significant difference between pneumonia and controls (mean = 10.2 ± 0.7, 8 ± 0.5) respectively. At cutoff point 9.0, it has 80% sensitivity and specificity.
The present study showed for the first time that both salivary CRP and MPV are suitable as diagnostic markers in late‐onset neonatal pneumonia.
Từ khóa
Tài liệu tham khảo
The Child Health Research Project. Reducing perinatal and neonatal mortality: report of a meeting Baltimore Maryland; vol3;1999:6–12.
Catal F, 2014, Mean platelet volume (MPV) may simply predict the severity of sepsis in preterm infants, Clin Lab., 60, 1193
Bekdas M, 2014, Neutrophil/lymphocyte and C‐reactive protein/mean platelet volume ratios in differentiating between viral and bacterial pneumonias and diagnosing early complications in children, Saudi Med J., 35, 442
Kumar R, 2010, Validation of c‐reactive protein in the early diagnosis of neonatal sepsis in a tertiary care hospital in Kenya, East Afr Med J., 87, 255
Ahmad MS, 2014, Platelet counts, MPV and PDW in culture proven and probable neonatal sepsis and association of platelet counts with mortality rate, J Coll Physicians Surg Pak., 24, 340