Salivary Biomarkers: Toward Future Clinical and Diagnostic Utilities

Clinical Microbiology Reviews - Tập 26 Số 4 - Trang 781-791 - 2013
Janice Yoshizawa1, Christopher A. Schafer1, Jason J. Schafer2, James J. Farrell3, Bruce J. Paster4,5, David T. Wong1
1UCLA School of Dentistry and Center of Oral/Head & Neck Oncology Research, Los Angeles, California, USA
2Department of Pharmacy Practice, Jefferson School of Pharmacy, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
3Yale Center for Pancreatic Disease and Endoscopic Oncology, Yale University School of Medicine, New Haven, Connecticut, USA
4Department of Oral Biology Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts, USA
5The Forsyth Institute, Cambridge, Massachusetts, USA

Tóm tắt

SUMMARYThe pursuit of timely, cost-effective, accurate, and noninvasive diagnostic methodologies is an endeavor of urgency among clinicians and scientists alike. Detecting pathologies at their earliest stages can significantly affect patient discomfort, prognosis, therapeutic intervention, survival rates, and recurrence. Diagnosis and monitoring often require painful invasive procedures such as biopsies and repeated blood draws, adding undue stress to an already unpleasant experience. The discovery of saliva-based microbial, immunologic, and molecular biomarkers offers unique opportunities to bypass these measures by utilizing oral fluids to evaluate the condition of both healthy and diseased individuals. Here we discuss saliva and its significance as a source of indicators for local, systemic, and infectious disorders. We highlight contemporary innovations and explore recent discoveries that deem saliva a mediator of the body's physiological condition. Additionally, we examine the current state of salivary diagnostics and its associated technologies, future aspirations, and potential as the preferred route of disease detection, monitoring, and prognosis.

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Clinical Microbiology Reviews

Tập 26 Số 4

781-791

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