Salivary α‐Amylase in Biobehavioral Research

Annals of the New York Academy of Sciences - Tập 1098 Số 1 - Trang 122-144 - 2007
Douglas A. Granger1, Katie T. Kivlighan2, Mona El‐Sheikh3, Elana B. Gordis4, Laura R. Stroud5
1Behavioral Endocrinology Laboratory, Departments of Biobehavioral Health and Human Development and Family Studies, Pennsylvania State University, University Park, Pennsylvania, USA
2Department of population, family and reproductive health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
3 Department of Human Development & Family Studies, Auburn University, Auburn, Alabama USA
4Department of Psychology University at Albany, SUNY Albany New York USA
5Centers for Behavioral and Preventive Medicine, Brown Medical School, Providence, Rhode Island, USA

Tóm tắt

Abstract:  In the history of science, technical advances often precede periods of rapid accumulation of knowledge. Within the past three decades, discoveries that enabled the noninvasive measurement of the psychobiology of stress (in saliva) have added new dimensions to the study of health and human development. This widespread enthusiasm has led to somewhat of a renaissance in behavioral science. At the cutting edge, the focus is on testing innovative theoretical models of individual differences in behavior as a function of multilevel biosocial processes in the context of everyday life. Several new studies have generated renewed interest in salivary α‐amylase (sAA) as a surrogate marker of the autonomic/sympathetic nervous system component of the psychobiology of stress. This article reviews sAA's properties and functions; presents illustrative findings relating sAA to stress and the physiology of stress, behavior, cognitive function, and health; and provides practical information regarding specimen collection and assay. The overarching intent is to accelerate the learning curve such that investigators avoid potential pitfalls associated with integrating this unique salivary analyte into the next generation of biobehavioral research.

Từ khóa


Tài liệu tham khảo

Malamud D., 1993, Saliva as a Diagnostic Fluid, Ann. N.Y. Acad. Sci., 694

10.1159/000118611

10.1016/0306-4530(94)90013-2

10.1097/00004703-200204000-00007

10.1002/1098-2302(2000)37:4<209::AID-DEV1>3.0.CO;2-S

10.1111/1467-8624.00590

Lovallo W.R., 2000, Handbook of Psychophysiology, 342

10.1001/jama.1992.03480090092034

Cacioppo J.T., 2000, Handbook of Psychophysiology

10.1002/dev.10136

10.1002/1098-2302(200011)37:3<153::AID-DEV4>3.0.CO;2-Y

Engel B.T., 1972, Handbook of Psychophysiology, 571

Schwab K.O., 1992, Assessment of Hormones and Drugs in Saliva in Biobehavioral Research, 331

10.1016/0003-9969(92)90141-T

10.1016/0003-9969(74)90161-7

Kirschbaum C., 1992, Assessment of Hormones and Drugs in Saliva in Biobehavioral Research

10.1016/S0899-9007(98)00170-1

Susman E.J. D.A.Granger S.Dockray et al.2006.Alpha amylase timing of puberty and disruptive behavior in young adolescents: a test of the attenuation hypothesis.Presented at the biennial meeting of the Society for Research on Adolescence San Francisco CA March.

Marcotte H., 1998, Oral microbial ecology and the role of salivary immunoglobulin A, Microbiol. Molec. Biol. Rev., 62, 71, 10.1128/MMBR.62.1.71-109.1998

10.1159/000047477

10.1016/0009-8981(80)90384-8

El‐Sheikh M. J.Mize&D.A.Granger.2005.Endocrine and parasympathetic responses to stress predict child adjustment physical health and cognitive functioning.Presented at the Biennial meeting of Society for Research in Child Development. Altanta GA March.

10.1111/j.1475-097X.1996.tb00731.x

10.1210/jc.82.8.2503

10.1016/S0167-8760(99)00100-2

10.1016/j.psyneuen.2006.05.010

10.1016/j.ijpsycho.2004.09.009

10.1016/j.psyneuen.2005.05.010

Stroud L.R.et al.2006.Saliva alpha‐amylase stress reactivity in children and adolescents: validity associations with cortisol and links behavior.Presented at the Annual Meeting of the American Psychosomatic Society. Denver CO March.

10.1016/j.psyneuen.2005.05.012

10.1016/j.psyneuen.2006.01.007

Stroud L.R.et al.2006.Alpha amylase responses to achievement and interpersonal stressors over adolescence: developmental differences and associations with cortisol and cardiovascular responses.Presented at the Biennial Meeting of the Society for Research on Adolescence. San Francisco CA March.

10.1196/annals.1314.033

Gallacher D.V., 1983, Stimulus‐secretion coupling in mammalian salivary glands, Int. Rev. Physiol., 28, 1

10.1037/0033-2909.130.3.355

Kivlighan K.T.et al.2005.Salivary alpha amylase and cortisol: levels and stress reactivity in 6‐month old infants and their mothers.Presented at the Biennial Meeting of Society for Research in Child Development. Altanta GA March.

Gordis E.B.et al.2006.Salivary alpha‐amylase and cortisol responses to social stress among maltreated and comparison youth.Presented at the Biennial Meeting of the Society for Research on Adolescence. San Francisco CA March.

10.1177/0265407506062479

10.1210/en.133.3.1411

10.1016/0009-9236(95)90076-4

10.1016/j.psyneuen.2005.04.006

10.1007/BF02691093

10.1111/j.1467-9450.1982.tb00466.x

10.1097/01.PSY.0000058376.50240.2D

West S.G.et al.2006.Salivary alpha‐amylase response to the cold pressor is correlated with cardiac markers of sympathetic activation.Presented at the Annual Meeting of the American Psychosomatic Society. Denver CO March.

10.1016/0167-8760(92)90007-X

Klein L.C.et al.2006.Effects of caffeine and stress on salivary alpha‐amylase in young men: a salivary biomarker of sympathetic activity.Presented at the Annual Meeting of the American Psychosomatic Society. Denver CO March.

Kivlighan K.T.et al.2006.Salivary alpha amylase reactivity to the Trier Social Stress Test: relation to cortisol and autonomic responses in normally developing adolescents. Unpublished manuscript.

Shea A.K.et al.2006.Maternal depression and salivary alpha amylase response to stress in their infants.Presented at the Annual Meeting of the American Psychosomatic Society. Denver CO March.

Hill A.L.et al.2006.Physiological responses to Strange Situation as a function of attachment status: vagal withdrawal salivary alpha‐amylase and salivary cortisol. Unpublished manuscript.

Mize J. J.Lisonbee&D.A.Granger.2005.Stress in child care: cortisol and alpha‐amylase may reflect different components of the stress response.Presented at the Biennial Meeting of Society for Research in Child Development. Altanta GA March.

El‐Sheikh M.et al.2006.Asymmetry between salivary alpha‐amylase and cortisol reactivity to stress and children's adjustment. Unpublished manuscript.

Buckhalt J.A. M.El‐Sheikh&D.A.Granger.2006.Children's cognitive functioning and academic performance: the role of cortisol and alpha‐amylase. Unpublished manuscript.

Lyons‐Ruth K., 1997, Infant attachment strategies, infant mental lag, and maternal depressive symptoms: predictors of internalizing and externalizing problems at age 7, Dev. Psychol., 33, 681, 10.1037/0012-1649.33.4.681

10.1016/0022-3999(80)90033-1

10.1111/j.1469-8986.1981.tb02467.x

Nater U.M.et al.2006.Determinants of diurnal course of salivary alpha‐amylase activity.Presented at the Annual Meeting of the American Psychosomatic Society. Denver CO March.

10.1161/01.CIR.90.1.248

10.1006/abbi.2000.1877

10.1016/S0306-4530(00)00042-1

Ader R., 1995, Psychoneuroimmunology

Thông tin
Thông tin xuất bản

Annals of the New York Academy of Sciences

Tập 1098 Số 1

122-144

Thông tin tác giả