Safety of COX-2 Inhibitors in Asthma Patients with Aspirin Hypersensitivity

Annals of Pharmacotherapy - Tập 37 Số 10 - Trang 1497-1501 - 2003
Patricia M. West1, Cristina Fernández2
1Patricia M West PharmD BCPS, Clinical Assistant Professor, Department of Pharmacy Practice, College of Pharmacy, University of Illinois at Chicago, Chicago, IL
2Cristina Fernández PharmD, Pharmacy Practice Resident, Clinical Associate, Department of Pharmacy Practice, College of Pharmacy, University of Illinois at Chicago

Tóm tắt

Objective To review the safety of cyclooxygenase-2 (COX-2) inhibitors in asthma patients with aspirin hypersensitivity. Data Sources Clinical studies were identified using MEDLINE (1966–September 2002). Key search terms included cyclooxygenase inhibitors, aspirin, asthma, and hypersensitivity. English-language articles were identified and included. References from the identified articles were also reviewed. Data Synthesis The literature provides information regarding the safety of COX-2 inhibitors in asthma patients with aspirin-exacerbated respiratory disease (AERD). The mechanism of AERD involves inhibition of cyclooxygenase, particularly COX-1. Inhibition of COX-1 causes an increased production of certain inflammatory mediators, which results in the reactions seen with AERD. Considering this mechanism, COX-2 inhibitors may be an alternative to aspirin or nonsteroidal antiinflammatory drugs (NSAIDs) in a patient with AERD. This article analyzes 4 studies to evaluate the safety of COX-2 inhibitors in this population. Results The 4 studies evaluated included a total of 172 patients with AERD. All patients included demonstrated intolerance to aspirin or NSAIDs and tolerated the selective COX-2 inhibitor administered. Conclusions COX-2 inhibitors provide a potentially safe alternative for treatment of inflammatory conditions in patients with AERD.

Từ khóa


Tài liệu tham khảo

10.1097/00045391-200205000-00009

10.1016/S1081-1206(10)62099-6

10.1136/thorax.55.suppl_2.S42

Sanchez-Borges M, 2001, ACI Int, 13, 211

10.1378/chest.118.5.1470

10.1034/j.1398-9995.2002.13447.x

10.1097/00130832-200102000-00006

Niz Ankowska E, 1989, Ann Allergy, 63, 159

10.1016/S1081-1206(10)62432-5

10.1016/S1081-1206(10)62575-6

10.1046/j.1365-2222.2001.01075.x

10.1378/chest.121.6.1812

10.1002/art.10426

10.1067/mai.2001.116290

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Annals of Pharmacotherapy

Tập 37 Số 10

1497-1501

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