Safety and bioactive potential of nanoparticles containing Cantaloupe melon (Cucumis melo L.) carotenoids in an experimental model of chronic inflammation

Rao, 2007, Carotenoids and human health, Pharmacol. Res., 55, 207, 10.1016/j.phrs.2007.01.012 Ezzat, 2019, In vivo anti-inflammatory activity and UPLC-MS/MS profiling of the peels and pulps of Cucumis melo var. cantalupensis and Cucumis melo var. reticulatus, J. Ethnopharmacol., 237, 245, 10.1016/j.jep.2019.03.015 Leão, 2017, Physicochemical characterization, antioxidant capacity, total phenolic and proanthocyanidin content of flours prepared from pequi (Caryocar brasilense Camb.) fruit by-products, Food Chem., 225, 146, 10.1016/j.foodchem.2017.01.027 Murillo, 2013, Native carotenoids composition of some tropical fruits, Food Chem., 825, 10.1016/j.foodchem.2012.11.014 Laur, 2011, Provitamin A and vitamin C contents in selected California-grown cantaloupe and honeydew melons and imported melons, J. Food Compos. Anal., 24, 194, 10.1016/j.jfca.2010.07.009 Bonet, 2015, Carotenoids and their conversion products in the control of adipocyte function, adiposity and obesity, Arch. Biochem. Biophys., 572, 112, 10.1016/j.abb.2015.02.022 Kaulmann, 2014, Carotenoids, inflammation, and oxidative stress-implications of cellular signaling pathways and relation to chronic disease prevention, Nutr. Res., 34, 907, 10.1016/j.nutres.2014.07.010 Tripathi, 2010, Astaxanthin intervention ameliorates cyclophosphamide-induced oxidative stress, DNA damage and early hepatocarcinogenesis in rat: role of Nrf2, p53, p38 and phase-II enzymes, Mutat. Res. – Genet. Toxicol. Environ. Mutagen., 696, 69, 10.1016/j.mrgentox.2009.12.014 Rubin, 2017, Metabolic effects of inflammation on vitamin A and carotenoids in humans and animal models, Adv. Nutr., 8, 197, 10.3945/an.116.014167 Bonet, 2020, Carotenoids and carotenoid conversion products in adipose tissue biology and obesity : pre-clinical and human studies, BBA – Mol. Cell Biol. Lipids, 1865, 1, 10.1016/j.bbalip.2020.158676 Soukoulis, 2018, A comprehensive overview on the micro- and nano-technological encapsulation advances for enhancing the chemical stability and bioavailability of carotenoids, Crit. Rev. Food Sci. Nutr., 58, 1, 10.1080/10408398.2014.971353 Augustin, 2008, Encapsulation of bioactives, 1 Medeiros, 2019, Nanoencapsulation improved water solubility and color stability of carotenoids extracted from Cantaloupe melon (Cucumis melo L.), Food Chem., 270 European Food Safety Authorit (EFSA), 2018, Guidance on risk assessment of the application of nanoscience and nanotechnologies in the food and feed chain: part 1, human and animal health, EFSA J., 16, 95 Biehler, 2010, Methods for assessing aspects of carotenoid bioavailability, Curr. Nutr. Food Sci., 6, 44, 10.2174/157340110790909545 Rodriguez-Amaya, 2001 Hu, 2015, Core – shell biopolymer nanoparticle delivery systems: synthesis and characterization of curcumin fortified zein – pectin nanoparticles, Food Chem., 182, 275, 10.1016/j.foodchem.2015.03.009 OECD (Organisation for Economic Co-operation and Development), 2001, 14 Committee for the Update of the Guide for the Care and Use of Laboratory And Animals; Institute for Laboratory Animal Research; Division on Life Studies, 2011, 246 Pinzón-García, 2018, Evidence of hypoglycemic, lipid-lowering and hepatoprotective effects of the Bixin and Bixin: β-CD inclusion compound in high-fat-fed obese mice, Biomed. Pharmacother., 106, 363, 10.1016/j.biopha.2018.06.144 Luz, 2018, Adipocytes and intestinal epithelium dysfunctions linking obesity to inflammation induced by high glycemic index pellet-diet in Wistar rats, Biosci. Rep., 38, 10.1042/BSR20180304 Matias, 2019, Tamarind trypsin inhibitor in chitosan–whey protein nanoparticles reduces fasting blood glucose levels without compromising insulinemia: a preclinical study, Nutrients, 11 Silva, 2015, Acute and sub-acute oral toxicity of Brazilian red propolis in rats, J. Ethnopharmacol., 170, 66, 10.1016/j.jep.2015.05.009 Martins, 2018, Paradoxical role of tumor necrosis factor on metabolic dysfunction and adipose tissue expansion in mice, Nutrition, 50, 1, 10.1016/j.nut.2017.07.006 Silva, 2015, Histological evaluation of soya bean-induced enteritis in Atlantic salmon (Salmo salar L.): quantitative image analysis vs. semi-quantitative visual scoring, Aquaculture, 445, 42, 10.1016/j.aquaculture.2015.04.002 Rodriguez-Amaya, 2008, Updated Brazilian database on food carotenoids: factors affecting carotenoid composition, J. Food Compos. Anal., 21, 445, 10.1016/j.jfca.2008.04.001 Fleshman, 2011, Carotene and novel apocarotenoid concentrations in orange-fleshed Cucumis melo Melons: determinations of β-carotene bioaccessibility and bioavailability, J. Agric. Food Chem., 59, 4448, 10.1021/jf200416a Hernández, 2015, Increased temperature produces changes in the bioactive composition of tomato, depending on its developmental stage, J. Agric. Food Chem., 63, 2378, 10.1021/jf505507h Moura, 2015, Retention of provitamin A carotenoids in staple crops targeted for biofortification in Africa: cassava, maize and sweet potato, Crit. Rev. Food Sci. Nutr., 55, 1246, 10.1080/10408398.2012.724477 Wu, 2019, Therapeutic and protective effects of liposomal encapsulation of astaxanthin in mice with alcoholic liver fibrosis, Int. J. Mol. Sci., 20, 10.3390/ijms20164057 Lima, 2017, Acute and subacute oral toxicity assessment of the oil extracted from Attalea phalerata Mart ex Spreng. pulp fruit in rats, Food Res. Int., 91, 11, 10.1016/j.foodres.2016.11.019 Farhangi, 2013, Vitamin A supplementation, serum lipids, liver enzymes and C-reactive protein concentrations in obese women of reproductive age, Ann. Clin. Biochem., 50, 25, 10.1258/acb.2012.012096 Cray, 2009, Acute phase response in animals: a review, Comp. Med., 59, 517 Stojiljkovic, 2018, The encapsulation of lycopene in nanoliposomes enhances its protective potential in methotrexate-induced kidney injury model, Oxid. Med. Cell. Longev., 2018, 10.1155/2018/2627917 Chiu, 2016, Improved hepatoprotective effect of liposome-encapsulated astaxanthin in lipopolysaccharide-induced acute hepatotoxicity, Int. J. Mol. Sci., 17, 10.3390/ijms17071128 Castro, 2012, Association between hepatic cholesterol and oleic acid in the liver of rats treated with partially hydrogenated vegetable oil, Rev. Nutr., 25, 45, 10.1590/S1415-52732012000100005 Guillén, 2009, Microarray analysis of hepatic gene expression identifies new genes involved in steatotic liver, Physiol. Genomics, 37, 187, 10.1152/physiolgenomics.90339.2008