Safe and effective conversion of persistent atrial fibrillation to sinus rhythm by intravenous AZD7009

Lip, 1994, Treatment of atrial fibrillation in a district general hospital, Br Heart J, 71, 92, 10.1136/hrt.71.1.92 Benjamin, 1998, Impact of atrial fibrillation on the risk of death: the Framingham Heart Study, Circulation, 98, 946, 10.1161/01.CIR.98.10.946 Dorian, 2000, The impairment of health-related quality of life in patients with intermittent atrial fibrillation: implications for the assessment of investigational therapy, J Am Coll Cardiol, 36, 1303, 10.1016/S0735-1097(00)00886-X Luderitz, 2000, Quality of life in patients with atrial fibrillation, Arch Intern Med, 160, 1749, 10.1001/archinte.160.12.1749 Go, 2001, Prevalence of diagnosed atrial fibrillation in adults, Jama, 285, 2370, 10.1001/jama.285.18.2370 Pappone, 2003, Mortality, morbidity, and quality of life after circumferential pulmonary vein ablation for atrial fibrillation: outcomes from a controlled nonrandomized long-term study, J Am Coll Cardiol, 42, 185, 10.1016/S0735-1097(03)00577-1 Hagens, 2004, Effect of rate or rhythm control on quality of life in persistent atrial fibrillation, J Am Coll Cardiol, 43, 241, 10.1016/j.jacc.2003.08.037 Fuster, 2001, American College of Cardiology/American Heart Association Task Force on Practice Guidelines; European Society of Cardiology Committee for Practice Guidelines and Policy Conferences (Committee to Develop Guidelines for the Management of Patients With Atrial Fibrillation); North American Society of Pacing and Electrophysiology, Circulation, 104, 2118, 10.1161/circ.104.17.2118 Kobayashi, 1997, Clinical and electrophysiologic effects of dofetilide in patients with supraventricular tachyarrhythmias, J Cardiovasc Pharmacol, 30, 367, 10.1097/00005344-199709000-00015 Oshikawa, 2001, Frequency-dependent electrophysiological effect of ibutilide on human atrium and ventricle, J Interv Card Electrophysiol, 5, 81, 10.1023/A:1009866126492 Darpö, 1995, Selective IK blocker almokalant exhibits class III-specific effects on the repolarization and refractoriness of the human heart: a study of healthy volunteers using right ventricular monophasic action potential recordings, J Cardiovasc Pharmacol, 26, 530, 10.1097/00005344-199510000-00005 Fenichel, 2004, Drug-induced torsades de pointes and implications for drug development, J Cardiovasc Electrophysiol, 15, 475, 10.1046/j.1540-8167.2004.03534.x Duker, 2004, AZD7009—a new atrial antifibrillatory compound that markedly delays atrial refractoriness in the anaesthetised dog, Heart Rhythm, 1, S159 Goldstein, 2004, AZD7009: a new antiarrhythmic drug with predominant effects on the atria effectively terminates and prevents reinduction of atrial fibrillation and flutter in the sterile pericarditis model, J Cardiovasc Electrophysiol, 15, 1444, 10.1046/j.1540-8167.2004.04354.x Persson, 2005, Blocking characteristics of hERG, hNav1.5 and hKvLQT1/hminK after administration of the novel antiarrhythmic compound AZD7009, J Cardiovasc Electrophysiol, 16, 329, 10.1046/j.1540-8167.2005.40427.x Edvardsson, 2005, Predominant effects on atrial versus ventricular refractoriness in man by the novel antiarrhythmic agent AZD7009, Eur Heart J, 26, 506 2005 Ellenbogen, 1996, Efficacy of intravenous ibutilide for rapid termination of atrial fibrillation and atrial flutter: a dose-response study, J Am Coll Cardiol, 28, 130, 10.1016/0735-1097(96)00121-0 Reisinger, 1998, Prospective comparison of flecainide versus sotalol for immediate cardioversion of atrial fibrillation, Am J Cardiol, 81, 1450, 10.1016/S0002-9149(98)00223-9 Vardas, 2000, Amiodarone as a first-choice drug for restoring sinus rhythm in patients with atrial fibrillation: a randomized, controlled study, Chest, 117, 1538, 10.1378/chest.117.6.1538 Pratt, 2005, Efficacy and safety of RSD1235 in the treatment of recent onset atrial fibrillation in ACT I (Atrial arrhythmia Conversion Trial I), a phase III, randomised, placebo-controlled, multi-center trial, Eur Heart J, 26, 506 Wu, 2005, Assessment of the proarrhythmic potential of the novel antiarrhythmic agent AZD7009 and dofetilide in experimental models of torsades de pointes, J Cardiovasc Electrophysiol, 8, 898, 10.1111/j.1540-8167.2005.40720.x Carlsson, 1993, Attenuation of proarrhythmias related to delayed repolarization by low-dose lidocaine in the anesthetized rabbit, J Pharmacol Exp Ther, 267, 1076 Shimizu, 1997, Sodium channel block with mexiletine is effective in reducing dispersion of repolarization and preventing torsade des pointes in LQT2 and LQT3 models of the long-QT syndrome, Circulation, 96, 2038, 10.1161/01.CIR.96.6.2038 Antzelevitch, 2001, Tpeak-Tend interval as an index of transmural dispersion of repolarization, Eur J Clin Invest, 31, 555, 10.1046/j.1365-2362.2001.00849.x