SUMMER, a shiny utility for metabolomics and multiomics exploratory research

Metabolomics - Tập 16 Số 12 - 2020
Ling Huang1, António Currais2, Maxim N. Shokhirev1
1Razavi Newman Integrative Genomics and Bioinformatics Core, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
2Cellular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, 92037, USA

Tóm tắt

Abstract Introduction Cellular metabolites are generated by a complex network of biochemical reactions. This makes interpreting changes in metabolites exceptionally challenging. Objectives To develop a computational tool that integrates multiomics data at the level of reactions. Methods Changes in metabolic reactions are modeled with input from transcriptomics/proteomics measurements of enzymes and metabolomic measurements of metabolites. Results We developed SUMMER, which identified more relevant signals, key metabolic reactions, and relevant underlying biological pathways in a real-world case study. Conclusion SUMMER performs integrative analysis for data interpretation and exploration. SUMMER is freely accessible at http://summer.salk.edu and the code is available at https://bitbucket.org/salkigc/summer.

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Metabolomics

Tập 16 Số 12

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