SREBP transcription factors: master regulators of lipid homeostasis
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Hua, 1995, Hairpin orientation of sterol regulatory element-binding protein-2 in cell membranes as determined by protease protection, J. Biol. Chem., 270, 29422, 10.1074/jbc.270.49.29422
Lee, 2003, The structure of importin-beta bound to SREBP-2: nuclear import of a transcription factor, Science, 302, 1571, 10.1126/science.1088372
Nagoshi, 2001, Dimerization of sterol regulatory element-binding protein 2 via the helix-loop-helix-leucine zipper domain is a prerequisite for its nuclear localization mediated by importin beta, Mol. Cell. Biol., 21, 2779, 10.1128/MCB.21.8.2779-2789.2001
Nagoshi, 1999, Nuclear import of sterol regulatory element-binding protein-2, a basic helix-loop-helix-leucine zipper (bHLH-Zip)-containing transcription factor, occurs through the direct interaction of importin beta with HLH-Zip, Mol. Biol. Cell, 10, 2221, 10.1091/mbc.10.7.2221
Hua, 1995, Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13, Genomics, 25, 667, 10.1016/0888-7543(95)80009-B
Miserez, 1997, Structure of the human gene encoding sterol regulatory element binding protein-2 (SREBF2), Genomics, 40, 31, 10.1006/geno.1996.4525
Tontonoz, 1993, ADD1: a novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation, Mol. Cell. Biol., 13, 4753, 10.1128/MCB.13.8.4753
Shimano, 1997, Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells, J. Clin. Invest., 99, 846, 10.1172/JCI119248
Shimomura, 1997, Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells, J. Clin. Invest., 99, 838, 10.1172/JCI119247
Kim, 1995, Dual DNA binding specificity of ADD1/SREBP1 controlled by a single amino acid in the basic helix-loop-helix domain, Mol. Cell. Biol., 15, 2582, 10.1128/MCB.15.5.2582
Shimano, 1996, Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a, J. Clin. Invest., 98, 1575, 10.1172/JCI118951
Horton, 2003, Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes, Proc. Natl. Acad. Sci. USA, 100, 12027, 10.1073/pnas.1534923100
Horton, 2003, Overexpression of SREBP-1a in mouse adipose tissue produces adipocyte hypertrophy, increased fatty acid secretion, and fatty liver, J. Biol. Chem., 278, 36652, 10.1074/jbc.M306540200
Foretz, 1999, Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes, Proc. Natl. Acad. Sci. USA, 96, 12737, 10.1073/pnas.96.22.12737
Horton, 1998, Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2, J. Clin. Invest., 101, 2331, 10.1172/JCI2961
Horton, 2002, SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver, J. Clin. Invest., 109, 1125, 10.1172/JCI0215593
Amemiya-Kudo, 2002, Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes, J. Lipid Res., 43, 1220, 10.1194/jlr.M100417-JLR200
Liang, 2002, Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c, J. Biol. Chem., 277, 9520, 10.1074/jbc.M111421200
Shimano, 1997, Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene, J. Clin. Invest., 100, 2115, 10.1172/JCI119746
Horton, 1998, Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice, Proc. Natl. Acad. Sci. USA, 95, 5987, 10.1073/pnas.95.11.5987
Kim, 1998, Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1, J. Clin. Invest., 101, 1, 10.1172/JCI1411
Bizeau, 2003, Skeletal muscle sterol regulatory element binding protein-1c decreases with food deprivation and increases with feeding in rats, J. Nutr., 133, 1787, 10.1093/jn/133.6.1787
Commerford, 2004, In vivo regulation of SREBP-1c in skeletal muscle: effects of nutritional status, glucose, insulin, and leptin, Am. J. Physiol. Regul. Integr. Comp. Physiol., 287, R218, 10.1152/ajpregu.00377.2003
Foretz, 1999, ADD1/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose, Mol. Cell. Biol., 19, 3760, 10.1128/MCB.19.5.3760
Azzout-Marniche, 2000, Insulin effects on sterol regulatory-element-binding protein-1c (SREBP-1c) transcriptional activity in rat hepatocytes, Biochem. J., 350, 389, 10.1042/0264-6021:3500389
Ducluzeau, 2001, Regulation by insulin of gene expression in human skeletal muscle and adipose tissue. Evidence for specific defects in type 2 diabetes, Diabetes, 50, 1134, 10.2337/diabetes.50.5.1134
Sewter, 2002, Human obesity and type 2 diabetes are associated with alterations in SREBP1 isoform expression that are reproduced ex vivo by tumor necrosis factor-alpha, Diabetes, 51, 1035, 10.2337/diabetes.51.4.1035
Shimomura, 1999, Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes, Proc. Natl. Acad. Sci. USA, 96, 13656, 10.1073/pnas.96.24.13656
Becard, 2001, Adenovirus-mediated overexpression of sterol regulatory element binding protein-1c mimics insulin effects on hepatic gene expression and glucose homeostasis in diabetic mice, Diabetes, 50, 2425, 10.2337/diabetes.50.11.2425
Fleischmann, 2000, Regulation of sterol regulatory-element binding protein 1 gene expression in liver: role of insulin and protein kinase B/cAkt, Biochem. J., 349, 13, 10.1042/0264-6021:3490013
Ribaux, 2003, Analysis of the role of protein kinase B (cAKT) in insulin-dependent induction of glucokinase and sterol regulatory element-binding protein 1 (SREBP1) mRNAs in hepatocytes, Biochem. J., 376, 697, 10.1042/bj20031287
Matsumoto, 2003, PKClambda in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity, J. Clin. Invest., 112, 935, 10.1172/JCI200318816
Lehmann, 1997, Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway, J. Biol. Chem., 272, 3137, 10.1074/jbc.272.6.3137
Janowski, 1999, Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta, Proc. Natl. Acad. Sci. USA, 96, 266, 10.1073/pnas.96.1.266
Steffensen, 2004, Putative metabolic effects of the liver X receptor (LXR), Diabetes, 53, S36, 10.2337/diabetes.53.2007.S36
Peet, 1998, Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha, Cell., 93, 693, 10.1016/S0092-8674(00)81432-4
Repa, 2000, Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta, Genes Dev., 14, 2819, 10.1101/gad.844900
Laffitte, 2003, Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue, Proc. Natl. Acad. Sci. USA, 100, 5419, 10.1073/pnas.0830671100
Tontonoz, 2003, Liver X receptor signaling pathways in cardiovascular disease, Mol. Endocrinol., 17, 985, 10.1210/me.2003-0061
Joseph, 2002, Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors, J. Biol. Chem., 277, 11019, 10.1074/jbc.M111041200
Zhang, 2003, SREBP-1 integrates the actions of thyroid hormone, insulin, cAMP, and medium-chain fatty acids on ACCalpha transcription in hepatocytes, J. Lipid Res., 44, 356, 10.1194/jlr.M200283-JLR200
Yoshikawa, 2001, Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter, Mol. Cell. Biol., 21, 2991, 10.1128/MCB.21.9.2991-3000.2001
Chen, 2004, Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver, Proc. Natl. Acad. Sci. USA, 101, 11245, 10.1073/pnas.0404297101
Tobin, 2002, Liver X receptors as insulin-mediating factors in fatty acid and cholesterol biosynthesis, J. Biol. Chem., 277, 10691, 10.1074/jbc.M109771200
Hasty, 2000, Sterol regulatory element-binding protein-1 is regulated by glucose at the transcriptional level, J. Biol. Chem., 275, 31069, 10.1074/jbc.M003335200
Guillet-Deniau, 2004, Glucose induces de novo lipogenesis in rat muscle satellite cells through a sterol-regulatory-element-binding-protein-1c-dependent pathway, J. Cell. Sci., 117, 1937, 10.1242/jcs.01069
Deng, 2002, Regulation of the rat SREBP-1c promoter in primary rat hepatocytes, Biochem. Biophys. Res. Commun., 290, 256, 10.1006/bbrc.2001.6148
Scott, 2003, A modest glucokinase overexpression in the liver promotes fed expression levels of glycolytic and lipogenic enzyme genes in the fasted state without altering SREBP-1c expression, Mol. Cell. Biochem., 254, 327, 10.1023/A:1027306122336
Matsuzaka, 2004, Insulin-independent induction of sterol regulatory element-binding protein-1c expression in the livers of streptozotocin-treated mice, Diabetes, 53, 560, 10.2337/diabetes.53.3.560
Heemers, 2001, Androgens stimulate lipogenic gene expression in prostate cancer cells by activation of the sterol regulatory element-binding protein cleavage activating protein/sterol regulatory element-binding protein pathway, Mol. Endocrinol., 15, 1817, 10.1210/me.15.10.1817
Heemers, 2003, Androgens stimulate coordinated lipogenic gene expression in normal target tissues in vivo, Mol. Cell. Endocrinol., 205, 21, 10.1016/S0303-7207(03)00205-3
Lacasa, 2001, Progesterone stimulates adipocyte determination and differentiation 1/sterol regulatory element-binding protein 1c gene expression. Potential mechanism for the lipogenic effect of progesterone in adipose tissue, J. Biol. Chem., 276, 11512, 10.1074/jbc.M008556200
Zhou, 2001, Role of AMP-activated protein kinase in mechanism of metformin action, J. Clin. Invest., 108, 1167, 10.1172/JCI13505
Foretz, 1998, AMP-activated protein kinase inhibits the glucose-activated expression of fatty acid synthase gene in rat hepatocytes, J. Biol. Chem., 273, 14767, 10.1074/jbc.273.24.14767
Sato, 1996, Sterol-dependent transcriptional regulation of sterol regulatory element-binding protein-2, J. Biol. Chem., 271, 26461, 10.1074/jbc.271.43.26461
Amemiya-Kudo, 2000, Promoter analysis of the mouse sterol regulatory element-binding protein-1c gene, J. Biol. Chem., 275, 31078, 10.1074/jbc.M005353200
Nohturfft, 1998, Topology of SREBP cleavage-activating protein, a polytopic membrane protein with a sterol-sensing domain, J. Biol. Chem., 273, 17243, 10.1074/jbc.273.27.17243
Wang, 1994, SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis, Cell., 77, 53, 10.1016/0092-8674(94)90234-8
Sakai, 1998, Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells, Mol. Cell., 2, 505, 10.1016/S1097-2765(00)80150-1
Duncan, 1997, Cleavage site for sterol-regulated protease localized to a leu-Ser bond in the lumenal loop of sterol regulatory element-binding protein-2, J. Biol. Chem., 272, 12778, 10.1074/jbc.272.19.12778
Espenshade, 1999, Autocatalytic processing of site-1 protease removes propeptide and permits cleavage of sterol regulatory element-binding proteins, J. Biol. Chem., 274, 22795, 10.1074/jbc.274.32.22795
Duncan, 1998, Second-site cleavage in sterol regulatory element-binding protein occurs at transmembrane junction as determined by cysteine panning, J. Biol. Chem., 273, 17801, 10.1074/jbc.273.28.17801
Brown, 2000, Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans, Cell., 100, 391, 10.1016/S0092-8674(00)80675-3
Brown, 1999, A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood, Proc. Natl. Acad. Sci. USA, 96, 11041, 10.1073/pnas.96.20.11041
Radhakrishnan, 2004, Direct binding of cholesterol to the purified membrane region of SCAP: mechanism for a sterol-sensing domain, Mol. Cell., 15, 259, 10.1016/j.molcel.2004.06.019
Brown, 2002, Cholesterol addition to ER membranes alters conformation of SCAP, the SREBP escort protein that regulates cholesterol metabolism, Mol. Cell., 10, 237, 10.1016/S1097-2765(02)00591-9
Yang, 2002, Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER, Cell., 110, 489, 10.1016/S0092-8674(02)00872-3
Yabe, 2002, Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins, Proc. Natl. Acad. Sci. USA, 99, 12753, 10.1073/pnas.162488899
Sheng, 1995, Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver, Proc. Natl. Acad. Sci. USA, 92, 935, 10.1073/pnas.92.4.935
Yabe, 2003, Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis, Proc. Natl. Acad. Sci. USA, 100, 3155, 10.1073/pnas.0130116100
Roth, 2000, MAP kinases Erk1/2 phosphorylate sterol regulatory element-binding protein (SREBP)-1a at serine 117 in vitro, J. Biol. Chem., 275, 33302, 10.1074/jbc.M005425200
Kotzka, 2004, Insulin-activated Erk-mitogen-activated protein kinases phosphorylate sterol regulatory element-binding protein-2 at serine residues 432 and 455 in vivo, J. Biol. Chem., 279, 22404, 10.1074/jbc.M401198200
Wang, 1998, Insulin stimulation of the fatty acid synthase promoter is mediated by the phosphatidylinositol 3-kinase pathway. Involvement of protein kinase B/Akt, J. Biol. Chem., 273, 25420, 10.1074/jbc.273.39.25420
Iynedjian, 2000, Activation of protein kinase B/cAkt in hepatocytes is sufficient for the induction of expression of the gene encoding glucokinase, Biochem. J., 351, 621, 10.1042/0264-6021:3510621
Hirano, 2001, Direct demonstration of rapid degradation of nuclear sterol regulatory element-binding proteins by the ubiquitin-proteasome pathway, J. Biol. Chem., 276, 36431, 10.1074/jbc.M105200200
Sundqvist, 2003, Transcription-dependent degradation controls the stability of the SREBP family of transcription factors, Proc. Natl. Acad. Sci. USA, 100, 13833, 10.1073/pnas.2335135100
Hirano, 2003, Sterol regulatory element-binding proteins are negatively regulated through SUMO-1 modification independent of the ubiquitin/26 S proteasome pathway, J. Biol. Chem., 278, 16809, 10.1074/jbc.M212448200
Naar, 1998, Chromatin, TAFs, and a novel multiprotein coactivator are required for synergistic activation by Sp1 and SREBP-1a in vitro, Genes Dev., 12, 3020, 10.1101/gad.12.19.3020
Naar, 1999, Composite co-activator ARC mediates chromatin-directed transcriptional activation, Nature, 398, 828, 10.1038/19789
Lee, 2003, Twist2, a novel ADD1/SREBP1c interacting protein, represses the transcriptional activity of ADD1/SREBP1c, Nucleic Acids Res., 31, 7165, 10.1093/nar/gkg934
Rosen, 2000, Transcriptional regulation of adipogenesis, Genes Dev., 14, 1293, 10.1101/gad.14.11.1293
Shimomura, 1998, Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy, Genes Dev., 12, 3182, 10.1101/gad.12.20.3182
Kolehmainen, 2001, Sterol regulatory element binding protein-1c (SREBP-1c) expression in human obesity, Obes. Res., 9, 706, 10.1038/oby.2001.95
Diraison, 2002, Increased hepatic lipogenesis but decreased expression of lipogenic gene in adipose tissue in human obesity, Am. J. Physiol. Endocrinol. Metab., 282, E46, 10.1152/ajpendo.2002.282.1.E46
Oberkofler, 2002, Sterol regulatory element binding proteins: relationship of adipose tissue gene expression with obesity in humans, Biochim. Biophys. Acta., 1575, 75, 10.1016/S0167-4781(02)00279-8
Yang, 2004, Evidence of impaired adipogenesis in insulin resistance, Biochem. Biophys. Res. Commun., 317, 1045, 10.1016/j.bbrc.2004.03.152
Nadler, 2000, The expression of adipogenic genes is decreased in obesity and diabetes mellitus, Proc. Natl. Acad. Sci. USA, 97, 11371, 10.1073/pnas.97.21.11371
Soukas, 2000, Leptin-specific patterns of gene expression in white adipose tissue, Genes Dev., 14, 963, 10.1101/gad.14.8.963
Shimomura, 1999, Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus, J. Biol. Chem., 274, 30028, 10.1074/jbc.274.42.30028
Shimomura, 2000, Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice, Mol. Cell., 6, 77, 10.1016/S1097-2765(00)00009-5
Kissebah, 2000, Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome, Proc. Natl. Acad. Sci. USA, 97, 14478, 10.1073/pnas.97.26.14478
Wu, 2002, A combined analysis of genomewide linkage scans for body mass index from the National Heart, Lung, and Blood Institute Family Blood Pressure Program, Am. J. Hum. Genet., 70, 1247, 10.1086/340362
Demenais, 2003, A meta-analysis of four European genome screens (GIFT Consortium) shows evidence for a novel region on chromosome 17p11.2–q22 linked to type 2 diabetes, Hum. Mol. Genet., 12, 1865, 10.1093/hmg/ddg195
Eberle, 2004, SREBF-1 gene polymorphisms are associated with obesity and type 2 diabetes in French obese and diabetic cohorts, Diabetes, 53, 2153, 10.2337/diabetes.53.8.2153
Laudes, 2004, Genetic variants in human sterol regulatory element binding protein-1c in syndromes of severe insulin resistance and type 2 diabetes, Diabetes, 53, 842, 10.2337/diabetes.53.3.842
Vedie, 2001, A new DNA polymorphism in the 5′ untranslated region of the human SREBP-1a is related to development of atherosclerosis in high cardiovascular risk population, Atherosclerosis, 154, 589, 10.1016/S0021-9150(00)00569-4
Miserez, 2001, A single-nucleotide polymorphism in the sterol-regulatory element-binding protein 1c gene is predictive of HIV-related hyperlipoproteinaemia, AIDS, 15, 2045, 10.1097/00002030-200110190-00020
Salek, 2002, Effects of SREBF-1a and SCAP polymorphisms on plasma levels of lipids, severity, progression and regression of coronary atherosclerosis and response to therapy with fluvastatin, J. Mol. Med., 80, 737, 10.1007/s00109-002-0381-z
Horton, 1999, Disruption of LDL receptor gene in transgenic SREBP-1a mice unmasks hyperlipidemia resulting from production of lipid-rich VLDL, J. Clin. Invest., 103, 1067, 10.1172/JCI6246
Miserez, 2002, Sterol-regulatory element-binding protein (SREBP)-2 contributes to polygenic hypercholesterolaemia, Atherosclerosis, 164, 15, 10.1016/S0021-9150(01)00762-6