SIRT3 in cardiovascular diseases: Emerging roles and therapeutic implications
Tài liệu tham khảo
Rine, 1979, A suppressor of mating-type locus mutations in Saccharomyces cerevisiae: evidence for and identification of cryptic mating-type loci, Genetics, 93, 877, 10.1093/genetics/93.4.877
Bellizzi, 2005, A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages, Genomics, 85, 258, 10.1016/j.ygeno.2004.11.003
Rose, 2003, Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly, Exp. Gerontol., 38, 1065, 10.1016/S0531-5565(03)00209-2
Palacios, 2009, Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1alpha in skeletal muscle, Aging, 1, 771, 10.18632/aging.100075
Giralt, 2011, Peroxisome proliferator-activated receptor-gamma coactivator-1alpha controls transcription of the Sirt3 gene, an essential component of the thermogenic brown adipocyte phenotype, J. Biol. Chem., 286, 16958, 10.1074/jbc.M110.202390
Nemoto, 2005, SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}, J. Biol. Chem., 280, 16456, 10.1074/jbc.M501485200
Pillai, 2015, Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3, Nat. Commun., 6, 6656, 10.1038/ncomms7656
Schwer, 2002, The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase, J. Cell Biol., 158, 647, 10.1083/jcb.200205057
Sundaresan, 2008, SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70, Mol. Cell. Biol., 28, 6384, 10.1128/MCB.00426-08
Bao, 2010, Characterization of the murine SIRT3 mitochondrial localization sequence and comparison of mitochondrial enrichment and deacetylase activity of long and short SIRT3 isoforms, J. Cell. Biochem., 110, 238
Cooper, 2008, The human SIRT3 protein deacetylase is exclusively mitochondrial, Biochem. J., 411, 279, 10.1042/BJ20071624
Scher, 2007, SirT3 is a nuclear NAD+-dependent histone deacetylase that translocates to the mitochondria upon cellular stress, Genes Dev., 21, 920, 10.1101/gad.1527307
Kim, 2006, Substrate and functional diversity of lysine acetylation revealed by a proteomics survey, Mol. Cell, 23, 607, 10.1016/j.molcel.2006.06.026
Rardin, 2013, Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways, Proc. Natl. Acad. Sci. U. S. A., 110, 6601, 10.1073/pnas.1302961110
Lombard, 2007, Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation, Mol. Cell. Biol., 27, 8807, 10.1128/MCB.01636-07
Pillai, 2010, Mitochondrial SIRT3 and heart disease, Cardiovasc. Res., 88, 250, 10.1093/cvr/cvq250
Hirschey, 2010, SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation, Nature, 464, 121, 10.1038/nature08778
Hirschey, 2011, SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome, Mol. Cell, 44, 177, 10.1016/j.molcel.2011.07.019
Jing, 2011, Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production, Proc. Natl. Acad. Sci. U. S. A., 108, 14608, 10.1073/pnas.1111308108
Haigis, 2012, SIRT3 is a mitochondrial tumor suppressor: a scientific tale that connects aberrant cellular ROS, the Warburg effect, and carcinogenesis, Cancer Res., 72, 2468, 10.1158/0008-5472.CAN-11-3633
Jeong, 2015, SIRT3 regulates cellular iron metabolism and cancer growth by repressing iron regulatory protein 1, Oncogene, 34, 2115, 10.1038/onc.2014.124
Sack, 2012, The role of SIRT3 in mitochondrial homeostasis and cardiac adaptation to hypertrophy and aging, J. Mol. Cell. Cardiol., 52, 520, 10.1016/j.yjmcc.2011.11.004
Tao, 2010, Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress, Mol. Cell, 40, 893, 10.1016/j.molcel.2010.12.013
Ventura-Clapier, 2004, Energy metabolism in heart failure, J. Physiol., 555, 1, 10.1113/jphysiol.2003.055095
Kolwicz, 2013, Cardiac metabolism and its interactions with contraction, growth, and survival of cardiomyocytes, Circ. Res., 113, 603, 10.1161/CIRCRESAHA.113.302095
Schaper, 1985, Ultrastructural morphometric analysis of myocardium from dogs, rats, hamsters, mice, and from human hearts, Circ. Res., 56, 377, 10.1161/01.RES.56.3.377
Matsushima, 2015, The role of sirtuins in cardiac disease, Am. J. Physiol. Heart Circ. Physiol., 309, H1375, 10.1152/ajpheart.00053.2015
Sundaresan, 2009, Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice, J. Clin. Invest., 119, 2758
Pillai, 2010, Exogenous NAD blocks cardiac hypertrophic response via activation of the SIRT3–LKB1–AMP-activated kinase pathway, J. Biol. Chem., 285, 3133, 10.1074/jbc.M109.077271
Alam, 2015, Cyclophilin D and myocardial ischemia–reperfusion injury: a fresh perspective, J. Mol. Cell. Cardiol., 78, 80, 10.1016/j.yjmcc.2014.09.026
Cheng, 2013, Interaction of Sirt3 with OGG1 contributes to repair of mitochondrial DNA and protects from apoptotic cell death under oxidative stress, Cell Death Dis., 4, e731, 10.1038/cddis.2013.254
Samant, 2014, SIRT3 deacetylates and activates OPA1 to regulate mitochondrial dynamics during stress, Mol. Cell. Biol., 34, 807, 10.1128/MCB.01483-13
Sundaresan, 2015, SIRT3 blocks aging-associated tissue fibrosis in mice by deacetylating and activating glycogen synthase kinase 3beta, Mol. Cell. Biol., 36, 678, 10.1128/MCB.00586-15
Yang, 2015, SIRT3-dependent GOT2 acetylation status affects the malate–aspartate NADH shuttle activity and pancreatic tumor growth, EMBO J., 34, 1110, 10.15252/embj.201591041
Li, 2013, SIRT3 regulates cell proliferation and apoptosis related to energy metabolism in non-small cell lung cancer cells through deacetylation of NMNAT2, Int. J. Oncol., 43, 1420, 10.3892/ijo.2013.2103
Schlicker, 2008, Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5, J. Mol. Biol., 382, 790, 10.1016/j.jmb.2008.07.048
Yang, 2010, NAD+-dependent deacetylase SIRT3 regulates mitochondrial protein synthesis by deacetylation of the ribosomal protein MRPL10, J. Biol. Chem., 285, 7417, 10.1074/jbc.M109.053421
Liang, 2015, Sirt3 binds to and deacetylates mitochondrial pyruvate carrier 1 to enhance its activity, Biochem. Biophys. Res. Commun., 468, 807, 10.1016/j.bbrc.2015.11.036
Hallows, 2006, Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases, Proc. Natl. Acad. Sci. U. S. A., 103, 10230, 10.1073/pnas.0604392103
Schwer, 2006, Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2, Proc. Natl. Acad. Sci. U. S. A., 103, 10224, 10.1073/pnas.0603968103
Rauh, 2013, An acetylome peptide microarray reveals specificities and deacetylation substrates for all human sirtuin isoforms, Nat. Commun., 4, 2327, 10.1038/ncomms3327
Bharathi, 2013, Sirtuin 3 (SIRT3) protein regulates long-chain acyl-CoA dehydrogenase by deacetylating conserved lysines near the active site, J. Biol. Chem., 288, 33837, 10.1074/jbc.M113.510354
Shimazu, 2010, SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production, Cell Metab., 12, 654, 10.1016/j.cmet.2010.11.003
Ahn, 2008, A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis, Proc. Natl. Acad. Sci. U. S. A., 105, 14447, 10.1073/pnas.0803790105
Cimen, 2010, Regulation of succinate dehydrogenase activity by SIRT3 in mammalian mitochondria, Biochemistry, 49, 304, 10.1021/bi901627u
Rahman, 2014, Drosophila Sirt2/mammalian SIRT3 deacetylates ATP synthase beta and regulates complex V activity, J. Cell Biol., 206, 289, 10.1083/jcb.201404118
Vassilopoulos, 2014, SIRT3 deacetylates ATP synthase F1 complex proteins in response to nutrient- and exercise-induced stress, Antioxid. Redox Signal., 21, 551, 10.1089/ars.2013.5420
Frey, 2004, Hypertrophy of the heart: a new therapeutic target?, Circulation, 109, 1580, 10.1161/01.CIR.0000120390.68287.BB
Chen, 2015, Mouse SIRT3 attenuates hypertrophy-related lipid accumulation in the heart through the deacetylation of LCAD, PLoS One, 10, e0118909, 10.1371/journal.pone.0118909
Hafner, 2010, Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy, Aging, 2, 914, 10.18632/aging.100252
Koentges, 2015, SIRT3 deficiency impairs mitochondrial and contractile function in the heart, Basic Res. Cardiol., 110, 36, 10.1007/s00395-015-0493-6
Takimoto, 2007, Role of oxidative stress in cardiac hypertrophy and remodeling, Hypertension, 49, 241, 10.1161/01.HYP.0000254415.31362.a7
Lai, 2016, SIRT3-AMP-activated protein kinase activation by nitrite and metformin improves hyperglycemia and normalizes pulmonary hypertension associated with heart failure with preserved ejection fraction, Circulation, 133, 717, 10.1161/CIRCULATIONAHA.115.018935
Dorn, 2005, Protein kinase cascades in the regulation of cardiac hypertrophy, J. Clin. Invest., 115, 527, 10.1172/JCI24178
Shulga, 2010, Ethanol sensitizes mitochondria to the permeability transition by inhibiting deacetylation of cyclophilin-D mediated by sirtuin-3, J. Cell Sci., 123, 4117, 10.1242/jcs.073502
Lloyd-Jones, 2010, Executive summary: heart disease and stroke statistics—2010 update: a report from the American Heart Association, Circulation, 121, 948, 10.1161/CIRCULATIONAHA.109.192666
Nichols, 2014, Cardiovascular disease in Europe 2014: epidemiological update, Eur. Heart J., 35, 2950, 10.1093/eurheartj/ehu299
Bell, 2011, There is more to life than revascularization: therapeutic targeting of myocardial ischemia/reperfusion injury, Cardiovasc. Ther., 29, e67, 10.1111/j.1755-5922.2010.00190.x
Winnik, 2014, Deletion of Sirt3 does not affect atherosclerosis but accelerates weight gain and impairs rapid metabolic adaptation in LDL receptor knockout mice: implications for cardiovascular risk factor development, Basic Res. Cardiol., 109, 399, 10.1007/s00395-013-0399-0
Klishadi, 2015, Losartan protects the heart against ischemia reperfusion injury: sirtuin3 involvement, Int J Pharm Pharm Sci, 18, 112, 10.18433/J3XG7T
Porter, 2014, SIRT3 deficiency exacerbates ischemia–reperfusion injury: implication for aged hearts, Am. J. Physiol. Heart Circ. Physiol., 306, H1602, 10.1152/ajpheart.00027.2014
Koentges, 2016, Preserved recovery of cardiac function following ischemia–reperfusion in mice lacking SIRT3, Can. J. Physiol. Pharmacol., 94, 72, 10.1139/cjpp-2015-0152
Greer, 2012, The updated biology of hypoxia-inducible factor, EMBO J., 31, 2448, 10.1038/emboj.2012.125
Wang, 1995, Purification and characterization of hypoxia-inducible factor 1, J. Biol. Chem., 270, 1230, 10.1074/jbc.270.3.1230
Bruick, 2001, A conserved family of prolyl-4-hydroxylases that modify HIF, Science, 294, 1337, 10.1126/science.1066373
Semenza, 2009, Regulation of oxygen homeostasis by hypoxia-inducible factor 1, Physiology, 24, 97, 10.1152/physiol.00045.2008
Lee, 2000, Early expression of angiogenesis factors in acute myocardial ischemia and infarction, N. Engl. J. Med., 342, 626, 10.1056/NEJM200003023420904
Shyu, 2002, Intramyocardial injection of naked DNA encoding HIF-1alpha/VP16 hybrid to enhance angiogenesis in an acute myocardial infarction model in the rat, Cardiovasc. Res., 54, 576, 10.1016/S0008-6363(02)00259-6
Bell, 2011, SirT3 suppresses hypoxia inducible factor 1alpha and tumor growth by inhibiting mitochondrial ROS production, Oncogene, 30, 2986, 10.1038/onc.2011.37
Schumacker, 2011, SIRT3 controls cancer metabolic reprogramming by regulating ROS and HIF, Cancer Cell, 19, 299, 10.1016/j.ccr.2011.03.001
Baker, 1992, Cardiac actions of angiotensin II: role of an intracardiac renin–angiotensin system, Annu. Rev. Physiol., 54, 227, 10.1146/annurev.ph.54.030192.001303
Yang, 1997, Increase in angiotensin II type 1 receptor expression immediately after ischemia–reperfusion in isolated rat hearts, Circulation, 96, 922, 10.1161/01.CIR.96.3.922
Benigni, 2009, Disruption of the Ang II type 1 receptor promotes longevity in mice, J. Clin. Invest., 119, 524, 10.1172/JCI36703
Parodi-Rullan, 2012, Direct renin inhibition exerts an anti-hypertrophic effect associated with improved mitochondrial function in post-infarction heart failure in diabetic rats, Cell. Physiol. Biochem., 29, 841, 10.1159/000178526
Bolli, 1989, Direct evidence that oxygen-derived free radicals contribute to postischemic myocardial dysfunction in the intact dog, Proc. Natl. Acad. Sci. U. S. A., 86, 4695, 10.1073/pnas.86.12.4695
Nayler, 1991, Basic mechanisms involved in the protection of the ischaemic myocardium. The role of calcium antagonists, Drugs, 42, 21, 10.2165/00003495-199100422-00005
Kalogeris, 2012, Cell biology of ischemia/reperfusion injury, Int. Rev. Cell Mol. Biol., 298, 229, 10.1016/B978-0-12-394309-5.00006-7
Haworth, 1979, The Ca2+-induced membrane transition in mitochondria. II. Nature of the Ca2+ trigger site, Arch. Biochem. Biophys., 195, 460, 10.1016/0003-9861(79)90372-2
Crompton, 1990, A heart mitochondrial Ca2(+)-dependent pore of possible relevance to re-perfusion-induced injury. Evidence that ADP facilitates pore interconversion between the closed and open states, Biochem. J., 266, 33, 10.1042/bj2660033
Halestrap, 2015, The mitochondrial permeability transition: a current perspective on its identity and role in ischaemia/reperfusion injury, J. Mol. Cell. Cardiol., 78, 129, 10.1016/j.yjmcc.2014.08.018
Park, 2011, Sirt3, mitochondrial ROS, ageing, and carcinogenesis, Int. J. Mol. Sci., 12, 6226, 10.3390/ijms12096226
Zeng, 2014, Age-related decrease in the mitochondrial sirtuin deacetylase Sirt3 expression associated with ROS accumulation in the auditory cortex of the mimetic aging rat model, PLoS One, 9, e88019, 10.1371/journal.pone.0088019
Koyama, 2011, SIRT3 attenuates palmitate-induced ROS production and inflammation in proximal tubular cells, Free Radic. Biol. Med., 51, 1258, 10.1016/j.freeradbiomed.2011.05.028
Hausenloy, 2009, The mitochondrial permeability transition pore as a target for preconditioning and postconditioning, Basic Res. Cardiol., 104, 189, 10.1007/s00395-009-0010-x
Kinnally, 1813, Is mPTP the gatekeeper for necrosis, apoptosis, or both?, Biochim. Biophys. Acta, 2011, 616
Elrod, 2013, Physiologic functions of cyclophilin D and the mitochondrial permeability transition pore, Circ. J., 77, 1111, 10.1253/circj.CJ-13-0321
Di Lisa, 1813, The mitochondrial permeability transition pore and cyclophilin D in cardioprotection, Biochim. Biophys. Acta, 2011, 1316
Connern, 1996, Chaotropic agents and increased matrix volume enhance binding of mitochondrial cyclophilin to the inner mitochondrial membrane and sensitize the mitochondrial permeability transition to [Ca2+], Biochemistry, 35, 8172, 10.1021/bi9525177
Cheng, 2016, Mitochondrial SIRT3 mediates adaptive responses of neurons to exercise and metabolic and excitatory challenges, Cell Metab., 23, 128, 10.1016/j.cmet.2015.10.013
Bochaton, 2015, Inhibition of myocardial reperfusion injury by ischemic postconditioning requires sirtuin 3-mediated deacetylation of cyclophilin D, J. Mol. Cell. Cardiol., 84, 61, 10.1016/j.yjmcc.2015.03.017
Felker, 2000, Underlying causes and long-term survival in patients with initially unexplained cardiomyopathy, N. Engl. J. Med., 342, 1077, 10.1056/NEJM200004133421502
Go, 2013, Heart disease and stroke statistics—2013 update: a report from the American Heart Association, Circulation, 127, e6, 10.1161/CIR.0b013e31828124ad
Allard, 1994, Contribution of oxidative metabolism and glycolysis to ATP production in hypertrophied hearts, Am. J. Phys., 267, H742
Barger, 1999, Fatty acid utilization in the hypertrophied and failing heart: molecular regulatory mechanisms, Am. J. Med. Sci., 318, 36, 10.1016/S0002-9629(15)40570-1
Lu, 2015, Prolonged fasting identifies heat shock protein 10 as a Sirtuin 3 substrate: elucidating a new mechanism linking mitochondrial protein acetylation to fatty acid oxidation enzyme folding and function, J. Biol. Chem., 290, 2466, 10.1074/jbc.M114.606228
Hirschey, 2011, SIRT1 and SIRT3 deacetylate homologous substrates: AceCS1,2 and HMGCS1,2, Aging, 3, 635, 10.18632/aging.100339
Yu, 2012, SIRT3 protein deacetylates isocitrate dehydrogenase 2 (IDH2) and regulates mitochondrial redox status, J. Biol. Chem., 287, 14078, 10.1074/jbc.M112.355206
Lantier, 2015, SIRT3 is crucial for maintaining skeletal muscle insulin action and protects against severe insulin resistance in high-fat-fed mice, Diabetes, 64, 3081, 10.2337/db14-1810
Swan, 1997, Insulin resistance in chronic heart failure: relation to severity and etiology of heart failure, J. Am. Coll. Cardiol., 30, 527, 10.1016/S0735-1097(97)00185-X
Perrone-Filardi, 2015, The role of metabolic syndrome in heart failure, Eur. Heart J., 36, 2630, 10.1093/eurheartj/ehv350
Lin, 2014, Regulation of skeletal muscle oxidative capacity and muscle mass by SIRT3, PLoS One, 9, e85636, 10.1371/journal.pone.0085636
Kostin, 2003, Myocytes die by multiple mechanisms in failing human hearts, Circ. Res., 92, 715, 10.1161/01.RES.0000067471.95890.5C
Chambers, 2007, Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation, PLoS Biol., 5, e201, 10.1371/journal.pbio.0050201
Paulin, 2014, Sirtuin 3 deficiency is associated with inhibited mitochondrial function and pulmonary arterial hypertension in rodents and humans, Cell Metab., 20, 827, 10.1016/j.cmet.2014.08.011
Liu, 2014, The sirtuin 3 expression profile is associated with pathological and clinical outcomes in colon cancer patients, J. Biomed. Biotechnol., 2014, 871263
Yang, 2014, Effects of downregulation of SIRT3 expression on proliferation and apoptosis in esophageal squamous cell carcinoma EC9706 cells and its molecular mechanisms, Biomed. Mater. Eng., 24, 3883
Pillai, 2016, Sirt3 protects mitochondrial DNA damage and blocks the development of doxorubicin-induced cardiomyopathy in Mice, Am. J. Phys. Heart Circ. Phys.
Sawada, 2003, Ku70 suppresses the apoptotic translocation of Bax to mitochondria, Nat. Cell Biol., 5, 320, 10.1038/ncb950
Cohen, 2004, Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis, Mol. Cell, 13, 627, 10.1016/S1097-2765(04)00094-2
Cohen, 2004, Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase, Science, 305, 390, 10.1126/science.1099196
