SERCA Overexpression Improves Mitochondrial Quality Control and Attenuates Cardiac Microvascular Ischemia-Reperfusion Injury

Molecular Therapy - Nucleic Acids - Tập 22 - Trang 696-707 - 2020
Ying Tan1, David Mui2, Sam Toan3, Pingjun Zhu4, Jia Li4, Hao Zhou4,5
1Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
2Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
3Department of Chemical Engineering, University of Minnesota-Duluth, Duluth, MN 55812, USA
4Chinese PLA Medical School, Chinese PLA General Hospital, Beijing 100853, China
5Department of Cardiology, Chinese PLA General Hospital, Beijing 100853, China

Tóm tắt

Từ khóa


Tài liệu tham khảo

Davidson, 2019, Multitarget Strategies to Reduce Myocardial Ischemia/Reperfusion Injury: JACC Review Topic of the Week, J. Am. Coll. Cardiol., 73, 89, 10.1016/j.jacc.2018.09.086

Favero, 2014, Endothelium and its alterations in cardiovascular diseases: life style intervention, BioMed Res. Int., 2014, 801896, 10.1155/2014/801896

Boengler, 2019, P66shc and its role in ischemic cardiovascular diseases, Basic Res. Cardiol., 114, 29, 10.1007/s00395-019-0738-x

Heusch, 2019, Coronary microvascular obstruction: the new frontier in cardioprotection, Basic Res. Cardiol., 114, 45, 10.1007/s00395-019-0756-8

Davidson, 2018, The 10th Biennial Hatter Cardiovascular Institute workshop: cellular protection-evaluating new directions in the setting of myocardial infarction, ischaemic stroke, and cardio-oncology, Basic Res. Cardiol., 113, 43, 10.1007/s00395-018-0704-z

Zhou, 2017, Mff-Dependent Mitochondrial Fission Contributes to the Pathogenesis of Cardiac Microvasculature Ischemia/Reperfusion Injury via Induction of mROS-Mediated Cardiolipin Oxidation and HK2/VDAC1 Disassociation-Involved mPTP Opening, J. Am. Heart Assoc., 6, e005328, 10.1161/JAHA.116.005328

Zhou, 2018, BI1 is associated with microvascular protection in cardiac ischemia reperfusion injury via repressing Syk-Nox2-Drp1-mitochondrial fission pathways, Angiogenesis, 21, 599, 10.1007/s10456-018-9611-z

Zhou, 2018, NR4A1 aggravates the cardiac microvascular ischemia reperfusion injury through suppressing FUNDC1-mediated mitophagy and promoting Mff-required mitochondrial fission by CK2α, Basic Res. Cardiol., 113, 23, 10.1007/s00395-018-0682-1

Zhou, 2017, Melatonin protects cardiac microvasculature against ischemia/reperfusion injury via suppression of mitochondrial fission-VDAC1-HK2-mPTP-mitophagy axis, J. Pineal Res., 63, e12413, 10.1111/jpi.12413

Zhong, 2019, Tanshinone IIA attenuates cardiac microvascular ischemia-reperfusion injury via regulating the SIRT1-PGC1α-mitochondrial apoptosis pathway, Cell Stress Chaperones, 24, 991, 10.1007/s12192-019-01027-6

Wei, 2010, A PKC-beta inhibitor protects against cardiac microvascular ischemia reperfusion injury in diabetic rats, Apoptosis, 15, 488, 10.1007/s10495-009-0439-2

Wang, 2020, New insights into the role of mitochondria in cardiac microvascular ischemia/reperfusion injury, Angiogenesis, 23, 299, 10.1007/s10456-020-09720-2

Zhou, 2018, ER-Mitochondria Microdomains in Cardiac Ischemia-Reperfusion Injury: A Fresh Perspective, Front. Physiol., 9, 755, 10.3389/fphys.2018.00755

Zhou, 2018, Protective role of melatonin in cardiac ischemia-reperfusion injury: From pathogenesis to targeted therapy, J. Pineal Res., 64, e12471, 10.1111/jpi.12471

Zhang, 2020, Activating α7nAChRs enhances endothelial progenitor cell function partially through the JAK2/STAT3 signaling pathway, Microvasc. Res., 129, 103975, 10.1016/j.mvr.2020.103975

Zhu, 2017, Prostaglandin E1 protects coronary microvascular function via the glycogen synthase kinase 3β-mitochondrial permeability transition pore pathway in rat hearts subjected to sodium laurate-induced coronary microembolization, Am. J. Transl. Res., 9, 2520

Wang, 2019, Mitochondrial fission protein 1 up-regulation ameliorates senescence-related endothelial dysfunction of human endothelial progenitor cells, Angiogenesis, 22, 569, 10.1007/s10456-019-09680-2

Tang, 2019, 8-Chloroadenosine induces apoptosis in human coronary artery endothelial cells through the activation of the unfolded protein response, Redox Biol., 26, 101274, 10.1016/j.redox.2019.101274

Dalal, 2020, Endothelial Cell Calcium Signaling during Barrier Function and Inflammation, Am. J. Pathol., 190, 535, 10.1016/j.ajpath.2019.11.004

Wang, 2020, Targeting Calcium Homeostasis in Myocardial Ischemia/Reperfusion Injury: An Overview of Regulatory Mechanisms and Therapeutic Reagents, Front. Pharmacol., 11, 872, 10.3389/fphar.2020.00872

Juni, 2019, Cardiac Microvascular Endothelial Enhancement of Cardiomyocyte Function Is Impaired by Inflammation and Restored by Empagliflozin, JACC Basic Transl. Sci., 4, 575, 10.1016/j.jacbts.2019.04.003

Gambardella, 2018, New Insights in Cardiac Calcium Handling and Excitation-Contraction Coupling, Adv. Exp. Med. Biol., 1067, 373, 10.1007/5584_2017_106

Abi-Samra, 2016, Cardiac contractility modulation: a novel approach for the treatment of heart failure, Heart Fail. Rev., 21, 645, 10.1007/s10741-016-9571-6

Guo, 2013, Globular adiponectin attenuates myocardial ischemia/reperfusion injury by upregulating endoplasmic reticulum Ca2+-ATPase activity and inhibiting endoplasmic reticulum stress, J. Cardiovasc. Pharmacol., 62, 143, 10.1097/FJC.0b013e31829521af

Hiranandani, 2006, SERCA overexpression reduces hydroxyl radical injury in murine myocardium, Am. J. Physiol. Heart Circ. Physiol., 291, H3130, 10.1152/ajpheart.01315.2005

Kang, 2006, Allopurinol modulates reactive oxygen species generation and Ca2+ overload in ischemia-reperfused heart and hypoxia-reoxygenated cardiomyocytes, Eur. J. Pharmacol., 535, 212, 10.1016/j.ejphar.2006.01.013

Zhou, 2018, Inhibitory effect of melatonin on necroptosis via repressing the Ripk3-PGAM5-CypD-mPTP pathway attenuates cardiac microvascular ischemia-reperfusion injury, J. Pineal Res., 65, e12503, 10.1111/jpi.12503

Schanze, 2019, Platelet Contributions to Myocardial Ischemia/Reperfusion Injury, Front. Immunol., 10, 1260, 10.3389/fimmu.2019.01260

Amanakis, 2019, Attenuation of ST-segment elevation after ischemic conditioning maneuvers reflects cardioprotection online, Basic Res. Cardiol., 114, 22, 10.1007/s00395-019-0732-3

Bacmeister, 2019, Inflammation and fibrosis in murine models of heart failure, Basic Res. Cardiol., 114, 19, 10.1007/s00395-019-0722-5

Wang, 2020, Mitochondrial quality control in cardiac microvascular ischemia-reperfusion injury: New insights into the mechanisms and therapeutic potentials, Pharmacol. Res., 156, 104771, 10.1016/j.phrs.2020.104771

Zhou, 2019, DNA-PKcs promotes alcohol-related liver disease by activating Drp1-related mitochondrial fission and repressing FUNDC1-required mitophagy, Signal Transduct. Target. Ther., 4, 56, 10.1038/s41392-019-0094-1

Zhou, 2017, Ripk3 induces mitochondrial apoptosis via inhibition of FUNDC1 mitophagy in cardiac IR injury, Redox Biol., 13, 498, 10.1016/j.redox.2017.07.007

Li, 2018, Aging aggravates hepatic ischemia-reperfusion injury in mice by impairing mitophagy with the involvement of the EIF2α-parkin pathway, Aging (Albany NY), 10, 1902, 10.18632/aging.101511

Zhou, 2020, Pathological Roles of Mitochondrial Oxidative Stress and Mitochondrial Dynamics in Cardiac Microvascular Ischemia/Reperfusion Injury, Biomolecules, 10, 85, 10.3390/biom10010085

Zhang, 2016, Liraglutide protects cardiac microvascular endothelial cells against hypoxia/reoxygenation injury through the suppression of the SR-Ca(2+)-XO-ROS axis via activation of the GLP-1R/PI3K/Akt/survivin pathways, Free Radic. Biol. Med., 95, 278, 10.1016/j.freeradbiomed.2016.03.035

Zhu, 2018, Melatonin protected cardiac microvascular endothelial cells against oxidative stress injury via suppression of IP3R-[Ca2+]c/VDAC-[Ca2+]m axis by activation of MAPK/ERK signaling pathway, Cell Stress Chaperones, 23, 101, 10.1007/s12192-017-0827-4

Hadebe, 2018, The SAFE pathway for cardioprotection: is this a promising target?, Basic Res. Cardiol., 113, 9, 10.1007/s00395-018-0670-5

Zhang, 2020, Regulatory Roles of Circular RNAs in Coronary Artery Disease, Mol. Ther. Nucleic Acids, 21, 172, 10.1016/j.omtn.2020.05.024

Hasenfuss, 2011, Cardiac inotropes: current agents and future directions, Eur. Heart J., 32, 1838, 10.1093/eurheartj/ehr026

Kranias, 2012, Modulation of cardiac contractility by the phospholamban/SERCA2a regulatome, Circ. Res., 110, 1646, 10.1161/CIRCRESAHA.111.259754

Kuznetsov, 2019, 8

Lee, 2019, Redox regulation of cell state and fate, Redox Biol., 25, 101056, 10.1016/j.redox.2018.11.014

Kowaltowski, 2019, Strategies to detect mitochondrial oxidants, Redox Biol., 21, 101065, 10.1016/j.redox.2018.101065

Cadenas, 2018, ROS and redox signaling in myocardial ischemia-reperfusion injury and cardioprotection, Free Radic. Biol. Med., 117, 76, 10.1016/j.freeradbiomed.2018.01.024

Kou, 2008, Xanthine oxidase interaction with vascular endothelial growth factor in human endothelial cell angiogenesis, Microcirculation, 15, 251, 10.1080/10739680701651495

Jin, 2018, DUSP1 alleviates cardiac ischemia/reperfusion injury by suppressing the Mff-required mitochondrial fission and Bnip3-related mitophagy via the JNK pathways, Redox Biol., 14, 576, 10.1016/j.redox.2017.11.004

Heusch, 2018, 25 years of remote ischemic conditioning: from laboratory curiosity to clinical outcome, Basic Res. Cardiol., 113, 15, 10.1007/s00395-018-0673-2

Zhu, 2018, Ripk3 promotes ER stress-induced necroptosis in cardiac IR injury: A mechanism involving calcium overload/XO/ROS/mPTP pathway, Redox Biol., 16, 157, 10.1016/j.redox.2018.02.019

Kim, 2019, Transient inhibition of p53 homologs protects ovarian function from two distinct apoptotic pathways triggered by anticancer therapies, Cell Death Differ., 26, 502, 10.1038/s41418-018-0151-2

Zhou, 2018, Pathogenesis of cardiac ischemia reperfusion injury is associated with CK2α-disturbed mitochondrial homeostasis via suppression of FUNDC1-related mitophagy, Cell Death Differ., 25, 1080, 10.1038/s41418-018-0086-7

Ndongson-Dongmo, 2019, Reduced ambient temperature exacerbates SIRS-induced cardiac autonomic dysregulation and myocardial dysfunction in mice, Basic Res. Cardiol., 114, 26, 10.1007/s00395-019-0734-1

Battistelli, 2019, The lncRNA HOTAIR transcription is controlled by HNF4α-induced chromatin topology modulation, Cell Death Differ., 26, 890, 10.1038/s41418-018-0170-z

Li, 2019, Angiogenesis in pancreatic cancer: current research status and clinical implications, Angiogenesis, 22, 15, 10.1007/s10456-018-9645-2

Karwi, 2017, Pre- and postconditioning the heart with hydrogen sulfide (H2S) against ischemia/reperfusion injury in vivo: a systematic review and meta-analysis, Basic Res. Cardiol., 113, 6, 10.1007/s00395-017-0664-8

Kraft, 2019, Blocking the IL-1β signalling pathway prevents chronic viral myocarditis and cardiac remodeling, Basic Res. Cardiol., 114, 11, 10.1007/s00395-019-0719-0

Hao, 2018, Mitochondria-targeted ubiquinone (MitoQ) enhances acetaldehyde clearance by reversing alcohol-induced posttranslational modification of aldehyde dehydrogenase 2: A molecular mechanism of protection against alcoholic liver disease, Redox Biol., 14, 626, 10.1016/j.redox.2017.11.005

Na, 2019, TSPYL5-mediated inhibition of p53 promotes human endothelial cell function, Angiogenesis, 22, 281, 10.1007/s10456-018-9656-z

Imber, 2019, Redox regulation by reversible protein S-thiolation in Gram-positive bacteria, Redox Biol., 20, 130, 10.1016/j.redox.2018.08.017

Hasna, 2018, Orai3 calcium channel and resistance to chemotherapy in breast cancer cells: the p53 connection, Cell Death Differ., 25, 693, 10.1038/s41418-017-0007-1

Wang, 2020, Fundc1-dependent mitophagy is obligatory to ischemic preconditioning-conferred renoprotection in ischemic AKI via suppression of Drp1-mediated mitochondrial fission, Redox Biol., 30, 101415, 10.1016/j.redox.2019.101415

Denton, 2019, Dpp regulates autophagy-dependent midgut removal and signals to block ecdysone production, Cell Death Differ., 26, 763, 10.1038/s41418-018-0154-z

Guidarelli, 2019, Calcium signals between the ryanodine receptor- and mitochondria critically regulate the effects of arsenite on mitochondrial superoxide formation and on the ensuing survival vs apoptotic signaling, Redox Biol., 20, 285, 10.1016/j.redox.2018.10.015

Zhou, 2019, BI1 alleviates cardiac microvascular ischemia-reperfusion injury via modifying mitochondrial fission and inhibiting XO/ROS/F-actin pathways, J. Cell. Physiol., 234, 5056, 10.1002/jcp.27308

Lionnard, 2019, TRIM17 and TRIM28 antagonistically regulate the ubiquitination and anti-apoptotic activity of BCL2A1, Cell Death Differ., 26, 902, 10.1038/s41418-018-0169-5

Kim, 2019, Therapeutic potential of the mitochondria-targeted antioxidant MitoQ in mitochondrial-ROS induced sensorineural hearing loss caused by Idh2 deficiency, Redox Biol., 20, 544, 10.1016/j.redox.2018.11.013

Wolint, 2019, Cellular self-assembly into 3D microtissues enhances the angiogenic activity and functional neovascularization capacity of human cardiopoietic stem cells, Angiogenesis, 22, 37, 10.1007/s10456-018-9635-4

Kohlhauer, 2019, Protection against cardiac ischemia-reperfusion injury by hypothermia and by inhibition of succinate accumulation and oxidation is additive, Basic Res. Cardiol., 114, 18, 10.1007/s00395-019-0727-0