SARS-CoV-2 Viral Variants—Tackling a Moving Target

JAMA - Journal of the American Medical Association - Tập 325 Số 13 - Trang 1261 - 2021
John R. Mascola1, Barney S. Graham1, Anthony S. Fauci2
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland
2Office of the Director, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland

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Tài liệu tham khảo

Zhang, Emergence of a novel SARS-CoV-2 strain in Southern California., JAMA

Korber, 2020, Tracking changes in SARS-CoV-2 spike: evidence that D614G increases infectivity of the COVID-19 virus., Cell, 182, 812, 10.1016/j.cell.2020.06.043

Yurkovetskiy, 2020, Structural and functional analysis of the D614G SARS-CoV-2 spike protein variant., Cell, 183, 739, 10.1016/j.cell.2020.09.032

Hou, 2020, SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo., Science, 370, 1464, 10.1126/science.abe8499

Nextstrain. Accessed February 8, 2021. https://nextstrain.org/

PANGO lineages. Accessed February 8, 2021. https://cov-lineages.org

Rambaut? A, Loman? N, Pybus? O, ; COVID-19 Genomics Consortium UK. Preliminary genomic characterisation of an emergent SARS-CoV-2 lineage in the UK defined by a novel set of spike mutations. Virological.org. Posted December 18, 2020. Accessed January 3, 2021. https://virological.org/t/preliminary-genomic-characterisation-of-anemergent-sars-cov-2-lineage-in-the-uk-definedby-a-novel-set-of-spike-mutations/563

Horby P, Huntley C, Davies N, et al. Paper from the New and Emerging Respiratory Virus Threats Advisory Group (NERVTAG) on new coronavirus (COVID-19) variant B.1.1.7. Posted January 21, 2021. Accessed February 8, 2021. https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/955239/NERVTAG_paper_on_variant_of_concern__VOC__B.1.1.7.pdf

Tegally? H, Wilkinson? E, Giovanetti? M, . Emergence and rapid spread of a new severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) lineage with multiple spike mutations in South Africa.? medRxiv. Preprint published online December 22, 2020. doi:10.1101/2020.12.21.20248640

Wibmer? CK, Ayres? F, Hermanus? T, . SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma.? bioRxiv. Preprint published online January 19, 2021. doi:10.1101/2021.01.18.427166

Wu? K, Werner? AP, Moliva? JI, . mRNA-1273 vaccine induces neutralizing antibodies against spike mutants from global SARS-CoV-2 variants.? bioRxiv. Preprint published online January 25, 2021. doi:10.1101/2021.01.25.427948

Ho? D, Wang? P, Liu? L, . Increased resistance of SARS-CoV-2 variants B.1.351 and B.1.1.7 to antibody neutralization.? Res Sq. Preprint published online January 29, 2021. doi:10.21203/rs.3.rs-155394/v1

Johnson & Johnson announces single-shot Janssen COVID-19 vaccine candidate met primary endpoints in interim analysis of its phase 3 ENSEMBLE trial. Johnson & Johnson. Posted January 29, 2021. Accessed February 8, 2021. https://www.jnj.com/johnson-johnson-announces-single-shot-janssen-covid-19-vaccine-candidate-met-primary-endpoints-in-interim-analysis-of-its-phase-3-ensemble-trial

Novavax COVID-19 vaccine demonstrates 89.3% efficacy in UK phase 3 trial. Novavax. Posted January 28, 2021. Accessed February 8, 2021. https://ir.novavax.com/news-releases/news-release-details/novavax-covid-19-vaccine-demonstrates-893-efficacy-uk-phase-3