S-Nitrosylation-mediated dysfunction of TCA cycle enzymes in synucleinopathy studied in postmortem human brains and hiPSC-derived neurons

Cell Chemical Biology - Tập 30 - Trang 965-975.e6 - 2023
Paschalis-Thomas Doulias1,2, Hongmei Yang3,4, Alexander Y. Andreyev5, Nima Dolatabadi5, Henry Scott5, Charlene K Raspur5, Parth R. Patel5, Tomohiro Nakamura5, Steven R. Tannenbaum6, Harry Ischiropoulos1, Stuart A. Lipton5,7
1Children’s Hospital of Philadelphia Departments of Pediatrics and Pharmacology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
2Department of Chemistry and University Research Center of Ioannina, University of Ioannina, 45110 Ioannina, Greece
3Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
4Changchun University of Chinese Medicine, Changchun 130021, China
5Neurodegeneration New Medicines Center, The Scripps Research Institute, La Jolla, CA 92037, USA
6Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139 USA
7Department of Neurosciences, University of California, San Diego, School of Medicine, La Jolla, CA 92093, USA

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