S-Nitrosylation-mediated dysfunction of TCA cycle enzymes in synucleinopathy studied in postmortem human brains and hiPSC-derived neurons
Tài liệu tham khảo
Exner, 2012, Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences, EMBO J., 31, 3038, 10.1038/emboj.2012.170
Vázquez-Vélez, 2021, Parkinson's disease genetics and pathophysiology, Annu. Rev. Neurosci., 44, 87, 10.1146/annurev-neuro-100720-034518
Cooper, 2012, Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease, Sci. Transl. Med., 4, 141ra90, 10.1126/scitranslmed.3003985
Chung, 2013, Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons, Science, 342, 983, 10.1126/science.1245296
Ryan, 2013, Isogenic human iPSC Parkinson's model shows nitrosative stress-induced dysfunction in MEF2-PGC1α transcription, Cell, 155, 1351, 10.1016/j.cell.2013.11.009
Ryan, 2018, Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein, Nat. Commun., 9, 817, 10.1038/s41467-018-03241-9
Czaniecki, 2019, Axonal pathology in hPSC-based models of Parkinson's disease results from loss of Nrf2 transcriptional activity at the Map1b gene locus, Proc. Natl. Acad. Sci. USA, 116, 14280, 10.1073/pnas.1900576116
Trudler, 2021, α-Synuclein oligomers induce glutamate release from astrocytes and excessive extrasynaptic NMDAR Activity in neurons, thus contributing to synapse loss, J. Neurosci., 41, 2264, 10.1523/JNEUROSCI.1871-20.2020
Caminiti, 2019, Brain glucose metabolism in Lewy body dementia: implications for diagnostic criteria, Alzheimer's Res. Ther., 11, 20, 10.1186/s13195-019-0473-4
Gibson, 2010, Cause and consequence: mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases, Biochim. Biophys. Acta, 1802, 122, 10.1016/j.bbadis.2009.08.010
Doulias, 2021, TCA cycle metabolic compromise due to an aberrant S-nitrosoproteome in HIV-associated neurocognitive disorder with methamphetamine use, J. Neurovirol., 27, 367, 10.1007/s13365-021-00970-4
Kam, 2018, Poly(ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson's disease, Science, 362, eaat8407, 10.1126/science.aat8407
Bolaños, 1994, Nitric oxide-mediated inhibition of the mitochondrial respiratory chain in cultured astrocytes, J. Neurochem., 63, 910, 10.1046/j.1471-4159.1994.63030910.x
Brown, 1994, Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase, FEBS Lett., 356, 295, 10.1016/0014-5793(94)01290-3
Schweizer, 1994, Nitric oxide potently and reversibly deenergizes mitochondria at low oxygen tension, Biochem. Biophys. Res. Commun., 204, 169, 10.1006/bbrc.1994.2441
Clementi, 1998, Persistent inhibition of cell respiration by nitric oxide: crucial role of S-nitrosylation of mitochondrial complex I and protective action of glutathione, Proc. Natl. Acad. Sci. USA, 95, 7631, 10.1073/pnas.95.13.7631
Beltrán, 2000, Oxidative stress and S-nitrosylation of proteins in cells, Br. J. Pharmacol., 129, 953, 10.1038/sj.bjp.0703147
Almeida, 2001, Different responses of astrocytes and neurons to nitric oxide: the role of glycolytically generated ATP in astrocyte protection, Proc. Natl. Acad. Sci. USA, 98, 15294, 10.1073/pnas.261560998
Stewart, 2003, Nitric oxide-induced mitochondrial dysfunction: implications for neurodegeneration, Free Radic. Biol. Med., 34, 287, 10.1016/S0891-5849(02)01327-8
Antunes, 2004, On the mechanism and biology of cytochrome oxidase inhibition by nitric oxide, Proc. Natl. Acad. Sci. USA, 101, 16774, 10.1073/pnas.0405368101
Cooper, 2007, Nitric oxide regulation of mitochondrial oxygen consumption II: Molecular mechanism and tissue physiology, Am. J. Physiol. Cell Physiol., 292, C1993, 10.1152/ajpcell.00310.2006
Ledo, 2010, Dynamic and interacting profiles of ∗NO and O2 in rat hippocampal slices, Free Radic. Biol. Med., 48, 1044, 10.1016/j.freeradbiomed.2010.01.024
Martínez-Ruiz, 2011, Nitric oxide signaling: classical, less classical, and nonclassical mechanisms, Free Radic. Biol. Med., 51, 17, 10.1016/j.freeradbiomed.2011.04.010
San Martín, 2017, Nanomolar nitric oxide concentrations quickly and reversibly modulate astrocytic energy metabolism, J. Biol. Chem., 292, 9432, 10.1074/jbc.M117.777243
Laranjinha, 2021, The peculiar facets of nitric oxide as a cellular messenger: From disease-associated signaling to the regulation of brain bioenergetics and neurovascular coupling, Neurochem. Res., 46, 64, 10.1007/s11064-020-03015-0
Zheng, 2016, Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation, Elife, 5, e13374, 10.7554/eLife.13374
Pellerin, 1994, Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization, Proc. Natl. Acad. Sci. USA, 91, 10625, 10.1073/pnas.91.22.10625
Magistretti, 2015, A cellular perspective on brain energy metabolism and functional imaging, Neuron, 86, 883, 10.1016/j.neuron.2015.03.035
Magistretti, 2018, Lactate in the brain: from metabolic end-product to signalling molecule, Nat. Rev. Neurosci., 19, 235, 10.1038/nrn.2018.19
Diaz-Garcia, 2017, Neuronal stimulation triggers neuronal glycolysis and not lactate uptake, Cell Metab, 26, 361, 10.1016/j.cmet.2017.06.021
Li, 2022, Energy matters: presynaptic metabolism and the maintenance of synaptic transmission, Nat. Rev. Neurosci., 23, 4, 10.1038/s41583-021-00535-8
Cheng, 2022, Programming axonal mitochondrial maintenance and bioenergetics in neurodegeneration and regeneration, Neuron, 110, 1899, 10.1016/j.neuron.2022.03.015
Dembitskaya, 2022, Lactate supply overtakes glucose when neural computational and cognitive loads scale up, Proc. Natl. Acad. Sci. USA, 119, 10.1073/pnas.2212004119
Soldner, 2011, Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations, Cell, 146, 318, 10.1016/j.cell.2011.06.019
Frane, 2019
Ruiz, 2015, Metabolic tracing using stable isotope-labeled substrates and mass spectrometry in the perfused mouse heart, Methods Enzymol., 561, 107, 10.1016/bs.mie.2015.06.026
Cordes, 2019, Quantifying intermediary metabolism and lipogenesis in cultured mammalian cells using stable isotope tracing and mass spectrometry, Methods Mol. Biol., 1978, 219, 10.1007/978-1-4939-9236-2_14
Torrini, 2022, Lactate is an epigenetic metabolite that drives survival in model systems of glioblastoma, Mol. Cell, 82, 3061, 10.1016/j.molcel.2022.06.030
Fernández-García, 2020, Stable isotopes for tracing mammalian-cell metabolism in vivo, Trends Biochem. Sci., 45, 185, 10.1016/j.tibs.2019.12.002
Nakamura, 2017, 'SNO’-storms compromise protein activity and mitochondrial metabolism in neurodegenerative disorders, Trends Endocrinol. Metab., 28, 879, 10.1016/j.tem.2017.10.004
Liu, 2019, L-NAME releases nitric oxide and potentiates subsequent nitroglycerin-mediated vasodilation, Redox Biol., 26, 101238, 10.1016/j.redox.2019.101238
Lewis, 2014, Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells, Mol. Cell, 55, 253, 10.1016/j.molcel.2014.05.008
Buescher, 2015, A roadmap for interpreting (13)C metabolite labeling patterns from cells, Curr. Opin. Biotechnol., 34, 189, 10.1016/j.copbio.2015.02.003
Jang, 2018, Metabolomics and isotope tracing, Cell, 173, 822, 10.1016/j.cell.2018.03.055
Butterfield, 2019, Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease, Nat. Rev. Neurosci., 20, 148, 10.1038/s41583-019-0132-6
Doulias, 2010, Structural profiling of endogenous S-nitrosocysteine residues reveals unique features that accommodate diverse mechanisms for protein S-nitrosylation, Proc. Natl. Acad. Sci. USA, 107, 16958, 10.1073/pnas.1008036107
Doulias, 2013, Site specific identification of endogenous S-nitrosocysteine proteomes, J. Proteomics, 92, 195, 10.1016/j.jprot.2013.05.033
Bruegger, 2018, Comparative and integrative metabolomics reveal that S-nitrosation inhibits physiologically relevant metabolic enzymes, J. Biol. Chem., 293, 6282, 10.1074/jbc.M117.817700
González-Rodríguez, 2021, Disruption of mitochondrial complex I induces progressive parkinsonism, Nature, 599, 650, 10.1038/s41586-021-04059-0
von Bartheld, 2016, The search for true numbers of neurons and glial cells in the human brain: A review of 150 years of cell counting, J. Comp. Neurol., 524, 3865, 10.1002/cne.24040
Uehara, 2006, S-Nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration, Nature, 441, 513, 10.1038/nature04782
Cho, 2009, S-Nitrosylation of Drp1 mediates β-amyloid-related mitochondrial fission and neuronal injury, Science, 324, 102, 10.1126/science.1171091
Nakamura, 2021, Noncanonical transnitrosylation network contributes to synapse loss in Alzheimer's disease, Science, 371, eaaw0843, 10.1126/science.aaw0843
Akhtar, 2016, Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation, Nat. Commun., 7, 10242, 10.1038/ncomms10242
Barsoum, 2006, Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons, EMBO J., 25, 3900, 10.1038/sj.emboj.7601253
Nakamura, 2020, Nitric oxide-dependent protein post-translational modifications impair mitochondrial function and metabolism to contribute to neurodegenerative diseases, Antioxid. Redox Signal., 32, 817, 10.1089/ars.2019.7916
Bhaduri, 2020, Are organoids ready for prime time?, Cell Stem Cell, 27, 361, 10.1016/j.stem.2020.08.013
Forrester, 2007, Assessment and application of the biotin switch technique for examining protein S-nitrosylation under conditions of pharmacologically induced oxidative stress, J. Biol. Chem., 282, 13977, 10.1074/jbc.M609684200
Forrester, 2009, Detection of protein S-nitrosylation with the biotin-switch technique, Free Radic. Biol. Med., 46, 119, 10.1016/j.freeradbiomed.2008.09.034
Wang, 2008, A strategy for direct identification of protein S-nitrosylation sites by quadrupole time-of-flight mass spectrometry, J. Am. Soc. Mass Spectrom., 19, 1353, 10.1016/j.jasms.2008.06.001
Raju, 2015, Regulation of brain glutamate metabolism by nitric oxide and S-nitrosylation, Sci. Signal., 8, ra68, 10.1126/scisignal.aaa4312
Seneviratne, 2016, S-nitrosation of proteins relevant to Alzheimer's disease during early stages of neurodegeneration, Proc. Natl. Acad. Sci. USA, 113, 4152, 10.1073/pnas.1521318113
Seneviratne, 2013, Mechanism-based triarylphosphine-ester probes for capture of endogenous RSNOs, J. Am. Chem. Soc., 135, 7693, 10.1021/ja401565w
Lin, 2009, A chemical platform for improved induction of human iPSCs, Nat. Methods, 6, 805, 10.1038/nmeth.1393
Kriks, 2011, Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's disease, Nature, 480, 547, 10.1038/nature10648
Vantaku, 2017, Expression of ganglioside GD2, reprogram the lipid metabolism and EMT phenotype in bladder cancer, Oncotarget, 8, 95620, 10.18632/oncotarget.21038
Jin, 2017, Tobacco-specific carcinogens induce hypermethylation, DNA adducts, and DNA damage in bladder cancer, Cancer Prev. Res., 10, 588, 10.1158/1940-6207.CAPR-17-0198
Piyarathna, 2018, Distinct lipidomic landscapes associated with clinical stages of urothelial cancer of the bladder, Eur. Urol. Focus, 4, 907, 10.1016/j.euf.2017.04.005
Kornberg, 2018, Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity, Science, 360, 449, 10.1126/science.aan4665
Gupta, 2009, An integrated model of eicosanoid metabolism and signaling based on lipidomics flux analysis, Biophys. J., 96, 4542, 10.1016/j.bpj.2009.03.011
Doulias, 2013, Nitric oxide regulates mitochondrial fatty acid metabolism through reversible protein S-nitrosylation, Sci. Signal., 6, rs1, 10.1126/scisignal.2003252
van Ooijen, 2018, Identification of differentially expressed peptides in high-throughput proteomics data, Brief. Bioinform., 19, 971, 10.1093/bib/bbx031
Mi, 2013, Large-scale gene function analysis with the PANTHER classification system, Nat. Protoc., 8, 1551, 10.1038/nprot.2013.092