Christine Tran1, Mansour Haddad1, Virginie Ratovelomanana‐Vidal2
1Institute of Chemistry for Life and Health Sciences
2PSL Research University, Chimie ParisTech, CNRS, Institute of Chemistry for Life and Health Sciences
Tóm tắt
A novel synthetic method for the preparation of selenopyridine derivatives, involving a [2+2+2] cycloaddition of α,ω-diynes and selenocyanates that is catalyzed by a ruthenium complex is described. This mild and straightforward reaction allows access to a wide range of selenopyridines with high yields and excellent regioselectivities, using dichloromethane or dichloroethane as solvents, at either 50 or 80 °C. Post-functionalization of halogenated cycloadducts via cyanation using copper and SNAr reaction provides substituted selenopyridines with good yields.
