Rostral Anterior Cingulate Glutamine/Glutamate Disbalance in Major Depressive Disorder Depends on Symptom Severity

Lejla Colic1,2, Felicia von Düring1, Dominik Denzel1, Liliana Ramona Demenescu1, Anton R. Lord3, Louise Martens4,5, Sarah Lison6, Joerg Frommer6, Mathias Vogel6, Joern Kaufmann7, Oliver Speck2,8,9,10, Meng Li1,4,5, Martin Walter1,2,8,4,5
1Clinical Affective Neuroimaging Laboratory, Otto von Guericke University, Magdeburg, Germany
2Department of Behavioral Neurology, Leibniz-Institute for Neurobiology, Magdeburg, Germany
3QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia
4Department of High-field Magnetic Resonance, Max Planck Institute for Biological Cybernetics Tübingen, Tübingen, Germany
5Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany
6Department of Psychosomatics and Psychotherapy, Otto von Guericke University, Magdeburg, Germany
7Department of Neurology, Otto-von-Guericke University, Magdeburg, Germany
8Center for Behavioral Brain Sciences, Otto von Guericke University, Magdeburg, Germany
9Department of Biomedical Magnetic Resonance, Otto von Guericke University, Magdeburg, Germany
10German Centre for Neurodegenerative Diseases, Helmholz Association of Germany Research Centres, Magdeburg, Germany

Tài liệu tham khảo

Ferrari, 2013, Burden of depressive disorders by country, sex, age, and year: Findings from the Global Burden of Disease Study 2010, PLoS Med, 10, e1001547, 10.1371/journal.pmed.1001547 Østergaard, 2011, The heterogeneity of the depressive syndrome: When numbers get serious, Acta Psychiatr Scand, 124, 495, 10.1111/j.1600-0447.2011.01744.x Sanacora, 2012, Towards a glutamate hypothesis of depression An emerging frontier of neuropsychopharmacology for mood disorders, Neuropharmacology, 62, 63, 10.1016/j.neuropharm.2011.07.036 Sanacora, 2008, Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders, Nat Rev Drug Discov, 7, 426, 10.1038/nrd2462 Yüksel, 2010, Magnetic resonance spectroscopy studies of glutamate-related abnormalities in mood disorders, Biol Psychiatry, 68, 785, 10.1016/j.biopsych.2010.06.016 Maddock, 2011, MR spectroscopic studies of the brain in psychiatric disorders, Curr Top Behav Neurosci, 11, 199, 10.1007/7854_2011_197 Rothman, 2003, In vivo NMR studies of the glutamate neurotransmitter flux and neuroenergetics: Implications for brain function, Annu Rev Physiol, 65, 401, 10.1146/annurev.physiol.65.092101.142131 Luykx, 2012, Region and state specific glutamate downregulation in major depressive disorder: A meta-analysis of (1)H-MRS findings, Neurosci Biobehav Rev, 36, 198, 10.1016/j.neubiorev.2011.05.014 Arnone, 2015, Indirect evidence of selective glial involvement in glutamate-based mechanisms of mood regulation in depression: Meta-analysis of absolute prefrontal neuro-metabolic concentrations, Eur Neuropsychopharmacol, 25, 1109, 10.1016/j.euroneuro.2015.04.016 Moriguchi, 2019, Glutamatergic neurometabolite levels in major depressive disorder: A systematic review and meta-analysis of proton magnetic resonance spectroscopy studies, Mol Psychiatry, 24, 952, 10.1038/s41380-018-0252-9 Taylor, 2012, Early increase in marker of neuronal integrity with antidepressant treatment of major depression: 1 H-magnetic resonance spectroscopy of N-acetyl-aspartate, Int J Neuropsychopharmacol, 15, 1541, 10.1017/S1461145712000272 Li, 2014, Dissociation of glutamate and cortical thickness is restricted to regions subserving trait but not state markers in major depressive disorder, J Affect Disord, 169, 91, 10.1016/j.jad.2014.08.001 Ramadan, 2014, Glutamate and glutamine: A review of in vivo MRS in the human brain, NMR Biomed, 26, 1630, 10.1002/nbm.3045 Dou, 2015, The separation of Gln and Glu in STEAM: A comparison study using short and long TEs/TMs at 3 and 7 T, MAGMA, 28, 395, 10.1007/s10334-014-0479-7 Hertz, 2013, The glutamate-glutamine (GABA) cycle: Importance of late postnatal development and potential reciprocal interactions between biosynthesis and degradation, Front Endocrinol (Lausanne), 4, 1, 10.3389/fendo.2013.00059 Rothman, 2011, 13C MRS studies of neuroenergetics and neurotransmitter cycling in humans, NMR Biomed, 24, 943, 10.1002/nbm.1772 Godlewska, 2017, Brain glutamate in medication-free depressed patients: A proton MRS study at 7 Tesla, Psychol Med, 48, 1731, 10.1017/S0033291717003373 Veeraiah, 2014, Dysfunctional glutamatergic and γ-aminobutyric acidergic activities in prefrontal cortex of mice in social defeat model of depression, Biol Psychiatry, 76, 231, 10.1016/j.biopsych.2013.09.024 Banasr, 2008, Glial loss in the prefrontal cortex is sufficient to induce depressive-like behaviors, Biol Psychiatry, 64, 863, 10.1016/j.biopsych.2008.06.008 Rajkowska, 2003, Depression: What we can learn from postmortem studies, Neuroscientist, 9, 273, 10.1177/1073858403252773 Si, 2004, Age-dependent reductions in the level of glial fibrillary acidic protein in the prefrontal cortex in major depression, Neuropsychopharmacology, 29, 2088, 10.1038/sj.npp.1300525 Choudary, 2005, Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression, Proc Natl Acad Sci U S A, 102, 15653, 10.1073/pnas.0507901102 Bernstein, 2015, Reduced density of glutamine synthetase immunoreactive astrocytes in different cortical areas in major depression but not in bipolar I disorder, Front Cell Neurosci, 9, 273, 10.3389/fncel.2015.00273 Rajkowska, 2000, Postmortem studies in mood disorders indicate altered numbers of neurons and glial cells, Biol Psychiatry, 48, 766, 10.1016/S0006-3223(00)00950-1 Rajkowska, 2013, Astrocyte pathology in major depressive disorder: Insights from human postmortem brain tissue, Curr Drug Targets, 14, 1225, 10.2174/13894501113149990156 Murrough, 2017, Targeting glutamate signalling in depression: progress and prospects, Nat Rev Drug Discov, 16, 472, 10.1038/nrd.2017.16 Zarate, 2006, A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression, Arch Gen Psychiatry, 63, 856, 10.1001/archpsyc.63.8.856 Li, 2016, Temporal dynamics of antidepressant ketamine effects on glutamine cycling follow regional fingerprints of AMPA and NMDA receptor densities, Neuropsychopharmacology, 42, 1201, 10.1038/npp.2016.184 Caddy, 2014, Ketamine as the prototype glutamatergic antidepressant: Pharmacodynamic actions, and a systematic review and meta-analysis of efficacy, Ther Adv Psychopharmacol, 4, 75, 10.1177/2045125313507739 Salvadore, 2012, An investigation of amino-acid neurotransmitters as potential predictors of clinical improvement to ketamine in depression, Int J Neuropsychopharmacol, 15, 1063, 10.1017/S1461145711001593 Walter, 2014, Multistage drug effects of ketamine in the treatment of major depression, Eur Arch Psychiatry Clin Neurosci, 264, 55, 10.1007/s00406-014-0535-3 Brennan, 2010, Rapid enhancement of glutamatergic neurotransmission in bipolar depression following treatment with riluzole, Neuropsychopharmacology, 35, 834, 10.1038/npp.2009.191 Salvadore, 2010, Anterior cingulate desynchronization and functional connectivity with the amygdala during a working memory task predict rapid antidepressant response to ketamine, Neuropsychopharmacology, 35, 1415, 10.1038/npp.2010.24 Soeiro-de-souza, 2015, Anterior cingulate glutamate – glutamine cycle metabolites are altered in euthymic bipolar I disorder, Eur Neuropsychopharmacol, 25, 2221, 10.1016/j.euroneuro.2015.09.020 Théberge, 2002, Glutamate and glutamine measured with 4.0 T proton MRS in never-treated patients with schizophrenia and healthy volunteers, Am J Psychiatry, 159, 1944, 10.1176/appi.ajp.159.11.1944 Kalueff, 2007, Role of GABA in anxiety and depression, Depress Anxiety, 24, 495, 10.1002/da.20262 Bhagwagar, 2008, Low GABA concentrations in occipital cortex and anterior cingulate cortex in medication-free, recovered depressed patients, Int J Neuropsychopharmacol, 11, 255, 10.1017/S1461145707007924 Price, 2009, Amino acid neurotransmitters assessed by proton magnetic resonance spectroscopy: Relationship to treatment resistance in major depressive disorder, Biol Psychiatry, 65, 792, 10.1016/j.biopsych.2008.10.025 Schür, 2016, Brain GABA levels across psychiatric disorders: A systematic literature review and meta-analysis of 1H-MRS studies, Hum Brain Mapp, 37, 3337, 10.1002/hbm.23244 Vogt, 1995, Human cingulate cortex: Surface features, flat maps, and cytoarchitecture, J Comp Neurol, 359, 490, 10.1002/cne.903590310 Palomero-Gallagher, 2009, Receptor architecture of human cingulate cortex: Evaluation of the four-region neurobiological model, Hum Brain Mapp, 30, 2336, 10.1002/hbm.20667 Dou, 2013, Systematic regional variations of GABA, glutamine, and glutamate concentrations follow receptor fingerprints of human cingulate cortex, J Neurosci, 33, 12698, 10.1523/JNEUROSCI.1758-13.2013 Palomero-Gallagher, 2018, Cyto-and receptor architectonic mapping of the human brain, Handb Clin Neurol, 150, 355, 10.1016/B978-0-444-63639-3.00024-4 Walter, 2008, Distinguishing specific sexual and general emotional effects in fMRI-Subcortical and cortical arousal during erotic picture viewing, Neuroimage, 40, 1482, 10.1016/j.neuroimage.2008.01.040 Grimm, 2009, Altered negative BOLD responses in the default-mode network during emotion processing in depressed subjects, Neuropsychopharmacology, 34, 10.1038/npp.2008.81 Horn, 2010, Glutamatergic and resting-state functional connectivity correlates of severity in major depression - the role of pregenual anterior cingulate cortex and anterior insula, Front Syst Neurosci, 4, 33 Sambataro, 2018, Revisiting default mode network function in major depression: Evidence for disrupted subsystem connectivity, Psychol Med, 44, 2041, 10.1017/S0033291713002596 McGrath, 2008, Response to a selective serotonin reuptake inhibitor (citalopram) in major depressive disorder with melancholic features: A STAR* D report, J Clin Psychiatry, 69, 1847, 10.4088/JCP.v69n1201 Fournier, 2010, Antidepressant drug effects and depression severity, JAMA, 303, 47, 10.1001/jama.2009.1943 Auer, 2000, Reduced glutamate in the anterior cingulate cortex in depression: An in vivo proton magnetic resonance spectroscopy study, Biol Psychiatry, 47, 305, 10.1016/S0006-3223(99)00159-6 Walter, 2009, The relationship between aberrant neuronal activation in the pregenual anterior cingulate, altered glutamatergic metabolism, and anhedonia in major depression, Arch Gen Psychiatry, 66, 478, 10.1001/archgenpsychiatry.2009.39 Taylor, 2008, Differential effects of citalopram and reboxetine on cortical Glx measured with proton MR spectroscopy, J Psychopharmacol, 22, 473, 10.1177/0269881107081510 Sanacora, 2002, Increased occipital cortex GABA concentrations in depressed patients after therapy with selective serotonin reuptake inhibitors, Am J Psychiatry, 159, 663, 10.1176/appi.ajp.159.4.663 Dilling, 2011 Snaith, 1995, A scale for the assessment of hedonic tone the Snaith-Hamilton Pleasure Scale, Br J Psychiatry, 167, 99, 10.1192/bjp.167.1.99 Franz, 1998, Deutsche Version der Snaith-Hamilton-Pleasure-Scale (SHAPS-D), Fortschr Neurol Psychiatr, 66, 407, 10.1055/s-2007-995279 Sheehan, 1998, The Mini-International Neuropsychiatric Interview (M.I.N.I.): The development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10, J Clin Psychiatry, 59, 22 Oldfield, 1971, The assessment and analysis of handedness: The Edinburgh Inventory, Neuropsychologia, 9, 97, 10.1016/0028-3932(71)90067-4 Provencher, 1993, Estimation of metabolite concentrations from localized in vivo proton NMR spectra, Magn Reson Med, 30, 672, 10.1002/mrm.1910300604 Provencher, 2001, Automatic quantitation of localized in vivo 1 H spectra with LCModel, NMR Biomed, 14, 260, 10.1002/nbm.698 Zimmerman, 2002, Symptom severity and exclusion from antidepressant efficacy trials, J Clin Psychopharmacol, 22, 610, 10.1097/00004714-200212000-00011 Rush, 2009 Hayes, 2017 Evans, 2018, 7T 1H-MRS in major depressive disorder: A ketamine treatment Study, Neuropharmacology, 43, 1908 Rajkowska, 2007, Gliogenesis and glial pathology in depression, CNS Neurol Disord Drug Targets, 6, 219, 10.2174/187152707780619326 Khundakar, 2009, Morphometric changes in early-and late-life major depressive disorder: Evidence from postmortem studies, Int Psychogeriatr, 21, 844, 10.1017/S104161020999007X Duman, 2016, Synaptic plasticity and depression: New insights from stress and rapid-acting antidepressants, Nat Med, 22, 238, 10.1038/nm.4050 Bogerts, 2016, Funktionell-neuroanatomische und neuropathologische Grundlagen psychischer Erkrankungen, 1 Théberge, 2003, Glutamate and glutamine in the anterior cingulate and thalamus of medicated patients with chronic schizophrenia and healthy comparison subjects measured with 4.0-T proton MRS, Am J Psychiatry, 160, 2231, 10.1176/appi.ajp.160.12.2231 Portella, 2011, Ventromedial prefrontal spectroscopic abnormalities over the course of depression: A comparison among first episode, remitted recurrent and chronic patients, J Psychiatr Res, 45, 427, 10.1016/j.jpsychires.2010.08.010 Ballard, 2018, Parsing the heterogeneity of depression: An exploratory factor analysis across commonly used depression rating scales, J Affect Disord, 231, 51, 10.1016/j.jad.2018.01.027 Palomero-Gallagher, 2019, Human pregenual anterior cingulate cortex: Structural, functional, and connectional heterogeneity, Cereb Cortex, 29, 2552, 10.1093/cercor/bhy124 Romeo, 2018, Meta-analysis of central and peripheral γ-aminobutyric acid levels in patients with unipolar and bipolar depression, J Psychiatry Neurosci, 43, 58, 10.1503/jpn.160228 Epperson, 2005, Sex, GABA, and nicotine: The impact of smoking on cortical GABA levels across the menstrual cycle as measured with proton magnetic resonance spectroscopy, Biol Psychiatry, 57, 44, 10.1016/j.biopsych.2004.09.021 Ham, 2007, Decreased GABA levels in anterior cingulate and basal ganglia in medicated subjects with panic disorder: A proton magnetic resonance spectroscopy (1H-MRS) study, Prog Neuro-Psychopharmacology Biol Psychiatry, 31, 403, 10.1016/j.pnpbp.2006.10.011 Sartorius, 1996, Depression comorbid with anxiety: Results from the WHO study on psychological disorders in primary health care, Br J Psychiatry, 168, 38, 10.1192/S0007125000298395 Li, 2003, Metabolite ratios to assumed stable creatine level may confound the quantification of proton brain MR spectroscopy, Magn Reson Imaging, 21, 923, 10.1016/S0730-725X(03)00181-4 Ongür, 2009, Creatine abnormalities in schizophrenia and bipolar disorder, Psychiatry Res, 172, 44, 10.1016/j.pscychresns.2008.06.002