Roles of tau protein in health and disease

Aamodt EJ, Williams RC Jr (1984) Biochemistry 23:6023–6031

Abisambra JF, Jinwal UK, Blair LJ, O’Leary JC 3rd, Li Q, Brady S, Wang L, Guidi CE, Zhang B, Nordhues BA et al (2013) J Neurosci 33:9498–9507. doi: 10.1523/JNEUROSCI.5397-12.2013

Abraha A, Ghoshal N, Gamblin TC, Cryns V, Berry RW, Kuret J, Binder LI (2000) J Cell Sci 113:3737–3745

Ahmed T, Van der Jeugd A, Blum D, Galas MC, D’Hooge R, Buee L, Balschun D (2014) Neurobiol Aging 35:2474–2478. doi: 10.1016/j.neurobiolaging.2014.05.005

Akiyama H, Ikeda K, Kondo H, McGeer PL (1992) Neurosci Lett 146:152–154. doi: 10.1016/0304-3940(92)90065-F

Alonso ADC, Mederlyova A, Novak M, Grundke-Iqbal I, Iqbal K (2004) J Biol Chem 279:34873–34881. doi: 10.1074/jbc.M405131200

Amadoro G, Corsetti V, Atlante A, Florenzano F, Capsoni S, Bussani R, Mercanti D, Calissano P (2012) Neurobiol Aging 33:833.e831–833.e825. doi: 10.1016/j.neurobiolaging.2011.08.001

Amadoro G, Corsetti V, Ciotti MT, Florenzano F, Capsoni S, Amato G, Calissano P (2011) Neurobiol Aging 32:969–990. doi: 10.1016/j.neurobiolaging.2009.06.005

Amadoro G, Corsetti V, Florenzano F, Atlante A, Ciotti MT, Mongiardi MP, Bussani R, Nicolin V, Nori SL, Campanella M et al (2014) Neurobiol Dis 62:489–507. doi: 10.1016/j.nbd.2013.10.018

Amadoro G, Corsetti V, Stringaro A, Colone M, D’Aguanno S, Meli G, Ciotti M, Sancesario G, Cattaneo A, Bussani R et al (2010) J Alzheimers Dis 21:445–470. doi: 10.3233/JAD-2010-100120

Anderson AJ, Stoltzner S, Lai F, Su J, Nixon RA (2000) Neurobiol Aging 21:511–524. doi: 10.1016/S0197-4580(00)00126-3

Anderson JP, Walker DE, Goldstein JM, De Laat R, Banducci K, Caccavello RJ, Barbour R, Huang J, Kling K, Lee M et al (2006) J Biol Chem 281:29739–29752. doi: 10.1074/jbc.M600933200

Andorfer C, Kress Y, Espinoza M, de Silva R, Tucker KL, Barde YA, Duff K, Davies P (2003) J Neurochem 86:582–590

Andreadis A (2006) Prog Mol Subcell Biol 44:89–107

Arai T, Guo JP, McGeer PL (2005) J Biol Chem 280:5145–5153. doi: 10.1074/jbc.M409234200

Arai T, Ikeda K, Akiyama H, Nonaka T, Hasegawa M, Ishiguro K, Iritani S, Tsuchiya K, Iseki E, Yagishita S et al (2004) Ann Neurol 55:72–79. doi: 10.1002/ana.10793

Arai T, Ikeda K, Akiyama H, Tsuchiya K, Iritani S, Ishiguro K, Yagishita S, Oda T, Odawara T, Iseki E (2003) Acta Neuropathol 105:489–498. doi: 10.1007/s00401-003-0671-8

Arai T, Miklossy J, Klegeris A, Quo JP, McGeer PL (2006) J Neuropathol Exp Neurol 65:19–25. doi: 10.1097/01.jnen.0000196133.74087.cb

Arendt T, Stieler JT, Holzer M (2016) Brain Res Bull 126:238–292. doi: 10.1016/j.brainresbull.2016.08.018

Arima K, Mizutani T, Alim MA, Tonozuka-Uehara H, Izumiyama Y, Hirai S, Ueda K (2000) Acta Neuropathol 100:115–121

Aronov S, Aranda G, Behar L, Ginzburg I (2001) J Neurosci 21:6577–6587

Asai H, Ikezu S, Tsunoda S, Medalla M, Luebke J, Haydar T, Wolozin B, Butovsky O, Kugler S, Ikezu T (2015) Nat Neurosci 18:1584–1593. doi: 10.1038/nn.4132

Asuni AA, Boutajangout A, Quartermain D, Sigurdsson EM (2007) J Neurosci 27:9115–9129. doi: 10.1523/JNEUROSCI.2361-07.2007

Atlante A, Amadoro G, Bobba A, de Bari L, Corsetti V, Pappalardo G, Marra E, Calissano P, Passarella S (2008) Biochim Biophys Acta 1777:1289–1300. doi: 10.1016/j.bbabio.2008.07.004

Avila J, Jimenez JS, Sayas CL, Bolos M, Zabala JC, Rivas G, Hernandez F (2016) Front Aging Neurosci 8:262. doi: 10.3389/Fnagi.2016.00262

Badiola N, de Oliveira RM, Herrera F, Guardia-Laguarta C, Goncalves SA, Pera M, Suarez-Calvet M, Clarimon J, Outeiro TF, Lleo A (2011) PLoS One 6:e26609. doi: 10.1371/journal.pone.0026609

Bakota L, Ussif A, Jeserich G, Brandt R (2017) Mol Cell Neurosci. doi: 10.1016/j.mcn.2017.03.003

Ballatore C, Lee VM, Trojanowski JQ (2007) Nat Rev Neurosci 8:663–672. doi: 10.1038/nrn2194

Barghorn S, Mandelkow E (2002) Biochemistry 41:14885–14896. doi: 10.1021/bi026469j

Basurto-Islas G, Luna-Muñoz J, Guillozet-Bongaarts AL, Binder LI, Mena R, García-Sierra F (2008) J Neuropathol Exp Neurol 67:470–483. doi: 10.1097/NEN.0b013e31817275c7

Bednarski E, Lynch G (1996) J Neurochem 67:1846–1855

Berger Z, Ravikumar B, Menzies FM, Oroz LG, Underwood BR, Pangalos MN, Schmitt I, Wullner U, Evert BO, O’Kane CJ et al (2006) Hum Mol Genet 15:433–442. doi: 10.1093/hmg/ddi458

Berry RW, Abraha A, Lagalwar S, LaPointe N, Gamblin TC, Cryns VL, Binder LI (2003) Biochemistry 42:8325–8331. doi: 10.1021/bi027348m

Bewley CA, Gronenborn AM, Clore GM (1998) Annu Rev Biophys Biomol Struct 27:105–131. doi: 10.1146/annurev.biophys.27.1.105

Bhaskar K, Hobbs GA, Yen SH, Lee G (2010) Neuropathol Appl Neurobiol 36:462–477. doi: 10.1111/j.1365-2990.2010.01103.x

Bhaskar K, Yen SH, Lee G (2005) J Biol Chem 280:35119–35125. doi: 10.1074/jbc.M505895200

Bi M, Ittner A, Ke YD, Gotz J, Ittner LM (2011) PLoS One 6:e26860. doi: 10.1371/journal.pone.0026860

Bloom GS (2014) JAMA Neurol 71:505–508. doi: 10.1001/jamaneurol.2013.5847

Blum D, Herrera F, Francelle L, Mendes T, Basquin M, Obriot H, Demeyer D, Sergeant N, Gerhardt E, Brouillet E et al (2015) Hum Mol Genet 24:76–85. doi: 10.1093/hmg/ddu421

Boland B, Kumar A, Lee S, Platt FM, Wegiel J, Yu WH, Nixon RA (2008) J Neurosci 28:6926–6937. doi: 10.1523/JNEUROSCI.0800-08.2008

Boluda S, Iba M, Zhang B, Raible KM, Lee VM, Trojanowski JQ (2015) Acta Neuropathol 129:221–237. doi: 10.1007/s00401-014-1373-0

Bondulich MK, Guo T, Meehan C, Manion J, Rodriguez Martin T, Mitchell JC, Hortobagyi T, Yankova N, Stygelbout V, Brion JP et al (2016) Brain 139:2290–2306. doi: 10.1093/brain/aww137

Boutajangout A, Authelet M, Blanchard V, Touchet N, Tremp G, Pradier L, Brion JP (2004) Neurobiol Dis 15:47–60

Boutajangout A, Ingadottir J, Davies P, Sigurdsson EM (2011) J Neurochem 118:658–667. doi: 10.1111/j.1471-4159.2011.07337.x

Braak F, Braak H, Mandelkow EM (1994) Acta Neuropathol 87:554–567. doi: 10.1007/BF00293315

Braak H, Braak E (1991) Acta Neuropathol 82:239–259. doi: 10.1007/BF00308809

Braak H, Braak E (1995) Neurobiol Aging 16:271–278. doi: 10.1016/0197-4580(95)00021-6

Braak H, Del Tredici K (2011) Acta Neuropathol 121:589–595. doi: 10.1007/s00401-011-0825-z

Brady RM, Zinkowski RP, Binder LI (1995) Neurobiol Aging 16:479–486

Brandt R, Leger J, Lee G (1995) J Cell Biol 131:1327–1340

Brion JP, Passareiro H, Nunez J, Flament-Durand J (1985) Arch Biol 96:229–235

Brunden KR, Trojanowski JQ, Lee VM (2009) Nat Rev Drug Discov 8:783–793. doi: 10.1038/nrd2959

Brunello CA, Yan X, Huttunen HJ (2016) Sci Rep 6:30498. doi: 10.1038/srep30498

Bukar Maina M, Al-Hilaly YK, Serpell LC (2016) Biomolecules 6:9. doi: 10.3390/biom6010009

Bulic B, Pickhardt M, Mandelkow EM, Mandelkow E (2010) Neuropharmacology 59:276–289. doi: 10.1016/j.neuropharm.2010.01.016

Caccamo A, Magri A, Medina DX, Wisely EV, Lopez-Aranda MF, Silva AJ, Oddo S (2013) Aging Cell 12:370–380. doi: 10.1111/acel.12057

Caccamo A, Oddo S, Tran LX, LaFerla FM (2007) Am J Pathol 170:1669–1675. doi: 10.2353/ajpath.2007.061178

Calafate S, Buist A, Miskiewicz K, Vijayan V, Daneels G, de Strooper B, de Wit J, Verstreken P, Moechars D (2015) Cell Rep 11:1176–1183. doi: 10.1016/j.celrep.2015.04.043

Calafate S, Flavin W, Verstreken P, Moechars D (2016) Cell Rep 17:931–940. doi: 10.1016/j.celrep.2016.09.063

Camero S, Benitez MJ, Barrantes A, Ayuso JM, Cuadros R, Avila J, Jimenez JS (2014) J Alzheimers Dis 39:649–660. doi: 10.3233/JAD-131415

Camero S, Benitez MJ, Cuadros R, Hernandez F, Avila J, Jimenez JS (2014) PLoS One 9:e104690. doi: 10.1371/journal.pone.0104690

Canu N, Dus L, Barbato C, Ciotti MT, Brancolini C, Rinaldi AM, Novak M, Cattaneo A, Bradbury A, Calissano P (1998) J Neurosci 18:7061–7074

Capsoni S, Giannotta S, Cattaneo A (2002) Proc Natl Acad Sci USA 99:12432–12437. doi: 10.1073/pnas.192442999

Carter RJ, Lione LA, Humby T, Mangiarini L, Mahal A, Bates GP, Dunnett SB, Morton AJ (1999) J Neurosci 19:3248–3257

Cataldo AM, Thayer CY, Bird ED, Wheelock TR, Nixon RA (1990) Brain Res 513:181–192. doi: 10.1016/0006-8993(90)90456-L

Cente M, Filipcik P, Pevalova M, Novak M (2006) Eur J Neurosci 24:1085–1090. doi: 10.1111/j.1460-9568.2006.04986.x

Chabrier MA, Blurton-Jones M, Agazaryan AA, Nerhus JL, Martinez-Coria H, LaFerla FM (2012) J Neurosci 32:17345–17350. doi: 10.1523/JNEUROSCI.0172-12.2012

Chai X, Dage JL, Citron M (2012) Neurobiol Dis 48:356–366. doi: 10.1016/j.nbd.2012.05.021

Chai X, Wu S, Murray TK, Kinley R, Cella CV, Sims H, Buckner N, Hanmer J, Davies P, O’Neill MJ et al (2011) J Biol Chem 286:34457–34467. doi: 10.1074/jbc.M111.229633

Chapuis J, Hansmannel F, Gistelinck M, Mounier A, Van Cauwenberghe C, Kolen KV, Geller F, Sottejeau Y, Harold D, Dourlen P et al (2013) Mol Psychiatry 18:1225–1234. doi: 10.1038/mp.2013.1

Chen J, Kanai Y, Cowan NJ, Hirokawa N (1992) Nature 360:674–676. doi: 10.1038/360674a0

Chen J, Yu JT, Wojta K, Wang HF, Zetterberg H, Blennow K, Yokoyama JS, Weiner MW, Kramer JH, Rosen H et al (2017) Neurology 88(7):669–676. doi: 10.1212/WNL.0000000000003615

Chen Q, Zhou Z, Zhang L, Wang Y, Zhang YW, Zhong M, Xu SC, Chen CH, Li L, Yu ZP (2012) Neurochem Int 60:233–242. doi: 10.1016/j.neuint.2011.12.013

Chiasseu M, Cueva Vargas JL, Destroismaisons L, Vande Velde C, Leclerc N, Di Polo A (2016) J Neurosci 36:5785–5798. doi: 10.1523/JNEUROSCI.3986-15.2016

Cho JH, Johnson GVW (2004) J Biol Chem 279:54716–54723. doi: 10.1074/jbc.M403364200

Ciaccioli G, Martins A, Rodrigues C, Vieira H, Calado P (2013) PLoS One 8:e55848. doi: 10.1371/journal.pone.0055848

Ciavardelli D, Silvestri E, Del Viscovo A, Bomba M, De Gregorio D, Moreno M, Di Ilio C, Goglia F, Canzoniero LM, Sensi SL (2010) Cell Death Dis 1:e90. doi: 10.1038/cddis.2010.68

Clausen T, Kaiser M, Huber R, Ehrmann M (2011) Nat Rev Mol Cell Biol 12:152–162. doi: 10.1038/nrm3065

Clavaguera F, Bolmont T, Crowther RA, Abramowski D, Frank S, Probst A, Fraser G, Stalder AK, Beibel M, Staufenbiel M et al (2009) Nat Cell Biol 11:909–913. doi: 10.1038/ncb1901

Cochran JN, Hall AM, Roberson ED (2014) Brain Res Bull 103:18–28. doi: 10.1016/j.brainresbull.2013.12.004

Cohen GM (1997) Biochem J 326:1–16

Cohen TJ, Constance BH, Hwang AW, James M, Yuan CX (2016) PLoS One 11:e0158470. doi: 10.1371/journal.pone.0158470

Cohen TJ, Friedmann D, Hwang AW, Marmorstein R, Lee VMY (2013) Nat Struct Mol Biol 20:756–762. doi: 10.1038/nsmb.2555

Cohen TJ, Guo JL, Hurtado DE, Kwong LK, Mills IP, Trojanowski JQ, Lee VMY (2011) Nat Commun 2:252. doi: 10.1038/ncomms1255

Congdon EE, Wu JW, Myeku N, Figueroa YH, Herman M, Marinec PS, Gestwicki JE, Dickey CA, Yu WH, Duff KE (2012) Autophagy 8:609–622. doi: 10.4161/auto.19048

Connell JW, Gibb GM, Betts JC, Blackstock WP, Gallo J, Lovestone S, Hutton M, Anderton BH (2001) FEBS Lett 493:40–44

Cook C, Carlomagno Y, Gendron TF, Dunmore J, Scheffel K, Stetler C, Davis M, Dickson D, Jarpe M, DeTure M et al (2014) Hum Mol Genet 23:104–116. doi: 10.1093/hmg/ddt402

Correas I, Padilla R, Avila J (1990) Biochem J 269:61–64

Corsetti V, Amadoro G, Gentile A, Capsoni S, Ciotti MT, Cencioni MT, Atlante A, Canu N, Rohn TT, Cattaneo A et al (2008) Mol Cell Neurosci 38:381–392. doi: 10.1016/j.mcn.2008.03.011

Corsetti V, Florenzano F, Atlante A, Bobba A, Ciotti MT, Natale F, Della Valle F, Borreca A, Manca A, Meli G et al (2015) Hum Mol Genet 24:3058–3081. doi: 10.1093/hmg/ddv059

Coutadeur S, Benyamine H, Delalonde L, de Oliveira C, Leblond B, Foucourt A, Besson T, Casagrande AS, Taverne T, Girard A et al (2015) J Neurochem 133:440–451. doi: 10.1111/jnc.13018

Cowan CM, Mudher A (2013) Front Neurol 13:4–114

Cox K, Combs B, Abdelmesih B, Morfini G, Brady ST, Kanaan NM (2016) Neurobiol Aging 47:113–126. doi: 10.1016/j.neurobiolaging.2016.07.015

Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA (1995) Nature 378:785–789. doi: 10.1038/378785a0

Cruz JC, Tseng HC, Goldman JA, Shih H, Tsai LH (2003) Neuron 40:471–483. doi: 10.1016/S0896-6273(03)00627-5

Cuerrier D, Moldoveanu T, Davies PL (2005) J Biol Chem 280:40632–40641. doi: 10.1074/jbc.M506870200

David DC, Hauptmann S, Scherping I, Schuessel K, Keil U, Rizzu P, Ravid R, Drose S, Brandt U, Muller WE et al (2005) J Biol Chem 280:23802–23814. doi: 10.1074/jbc.M500356200

David DC, Layfield R, Serpell L, Narain Y, Goedert M, Spillantini MG (2002) J Neurochem 83:176–185. doi: 10.1046/j.1471-4159.2002.01137.x

Davies SW, Turmaine M, Cozens BA, DiFiglia M, Sharp AH, Ross CA, Scherzinger E, Wanker EE, Mangiarini L, Bates GP (1997) Cell 90:537–548

Day RJ, Mason MJ, Thomas C, Poon WW, Rohn TT (2015) PLoS One 10:e0132637. doi: 10.1371/journal.pone.0132637

de Barreda EG, Dawson HN, Vitek MP, Avila J (2010) FEBS Lett 584:2265–2270. doi: 10.1016/j.febslet.2010.03.032

De Calignon A, Fox LM, Pitstick R, Carlson GA, Bacskai BJ, Spires-Jones TL, Hyman BT (2010) Nature 464:1201–1204. doi: 10.1038/nature08890

de Calignon A, Polydoro M, Suarez-Calvet M, William C, Adamowicz DH, Kopeikina KJ, Pitstick R, Sahara N, Ashe KH, Carlson GA et al (2012) Neuron 73:685–697. doi: 10.1016/j.neuron.2011.11.033

De Calignon A, Spires-Jones TL, Pitstick R, Carlson GA, Hyman BT (2009) J Neuropathol Exp Neurol 68:757–761. doi: 10.1097/NEN.0b013e3181a9fc66

de Silva R, Lashley T, Strand C, Shiarli AM, Shi J, Tian J, Bailey KL, Davies P, Bigio EH, Arima K et al (2006) Acta Neuropathol 111:329–340. doi: 10.1007/s00401-006-0048-x

De Vos KJ, Grierson AJ, Ackerley S, Miller CC (2008) Annu Rev Neurosci 31:151–173. doi: 10.1146/annurev.neuro.31.061307.090711

Deger JM, Gerson JE, Kayed R (2015) Aging Cell 14:715–724. doi: 10.1111/acel.12359

Deming Y, Xia J, Cai Y, Lord J, Holmans P, Bertelsen S, Holtzman D, Morris JC, Bales K, Pickering EH et al (2016) Neurobiol Aging 37(208):e201–e209. doi: 10.1016/j.neurobiolaging.2015.09.009

Derisbourg M, Leghay C, Chiappetta G, Fernandez-Gomez FJ, Laurent C, Demeyer D, Carrier S, Buée-Scherrer V, Blum D, Vinh J et al (2015) Sci Rep 5:9659. doi: 10.1038/srep09659

Derkinderen P, Scales TME, Hanger DP, Leung KY, Byers HL, Ward MA, Lenz C, Price C, Bird IN, Perera T et al (2005) J Neurosci 25:6584–6593. doi: 10.1523/JNEUROSCI.1487-05.2005

Dickey CA, Kamal A, Lundgren K, Klosak N, Bailey RM, Dunmore J, Ash P, Shoraka S, Zlatkovic J, Eckman CB et al (2007) J Clin Invest 117:648–658. doi: 10.1172/JCI29715

Dickson DW, Kouri N, Murray ME, Josephs KA (2011) J Mol Neurosci 45:384–389. doi: 10.1007/s12031-011-9589-0

Dihanich M, Kaser M, Reinhard E, Cunningham D, Monard D (1991) Neuron 6:575–581. doi: 10.1016/0896-6273(91)90060-D

Ding H, Dolan PJ, Johnson GV (2008) J Neurochem 106:2119–2130. doi: 10.1111/j.1471-4159.2008.05564.x

Dixit R, Ross JL, Goldman YE, Holzbaur EL (2008) Science 319:1086–1089. doi: 10.1126/science.1152993

Dolan PJ, Johnson GVW (2010) Curr Opin Drug Discov Dev 13:595–603

Dou F, Netzer WJ, Tanemura K, Li F, Hartl FU, Takashima A, Gouras GK, Greengard P, Xu H (2003) Proc Natl Acad Sci USA 100:721–726. doi: 10.1073/pnas.242720499

Drewes G, Trinczek B, Illenberger S, Biernat J, Schmitt-Ulms G, Meyer HE, Mandelkow EM, Mandelkow E (1995) J Biol Chem 270:7679–7688

Dujardin S, Begard S, Caillierez R, Lachaud C, Delattre L, Carrier S, Loyens A, Galas MC, Bousset L, Melki R et al (2014) PLoS One 9:e100760. doi: 10.1371/journal.pone.0100760

Ebneth A, Godemann R, Stamer K, Illenberger S, Trinczek B, Mandelkow EM, Mandelkow E (1998) J Cell Biol 143:777–794. doi: 10.1083/jcb.143.3.777

Eidenmuller J, Fath T, Maas T, Pool M, Sontag E, Brandt R (2001) Biochem J 357:759–767

Ekinci FJ, Shea TB (2000) Cell Mol Neurobiol 20:497–508

Elie A, Prezel E, Guerin C, Denarier E, Ramirez-Rios S, Serre L, Andrieux A, Fourest-Lieuvin A, Blanchoin L, Arnal I (2015) Sci Rep 5:9964. doi: 10.1038/srep09964

Esposito A, Dohm CP, Kermer P, Bahr M, Wouters FS (2007) Neurobiol Dis 26:521–531. doi: 10.1016/j.nbd.2007.01.014

Fasulo L, Ugolini G, Visintin M, Bradbury A, Brancolini C, Verzillo V, Novak M, Cattaneo A (2000) J Neurochem 75:624–633. doi: 10.1046/j.1471-4159.2000.0750624.x

Fels DR, Koumenis C (2006) Cancer Biol Ther 5:723–728

Fenton JW 2nd (1986) Ann N Y Acad Sci 485:5–15

Fernandez-Nogales M, Cabrera JR, Santos-Galindo M, Hoozemans JJ, Ferrer I, Rozemuller AJ, Hernandez F, Avila J, Lucas JJ (2014) Nat Med 20:881–885. doi: 10.1038/nm.3617

Fernandez-Nogales M, Santos-Galindo M, Hernandez IH, Cabrera JR, Lucas JJ (2016) Brain Pathol 26:772–778. doi: 10.1111/bpa.12430

Fernandez-Nogales M, Santos-Galindo M, Merchan-Rubira J, Hoozemans JJ, Rabano A, Ferrer I, Avila J, Hernandez F, Lucas JJ (2016) Brain Pathol. doi: 10.1111/bpa.12407

Ferreira A, Bigio EH (2011) Mol Med 17:676–685. doi: 10.2119/molmed.2010.00220

Filipcik P, Zilka N, Bugos O, Kucerak J, Koson P, Novak P, Novak M (2012) Neurobiol Aging 33:1448–1456. doi: 10.1016/j.neurobiolaging.2010.10.015

Flamment M, Hajduch E, Ferre P, Foufelle F (2012) Trends Endocrinol Metab 23:381–390. doi: 10.1016/j.tem.2012.06.003

Flanagan LA, Cunningham CC, Chen J, Prestwich GD, Kosik KS, Janmey PA (1997) Biophys J 73:1440–1447

Fontaine SN, Zheng D, Sabbagh JJ, Martin MD, Chaput D, Darling A, Trotter JH, Stothert AR, Nordhues BA, Lussier A et al (2016) EMBO J 35:1537–1549. doi: 10.15252/embj.201593489

Frandemiche ML, De Seranno S, Rush T, Borel E, Elie A, Arnal I, Lanté F, Buisson A (2014) J Neurosci 34:6084–6097. doi: 10.1523/JNEUROSCI.4261-13.2014

Fraser PE (2014) J Biol Chem 289:19839–19840. doi: 10.1074/jbc.R114.583492

Frasier M, Walzer M, McCarthy L, Magnuson D, Lee JM, Haas C, Kahle P, Wolozin B (2005) Exp Neurol 192:274–287. doi: 10.1016/j.expneurol.2004.07.016

Frost B, Hemberg M, Lewis J, Feany MB (2014) Nat Neurosci 17:357–366. doi: 10.1038/nn.3639

Frost B, Jacks RL, Diamond MI (2009) J Biol Chem 284:12845–12852. doi: 10.1074/jbc.M808759200

Frost B, Ollesch J, Wille H, Diamond MI (2009) J Biol Chem 284:3546–3551. doi: 10.1074/jbc.M805627200

Fu ZQ, Yang Y, Song J, Jiang Q, Liu ZC, Wang Q, Zhu LQ, Wang JZ, Tian Q (2010) J Alzheimers Dis 21:1107–1117. doi: 10.3233/JAD-2010-100687

Fulga TA, Elson-Schwab I, Khurana V, Steinhilb ML, Spires TL, Hyman BT, Feany MB (2007) Nat Cell Biol 9:139–148. doi: 10.1038/ncb1528

Funk KE, Thomas SN, Schafer KN, Cooper GL, Liao Z, Clark DJ, Yang AJ, Kuret J (2014) Biochem J 462:77–88. doi: 10.1042/BJ20140372

Fuster-Matanzo A, de Barreda EG, Dawson HN, Vitek MP, Avila J, Hernández F (2009) FEBS Lett 583:3063–3068. doi: 10.1016/j.febslet.2009.08.017

Fuster-Matanzo A, Llorens-Martin M, Jurado-Arjona J, Avila J, Hernandez F (2012) Front Neurosci 6:104. doi: 10.3389/fnins.2012.00104

Gómez-Isla T, Hollister R, West H, Mui S, Growdon JH, Petersen RC, Parisi JE, Hyman BT (1997) Ann Neurol 41:17–24. doi: 10.1002/ana.410410106

Götz J, Chen F, Van Dorpe J, Nitsch RM (2001) Science 293:1491–1495. doi: 10.1126/science.1062097

Gafni J, Hermel E, Young JE, Wellington CL, Hayden MR, Ellerby LM (2004) J Biol Chem 279:20211–20220. doi: 10.1074/jbc.M401267200

Galpern WR, Lang AE (2006) Ann Neurol 59:449–458. doi: 10.1002/ana.20819

Gamblin TC, Chen F, Zambrano A, Abraha A, Lagalwar S, Guillozet AL, Lu M, Fu Y, Garcia-Sierra F, LaPointe N et al (2003) Proc Natl Acad Sci USA 100:10032–10037. doi: 10.1073/pnas.1630428100

Garg S, Timm T, Mandelkow EM, Mandelkow E, Wang Y (2011) Neurobiol Aging 32:1–14. doi: 10.1016/j.neurobiolaging.2010.09.008

Garwood CJ, Pooler AM, Atherton J, Hanger DP, Noble W (2011) Cell Death Dis 2:e167. doi: 10.1038/cddis.2011.50

Gauthier-Kemper A, Weissmann C, Golovyashkina N, Sebo-Lemke Z, Drewes G, Gerke V, Heinisch JJ, Brandt R (2011) J Cell Biol 192:647–661. doi: 10.1083/jcb.201007161

Gauthier S, Feldman HH, Schneider LS, Wilcock GK, Frisoni GB, Hardlund JH, Moebius HJ, Bentham P, Kook KA, Wischik DJ et al (2016) Lancet 388:2873–2884. doi: 10.1016/S0140-6736(16)31275-2

Georgieva ER, Xiao SF, Borbat PP, Freed JH, Eliezer D (2014) Biophys J 107:1441–1452. doi: 10.1016/j.bpj.2014.07.046

Gerson JE, Sengupta U, Lasagna-Reeves CA, Guerrero-Munoz MJ, Troncoso J, Kayed R (2014) Acta Neuropathol Commun 2:73. doi: 10.1186/2051-5960-2-73

Ghetti B, Oblak AL, Boeve BF, Johnson KA, Dickerson BC, Goedert M (2015) Neuropathol Appl Neurobiol 41:24–46. doi: 10.1111/nan.12213

Giasson BI, Forman MS, Higuchi M, Golbe LI, Graves CL, Kotzbauer PT, Trojanowski JQ, Lee VM (2003) Science 300:636–640. doi: 10.1126/science.1082324

Goedert M, Jakes R (1990) EMBO J 9:4225–4230

Goedert M, Jakes R (2005) Biochim Biophys Acta 1739:240–250. doi: 10.1016/j.bbadis.2004.08.007

Goedert M, Masuda-Suzukake M, Falcon B (2016) Brain 140(2):266–278. doi: 10.1093/brain/aww230

Goedert M, Spillantini MG, Jakes R, Crowtherp RA, Vanmechelen E, Probst A, Götz J, Bürki K, Cohen P (1995) Neurobiol Aging 16:325–334. doi: 10.1016/0197-4580(95)00017-9

Goedert M, Spillantini MG, Jakes R, Rutherford D, Crowther RA (1989) Neuron 3:519–526. doi: 10.1016/0896-6273(89)90210-9

Goedert M, Wischik CM, Crowther RA, Walker JE, Klug A (1988) Proc Natl Acad Sci USA 85:4051–4055

Goll DE, Thompson VF, Taylor RG, Zalewska T (1992) BioEssays 14:549–556. doi: 10.1002/bies.950140810

Gong CX, Iqbal K (2008) Curr Med Chem 15:2321–2328. doi: 10.2174/092986708785909111

Gong CX, Lidsky T, Wegiel J, Zuck L, Grundke-Iqbal I, Iqbal K (2000) J Biol Chem 275:5535–5544. doi: 10.1074/jbc.275.8.5535

Goode BL, Denis PE, Panda D, Radeke MJ, Miller HP, Wilson L, Feinstein SC (1997) Mol Biol Cell 8:353–365

Goris A, Williams-Gray CH, Clark GR, Foltynie T, Lewis SJG, Brown J, Ban M, Spillantini MG, Compston A, Burn DJ et al (2007) Ann Neurol 62:145–153. doi: 10.1002/ana.21192

Gorsky MK, Burnouf S, Dols J, Mandelkow E, Partridge L (2016) Sci Rep 6:22685. doi: 10.1038/Srep22685

Gotz J, Ittner A, Ittner LM (2012) Br J Pharmacol 165:1246–1259. doi: 10.1111/j.1476-5381.2011.01713.x

Graham RK, Deng Y, Slow EJ, Haigh B, Bissada N, Lu G, Pearson J, Shehadeh J, Bertram L, Murphy Z et al (2006) Cell 125:1179–1191. doi: 10.1016/j.cell.2006.04.026

Gratuze M, Noel A, Julien C, Cisbani G, Milot-Rousseau P, Morin F, Dickler M, Goupil C, Bezeau F, Poitras I et al (2015) Hum Mol Genet 24:86–99. doi: 10.1093/hmg/ddu456

Grau S, Baldi A, Bussani R, Tian X, Stefanescu R, Przybylski M, Richards P, Jones SA, Shridhar V, Clausen T et al (2005) Proc Natl Acad Sci USA 102:6021–6026. doi: 10.1073/pnas.0501823102

Greenberg SG, Davies P (1990) Proc Natl Acad Sci USA 87:5827–5831. doi: 10.1073/pnas.87.15.5827

Greenwood JA, Johnson GV (1995) Exp Cell Res 220:332–337. doi: 10.1006/excr.1995.1323

Grinberg LT, Wang XH, Wang C, Sohn PD, Theofilas P, Sidhu M, Arevalo JB, Heinsen H, Huang EJ, Rosen H et al (2013) Acta Neuropathol 125:581–593. doi: 10.1007/s00401-013-1080-2

Grundke-Iqbal I, Iqbal K, Tung YC, Quinlan M, Wisniewski HM, Binder LI (1986) Proc Natl Acad Sci USA 83:4913–4917

Gu GJ, Wu D, Lund H, Sunnemark D, Kvist AJ, Milner R, Eckersley S, Nilsson LNG, Agerman K, Landegren U et al (2013) J Alzheimers Dis 33:699–713. doi: 10.3233/JAD-2012-121357

Guillozet-Bongaarts AL, Cahill ME, Cryns VL, Reynolds MR, Berry RW, Binder LI (2006) J Neurochem 97:1005–1014. doi: 10.1111/j.1471-4159.2006.03784.x

Guillozet-Bongaarts AL, Garcia-Sierra F, Reynolds MR, Horowitz PM, Fu Y, Wang T, Cahill ME, Bigio EH, Berry RW, Binder LI (2005) Neurobiol Aging 26:1015–1022. doi: 10.1016/j.neurobiolaging.2004.09.019

Guillozet-Bongaarts AL, Glajch KE, Libson EG, Cahill ME, Bigio E, Berry RW, Binder LI (2007) Acta Neuropathol 113:513–520. doi: 10.1007/s00401-007-0209-6

Gunawardana CG, Mehrabian M, Wang X, Mueller I, Lubambo IB, Jonkman JE, Wang H, Schmitt-Ulms G (2015) Mol Cell Proteom 14:3000–3014. doi: 10.1074/mcp.M115.050724

Guo H, Albrecht S, Bourdeau M, Petzke T, Bergeron C, LeBlanc AC (2004) Am J Pathol 165:523–531

Hamano T, Gendron TF, Causevic E, Yen SH, Lin WL, Isidoro C, Deture M, Ko LW (2008) Eur J Neurosci 27:1119–1130. doi: 10.1111/j.1460-9568.2008.06084.x

Hampel H, Schneider LS, Giacobini E, Kivipelto M, Sindi S, Dubois B, Broich K, Nistico R, Aisen PS, Lista S (2015) Expert Rev Neurother 15:83–105. doi: 10.1586/14737175.2015.995637

Hanger DP, Anderton BH, Noble W (2009) Trends Mol Med 15:112–119. doi: 10.1016/j.molmed.2009.01.003

Hanger DP, Byers HL, Wray S, Leung KY, Saxton MJ, Seereeram A, Reynolds CH, Ward MA, Anderton BH (2007) J Biol Chem 282:23645–23654. doi: 10.1074/jbc.M703269200

Hanger DP, Gibb GM, de Silva R, Boutajangout A, Brion JP, Revesz T, Lees AJ, Anderton BH (2002) FEBS Lett 531:538–542

Hanger DP, Hughes K, Woodgett JR, Brion JP, Anderton BH (1992) Neurosci Lett 147:58–62. doi: 10.1016/0304-3940(92)90774-2

Hanger DP, Wray S (2010) Biochem Soc Trans 38:1016–1020. doi: 10.1042/BST0381016

Hara K, Shiga A, Fukutake T, Nozaki H, Miyashita A, Yokoseki A, Kawata H, Koyama A, Arima K, Takahashi T et al (2009) N Engl J Med 360:1729–1739. doi: 10.1056/NEJMoa0801560

Hashiguchi M, Sobue K, Paudel HK (2000) J Biol Chem 275:25247–25254. doi: 10.1074/jbc.M003738200

Hatch RJ, Wei Y, Xia D, Gotz J (2017) Acta Neuropathol. doi: 10.1007/s00401-017-1674-1

He HJ, Wang XS, Pan R, Wang DL, Liu MN, He RQ (2009) BMC Cell Biol 10:81. doi: 10.1186/1471-2121-10-81

Heitz FD, Farinelli M, Mohanna S, Kahn M, Duning K, Frey MC, Pavenstadt H, Mansuy IM (2016) Neurobiol Learn Mem 135:100–114. doi: 10.1016/j.nlm.2016.07.028

Hempen B, Brion JP (1996) J Neuropathol Exp Neurol 55:964–972

Hernandez-Ortega K, Garcia-Esparcia P, Gil L, Lucas JJ, Ferrer I (2016) Brain Pathol 26:593–605. doi: 10.1111/bpa.12335

Hetz C, Mollereau B (2014) Nat Rev Neurosci 15:233–249. doi: 10.1038/nrn3689

Hinrichs MH, Jalal A, Brenner B, Mandelkow E, Kumar S, Scholz T (2012) J Biol Chem 287:38559–38568. doi: 10.1074/jbc.M112.369785

Ho YS, Yang X, Lau JC, Hung CH, Wuwongse S, Zhang Q, Wang J, Baum L, So KF, Chang RC (2012) J Alzheimers Dis 28:839–854. doi: 10.3233/JAD-2011-111037

Holmes BB, DeVos SL, Kfoury N, Li M, Jacks R, Yanamandra K, Ouidja MO, Brodsky FM, Marasa J, Bagchi DP et al (2013) Proc Natl Acad Sci USA 110:E3138–E3147. doi: 10.1073/pnas.1301440110

Hong XP, Peng CX, Wei W, Tian Q, Liu YH, Yao XQ, Zhang Y, Cao FY, Wang Q, Wang JZ (2010) Hippocampus 20:1339–1349. doi: 10.1002/hipo.20712

Hoover BR, Reed MN, Su J, Penrod RD, Kotilinek LA, Grant MK, Pitstick R, Carlson GA, Lanier LM, Yuan LL et al (2010) Neuron 68:1067–1081. doi: 10.1016/j.neuron.2010.11.030

Hoozemans JJ, van Haastert ES, Nijholt DA, Rozemuller AJ, Eikelenboom P, Scheper W (2009) Am J Pathol 174:1241–1251. doi: 10.2353/ajpath.2009.080814

Hoozemans JJ, Scheper W (2012) Int J Biochem Cell Biol 44:1295–1298. doi: 10.1016/j.biocel.2012.04.023

Horowitz PM, Patterson KR, Guillozet-Bongaarts AL, Reynolds MR, Carroll CA, Weintraub ST, Bennett DA, Cryns VL, Berry RW, Binder LI (2004) J Neurosci 24:7895–7902. doi: 10.1523/JNEUROSCI.1988-04.2004

Hsiao K, Chapman P, Nilsen S, Eckman C, Harigaya Y, Younkin S, Yang F, Cole G (1996) Science 274:99–102. doi: 10.1126/science.274.5284.99

Hu X, Wang T, Jin F (2016) Sci China Life Sci 59:1006–1023. doi: 10.1007/s11427-016-5083-9

Hua Q, He RQ, Haque N, Qu MH, del Carmen Alonso A, Grundke-Iqbal I, Iqbal K (2003) Cell Mol Life Sci 60:413–421

Huang DY, Weisgraber KH, Goedert M, Saunders AM, Roses AD, Strittmatter WJ (1995) Neurosci Lett 192:209–212

Hutton M, Lendon CL, Rizzu P, Baker M, Froelich S, Houlden HH, Pickering-Brown S, Chakraverty S, Isaacs A, Grover A et al (1998) Nature 393:702–704. doi: 10.1038/31508

Igaz LM, Kwong LK, Chen-Plotkin A, Winton MJ, Unger TL, Xu Y, Neumann M, Trojanowski JQ, Lee VMY (2009) J Biol Chem 284:8516–8524. doi: 10.1074/jbc.M809462200

Iijima M, Tabira T, Poorkaj P, Schellenberg GD, Trojanowski JQ, Lee VMY, Schmidt ML, Takahashi K, Nabika T, Matsumoto T et al (1999) NeuroReport 10:497–501

Ikeda C, Yokota O, Nagao S, Ishizu H, Oshima E, Hasegawa M, Okahisa Y, Terada S, Yamada N (2016) Brain Pathol 26:488–505. doi: 10.1111/bpa.12319

Ikeda K, Akiyama H, Arai T, Kondo H, Haga C, Tsuchiya K, Yamada S, Murayama S, Hori A (2000) Neurosci Lett 284:187–189

Ikeda K, Akiyama H, Arai T, Nishimura T (1998) Neurobiol Aging 19:S85–S91

Inoue K, Rispoli J, Kaphzan H, Klann E, Chen EI, Kim J, Komatsu M, Abeliovich A (2012) Mol Neurodegener 7:48. doi: 10.1186/1750-1326-7-48

Irizarry MC, Growdon W, Gomez-Isla T, Newell K, George JM, Clayton DF, Hyman BT (1998) J Neuropathol Exp Neurol 57:334–337

Irwin DJ, Cohen TJ, Grossman M, Arnold SE, McCarty-Wood E, Van Deerlin VM, Lee VMY, Trojanowski JQ (2013) Am J Pathol 183:344–351. doi: 10.1016/j.ajpath.2013.04.025

Irwin DJ, Lee VM, Trojanowski JQ (2013) Nat Rev Neurosci 14:626–636. doi: 10.1038/nrn3549

Ishizawa T, Mattila P, Davies P, Wang DS, Dickson DW (2003) J Neuropathol Exp Neurol 62:389–397

Ittner A, Chua SW, Bertz J, Volkerling A, van der Hoven J, Gladbach A, Przybyla M, Bi M, van Hummel A, Stevens CH et al (2016) Science 354:904–908. doi: 10.1126/science.aah6205

Ittner LM, Fath T, Ke YD, Bi M, van Eersel J, Li KM, Gunning P, Gotz J (2008) Proc Natl Acad Sci USA 105:15997–16002. doi: 10.1073/pnas.0808084105

Ittner LM, Ke YD, Delerue F, Bi M, Gladbach A, van Eersel J, Wölfing H, Chieng BC, Christie MJ, Napier IA et al (2010) Cell 142:387–397. doi: 10.1016/j.cell.2010.06.036

Ittner LM, Ke YD, Götz J (2009) J Biol Chem 284:20909–20916. doi: 10.1074/jbc.M109.014472

Jackson SJ, Kerridge C, Cooper J, Cavallini A, Falcon B, Cella CV, Landi A, Szekeres PG, Murray TK, Ahmed Z et al (2016) J Neurosci 36:762–772. doi: 10.1523/JNEUROSCI.3542-15.2016

Jeganathan S, Hascher A, Chinnathambi S, Biernat J, Mandelkow EM, Mandelkow E (2008) J Biol Chem 283:32066–32076. doi: 10.1074/jbc.M805300200

Jeganathan S, von Bergen M, Brutlach H, Steinhoff HJ, Mandelkow E (2006) Biochemistry 45:2283–2293. doi: 10.1021/bi0521543

Jeganathan S, Von Bergen M, Mandelkow EM, Mandelkow E (2008) Biochemistry 47:10526–10539. doi: 10.1021/bi800783d

Jellinger KA (2009) Acta Neuropathol 118:371–379. doi: 10.1007/s00401-009-0537-9

Jensen PH, Hager H, Nielsen MS, Hojrup P, Gliemann J, Jakes R (1999) J Biol Chem 274:25481–25489. doi: 10.1074/jbc.274.36.25481

Jin M, Shepardson N, Yang T, Chen G, Walsh D, Selkoe DJ (2011) Proc Natl Acad Sci USA 108:5819–5824. doi: 10.1073/pnas.1017033108

Joachim CL, Morris JH, Kosik KS, Selkoe DJ (1987) Ann Neurol 22:514–520. doi: 10.1002/ana.410220411

Johnson GVW, Jope RS, Binder LI (1989) Biochem Biophys Res Commun 163:1505–1511. doi: 10.1016/0006-291X(89)91150-9

Jones EM, Dubey M, Camp PJ, Vernon BC, Biernat J, Mandelkow E, Majewski J, Chi EY (2012) Biochemistry 51:2539–2550. doi: 10.1021/bi201857v

Jucker M, Walker LC (2013) Nature 501:45–51. doi: 10.1038/nature12481

Köpke E, Tung YC, Shaikh S, Alonso ADC, Iqbal K, Grundke-Iqbal I (1993) J Biol Chem 268:24374–24384

Kambe T, Motoi Y, Inoue R, Kojima N, Tada N, Kimura T, Sahara N, Yamashita S, Mizoroki T, Takashima A et al (2011) Neurobiol Dis 42:404–414. doi: 10.1016/j.nbd.2011.02.002

Kanaan NM, Morfini G, Pigino G, LaPointe NE, Andreadis A, Song Y, Leitman E, Binder LI, Brady ST (2012) Neurobiol Aging 33(826):e815–e830. doi: 10.1016/j.neurobiolaging.2011.06.006

Kanaan NM, Morfini GA, LaPointe NE, Pigino GF, Patterson KR, Song Y, Andreadis A, Fu Y, Brady ST, Binder LI (2011) J Neurosci 31:9858–9868. doi: 10.1523/JNEUROSCI.0560-11.2011

Kandimalla R, Reddy PH (2016) Biochim Biophys Acta 1862:814–828. doi: 10.1016/j.bbadis.2015.12.018

Karsten SL, Sang TK, Gehman L, Chatterjee S, Liu J, Lawless GM, Sengupta S, Berry R, Pomakian J, Oh HS et al (2006) Neuron 51:549–560. doi: 10.1016/j.neuron.2006.07.019

Kaufman SK, Sanders DW, Thomas TL, Ruchinskas AJ, Vaquer-Alicea J, Sharma AM, Miller TM, Diamond MI (2016) Neuron 92:796–812. doi: 10.1016/j.neuron.2016.09.055

Kauwe JS, Cruchaga C, Karch CM, Sadler B, Lee M, Mayo K, Latu W, Su’a M, Fagan AM, Holtzman DM et al (2011) PLoS One 6:e15918. doi: 10.1371/journal.pone.0015918

Kawakami F, Suzuki M, Shimada N, Kagiya G, Ohta E, Tamura K, Maruyama H, Ichikawa T (2011) FEBS J 278:4895–4904. doi: 10.1111/j.1742-4658.2011.08389.x

Kay BK, Williamson MP, Sudol P (2000) FASEB J 14:231–241

Keck S, Nitsch R, Grune T, Ullrich O (2003) J Neurochem 85:115–122

Keller JN, Hanni KB, Markesbery WR (2000) J Neurochem 75:436–439. doi: 10.1046/j.1471-4159.2000.0750436.x

Kenessey A, Nacharaju P, Ko LW, Yen SH (1997) J Neurochem 69:2026–2038

Khurana V, Elson-Schwab I, Fulga TA, Sharp KA, Loewen CA, Mulkearns E, Tyynela J, Scherzer CR, Feany MB (2010) PLoS Genet 6:e1001026. doi: 10.1371/journal.pgen.1001026

Kim AJ, Shi Y, Austin RC, Werstuck GH (2005) J Cell Sci 118:89–99. doi: 10.1242/jcs.01562

Kim W, Lee S, Jung C, Ahmed A, Lee G, Hall GF (2010) J Alzheimers Dis 19:647–664. doi: 10.3233/JAD-2010-1273

Kimura T, Whitcomb DJ, Jo J, Regan P, Piers T, Heo S, Brown C, Hashikawa T, Murayama M, Seok H et al (2014) Philos Trans R Soc Lond B Biol Sci 369:20130144. doi: 10.1098/Rstb.2013.0144

Klein C, Kramer EM, Cardine AM, Schraven B, Brandt R, Trotter J (2002) J Neurosci 22:698–707

Klunk WE, Engler H, Nordberg A, Wang Y, Blomqvist G, Holt DP, Bergstrom M, Savitcheva I, Huang GF, Estrada S et al (2004) Ann Neurol 55:306–319. doi: 10.1002/ana.20009

Konzack S, Thies E, Marx A, Mandelkow EM, Mandelkow E (2007) J Neurosci 27:9916–9927. doi: 10.1523/JNEUROSCI.0927-07.2007

Kopeikina KJ, Carlson GA, Pitstick R, Ludvigson AE, Peters A, Luebke JI, Koffie RM, Frosch MP, Hyman BT, Spires-Jones TL (2011) Am J Pathol 179:2071–2082. doi: 10.1016/j.ajpath.2011.07.004

Kosik KS, Orecchio LD, Bakalis S, Neve RL (1989) Neuron 2:1389–1397. doi: 10.1016/0896-6273(89)90077-9

Kosik KS, Orecchio LD, Binder L, Trojanowski JQ, Lee VMY, Lee G (1988) Neuron 1:817–825. doi: 10.1016/0896-6273(88)90129-8

Koson P, Zilka N, Kovac A, Kovacech B, Korenova M, Filipcik P, Novak M (2008) Eur J Neurosci 28:239–246. doi: 10.1111/j.1460-9568.2008.06329.x

Kovac A, Zilka N, Kazmerova Z, Cente M, Zilkova M, Novak M (2011) J Immunol 187:2732–2739. doi: 10.4049/jimmunol.1100216

Krüger U, Wang Y, Kumar S, Mandelkow EM (2012) Neurobiol Aging 33:2291–2305. doi: 10.1016/j.neurobiolaging.2011.11.009

Krylova SM, Musheev M, Nutiu R, Li Y, Lee G, Krylov SN (2005) FEBS Lett 579:1371–1375. doi: 10.1016/j.febslet.2005.01.032

Ksiezak-Reding H, Pyo HK, Feinstein B, Pasinetti GM (2003) Biochim Biophys Acta 1639:159–168

Kuret J, Chirita CN, Congdon EE, Kannanayakal T, Li G, Necula M, Yin H, Zhong Q (2005) Biochim Biophys Acta 1739:167–178. doi: 10.1016/j.bbadis.2004.06.016

L’Episcopo F, Drouin-Ouellet J, Tirolo C, Pulvirenti A, Giugno R, Testa N, Caniglia S, Serapide MF, Cisbani G, Barker RA et al (2016) Cell Death Dis 7:e2206. doi: 10.1038/cddis.2016.104

Labbadia J, Morimoto RI (2013) Trends Biochem Sci 38:378–385. doi: 10.1016/j.tibs.2013.05.003

Labbe C, Ross OA (2014) Curr Genom 15:2–10

Lang AE, Riherd Methner DN, Ferreira A (2014) Neuroscience 275:322–339. doi: 10.1016/j.neuroscience.2014.06.017

Lasagna-Reeves CA, Castillo-Carranza DL, Sengupta U, Clos AL, Jackson GR, Kayed R (2011) Mol Neurodegener 6:39. doi: 10.1186/1750-1326-6-39

Lau DH, Hogseth M, Phillips EC, O’Neill MJ, Pooler AM, Noble W, Hanger DP (2016) Acta Neuropathol Commun 4:49. doi: 10.1186/s40478-016-0317-4

Lebouvier T, Scales TME, Williamson R, Noble W, Duyckaerts C, Hanger DP, Reynolds CH, Anderton BH, Derkinderen P (2009) J Alzheimers Dis 18:1–9. doi: 10.3233/JAD-2009-1116

Ledesma MD, Bonay P, Avila J (1995) J Neurochem 65:1658–1664

Lee G (2005) Biochim Biophys Acta 1739:323–330. doi: 10.1016/j.bbadis.2004.09.002

Lee G, Thangavel R, Sharma VM, Litersky JM, Bhaskar K, Fang SM, Do LH, Andreadis A, Van Hoesen G, Ksiezak-Reding H (2004) J Neurosci 24:2304–2312. doi: 10.1523/JNEUROSCI.4162-03.2004

Lee G, Todd Newman S, Gard DL, Band H, Panchamoorthy G (1998) J Cell Sci 111:3167–3177

Lee MJ, Lee JH, Rubinsztein DC (2013) Prog Neurobiol 105:49–59. doi: 10.1016/j.pneurobio.2013.03.001

Lee SH, Le Pichon CE, Adolfsson O, Gafner V, Pihlgren M, Lin H, Solanoy H, Brendza R, Ngu H, Foreman O et al (2016) Cell Rep 16:1690–1700. doi: 10.1016/j.celrep.2016.06.099

Lee YI, Seo M, Kim Y, Kim SY, Kang UG, Kim YS, Juhnn YS (2005) J Biol Chem 280:22044–22052. doi: 10.1074/jbc.M413987200

Lefebvre T, Ferreira S, Dupont-Wallois L, Bussiere T, Dupire MJ, Delacourte A, Michalski JC, Caillet-Boudin ML (2003) Biochim Biophys Acta 1619:167–176

Leroy K, Ando K, Héraud C, Yilmaz Z, Authelet M, Boeynaems JM, Buée L, De Decker R, Brion JP (2010) J Alzheimers Dis 19:705–719. doi: 10.3233/JAD-2010-1276

Leroy K, Boutajangout A, Authelet M, Woodgett JR, Anderton BH, Brion JP (2002) Acta Neuropathol 103:91–99. doi: 10.1007/s004010100435

Leverenz JB, Umar I, Wang Q, Montine TJ, McMillan PJ, Tsuang DW, Jin JH, Pan C, Shin J, Zhu D et al (2007) Brain Pathol 17:139–145. doi: 10.1111/j.1750-3639.2007.00048.x

Levin J, Giese A, Boetzel K, Israel L, Hogen T, Nubling G, Kretzschmar H, Lorenzl S (2009) Exp Neurol 215:201–208. doi: 10.1016/j.expneurol.2008.10.010

Lewis J, Dickson DW, Lin WL, Chisholm L, Corral A, Jones G, Yen SH, Sahara N, Skipper L, Yager D et al (2001) Science 293:1487–1491. doi: 10.1126/science.1058189

Lewis J, McGowan E, Rockwood J, Melrose H, Nacharaju P, Van Slegtenhorst M, Gwinn-Hardy K, Murphy MP, Baker M, Yu X et al (2000) Nat Genet 25:402–405

Li X, Kumar Y, Zempel H, Mandelkow EM, Biernat J, Mandelkow E (2011) EMBO J 30:4825–4837. doi: 10.1038/emboj.2011.376

Li XC, Hu Y, Wang ZH, Luo Y, Zhang Y, Liu XP, Feng Q, Wang Q, Ye K, Liu GP et al (2016) Sci Rep 6:24756. doi: 10.1038/srep24756

Lin L, Yang SS, Chu J, Wang L, Ning LN, Zhang T, Jiang Q, Tian Q, Wang JZ (2014) J Alzheimers Dis 41:1149–1163. doi: 10.3233/JAD-140207

Lione LA, Carter RJ, Hunt MJ, Bates GP, Morton AJ, Dunnett SB (1999) J Neurosci 19:10428–10437

Litersky JM, Johnson GVW (1992) J Biol Chem 267:1563–1568

Liu C, Cholerton B, Shi M, Ginghina C, Cain KC, Auinger P, Parkinson Study Group DI, Zhang J (2015) Parkinsonism Relat Disord 21:271–276. doi: 10.1016/j.parkreldis.2014.12.027

Liu C, Gotz J (2013) PLoS One 8:e84849. doi: 10.1371/journal.pone.0084849

Liu C, Song X, Nisbet R, Gotz J (2016) J Biol Chem 291:8173–8188. doi: 10.1074/jbc.M115.641902

Liu F, Grundke-Iqbal I, Iqbal K, Gong CX (2005) Eur J Neurosci 22:1942–1950. doi: 10.1111/j.1460-9568.2005.04391.x

Liu F, Iqbal K, Grundke-Iqbal I, Hart GW, Gong CX (2004) Proc Natl Acad Sci USA 101:10804–10809. doi: 10.1073/pnas.0400348101

Liu F, Iqbal K, Grundke-Iqbal I, Rossie S, Gong CX (2005) J Biol Chem 280:1790–1796. doi: 10.1074/jbc.M410775200

Liu F, Li B, Tung EJ, Grundke-Iqbal I, Iqbal K, Gong CX (2007) Eur J Neurosci 26:3429–3436. doi: 10.1111/j.1460-9568.2007.05955.x

Liu F, Zaidi T, Iqbal K, Grundke-Iqbal I, Gong CX (2002) Neuroscience 115:829–837. doi: 10.1016/S0306-4522(02)00510-9

Liu L, Drouet V, Wu JW, Witter MP, Small SA, Clelland C, Duff K (2012) PLoS One 7:e31302. doi: 10.1371/journal.pone.0031302

Liu Z, Li T, Li P, Wei N, Zhao Z, Liang H, Ji X, Chen W, Xue M, Wei J (2015) Oxid Med Cell Longev 2015:352723. doi: 10.1155/2015/352723

Liu ZC, Chu J, Lin L, Song J, Ning LN, Luo HB, Yang SS, Shi Y, Wang Q, Qu N et al (2016) Mol Neurobiol 53:983–994. doi: 10.1007/s12035-014-9039-4

Liu ZC, Fu ZQ, Song J, Zhang JY, Wei YP, Chu J, Han L, Qu N, Wang JZ, Tian Q (2012) J Alzheimers Dis 29:727–740. doi: 10.3233/JAD-2012-111898

Llorens-Martin M, Teixeira CM, Fuster-Matanzo A, Jurado-Arjona J, Borrell V, Soriano E, Avila J, Hernández F (2012) J Alzheimers Dis 29:921–930. doi: 10.3233/JAD-2012-112057

Lloret A, Badia MC, Giraldo E, Ermak G, Alonso MD, Pallardo FV, Davies KJ, Vina J (2011) J Alzheimers Dis 27:701–709. doi: 10.3233/JAD-2011-110890

Lokireddy S, Kukushkin NV, Goldberg AL (2015) Proc Natl Acad Sci USA 112:E7176–E7185. doi: 10.1073/pnas.1522332112

Loomis PA, Howard TH, Castleberry RP, Binder LI (1990) Proc Natl Acad Sci USA 87:8422–8426

Lopes S, Lopes A, Pinto V, Guimaraes MR, Sardinha VM, Duarte-Silva S, Pinheiro S, Pizarro J, Oliveira JF, Sousa N et al (2016) Aging Cell 15:208–216. doi: 10.1111/acel.12391

Lu M, Kosik KS (2001) Mol Biol Cell 12:171–184

Lu Y, He HJ, Zhou J, Miao JY, Lu J, He YG, Pan R, Wei Y, Liu Y, He RQ (2013) J Alzheimers Dis 37:551–563. doi: 10.3233/JAD-130602

Luo HB, Xia YY, Shu XJ, Liu ZC, Feng Y, Liu XH, Yu G, Yin G, Xiong YS, Zeng K et al (2014) Proc Natl Acad Sci USA 111:16586–16591. doi: 10.1073/pnas.1417548111

Luo W, Dou F, Rodina A, Chip S, Kim J, Zhao Q, Moulick K, Aguirre J, Wu N, Greengard P et al (2007) Proc Natl Acad Sci USA 104:9511–9516. doi: 10.1073/pnas.0701055104

Luo Y, Ma BY, Nussinov R, Wei GH (2014) J Phys Chem Lett 5:3026–3031. doi: 10.1021/jz501457f

Maas T, Eidenmüller J, Brandt R (2000) J Biol Chem 275:15733–15740. doi: 10.1074/jbc.M000389200

Magnani E, Fan J, Gasparini L, Golding M, Williams M, Schiavo G, Goedert M, Amos LA, Spillantini MG (2007) EMBO J 26:4546–4554. doi: 10.1038/sj.emboj.7601878

Mairet-Coello G, Courchet J, Pieraut S, Courchet V, Maximov A, Polleux F (2013) Neuron 78:94–108. doi: 10.1016/j.neuron.2013.02.003

Manczak M, Calkins MJ, Reddy PH (2011) Hum Mol Genet 20:2495–2509. doi: 10.1093/hmg/ddr139

Manczak M, Reddy PH (2012) Hum Mol Genet 21:2538–2547. doi: 10.1093/hmg/dds072

Mandelkow EM, Mandelkow E (2012) Cold Spring Harb Perspect Med 2:a006247. doi: 10.1101/cshperspect.a006247

Mansuroglu Z, Benhelli-Mokrani H, Marcato V, Sultan A, Violet M, Chauderlier A, Delattre L, Loyens A, Talahari S, Begard S et al (2016) Sci Rep 6:33047. doi: 10.1038/Srep33047

Martin L, Latypova X, Terro F (2011) Neurochem Int 58:458–471. doi: 10.1016/j.neuint.2010.12.023

Marui W, Iseki E, Ueda K, Kosaka K (2000) J Neurol Sci 174:81–84

Masliah E (1995) Histol Histopathol 10:509–519

Matamoros AJ, Baas PW (2016) Brain Res Bull 126:217–225. doi: 10.1016/j.brainresbull.2016.06.016

Matsumoto SE, Motoi Y, Ishiguro K, Tabira T, Kametani F, Hasegawa M, Hattori N (2015) Hum Mol Genet 24:6403–6416. doi: 10.1093/hmg/ddv351

McLellan S, Dyer SH, Rodriguez G, Hersh LB (1988) J Neurochem 51:1552–1559

McMillan P, Korvatska E, Poorkaj P, Evstafjeva Z, Robinson L, Greenup L, Leverenz J, Schellenberg GD, D’Souza I (2008) J Comp Neurol 511:788–803. doi: 10.1002/cne.21867

Means JC, Gerdes BC, Kaja S, Sumien N, Payne AJ, Stark DA, Borden PK, Price JL, Koulen P (2016) Neurochem Res 41:2278–2288. doi: 10.1007/s11064-016-1942-9

Mena R, Edwards PC, Harrington CR, Mukaetova-Ladinska EB, Wischik CM (1996) Acta Neuropathol 91:633–641. doi: 10.1007/s004010050477

Meraz-Ríos MA, Lira-De León KI, Campos-Peña V, De Anda-Hernández MA, Mena-López R (2010) J Neurochem 112:1353–1367. doi: 10.1111/j.1471-4159.2009.06511.x

Mercken M, Grynspan F, Nixon RA (1995) FEBS Lett 368:10–14. doi: 10.1016/0014-5793(95)00590-6

Meske V, Albert F, Ohm TG (2008) J Biol Chem 283:100–109. doi: 10.1074/jbc.M704292200

Metuzals J, Robitaille Y, Houghton S, Gauthier S, Leblanc R (1988) J Neurocytol 17:827–833

Mietelska-Porowska A, Wasik U, Goras M, Filipek A, Niewiadomska G (2014) Int J Mol Sci 15:4671–4713. doi: 10.3390/ijms15034671

Millecamps S, Julien JP (2013) Nat Rev Neurosci 14:161–176. doi: 10.1038/nrn3380

Miller EC, Teravskis PJ, Dummer BW, Zhao XH, Huganir RL, Liao DZ (2014) Eur J Neurosci 39:1214–1224. doi: 10.1111/ejn.12507

Min SW, Chen X, Tracy TE, Li Y, Zhou Y, Wang C, Shirakawa K, Minami SS, Defensor E, Mok SA et al (2015) Nat Med 21:1154–1162. doi: 10.1038/nm.3951

Min SW, Cho SH, Zhou Y, Schroeder S, Haroutunian V, Seeley WW, Huang EJ, Shen Y, Masliah E, Mukherjee C et al (2010) Neuron 67:953–966. doi: 10.1016/j.neuron.2010.08.044

Minamide LS, Striegl AM, Boyle JA, Meberg PJ, Bamburg JR (2000) Nat Cell Biol 2:628–636. doi: 10.1038/35023579

Mirbaha H, Holmes BB, Sanders DW, Bieschke J, Diamond MI (2015) J Biol Chem 290:14893–14903. doi: 10.1074/jbc.M115.652693

Mondragón-Rodríguez S, Mena R, Binder LI, Smith MA, Perry G, García-Sierra F (2008) Neuropathol Appl Neurobiol 34:62–75. doi: 10.1111/j.1365-2990.2007.00853.x

Mondragón-Rodríguez S, Perry G, Zhu X, Moreira PI, Acevedo-Aquino MC, Williams S (2013) Oxid Med Cell Longev 2013:940603. doi: 10.1155/2013/940603

Mondragón-Rodríguez S, Trillaud-Doppia E, Dudilot A, Bourgeois C, Lauzon M, Leclerc N, Boehm J (2012) J Biol Chem 287:32040–32053. doi: 10.1074/jbc.M112.401240

Morel M, Héraud C, Nicaise C, Suain V, Brion JP (2012) Acta Neuropathol 123:71–84. doi: 10.1007/s00401-011-0901-4

Moreno H, Morfini G, Buitrago L, Ujlaki G, Choi S, Yu E, Moreira JE, Avila J, Brady ST, Pant H et al (2016) Neuroscience 325:30–38. doi: 10.1016/j.neuroscience.2016.03.044

Morfini G, Szebenyi G, Elluru R, Ratner N, Brady ST (2002) EMBO J 21:281–293. doi: 10.1093/emboj/21.3.281

Morita T, Sobuě K (2009) J Biol Chem 284:27734–27745. doi: 10.1074/jbc.M109.008177

Morozova OA, March ZM, Robinson AS, Colby DW (2013) Biochemistry 52:6960–6967. doi: 10.1021/bi400866w

Morris M, Knudsen GM, Maeda S, Trinidad JC, Ioanoviciu A, Burlingame AL, Mucke L (2015) Nat Neurosci 18:1183–1189. doi: 10.1038/nn.4067

Morris M, Maeda S, Vossel K, Mucke L (2011) Neuron 70:410–426. doi: 10.1016/j.neuron.2011.04.009

Moussaud S, Jones DR, Moussaud-Lamodiere EL, Delenclos M, Ross OA, McLean PJ (2014) Mol Neurodegener 9:43. doi: 10.1186/1750-1326-9-43

Mukrasch MD, Bibow S, Korukottu J, Jeganathan S, Biernat J, Griesinger C, Mandelkow E, Zweckstetter M (2009) PLoS Biol 7:399–414. doi: 10.1371/journal.pbio.1000034

Mukrasch MD, von Bergen M, Biernat J, Fischer D, Griesinger C, Mandelkow E, Zweckstetter M (2007) J Biol Chem 282:12230–12239. doi: 10.1074/jbc.M607159200

Muller R, Heinrich M, Heck S, Blohm D, Richter-Landsberg C (1997) Cell Tissue Res 288:239–249

Muntane G, Dalfo E, Martinez A, Ferrer I (2008) Neuroscience 152:913–923. doi: 10.1016/j.neuroscience.2008.01.030

Murray ME, Kouri N, Lin WL, Jack CR Jr, Dickson DW, Vemuri P (2014) Alzheimers Res Ther 6:1. doi: 10.1186/alzrt231

Myeku N, Clelland CL, Emrani S, Kukushkin NV, Yu WH, Goldberg AL, Duff KE (2016) Nat Med 22:46–53. doi: 10.1038/nm.4011

Nakanishi N, Ryan SD, Zhang XF, Khan A, Holland T, Cho EG, Huang XY, Liao FF, Xu HX, Lipton SA et al (2013) J Neurosci 33:14170–14183. doi: 10.1523/Jneurosci.4646-10.2013

Nakazawa T, Komai S, Tezuka T, Hisatsune C, Umemori H, Semba K, Mishina M, Manabe T, Yamamoto T (2001) J Biol Chem 276:693–699. doi: 10.1074/jbc.M008085200

Nalls MA, Pankratz N, Lill CM, Do CB, Hernandez DG, Saad M, DeStefano AL, Kara E, Bras J, Sharma M et al (2014) Nat Genet 46:989–993. doi: 10.1038/ng.3043

Nie CL, Wang XS, Liu Y, Perrett S, He RQ (2007) BMC Neurosci 8:9. doi: 10.1186/1471-2202-8-9

Nieto A, Correas I, López-Otín C, Avila J (1991) Biochim Biophys Acta 1096:197–204. doi: 10.1016/0925-4439(91)90005-T

Nijholt DA, Nolle A, van Haastert ES, Edelijn H, Toonen RF, Hoozemans JJ, Scheper W (2013) Neurobiol Aging 34:1759–1771. doi: 10.1016/j.neurobiolaging.2013.01.008

Nijholt DA, van Haastert ES, Rozemuller AJ, Scheper W, Hoozemans JJ (2012) J Pathol 226:693–702. doi: 10.1002/path.3969

Nixon RA (2013) Nat Med 19:983–997. doi: 10.1038/nm.3232

Noble M, Lewis SA, Cowan NJ (1989) J Cell Biol 109:3367–3376

Noble W, Garwood C, Stephenson J, Kinsey AM, Hanger DP, Anderton BH (2009) FASEB J 23:739–750. doi: 10.1096/fj.08-113795

Noble W, Hanger DP, Miller CC, Lovestone S (2013) Front Neurol 4:83. doi: 10.3389/fneur.2013.00083

Noble W, Olm V, Takata K, Casey E, Mary O, Meyerson J, Gaynor K, LaFrancois J, Wang L, Kondo T et al (2003) Neuron 38:555–565. doi: 10.1016/S0896-6273(03)00259-9

Novák M (1994) Acta Virol 38:173–189

Novak M, Kabat J, Wischik CM (1993) EMBO J 12:365–370

Nubling G, Bader B, Levin J, Hildebrandt J, Kretzschmar H, Giese A (2012) Mol Neurodegener 7:35. doi: 10.1186/1750-1326-7-35

Oaks AW, Frankfurt M, Finkelstein DI, Sidhu A (2013) PLoS One 8:e60378. doi: 10.1371/journal.pone.0060378

Oddo S, Billings L, Kesslak JP, Cribbs DH, LaFerla FM (2004) Neuron 43:321–332. doi: 10.1016/j.neuron.2004.07.003

Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, Metherate R, Mattson MP, Akbari Y, LaFerla FM (2003) Neuron 39:409–421. doi: 10.1016/S0896-6273(03)00434-3

Olesen OF (1994) Biochem Biophys Res Commun 201:716–721. doi: 10.1006/bbrc.1994.1759

Oyama F, Kotliarova S, Harada A, Ito M, Miyazaki H, Ueyama Y, Hirokawa N, Nukina N, Ihara Y (2004) J Biol Chem 279:27272–27277. doi: 10.1074/jbc.M401634200

Pérez M, Valpuesta JM, Medina M, Montejo De Garcini E, Avila J (1996) J Neurochem 67:1183–1190

Paholikova K, Salingova B, Opattova A, Skrabana R, Majerova P, Zilka N, Kovacech B, Zilkova M, Barath P, Novak M (2015) J Alzheimers Dis 43:915–926. doi: 10.3233/JAD-140996

Pallas-Bazarra N, Jurado-Arjona J, Navarrete M, Esteban JA, Hernandez F, Avila J, Llorens-Martin M (2016) EMBO J 35:1417–1436. doi: 10.15252/embj.201593518

Papasozomenos SC, Binder LI (1987) Cell Motil Cytoskelet 8:210–226

Park SY, Ferreira A (2005) J Neurosci 25:5365–5375. doi: 10.1523/JNEUROSCI.1125-05.2005

Peeraer E, Bottelbergs A, Van Kolen K, Stancu IC, Vasconcelos B, Mahieu M, Duytschaever H, Ver Donck L, Torremans A, Sluydts E et al (2015) Neurobiol Dis 73:83–95. doi: 10.1016/j.nbd.2014.08.032

Pei JJ, Tanaka T, Tung YC, Braak E, Iqbal K, Grundke-Iqbal I (1997) J Neuropathol Exp Neurol 56:70–78

Perez-Nievas BG, Stein TD, Tai HC, Dols-Icardo O, Scotton TC, Barroeta-Espar I, Fernandez-Carballo L, de Munain EL, Perez J, Marquie M et al (2013) Brain 136:2510–2526. doi: 10.1093/brain/awt171

Perez M, Santa-Maria I, De Barreda EG, Zhu X, Cuadros R, Cabrero JR, Sanchez-Madrid F, Dawson HN, Vitek MP, Perry G et al (2009) J Neurochem 109:1756–1766. doi: 10.1111/j.1471-4159.2009.06102.x

Perez MJ, Vergara-Pulgar K, Jara C, Cabezas-Opazo F, Quintanilla RA (2017) Mol Neurobiol. doi: 10.1007/s12035-017-0385-x

Perreault S, Bousquet O, Lauzon M, Paiement J, Leclerc N (2009) J Neuropathol Exp Neurol 68:503–514. doi: 10.1097/NEN.0b013e3181a1fc49

Peterson DW, Zhou H, Dahlquist FW, Lew J (2008) Biochemistry 47:7393–7404. doi: 10.1021/bi702466a

Petrucelli L, Dickson D, Kehoe K, Taylor J, Snyder H, Grover A, De Lucia M, McGowan E, Lewis J, Prihar G et al (2004) Hum Mol Genet 13:703–714. doi: 10.1093/hmg/ddh083

Pittman AM, Myers AJ, Abou-Sleiman P, Fung HC, Kaleem M, Marlowe L, Duckworth J, Leung D, Williams D, Kilford L et al (2005) J Med Genet 42:837–846. doi: 10.1136/jmg.2005.031377

Planel E, Yasutake K, Fujita SC, Ishiguro K (2001) J Biol Chem 276:34298–34306. doi: 10.1074/jbc.M102780200

Poepsel S, Sprengel A, Sacca B, Kaschani F, Kaiser M, Gatsogiannis C, Raunser S, Clausen T, Ehrmann M (2015) Nat Chem Biol 11:862–869. doi: 10.1038/nchembio.1931

Polanco JC, Scicluna BJ, Hill AF, Gotz J (2016) J Biol Chem 291:12445–12466. doi: 10.1074/jbc.M115.709485

Pooler AM, Hanger DP (2010) Biochem Soc Trans 38:1012–1015. doi: 10.1042/BST0381012

Pooler AM, Phillips EC, Lau DH, Noble W, Hanger DP (2013) EMBO Rep 14:389–394. doi: 10.1038/embor.2013.15

Pooler AM, Usardi A, Evans CJ, Philpott KL, Noble W, Hanger DP (2012) Neurobiol Aging 33(431):e427–e438. doi: 10.1016/j.neurobiolaging.2011.01.005

Poorkaj P, Bird TD, Wijsman E, Nemens E, Garruto RM, Anderson L, Andreadis A, Wiederholt WC, Raskind M, Schellenberg GD (1998) Ann Neurol 43:815–825. doi: 10.1002/ana.410430617

Poulopoulos M, Levy OA, Alcalay RN (2012) Mov Disord 27:831–842. doi: 10.1002/mds.24962

Prusiner SB (1982) Science 216:136–144

Qi H, Cantrelle FX, Benhelli-Mokrani H, Smet-Nocca C, Buee L, Lippens G, Bonnefoy E, Galas MC, Landrieu I (2015) Biochemistry 54:1525–1533. doi: 10.1021/bi5014613

Quintanilla RA, Matthews-Roberson TA, Dolan PJ, Johnsion GVW (2009) J Biol Chem 284:18754–18766. doi: 10.1074/jbc.M808908200

Radford H, Moreno JA, Verity N, Halliday M, Mallucci GR (2015) Acta Neuropathol 130:633–642. doi: 10.1007/s00401-015-1487-z

Rankin CA, Sun Q, Gamblin TC (2007) Mol Neurodegener 2:12. doi: 10.1186/1750-1326-2-12

Rao MV, Mohan PS, Peterhoff CM, Yang DS, Schmidt SD, Stavrides PH, Campbell J, Chen Y, Jiang Y, Paskevich PA et al (2008) J Neurosci 28:12241–12254. doi: 10.1523/JNEUROSCI.4119-08.2008

Rapoport M, Dawson HN, Binder LI, Vitek MP, Ferreira A (2002) Proc Natl Acad Sci USA 99:6364–6369. doi: 10.1073/pnas.092136199

Resende R, Ferreiro E, Pereira C, Oliveira CR (2008) J Neurosci Res 86:2091–2099. doi: 10.1002/jnr.21648

Reyes JF, Geula C, Vana L, Binder LI (2012) Acta Neuropathol 123:119–132. doi: 10.1007/s00401-011-0898-8

Reynolds CH, Garwood CJ, Wray S, Price C, Kellie S, Perera T, Zvelebil M, Yang A, Sheppard PW, Varndell IM et al (2008) J Biol Chem 283:18177–18186. doi: 10.1074/jbc.M709715200

Rissman RA, Poon WW, Blurton-Jones M, Oddo S, Torp R, Vitek MP, LaFerla FM, Rohn TT, Cotman CW (2004) J Clin Invest 114:121–130. doi: 10.1172/JCI200420640

Roberson ED, Halabisky B, Yoo JW, Yao J, Chin J, Yan F, Wu T, Hamto P, Devidze N, Yu GQ et al (2011) J Neurosci 31:700–711. doi: 10.1523/JNEUROSCI.4152-10.2011

Roberson ED, Scearce-Levie K, Palop JJ, Yan F, Cheng IH, Wu T, Gerstein H, Yu GQ, Mucke L (2007) Science 316:750–754. doi: 10.1126/science.1141736

Rockenstein E, Ubhi K, Trejo M, Mante M, Patrick C, Adame A, Novak P, Jech M, Doppler E, Moessler H et al (2014) BMC Neurosci 15:90. doi: 10.1186/1471-2202-15-90

Rodríguez-Martín T, Cuchillo-Ibáñez I, Noble W, Nyenya F, Anderton BH, Hanger DP (2013) Neurobiol Aging 34:2146–2157. doi: 10.1016/j.neurobiolaging.2013.03.015

Rodriguez-Martin T, Pooler AM, Lau DH, Morotz GM, De Vos KJ, Gilley J, Coleman MP, Hanger DP (2016) Neurobiol Dis 85:1–10. doi: 10.1016/j.nbd.2015.10.007

Rohn TT, Rissman RA, Davis MC, Kim YE, Cotman CW, Head E (2002) Neurobiol Dis 11:341–354. doi: 10.1006/nbdi.2002.0549

Ron D, Hubbard SR (2008) Cell 132:24–26. doi: 10.1016/j.cell.2007.12.017

Rong Y, Lu X, Bernard A, Khrestchatisky M, Baudry M (2001) J Neurochem 79:382–390. doi: 10.1046/j.1471-4159.2001.00565.x

Rossi G, Conconi D, Panzeri E, Redaelli S, Piccoli E, Paoletta L, Dalpra L, Tagliavini F (2013) J Alzheimers Dis 33:969–982. doi: 10.3233/JAD-2012-121633

Rossi G, Dalpra L, Crosti F, Lissoni S, Sciacca FL, Catania M, Di Fede G, Mangieri M, Giaccone G, Croci D et al (2008) Cell Cycle 7:1788–1794. doi: 10.4161/cc.7.12.6012

Rousseaux MWC, de Haro M, Lasagna-Reeves CA, De Maio A, Park J, Jafar-Nejad P, Al-Ramahi I, Sharma A, See L, Lu N et al (2016) eLife 5:e19809. doi: 10.7554/eLife.19809

Rubinsztein DC (2006) Nature 443:780–786. doi: 10.1038/nature05291

Rueli RH, Torres DJ, Dewing AS, Kiyohara AC, Barayuga SM, Bellinger MT, Uyehara-Lock JH, White LR, Moreira PI, Berry MJ et al (2017) J Alzheimers Dis 55:749–762. doi: 10.3233/JAD-151208

Ryoo SR, Hey KJ, Radnaabazar C, Yoo JJ, Cho HJ, Lee HW, Kim IS, Cheon YH, Young SA, Chung SH et al (2007) J Biol Chem 282:34850–34857. doi: 10.1074/jbc.M707358200

Saito KI, Elce JS, Hamos JE, Nixon RA (1993) Proc Natl Acad Sci USA 90:2628–2632

Salon ML, Morelli L, Castaño EM, Soto EF, Pasquini JM (2000) J Neurosci Res 62:302–310. doi: 10.1002/1097-4547(20001015)62:2<302:AID-JNR15>3.0.CO;2-L

Saman S, Kim W, Raya M, Visnick Y, Miro S, Saman S, Jackson B, McKee AC, Alvarez VE, Lee NC et al (2012) J Biol Chem 287:3842–3849. doi: 10.1074/jbc.M111.277061

Sambri I, D’Alessio R, Ezhova Y, Giuliano T, Sorrentino NC, Cacace V, De Risi M, Cataldi M, Annunziato L, De Leonibus E et al (2017) EMBO Mol Med 9:112–132. doi: 10.15252/emmm.201606965

Sanchez-Mejias E, Navarro V, Jimenez S, Sanchez-Mico M, Sanchez-Varo R, Nunez-Diaz C, Trujillo-Estrada L, Davila JC, Vizuete M, Gutierrez A et al (2016) Acta Neuropathol 132:897–916. doi: 10.1007/s00401-016-1630-5

Sanders DW, Kaufman SK, DeVos SL, Sharma AM, Mirbaha H, Li A, Barker SJ, Foley AC, Thorpe JR, Serpell LC et al (2014) Neuron 82:1271–1288. doi: 10.1016/j.neuron.2014.04.047

Santa-María I, Hernández F, Smith MA, Perry G, Avila J, Moreno FJ (2005) Mol Cell Biochem 278:203–212. doi: 10.1007/s11010-005-7499-6

Santa-Maria I, Varghese M, Ksiezak-Reding H, Dzhun A, Wang J, Pasinetti GM (2012) J Biol Chem 287:20522–20533. doi: 10.1074/jbc.M111.323279

SantaCruz K, Lewis J, Spires T, Paulson J, Kotilinek L, Ingelsson M, Guimaraes A, DeTure M, Ramsden M, McGowan E et al (2005) Science 309:476–481. doi: 10.1126/science.1113694

Sato S, Cerny RL, Buescher JL, Ikezu T (2006) J Neurochem 98:1573–1584. doi: 10.1111/j.1471-4159.2006.04059.x

Scheper W, Hoozemans JJ (2015) Acta Neuropathol 130:315–331. doi: 10.1007/s00401-015-1462-8

Schneider JA, Aggarwal NT, Barnes L, Boyle P, Bennett DA (2009) J Alzheimers Dis 18:691–701. doi: 10.3233/JAD-2009-1227

Schneider JA, Li JL, Li Y, Wilson RS, Kordower JH, Bennett DA (2006) Ann Neurol 59:166–173. doi: 10.1002/ana.20723

Schwab C, Demaggio AJ, Ghoshal N, Binder LI, Kuret J, McGeer PL (2000) Neurobiol Aging 21:503–510. doi: 10.1016/S0197-4580(00)00110-X

Seitz A, Kojima H, Oiwa K, Mandelkow EM, Song YH, Mandelkow E (2002) EMBO J 21:4896–4905. doi: 10.1093/emboj/cdf503

Sengupta A, Kabat J, Novak M, Wu Q, Grundke-Iqbal I, Iqbal K (1998) Arch Biochem Biophys 357:299–309. doi: 10.1006/abbi.1998.0813

Sengupta S, Horowitz PM, Karsten SL, Jackson GR, Geschwind DH, Fu Y, Berry RW, Binder LI (2006) Biochemistry 45:15111–15119. doi: 10.1021/bi061830d

Serenó L, Coma M, Rodríguez M, Sánchez-Ferrer P, Sánchez MB, Gich I, Agulló JM, Pérez M, Avila J, Guardia-Laguarta C et al (2009) Neurobiol Dis 35:359–367. doi: 10.1016/j.nbd.2009.05.025

Sergeant N, Delacourte A, Buée L (2005) Biochim Biophys Acta 1739:179–197. doi: 10.1016/j.bbadis.2004.06.020

Seward ME, Swanson E, Norambuena A, Reimann A, Nicholas Cochran J, Li R, Roberson ED, Bloom GS (2013) J Cell Sci 126:1278–1286. doi: 10.1242/jcs.1125880

Shaffer AL, Shapiro-Shelef M, Iwakoshi NN, Lee AH, Qian SB, Zhao H, Yu X, Yang L, Tan BK, Rosenwald A et al (2004) Immunity 21:81–93. doi: 10.1016/j.immuni.2004.06.010

Sharma M, Burre J, Bronk P, Zhang Y, Xu W, Sudhof TC (2012) EMBO J 31:829–841. doi: 10.1038/emboj.2011.467

Sharma M, Burre J, Sudhof TC (2011) Nat Cell Biol 13:30–39. doi: 10.1038/ncb2131

Shea TB (1997) J Neurosci Res 50:114–122. doi: 10.1002/(SICI)1097-4547(19971001)50:1<114:AID-JNR12>3.0.CO;2-B

Shea TB, Cressman CM (1998) Int J Dev Neurosci 16:41–48

Shimura H, Schwartz D, Gygi SP, Kosik KS (2004) J Biol Chem 279:4869–4876. doi: 10.1074/jbc.M305838200

Sibille N, Sillen A, Leroy A, Wieruszeski JM, Mulloy B, Landrieu I, Lippens G (2006) Biochemistry 45:12560–12572. doi: 10.1021/bi060964o

Sillen A, Barbier P, Landrieu I, Lefebvre S, Wieruszeski JM, Leroy A, Peyrot V, Lippens G (2007) Biochemistry 46:3055–3064. doi: 10.1021/bi061920i

Simon-Sanchez J, Schulte C, Bras JM, Sharma M, Gibbs JR, Berg D, Paisan-Ruiz C, Lichtner P, Scholz SW, Hernandez DG et al (2009) Nat Genet 41:1308–1312. doi: 10.1038/ng.487

Sjoberg MK, Shestakova E, Mansuroglu Z, Maccioni RB, Bonnefoy E (2006) J Cell Sci 119:2025–2034. doi: 10.1242/jcs.02907

Smet-Nocca C, Broncel M, Wieruszeski JM, Tokarski C, Hanoulle X, Leroy A, Landrieu I, Rolando C, Lippens G, Hackenberger CPR (2011) Mol BioSyst 7:1420–1429. doi: 10.1039/c0mb00337a

Sohn PD, Tracy TE, Son HI, Zhou YG, Leite REP, Miller BL, Seeley WW, Grinberg LT, Gan L (2016) Mol Neurodegener 11:47. doi: 10.1186/s13024-016-0109-0

Sokolow S, Henkins KM, Bilousova T, Gonzalez B, Vinters HV, Miller CA, Cornwell L, Poon WW, Gylys KH (2015) J Neurochem 133:368–379. doi: 10.1111/jnc.12991

Song L, De Sarno P, Jope RS (2002) J Biol Chem 277:44701–44708. doi: 10.1074/jbc.M206047200

Song L, Lu SX, Ouyang X, Melchor J, Lee J, Terracina G, Wang X, Hyde L, Hess JF, Parker EM et al (2015) Mol Neurodegener 10:14. doi: 10.1186/s13024-015-0011-1

Sottejeau Y, Bretteville A, Cantrelle FX, Malmanche N, Demiaute F, Mendes T, Delay C, Dos Alves HA, Flaig A, Davies P et al (2015) Acta Neuropathol Commun 3:58. doi: 10.1186/s40478-015-0237-8

Spillantini MG, Crowther RA, Jakes R, Cairns NJ, Lantos PL, Goedert M (1998) Neurosci Lett 251:205–208

Spillantini MG, Schmidt ML, Lee VM, Trojanowski JQ, Jakes R, Goedert M (1997) Nature 388:839–840. doi: 10.1038/42166

Spires-Jones TL, Kopeikina KJ, Koffie RM, De Calignon A, Hyman BT (2011) J Mol Neurosci 45:438–444. doi: 10.1007/s12031-011-9566-7

Stamer K, Vogel R, Thies E, Mandelkow E, Mandelkow EM (2002) J Cell Biol 156:1051–1063. doi: 10.1083/jcb.200108057

Sultan A, Nesslany F, Violet M, Begard S, Loyens A, Talahari S, Mansuroglu Z, Marzin D, Sergeant N, Humez S et al (2011) J Biol Chem 286:4566–4575. doi: 10.1074/jbc.M110.199976

Surridge CD, Burns RG (1994) Biochemistry 33:8051–8057. doi: 10.1021/bi00192a009

Tacik P, DeTure MA, Carlomagno Y, Lin WL, Murray ME, Baker MC, Josephs KA, Boeve BF, Wszolek ZK, Graff-Radford NR et al (2016) Brain Pathol. doi: 10.1111/bpa.12428

Takashima A, Murayama M, Murayama O, Kohno T, Honda T, Yasutake K, Nihonmatsu N, Mercken M, Yamaguchi H, Sugihara S et al (1998) Proc Natl Acad Sci USA 95:9637–9641

Tan CC, Yu JT, Tan MS, Jiang T, Zhu XC, Tan L (2014) Neurobiol Aging 35:941–957. doi: 10.1016/j.neurobiolaging.2013.11.019

Tardivel M, Begard S, Bousset L, Dujardin S, Coens A, Melki R, Buee L, Colin M (2016) Acta Neuropathol Commun 4:117. doi: 10.1186/s40478-016-0386-4

Tashiro K, Hasegawa M, Ihara Y, Iwatsubo T (1997) NeuroReport 8:2797–2801

Tavares IA, Touma D, Lynham S, Troakes C, Schober M, Causevic M, Garg R, Noble W, Killick R, Bodi I et al (2013) J Biol Chem 288:15418–15429. doi: 10.1074/jbc.M112.448183

Tennstaedt A, Popsel S, Truebestein L, Hauske P, Brockmann A, Schmidt N, Irle I, Sacca B, Niemeyer CM, Brandt R et al (2012) J Biol Chem 287:20931–20941. doi: 10.1074/jbc.M111.316232

Tiernan CT, Combs B, Cox K, Morfini G, Brady ST, Counts SE, Kanaan NM (2016) Exp Neurol 283:318–329. doi: 10.1016/j.expneurol.2016.06.030

Tiwari SS, d’Orange M, Troakes C, Shurovi BN, Engmann O, Noble W, Hortobagyi T, Giese KP (2015) Mol Brain 8:6. doi: 10.1186/s13041-015-0096-z

Tobler AR, Constam DB, Schmitt-Gräff A, Malipiero U, Schlapbach R, Fontana A (1997) J Neurochem 68:889–897

Tompa P, Buzder-Lantos P, Tantos A, Farkas A, Szilágyi A, Bánóczi Z, Hudecz F, Friedrich P (2004) J Biol Chem 279:20775–20785. doi: 10.1074/jbc.M313873200

Tracy TE, Gan L (2017) BioEssays. doi: 10.1002/bies.201600224

Tracy TE, Sohn PD, Minami SS, Wang C, Min SW, Li YQ, Zhou YG, Le D, Lo I, Ponnusamy R et al (2016) Neuron 90:245–260. doi: 10.1016/j.neuron.2016.03.005

Unterberger U, Höftberger R, Gelpi E, Flicker H, Budka H, Voigtländer T (2006) J Neuropathol Exp Neurol 65:348–357. doi: 10.1097/01.jnen.0000218445.30535.6f

Usardi A, Pooler AM, Seereeram A, Reynolds CH, Derkinderen P, Anderton B, Hanger DP, Noble W, Williamson R (2011) FEBS J 278:2927–2937. doi: 10.1111/j.1742-4658.2011.08218.x

Utton MA, Connell J, Asuni AA, van Slegtenhorst M, Hutton M, de Silva R, Lees AJ, Miller CC, Anderton BH (2002) J Neurosci 22:6394–6400

Utton MA, Noble WJ, Hill JE, Anderton BH, Hanger DP (2005) J Cell Sci 118:4645–4654. doi: 10.1242/jcs.02558

Valenstein ML, Roll-Mecak A (2016) Cell 164:911–921. doi: 10.1016/j.cell.2016.01.019

Van Der Harg JM, Nölle A, Zwart R, Boerema AS, Van Haastert ES, Strijkstra AM, Hoozemans JJM, Scheper W (2014) Cell Death Dis 5:e1393. doi: 10.1038/cddis.2014.354

Vanderweyde T, Apicco DJ, Youmans-Kidder K, Ash PE, Cook C, Lummertz da Rocha E, Jansen-West K, Frame AA, Citro A, Leszyk JD et al (2016) Cell Rep 15:1455–1466. doi: 10.1016/j.celrep.2016.04.045

Vechterova L, Kontsekova E, Zilka N, Ferencik M, Ravid R, Novak M (2003) NeuroReport 14:87–91. doi: 10.1097/00001756-200301200-00017

Vega IE, Cui L, Propst JA, Hutton ML, Lee G, Yen SH (2005) Brain Res Mol Brain Res 138:135–144. doi: 10.1016/j.molbrainres.2005.04.015

Vershinin M, Carter BC, Razafsky DS, King SJ, Gross SP (2007) Proc Natl Acad Sci USA 104:87–92. doi: 10.1073/pnas.0607919104

Vilarino-Guell C, Soto-Ortolaza AI, Rajput A, Mash DC, Papapetropoulos S, Pahwa R, Lyons KE, Uitti RJ, Wszolek ZK, Dickson DW et al (2011) Neurology 76:670–672. doi: 10.1212/WNL.0b013e31820c30c1

Vintilescu CR, Afreen S, Rubino AE, Ferreira A (2016) Mol Med 22:477–486. doi: 10.2119/molmed.2016.00095

Violet M, Chauderlier A, Delattre L, Tardivel M, Chouala MS, Sultan A, Marciniak E, Humez S, Binder L, Kayed R et al (2015) Neurobiol Dis 82:540–551. doi: 10.1016/j.nbd.2015.09.003

Violet M, Delattre L, Tardivel M, Sultan A, Chauderlier A, Caillierez R, Talahari S, Nesslany F, Lefebvre B, Bonnefoy E et al (2014) Front Cell Neurosci 8:84. doi: 10.3389/fncel.2014.00084

Voelzmann A, Okenve-Ramos P, Qu Y, Chojnowska-Monga M, Del Cano-Espinel M, Prokop A, Sanchez-Soriano N (2016) Elife 5:e14694. doi: 10.7554/eLife.14694

Von Bergen M, Barghorn S, Li L, Marx A, Biernat J, Mandelkow EM, Mandelkow E (2001) J Biol Chem 276:48165–48174

von Bergen M, Friedhoff P, Biernat J, Heberle J, Mandelkow EM, Mandelkow E (2000) Proc Natl Acad Sci U S A 97:5129–5134

Vonsattel JP, DiFiglia M (1998) J Neuropathol Exp Neurol 57:369–384

Vuono R, Winder-Rhodes S, de Silva R, Cisbani G, Drouin-Ouellet J, Network RIotEHsD, Spillantini MG, Cicchetti F, Barker RA (2015) Brain 138:1907–1918. doi: 10.1093/brain/awv107

Wade-Martins R (2012) Nat Rev Neurol 8:477–478. doi: 10.1038/nrneurol.2012.169

Wang AC, Jensen EH, Rexach JE, Vinters HV, Hsieh-Wilson LC (2016) Proc Natl Acad Sci USA 113:15120–15125. doi: 10.1073/pnas.1606899113

Wang JZ, Grundke-Iqbal I, Iqbal K (1996) Nat Med 2:871–875. doi: 10.1038/nm0896-871

Wang JZ, Grundke-Iqbal I, Iqbal K (2007) Eur J Neurosci 25:59–68. doi: 10.1111/j.1460-9568.2006.05226.x

Wang P, Joberty G, Buist A, Vanoosthuyse A, Stancu IC, Vasconcelos B, Pierrot N, Faelth-Savitski M, Kienlen-Campard P, Octave JN et al (2017) Acta Neuropathol. doi: 10.1007/s00401-016-1663-9

Wang X, An S, Wu JM (1996) Biochem Biophys Res Commun 219:591–597. doi: 10.1006/bbrc.1996.0278

Wang XS, Wang DL, Zhao J, Qu MH, Zhou XH, He HJ, He RQ (2006) Protein Pept Lett 13:679–685. doi: 10.2174/092986606777790566

Wang Y, Garg S, Mandelkow EM, Mandelkow E (2010) Biochem Soc Trans 38:955–961. doi: 10.1042/BST0380955

Wang Y, Loomis PA, Zinkowski RP, Binder LI (1993) J Cell Biol 121:257–267

Wang Y, Mandelkow E (2012) Biochem Soc Trans 40:644–652. doi: 10.1042/BST20120071

Wang Y, Mandelkow E (2016) Nat Rev Neurosci 17:5–21. doi: 10.1038/nrn.2015.1

Wang Y, Martinez-Vicente M, Krüger U, Kaushik S, Wong E, Mandelkow EM, Cuervo AM, Mandelkow E (2009) Hum Mol Genet 18:4153–4170. doi: 10.1093/hmg/ddp367

Wang YP, Biernat J, Pickhardt M, Mandelkow E, Mandelkow EM (2007) Proc Natl Acad Sci USA 104:10252–10257. doi: 10.1073/pnas.0703676104

Ward SM, Himmelstein DS, Lancia JK, Binder LI (2012) Biochem Soc Trans 40:667–671. doi: 10.1042/BST20120134

Watanabe A, Hong WK, Dohmae N, Takio K, Morishima-Kawashima M, Ihara Y (2004) J Neurochem 90:1302–1311. doi: 10.1111/j.1471-4159.2004.02611.x

Wills J, Credle J, Haggerty T, Lee JH, Oaks AW, Sidhu A (2011) PLoS One 6:e17953. doi: 10.1371/journal.pone.0017953

Wilson DM, Binder LI (1997) Am J Pathol 150:2181–2195

Wischik CM, Novak M, Edwards PC, Klug A, Tichelaar W, Crowther RA (1988) Proc Natl Acad Sci USA 85:4884–4888

Wong CW, Quaranta V, Glenner GG (1985) Proc Natl Acad Sci USA 82:8729–8732

Wray S, Saxton M, Anderton BH, Hanger DP (2008) J Neurochem 105:2343–2352. doi: 10.1111/j.1471-4159.2008.05321.x

Wu JW, Herman M, Liu L, Simoes S, Acker CM, Figueroa H, Steinberg JI, Margittai M, Kayed R, Zurzolo C et al (2013) J Biol Chem 288:1856–1870. doi: 10.1074/jbc.M112.394528

Wu JW, Hussaini SA, Bastille IM, Rodriguez GA, Mrejeru A, Rilett K, Sanders DW, Cook C, Fu H, Boonen RA et al (2016) Nat Neurosci 19:1085–1092. doi: 10.1038/nn.4328

Xia D, Gutmann JM, Gotz J (2016) Sci Rep 6:29074. doi: 10.1038/Srep29074

Xia D, Li CZ, Gotz J (2015) Biochim Biophys Acta 1852:913–924. doi: 10.1016/j.bbadis.2014.12.017

Yamada K, Holth JK, Liao F, Stewart FR, Mahan TE, Jiang H, Cirrito JR, Patel TK, Hochgräfe K, Mandelkow EM et al (2014) J Exp Med 211:387–393. doi: 10.1084/jem.20131685

Yamaguchi K, Cochran EJ, Murrell JR, Polymeropoulos MH, Shannon KM, Crowther RA, Goedert M, Ghetti B (2005) Acta Neuropathol 110:298–305. doi: 10.1007/s00401-005-1042-4

Yang XJ, Seto E (2008) Mol Cell 31:449–461. doi: 10.1016/j.molcel.2008.07.002

Yao J, Irwin RW, Zhao L, Nilsen J, Hamilton RT, Brinton RD (2009) Proc Natl Acad Sci USA 106:14670–14675. doi: 10.1073/pnas.0903563106

Yao XQ, Zhang XX, Yin YY, Liu B, Luo DJ, Liu D, Chen NN, Ni ZF, Wang X, Wang Q et al (2011) Biochem J 437:335–344. doi: 10.1042/BJ20110347

Yu W, Polepalli J, Wagh D, Rajadas J, Malenka R, Lu B (2012) Hum Mol Genet 21:1384–1390. doi: 10.1093/hmg/ddr576

Yuzwa SA, Cheung AH, Okon M, McIntosh LP, Vocadlo DJ (2014) J Mol Biol 426:1736–1752. doi: 10.1016/j.jmb.2014.01.004

Zempel H, Luedtke J, Kumar Y, Biernat J, Dawson H, Mandelkow E, Mandelkow EM (2013) EMBO J 32:2920–2937. doi: 10.1038/emboj.2013.207

Zempel H, Mandelkow EM (2012) Neurodegener Dis 10:64–72. doi: 10.1159/000332816

Zempel H, Mandelkow EM (2015) Mol Neurodegener 10:68. doi: 10.1186/s13024-015-0064-1

Zempel H, Thies E, Mandelkow E, Mandelkow EM (2010) J Neurosci 30:11938–11950. doi: 10.1523/JNEUROSCI.2357-10.2010

Zhang B, Carroll J, Trojanowski JQ, Yao Y, Iba M, Potuzak JS, Hogan AM, Xie SX, Ballatore C, Smith AB 3rd et al (2012) J Neurosci 32:3601–3611. doi: 10.1523/JNEUROSCI.4922-11.2012

Zhang Z, Song M, Liu X, Kang SS, Kwon IS, Duong DM, Seyfried NT, Hu WT, Liu Z, Wang JZ et al (2014) Nat Med 20:1254–1262. doi: 10.1038/nm.3700

Zhang Z, Xie M, Ye K (2016) Expert Opin Ther Targets 20:1237–1245. doi: 10.1080/14728222.2016.1182990

Zhao X, Kotilinek LA, Smith B, Hlynialuk C, Zahs K, Ramsden M, Cleary J, Ashe KH (2016) Nat Med 22:1268–1276. doi: 10.1038/nm.4199

Zhong Q, Congdon EE, Nagaraja HN, Kuret J (2012) J Biol Chem 287:20711–20719. doi: 10.1074/jbc.M112.364067

Zhu X, Rottkamp CA, Boux H, Takeda A, Perry G, Smith MA (2000) J Neuropathol Exp Neurol 59:880–888

Zilka N, Filipcik P, Koson P, Fialova L, Skrabana R, Zilkova M, Rolkova G, Kontsekova E, Novak M (2006) FEBS Lett 580:3582–3588. doi: 10.1016/j.febslet.2006.05.029

Zilka N, Kazmerova Z, Jadhav S, Neradil P, Madari A, Obetkova D, Bugos O, Novak M (2012) J Neuroinflammation 9:47. doi: 10.1186/1742-2094-9-47