Roles of Wnt signaling in bone formation and resorption

Friedenstein, 1971, Osteogenic precursor cells of bone marrow in radiation chimeras, Transplantation, 12, 99, 10.1097/00007890-197108000-00001 Tenenbaum, 1985, Dexamethasone stimulates osteogenesis in chick periosteum in vitro, Endocrinology, 117, 2211, 10.1210/endo-117-5-2211 Takahashi, 1988, Osteoblastic cells are involved in osteoclast formation, Endocrinology, 123, 2600, 10.1210/endo-123-5-2600 Suda, 1999, Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families, Endocr Rev, 20, 345, 10.1210/edrv.20.3.0367 Simonet, 1997, Osteoprotegerin: a novel secreted protein involved in the regulation of bone density, Cell, 89, 309, 10.1016/S0092-8674(00)80209-3 Gordon, 2006, Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factors, J Biol Chem, 281, 22429, 10.1074/jbc.R600015200 Miller, 2002, The Wnts, Genome Biol, 3, 3001.1 Mikels, 2006, Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context, PLoS Biol, 4, e115, 10.1371/journal.pbio.0040115 Huang, 2004, The Frizzled family: receptors for multiple signal transduction pathways, Genome Biol, 5, 234.1 He, 2004, LDL receptor-related proteins 5 and 6 in Wnt/b-catenin signaling: arrows point the way, Development, 131, 1663, 10.1242/dev.01117 Forrester, 2002, The Ror receptor tyrosine kinase family, Cell Mol Life Sci, 59, 83, 10.1007/s00018-002-8407-9 Kawano, 2003, Secreted antagonists of the Wnt signalling pathway, J Cell Sci, 116, 2627, 10.1242/jcs.00623 Niehrs, 2006, Function and biological roles of the Dickkopf family of Wnt modulators, Oncogene, 25, 7469, 10.1038/sj.onc.1210054 Mao, 2002, Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling, Nature, 417, 664, 10.1038/nature756 Weeraratna, 2002, Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma, Cancer Cell, 1, 279, 10.1016/S1535-6108(02)00045-4 Dejmek, 2006, Wnt-5a/Ca2+-induced NFAT activity is counteracted by Wnt-5a/Yes-Cdc42-casein kinase 1alpha signaling in human mammary epithelial cells, Mol Cell Biol, 26, 6024, 10.1128/MCB.02354-05 Ishitani, 2003, The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling, Mol Cell Biol, 23, 131, 10.1128/MCB.23.1.131-139.2003 Sheldahl, 2003, Dishevelled activates Ca2+ flux, PKC, and CamKII in vertebrate embryos, J Cell Biol, 161, 769, 10.1083/jcb.200211094 Qian, 2007, Wnt5a functions in planar cell polarity regulation in mice, Dev Biol, 306, 121, 10.1016/j.ydbio.2007.03.011 Boutros, 1998, Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling, Cell, 94, 109, 10.1016/S0092-8674(00)81226-X Li, 1999, Dishevelled proteins lead to two signaling pathways. Regulation of LEF-1 and c-Jun N-terminal kinase in mammalian cells, J Biol Chem, 274, 129, 10.1074/jbc.274.1.129 Oishi, 2003, The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway, Genes Cells, 8, 645, 10.1046/j.1365-2443.2003.00662.x Gong, 2001, LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development, Cell, 16, 513, 10.1016/S0092-8674(01)00571-2 Little, 2002, A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait, Am J Hum Genet, 70, 11, 10.1086/338450 Van Wesenbeeck, 2003, Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density, Am J Hum Genet, 72, 763, 10.1086/368277 Mani, 2007, LRP6 mutation in a family with early coronary disease and metabolic risk factors, Science, 315, 1278, 10.1126/science.1136370 Kato, 2002, Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor, J Cell Biol, 157, 303, 10.1083/jcb.200201089 Holmen, 2004, Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6, J Bone Miner Res, 19, 2033, 10.1359/jbmr.040907 Kokubu, 2004, Skeletal defects in ringelschwanz mutant mice reveal that Lrp6 is required for proper somitogenesis and osteogenesis, Development, 131, 5469, 10.1242/dev.01405 Clément-Lacroix, 2005, Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice, Proc Natl Acad Sci USA, 102, 17406, 10.1073/pnas.0505259102 Bodine, 2004, The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice, Mol Endocrinol, 18, 1222, 10.1210/me.2003-0498 Morvan, 2006, Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass, J Bone Miner Res, 21, 934, 10.1359/jbmr.060311 Li, 2005, Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation, Nat Genet, 37, 945, 10.1038/ng1614 Tu, 2007, Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation, Dev Cell, 12, 113, 10.1016/j.devcel.2006.11.003 Yamane, 2001, Wnt signaling regulates hemopoiesis through stromal cells, J Immunol, 167, 765, 10.4049/jimmunol.167.2.765 Glass, 2005, Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation, Dev Cell, 8, 751, 10.1016/j.devcel.2005.02.017 Spencer, 2006, Wnt signalling in osteoblasts regulates expression of the receptor activator of NFkappaB ligand and inhibits osteoclastogenesis in vitro, J Cell Sci, 119, 1283, 10.1242/jcs.02883 Häusler, 2004, Secreted frizzled-related protein-1 inhibits RANKL-dependent osteoclast formation, J Bone Miner Res, 19, 1873, 10.1359/JBMR.040807 Maeda, 2007, Wnt5a enhances RANKL-induced osteoclastogenesis, J Bone Miner Res, 22, S43 Sen, 2000, Expression and function of wingless and frizzled homologs in rheumatoid arthritis, Proc Natl Acad Sci USA, 97, 2791, 10.1073/pnas.050574297 Nakamura, 2005, Expression profiles and functional analyses of Wnt-related genes in human joint disorders, Am J Pathol, 167, 97, 10.1016/S0002-9440(10)62957-4 Diarra, 2007, Dickkopf-1 is a master regulator of joint remodeling, Nat Med, 13, 156, 10.1038/nm1538 Sen, 2001, Blockade of Wnt-5A/frizzled 5 signaling inhibits rheumatoid synoviocyte activation, Arthritis Rheum, 44, 772, 10.1002/1529-0131(200104)44:4<772::AID-ANR133>3.0.CO;2-L