Roles of HIF-1α in a novel optical orthotopic spontaneous metastatic bladder cancer animal model

Fidler, 1990, Critical factors in the biology of human cancer metastasis: 28th G. H. A. Clowes Memorial Award Lecture, Cancer Res, 50, 6130 Pham, 1997, Tumor-derived hyaluronidase: A diagnostic urine marker for high grade bladder cancer, Cancer Res, 57, 778 Naito, 2010, Glycogen synthase kinase-3β: A prognostic marker and a potential therapeutic target in human bladder cancer, Clin Cancer Res, 16, 5124, 10.1158/1078-0432.CCR-10-0275 Yang, 2011, Soluble vascular endothelial growth factor receptor-3 suppresses lymphangiogenesis and lymphatic metastasis in bladder cancer, Mol Cancer, 10, 36, 10.1186/1476-4598-10-36 Nitz, 2008, Invasion and metastasis models for studying RhoGDI2 in bladder cancer, Methods Enzymol, 439, 219, 10.1016/S0076-6879(07)00417-X Nicholson, 2004, Profiling the evolution of human metastatic bladder cancer, Cancer Res, 64, 7813, 10.1158/0008-5472.CAN-04-0826 Lou, 2011, Targeting Tumor Hypoxia: Suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors, Cancer Res, 71, 3364, 10.1158/0008-5472.CAN-10-4261 Finger, 2010, Hypoxia, inflammation, and the tumor microenvironment in metastatic disease, Cancer Metastasis Rev, 29, 285, 10.1007/s10555-010-9224-5 Koperek, 2011, Expression of hypoxia-associated proteins in sporadic medullary thyroid cancer is associated with desmoplastic stroma reaction and lymph node metastasis and may indicate somatic mutations in the VHL gene, J Pathol, 225, 63, 10.1002/path.2926 Kuiper, 2010, Low ascorbate levels are associated with increased hypoxia-inducible factor-1 activity and an aggressive tumor phenotype in endometrial cancer, Cancer Res, 70, 5749, 10.1158/0008-5472.CAN-10-0263 Zhong, 1999, Overexpression of hypoxia-inducible factor 1 alpha in common human cancers and their metastases, Cancer Res, 59, 5830 Pollard, 2004, Tumour-educated macrophages promote tumor progression and metastasis, Nat Rev Cancer, 4, 71, 10.1038/nrc1256 Shyu, 2007, Hypoxia-inducible factor 1α regulates lung adenocarcinoma cell invasion, Exp Cell Res, 313, 1181, 10.1016/j.yexcr.2007.01.013 Karam, 2010, Up-regulation of TRAG3 gene in urothelial carcinoma of the bladder, Int J Cancer, 128, 2823, 10.1002/ijc.25631 Elsner, 1996, Human eotaxin represents a potent activator of the respiratory burst of human eosinophils, Eur J Immunol, 26, 1919, 10.1002/eji.1830260837 Montgomery AMP, Becker JC, Siu CH, et al. Human neural cell adhesion molecule L1 and rat homologue NILE are ligands for integrin αV β3. J Cell Biol 196;132:475–85. Karam, 2011, Up-regulation of TRAG3 gene in urothelial carcinoma of the bladder, Int J Cancer, 128, 2823, 10.1002/ijc.25631 Montie, 2005, Profiling the evolution of human metastatic bladder cancer, J Urol, 174, 485, 10.1097/01.ju.0000171071.88466.cc Egeblad, 2002, New functions for the matrix metalloproteinases in cancer progression, Nature Rev Cancer, 2, 161, 10.1038/nrc745 Overall, 2002, Strategies for MMP inhibition in cancer: Innovations for the post-trial era, Nature Rev Cancer, 2, 657, 10.1038/nrc884 Generali, 2006, Hypoxia-inducible factor-1α expression predicts a poor response to primary chemoendocrine therapy and disease-free survival in primary human breast cancer, Clin Cancer Res, 12, 4562, 10.1158/1078-0432.CCR-05-2690 Kondo, 2005, Over expression of hypoxia-inducible factor-1α in renal and bladder cancer cells increases tumorigenic potency, J Urol, 173, 1762, 10.1097/01.ju.0000154343.35444.09 Aebersold, 2001, Expression of hypoxia-inducible factor-1α: A novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer, Cancer Res, 61, 2911 Blancher, 2000, Relationship of hypoxia-inducible factor (HIF)-1α and HIF-2α expression to vascular endothelial growth factor induction and hypoxia survival in human breast cancer cell lines, Cancer Res, 60, 7106 Rasheed, 2009, Hypoxia-inducible factor-1α and −2α are expressed in most rectal cancers but only hypoxia-inducible factor-1α is associated with prognosis, Brit J Cancer, 100/101, 742, 10.1038/sj.bjc.6605242 Hutchison GJ, Valentine HR, Loncaster JA, et al. Hypoxia-inducible factor 1α expression as an intrinsic marker of hypoxia: Correlation with tumor oxygen, pimonidazole measurements, and outcome in locally advanced carcinoma of the cervix. Clin Cancer Res 204;10:8405–12. Kimura, 2004, Expression of hypoxia-inducible factor (HIF)-1α is associated with vascular endothelial growth factor expression and tumor angiogenesis in human esophageal squamous cell carcinoma, Eur J Cancer, 40, 1904, 10.1016/j.ejca.2004.04.035