Roles for TNF-receptor associated factor 3 (TRAF3) in lymphocyte functions
Tài liệu tham khảo
Xu, 1996, Targeted disruption of TRAF3 leads to postnatal lethality and defective T-dependent immune responses, Immunity, 5, 407, 10.1016/S1074-7613(00)80497-5
Xie, 2007, TRAF3 is a critical regulator of B cell homeostasis in secondary lymphoid organs, Immunity, 27, 253, 10.1016/j.immuni.2007.07.012
Gardam, 2008, TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor, Immunity, 28, 391, 10.1016/j.immuni.2008.01.009
Hildebrand, 2011, Roles of TRAF3 and TRAF5 in immune cell function, Immunol Rev, 244, 55, 10.1111/j.1600-065X.2011.01055.x
Mackay, 2003, BAFF AND APRIL: a tutorial on B cell survival, Annu Rev Immunol, 21, 231, 10.1146/annurev.immunol.21.120601.141152
Weih, 2001, Essential role of RelB in germinal center and MZ formation and proper expression of homing chemokines, J Immunol, 167, 1909, 10.4049/jimmunol.167.4.1909
Franzoso, 1998, Mice deficient in NF-κB/p52 present with defects in humoral responses, GC reactions, and splenic microarchitecture, J Exp Med, 187, 147, 10.1084/jem.187.2.147
Xie, 2011, TRAF3 is required for T cell-mediated immunity and TCR/CD28 signaling, J Immunol, 186, 143, 10.4049/jimmunol.1000290
Keats, 2007, Promiscuous mutations activate the noncanonical NF-κB pathway in MM, Cancer Cell, 12, 131, 10.1016/j.ccr.2007.07.003
Annunziata, 2007, Frequent engagement of the classical and alternative NF-κB pathways by diverse genetic abnormalities in multiple myeloma, Cancer Cell, 12, 115, 10.1016/j.ccr.2007.07.004
Otto, 2012, Genetic lesions of the TRAF3 and MAP3K14 genes in classical Hodgkin lymphoma, Br J Haematol, 157, 702, 10.1111/j.1365-2141.2012.09113.x
Nagel, 2009, Biallelic inactivation of TRAF3 in a subset of B-cell lymphomas with interstitial del(14)(q24.1q32.33), Leukemia, 23, 2153, 10.1038/leu.2009.149
Moore, 2012, Specific deletion of TRAF3 in B lymphocytes leads to B-lymphoma development in mice, Leukemia, 26, 1122, 10.1038/leu.2011.309
Hu, 1994, A novel RING finger protein interacts with the cytoplasmic domain of CD40, J Biol Chem, 269, 30069, 10.1016/S0021-9258(18)43772-6
Cheng, 1995, Involvement of CRAF1, a relative of TRAF, in CD40 signaling, Science, 267, 1494, 10.1126/science.7533327
Hostager, 1999, Cutting edge: contrasting roles of TRAF2 and TRAF3 in CD40-mediated B lymphocyte activation, J Immunol, 162, 6307, 10.4049/jimmunol.162.11.6307
Pullen, 1998, CD40-TRAF interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization, Biochemistry, 37, 11836, 10.1021/bi981067q
Hostager, 2003, TRAF2-deficient B lymphocytes reveal novel roles for TRAF2 in CD40 signaling, J Biol Chem, 278, 45382, 10.1074/jbc.M306708200
Haxhinasto, 2003, A novel interaction between PKD and TRAFs regulates BCR-CD40 synergy, J Immunol, 171, 4655, 10.4049/jimmunol.171.9.4655
Xie, 2004, Requirement for TRAF3 in signaling by LMP1, but not CD40, in B lymphocytes, J Exp Med, 199, 661, 10.1084/jem.20031255
Bishop, 2001, Signaling by CD40 and its mimics in B cell activation, Immunol Res, 24, 97, 10.1385/IR:24:2:097
Graham, 2010, Differential B lymphocyte regulation by CD40 and its viral mimic, LMP1, Immunol Rev, 237, 226, 10.1111/j.1600-065X.2010.00932.x
Bishop, 2002, Mechanisms of TRAF regulation in B lymphocytes, J Leukoc Biol, 72, 19, 10.1189/jlb.72.1.19
Soni, 2007, LMP1 TRAFficking activates growth and survival pathways, Adv Exp Med Biol, 597, 173, 10.1007/978-0-387-70630-6_14
Arcipowski, 2011, Molecular mechanisms of TRAF6 utilization by the oncogenic viral mimic of CD40, LMP1, J Biol Chem, 286, 9948, 10.1074/jbc.M110.185983
Kraus, 2009, TRAF5 is a critical mediator of in vitro signals and in vivo functions of LMP1, the viral oncogenic mimic of CD40, Proc Natl Acad Sci USA, 106, 17140, 10.1073/pnas.0903786106
Wu, 2005, LMP1 protein from EBV is a structural decoy in B lymphocytes for binding to TRAF3, J Biol Chem, 280, 33620, 10.1074/jbc.M502511200
Ardila-Osorio, 1999, Evidence of LMP1–TRAF3 interactions in glycosphingolipid-rich complexes of lymphoblastoid and nasopharyngeal carcinoma cells, Int J Cancer, 81, 645, 10.1002/(SICI)1097-0215(19990517)81:4<645::AID-IJC22>3.0.CO;2-0
Hostager, 2000, Recruitment of CD40, TRAF2 and TRAF3 to membrane microdomains during CD40 signaling, J Biol Chem, 275, 15392, 10.1074/jbc.M909520199
Kaykas, 2001, CD40 and LMP-1 both signal from lipid rafts but LMP-1 assembles a distinct, more efficient signaling complex, EMBO J, 20, 2641, 10.1093/emboj/20.11.2641
Brown, 2001, Differential signaling and TRAF degradation by CD40 and the EBV oncoprotein LMP1, J Exp Med, 193, 943, 10.1084/jem.193.8.943
Moore, 2005, Differential regulation of CD40-mediated TRAF degradation in B lymphocytes, J Immunol, 175, 3780, 10.4049/jimmunol.175.6.3780
Ye, 1999, The structural basis for the recognition of diverse receptor sequences by TRAF2, Mol Cell, 4, 321, 10.1016/S1097-2765(00)80334-2
Graham, 2009, Roles of the TRAF2/3 binding site in differential B cell signaling by CD40 and its oncogenic mimic, LMP1, J Immunol, 183, 2966, 10.4049/jimmunol.0900442
Peters, 2008, A novel polymorphism of the human CD40 receptor with enhanced function, Blood, 112, 1863, 10.1182/blood-2008-02-138925
Peters, 2010, Differential TRAF3 utilization by a variant human CD40 receptor with enhanced signaling, J Immunol, 185, 6555, 10.4049/jimmunol.1000135
Khare, 2001, The role of TALL-1 and APRIL in immune regulation, Trends Immunol, 22, 61, 10.1016/S1471-4906(00)01843-3
Do, 2002, Mechanisms of BLyS action in B cell immunity, Cytokine Growth Factor Rev, 13, 19, 10.1016/S1359-6101(01)00025-9
Cancro, 2004, The BLyS family of ligands and receptors: an archetype for niche-specific homeostatic regulation, Immunol Rev, 202, 237, 10.1111/j.0105-2896.2004.00212.x
Xu, 2002, TRAF3 is associated with BAFF-R and negatively regulates BAFF-R-mediated NF-kB activation and IL-10 production, J Immunol, 169, 6883, 10.4049/jimmunol.169.12.6883
Morrison, 2005, An atypical TRAF binding motif of BAFFR mediates induction of the noncanonical NF-κB signaling pathway, J Biol Chem, 280, 10018, 10.1074/jbc.M413634200
Hatzoglou, 2000, TNF receptor family member BCMA associates with TRAF1, TRAF2, and TRAF3 and activates NF-κB, elk-1, JNK, and p38 MAPK, J Immunol, 165, 1322, 10.4049/jimmunol.165.3.1322
Shu, 2000, B cell maturation protein is a receptor for the TNF family member TALL-1, Proc Natl Acad Sci USA, 97, 9156, 10.1073/pnas.160213497
Xia, 2000, TACI is a TRAF-interacting receptor for TALL-1, a TNF family member involved in B cell regulation, J Exp Med, 192, 137, 10.1084/jem.192.1.137
Hildebrand, 2010, A BAFF-R mutation associated with Non-Hodgkin's lymphoma exhibits altered TRAF association and reveals new insights into proximal BAFF-R signaling, J Exp Med, 207, 2569, 10.1084/jem.20100857
Liao, 2004, Regulation of NIK by TRAF3-induced degradation, J Biol Chem, 279, 26243, 10.1074/jbc.M403286200
Lin, 2013, A complex relationship between TRAF3 and non-canonical NF-κB activation in B lymphocytes, Front Immunol, 4, 10.3389/fimmu.2013.00477
Qian, 2004, Act1, a negative regulator in CD40 and BAFF-mediated B cell survival, Immunity, 21, 575, 10.1016/j.immuni.2004.09.001
Claudio, 2009, The adaptor protein CIKS/Act1 is essential for IL-25-mediated allergic airway inflammation, J Immunol, 182, 1617, 10.4049/jimmunol.182.3.1617
Qian, 2007, The adaptor Act1 is required for IL-17-dependent signaling associated with autoimmune and inflammatory disease, Nat Immunol, 8, 247, 10.1038/ni1439
Chang, 2006, Act1 adaptor protein is an immediate and essential signaling component of IL-17R, J Biol Chem, 281, 35603, 10.1074/jbc.C600256200
Zhu, 2010, Modulation of EAE through TRAF3-mediated suppression of IL-17 receptor signaling, J Exp Med, 207, 2647, 10.1084/jem.20100703
Hauer, 2005, TRAF3 serves as an inhibitor of TRAF2/5-mediated activation of the noncanonical NF-κB pathway by TRAF-binding TNFRs, Proc Natl Acad Sci USA, 102, 2874, 10.1073/pnas.0500187102
Rothe, 1995, The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins, Cell, 83, 1243, 10.1016/0092-8674(95)90149-3
Munroe, 2004, Role of TRAF2 in distinct and overlapping CD40 and TNFR2/CD120b-mediated B lymphocyte activation, J Biol Chem, 279, 53222, 10.1074/jbc.M410539200
Hostager, 2002, Role of TRAF2 in the activation of IgM secretion by CD40 and CD120b, J Immunol, 168, 3318, 10.4049/jimmunol.168.7.3318
Peng, 2005, Signaling to B cells by TLRs, Curr Opin Immunol, 17, 230, 10.1016/j.coi.2005.03.003
Fillatreau, 2011, Novel regulatory functions for TLR-activated B cells during intracellular bacterial infection, Immunol Rev, 240, 52, 10.1111/j.1600-065X.2010.00991.x
Green, 2011, TLR driven B cell activation in the induction of systemic autoimmunity, Semin Immunol, 23, 106, 10.1016/j.smim.2011.01.016
Aderem, 2000, TLRs in the induction of the innate immune response, Nature, 406, 782, 10.1038/35021228
Häcker, 2006, Specificity in TLR signalling through distinct effector functions of TRAF3 and TRAF6, Nature, 439, 204, 10.1038/nature04369
Oganesyan, 2006, Critical role of TRAF3 in the TLR-dependent and independent antiviral response, Nature, 439, 208, 10.1038/nature04374
Perkins, 2013, Reprogramming of murine macrophages through TLR2 confers viral resistance via TRAF3-mediated, enhanced interferon production, PLoS Pathog, e1003479, 10.1371/journal.ppat.1003479
Pérez de Diego, 2010, Human TRAF3 adaptor molecule deficiency leads to impaired TLR3 response and susceptibility to Herpes simplex encephalitis, Immunity, 33, 400, 10.1016/j.immuni.2010.08.014
Xie, 2011, Enhanced TLR responses of TRAF3-deficient B lymphocytes, J Leukoc Biol, 90, 1149, 10.1189/jlb.0111044
Buchta, 2014, TRAF5 negatively regulates TLR signaling in B lymphocytes, J Immunol, 192, 145, 10.4049/jimmunol.1301901
Sun, 2004, The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes, Mol Cell, 14, 289, 10.1016/S1097-2765(04)00236-9
Xie, 2013, TRAF6 regulates TCR signaling via interaction with and modification of LAT adapter, J Immunol, 190, 4027, 10.4049/jimmunol.1202742
Yi, 2013, TRAF3 plays a key role in the development and function of iNKT cells, J Exp Med, 210, 1079, 10.1084/jem.20122135
Lee, 2001, A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival, Immunity, 15, 763, 10.1016/S1074-7613(01)00227-8
Tanigaki, 2004, Regulation of αβ/γδ T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling, Immunity, 20, 611, 10.1016/S1074-7613(04)00109-8
Godfrey, 2010, Raising the NKT cell family, Nat Immunol, 11, 197, 10.1038/ni.1841
Bajenoff, 2002, Repeated antigen exposure is necessary for the differentiation, but not the initial proliferation, of naive CD4+ T cells, J Immunol, 168, 1723, 10.4049/jimmunol.168.4.1723
Matsuoka, 2004, T-bet upregulation and subsequent IL-12 stimulation are essential for induction of Th1 mediated immunopathology in Crohn's disease, Gut, 53, 1303, 10.1136/gut.2003.024190
Matsuda, 2007, Temporal dissection of T-bet functions, J Immunol, 178, 3457, 10.4049/jimmunol.178.6.3457
Townsend, 2004, T-bet regulates the terminal maturation and homeostasis of NK and Vα14i NKT cells, Immunity, 20, 477, 10.1016/S1074-7613(04)00076-7
Bennett, 2001, The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3, Nat Genet, 27, 20, 10.1038/83713
Fontenot, 2003, Foxp3 programs the development and function of CD4+CD25+ regulatory T cells, Nat Immunol, 4, 330, 10.1038/ni904
Khattri, 2003, An essential role for Scurfin in CD4+CD25+ T regulatory cells, Nat Immunol, 4, 337, 10.1038/ni909
Kim, 2007, Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice, Nat Immunol, 8, 191, 10.1038/ni1428
Lahl, 2007, Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease, J Exp Med, 204, 57, 10.1084/jem.20061852
Wortzman, 2013, The contextual role of TNFR family members in CD8+ T-cell control of viral infections, Immunol Rev, 255, 125, 10.1111/imr.12086
Munroe, 2009, Functional roles for T cell CD40 in infection and autoimmune disese: the role of CD40 in lymphocyte homeostasis, Semin Immunol, 21, 283, 10.1016/j.smim.2009.05.008
So, 2012, Regulation of the PKCθ-NF-κB axis in T lymphocytes by the TNF-R family member OX40, Front Immunol, 3, 133, 10.3389/fimmu.2012.00133
Arch, 1998, 4-1BB and Ox40 are members of a TNF-R subfamily that bind TRAFs and activate NF-κB, Mol Cell Biol, 18, 558, 10.1128/MCB.18.1.558
Kawamata, 1998, Activation of OX40 signal transduction pathways leads to TRAF2 and TRAF5-mediated NF-κB activation, J Biol Chem, 273, 5805, 10.1074/jbc.273.10.5808
Takaori-Kondo, 2000, Both amino- and carboxyl-terminal domains of TRAF3 negatively regulate NF-κB activation induced by OX40 signaling, Biochem Biophys Res Commun, 272, 856, 10.1006/bbrc.2000.2860
Song, 2004, The costimulation-regulated duration of PKB activation controls T cell longevity, Nat Immunol, 5, 150, 10.1038/ni1030
Song, 2008, Activation of NF-κB1 by OX40 contributes to antigen-driven T cell expansion and survival, J Immunol, 180, 7240, 10.4049/jimmunol.180.11.7240
So, 2013, Regulation of PI-3 K and Akt signaling in T lymphocytes and other cells by TNFR family molecules, Front Immunol, 4, 139, 10.3389/fimmu.2013.00139
So, 2008, Immune regulation and control of regulatory T cells by OX40 and 4-1BB, Cytokine Growth Factor Rev, J19, 253, 10.1016/j.cytogfr.2008.04.003
Lin, 2013, GITR-dependent regulation of 4-1BB expression: implications for T cell memory and anti-4-1BB-induced pathology, J Immunol, 190, 4627, 10.4049/jimmunol.1201854
Lee, 2003, 4-1BB cross-linking enhances the survival and cell cycle progression of CD4 T lymphocytes, Cell Immunol, 223, 143, 10.1016/S0008-8749(03)00169-2
Lin, 2012, Contribution of 4-1BBL on radioresistant cells in providing survival signals through 4-1BB expressed on CD8+ memory T cells in the bone marrow, Eur J Immunol, 42, 2861, 10.1002/eji.201242503
Jang, 1998, Human 4-1BB (CD137) signals are mediated by TRAF2 and activate NF-κB, Biochem Biophys Res Commun, 242, 613, 10.1006/bbrc.1997.8016
Saoulli, 1998, CD28-independent, TRAF2-dependent costimulation of resting T cells by 4-1BB ligand, J Exp Med, 187, 1849, 10.1084/jem.187.11.1849
McPherson, 2012, Opposing roles for TRAF1 in the alternative versus classical NF-κB pathway in T cells, J Biol Chem, 287, 23010, 10.1074/jbc.M112.350538
Sabbagh, 2006, A critical role for TRAF1 and Bim down-regulation in CD8 memory T cell survival, Proc Natl Acad Sci USA, 103, 18703, 10.1073/pnas.0602919103
Lee, 2002, 4-1BB promotes the survival of CD8+ T lymphocytes by increasing expression of Bcl-xL and Bfl-1, J Immunol, 169, 4882, 10.4049/jimmunol.169.9.4882
Lee do, 2013, 4-1BB signaling activates the TCF-1 effector/β-catenin pathway with delayed kinetics via ERK signaling and delayed PI3 K/AKT activation to promote the proliferation of CD8+ T cells, PLoS ONE, 8, e69677, 10.1371/journal.pone.0069677
Ware, 2009, Targeting the LIGHT–HVEM pathway, Adv Exp Med Biol, 647, 146, 10.1007/978-0-387-89520-8_10
Marsters, 1997, HVEM, a member of the TNFR family, interacts with members of the TRAF family and activates the transcription factors NF-κB and AP-1, J Biol Chem, 272, 14029, 10.1074/jbc.272.22.14029
Soroosh, 2011, HVEM (TNFRSF14) regulates the persistence of T helper memory cell populations, J Exp Med, 208, 797, 10.1084/jem.20101562
Gurney, 1999, Identification of a new member of the TNF family and its receptor, a human ortholog of mouse GITR, Curr Biol, 9, 215, 10.1016/S0960-9822(99)80093-1
Kwon, 1999, Identification of a novel activation-inducible protein of the TNFR superfamily and its ligand, J Biol Chem, 274, 6056, 10.1074/jbc.274.10.6056
Snell, 2010, CD8 T cell-intrinsic GITR is required for T cell clonal expansion and mouse survival following severe influenza infection, J Immunol, 185, 7223, 10.4049/jimmunol.1001912
Kim, 2010, Blockade of GITR–GITRL interaction maintains Treg function to prolong allograft survival, Eur J Immunol, 40, 1369, 10.1002/eji.200940046
Aizawa, 1997, TRAF5 and TRAF2 are involved in CD30-mediated NF-κB activation, J Biol Chem, 272, 2042, 10.1074/jbc.272.4.2042
Boucher, 1997, Binding sites of cytoplasmic effectors TRAF1, 2, and 3 on CD30 and other members of the TNFR superfamily, Biochem Biophys Res Commun, 233, 592, 10.1006/bbrc.1997.6509
Nishimura, 2005, A novel role of CD30/CD30 ligand signaling in the generation of long-lived memory CD8+ T cells, J Immunol, 175, 4627, 10.4049/jimmunol.175.7.4627
Sun, 2010, CD30L/CD30 plays a critical role in Th17 differentiation in mice, J Immunol, 185, 2222, 10.4049/jimmunol.1000024
Reynolds, 2013, TLR regulation of effector T lymphocyte function, Trends Immunol, 34, 511, 10.1016/j.it.2013.06.003
Gelman, 2004, TLR ligands directly promote activated CD4+ T cell survival, J Immunol, 172, 6065, 10.4049/jimmunol.172.10.6065
Reynolds, 2012, TLR4 signaling in T cells promotes autoimmune inflammation, Proc Natl Acad Sci USA, 109, 13064, 10.1073/pnas.1120585109
Liu, 2007, TLRs and immune regulation: their direct and indirect modulation on regulatory CD4+CD25+ T cells, Immunology, 122, 149, 10.1111/j.1365-2567.2007.02651.x
Loo, 2011, Immune signaling by RIG-I-like receptors, Immunity, 34, 680, 10.1016/j.immuni.2011.05.003
Nakhaei, 2009, RIG-I-like receptors: sensing and responding to RNA virus infection, Semin Immunol, 21, 215, 10.1016/j.smim.2009.05.001
Saha, 2006, Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif, EMBO J, 25, 3257, 10.1038/sj.emboj.7601220
Nakhaei, 2009, The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradation, PLoS Pathog, 5, e1000650, 10.1371/journal.ppat.1000650
Suthar, 2012, The RIG-I-like receptor LGP2 controls CD8+ T cell survival and fitness, Immunity, 37, 235, 10.1016/j.immuni.2012.07.004
de Jong, 2010, Activation of noncanonical NF-κB signaling by the oncoprotein Tio, J Biol Chem, 285, 16495, 10.1074/jbc.M110.102848
Katsch, 2012, Species restriction of Herpesvirus saimiri and Herpesvirus ateles: human lymphocyte transformation correlates with distinct signaling properties of viral oncoproteins, Virus Res, 165, 179, 10.1016/j.virusres.2012.02.014
Albrecht, 1999, Herpesvirus ateles gene product Tio interacts with nonreceptor protein tyrosine kinases, J Virol, 73, 4631, 10.1128/JVI.73.6.4631-4639.1999
Heinemann, 2006, NFκB signaling is induced by the oncoprotein Tio through direct interaction with TRAF6, J Biol Chem, 281, 8565, 10.1074/jbc.M510891200
de Jong, 2013, Noncanonical NF-κB activation by the oncoprotein Tio occurs through a nonconserved TRAF3-binding motif, Sci Signal, 6, ra27, 10.1126/scisignal.2003309
Albrecht, 2005, Tyrosine phosphorylation of the Tio oncoprotein is essential for transformation of primary human T cells, J Virol, 79, 10507, 10.1128/JVI.79.16.10507-10513.2005
Abraham, 2012, HIV-1 Nef: a multifaceted modulator of TCR signaling, Cell Commun Signal, 10, 39, 10.1186/1478-811X-10-39
Mangino, 2011, HIV-1 Nef induces proinflammatory state in macrophages through its acidic cluster domain: involvement of TRAF2, PLoS ONE, 6, e22982, 10.1371/journal.pone.0022982
Mishra, 2012, HIV-1 Tat C-mediated regulation of TRAF3 by microRNA 32 in human microglia, J Neuroinflamm, 9, 131, 10.1186/1742-2094-9-131
Aya, 2005, NIK controls lymphocyte and osteoclast activities in inflammatory arthritis, J Clin Invest, 115, 1848, 10.1172/JCI23763
Jin, 2009, Regulation of Th17 cell differentiation and EAE induction by MAP3K NIK, Blood, 113, 6603, 10.1182/blood-2008-12-192914
Hofmann, 2011, NIK signaling in DC but not in T cells is required for the development of effector T cells and cell-mediated immune responses, J Exp Med, 208, 1917, 10.1084/jem.20110128
Boehm, 2003, Thymic medullary epithelial cell differentiation, thymocyte emigration, and the control of autoimmunity require lympho-epithelial cross talk via LTβR, J Exp Med, 198, 757, 10.1084/jem.20030794
Zhu, 2006, NF-κB2 is required for the establishment of central tolerance through an Aire-dependent pathway, J Clin Invest, 116, 2964, 10.1172/JCI28326
Elewaut, 2003, NIK-dependent RelB activation defines a unique signaling pathway for the development of Vα 14i NKT cells, J Exp Med, 197, 1623, 10.1084/jem.20030141
Sivakumar, 2003, Differential requirement for Rel/NF-κB family members in NKT cell development, J Exp Med, 197, 1613, 10.1084/jem.20022234
Murray, 2013, Cell-intrinsic role for NIK in peripheral maintenance but not thymic development of Foxp3+ regulatory T cells in mice, PLoS ONE, 8, e76216, 10.1371/journal.pone.0076216
Vallabhapurapu, 2008, Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-κB signaling, Nat Immunol, 9, 1364, 10.1038/ni.1678
Zarnegar, 2008, Noncanonical NF-κB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK, Nat Immunol, 9, 1371, 10.1038/ni.1676