Role of tumor associated macrophages in tumor angiogenesis and lymphangiogenesis
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Algars, 2012, Type and location of tumor-infiltrating macrophages and lymphatic vessels predict survival of colorectal cancer patients, Int. J. Cancer, 131, 864, 10.1002/ijc.26457
Allavena, 2008, The inflammatory micro-environment in tumor progression: the role of tumor-associated macrophages, Crit. Rev. Oncol. Hematol, 66, 1, 10.1016/j.critrevonc.2007.07.004
Allin, 2012, Cancer risk by combined levels of YKL-40 and C-reactive protein in the general population, Br. J. Cancer, 106, 199, 10.1038/bjc.2011.501
Arakane, 2010, Insect chitinase and chitinase-like proteins, Cell. Mol. Life Sci, 67, 201, 10.1007/s00018-009-0161-9
Basire, 2006, High urokinase expression contributes to the angiogenic properties of endothelial cells derived from circulating progenitors, Thromb. Haemost, 95, 678, 10.1160/TH05-07-0511
Bergers, 2000, Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis, Nat. Cell Biol, 2, 737, 10.1038/35036374
Bijnsdorp, 2011, Thymidine phosphorylase in cancer cells stimulates human endothelial cell migration and invasion by the secretion of angiogenic factors, Br. J. Cancer, 104, 1185, 10.1038/bjc.2011.74
Bingle, 2002, The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies, J. Pathol, 196, 254, 10.1002/path.1027
Bjorndahl, 2005a, Vascular endothelial growth factor-a promotes peritumoral lymphangiogenesis and lymphatic metastasis, Cancer Res, 65, 9261, 10.1158/0008-5472.CAN-04-2345
Bjorndahl, 2005b, Insulin-like growth factors 1 and 2 induce lymphangiogenesis in vivo, Proc. Natl. Acad. Sci. U.S.A, 102, 15593, 10.1073/pnas.0507865102
Brecht, 2011, Macrophages programmed by apoptotic cells promote angiogenesis via prostaglandin E2, FASEB J, 25, 2408, 10.1096/fj.10-179473
Burke, 2002, Expression of HIF-1alpha by human macrophages: implications for the use of macrophages in hypoxia-regulated cancer gene therapy, J. Pathol, 196, 204, 10.1002/path.1029
Cao, 1998, Vascular endothelial growth factor C induces angiogenesis in vivo, Proc. Natl. Acad. Sci. U.S.A, 95, 14389, 10.1073/pnas.95.24.14389
Casazza, 2013, Impeding macrophage entry into hypoxic tumor areas by sema3a/Nrp1 Signaling blockade inhibits angiogenesis and restores antitumor immunity, Cancer Cell, 24, 695, 10.1016/j.ccr.2013.11.007
Chen, 2003, Up-regulation of tumor interleukin-8 expression by infiltrating macrophages: its correlation with tumor angiogenesis and patient survival in non-small cell lung cancer, Clin. Cancer Res, 9, 729
Chen, 2011, Tumor-associated macrophages promote angiogenesis and melanoma growth via adrenomedullin in a paracrine and autocrine manner, Clin. Cancer Res, 17, 7230, 10.1158/1078-0432.CCR-11-1354
Chen, 2012, Macrophage-induced tumor angiogenesis is regulated by the TSC2-mTOR pathway, Cancer Res, 72, 1363, 10.1158/0008-5472.CAN-11-2684
Coffelt, 2011, Angiopoietin 2 stimulates TIE2-expressing monocytes to suppress T cell activation and to promote regulatory T cell expansion, J. Immunol, 186, 4183, 10.4049/jimmunol.1002802
Coffelt, 2009, Tumor-associated macrophages: effectors of angiogenesis and tumor progression, Biochim. Biophys. Acta, 1796, 11, 10.1016/j.bbcan.2009.02.004
Coffelt, 2010, Angiopoietin-2 regulates gene expression in TIE2-expressing monocytes and augments their inherent proangiogenic functions, Cancer Res, 70, 5270, 10.1158/0008-5472.CAN-10-0012
Cursiefen, 2004, VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment, J. Clin. Invest, 113, 1040, 10.1172/JCI20465
David, 2012, Stabilin-1 expression in tumor associated macrophages, Brain Res, 1481, 71, 10.1016/j.brainres.2012.08.048
De Palma, 2013, A new twist on radiation oncology: low-dose irradiation elicits immunostimulatory macrophages that unlock barriers to tumor immunotherapy, Cancer Cell, 24, 559, 10.1016/j.ccr.2013.10.019
De Palma, 2005, Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors, Cancer Cell, 8, 211, 10.1016/j.ccr.2005.08.002
Detry, 2012, Matrix metalloproteinase-2 governs lymphatic vessel formation as an interstitial collagenase, Blood, 119, 5048, 10.1182/blood-2011-12-400267
Ding, 2012, The effect of vascular endothelial growth factor C expression in tumor-associated macrophages on lymphangiogenesis and lymphatic metastasis in breast cancer, Mol. Med. Rep, 6, 1023, 10.3892/mmr.2012.1043
Du, 2008, HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion, Cancer Cell, 13, 206, 10.1016/j.ccr.2008.01.034
Duong, 2012, Tumor lymphangiogenesis as a potential therapeutic target, J. Oncol, 2012, 204946, 10.1155/2012/204946
Egami, 2003, Role of host angiotensin II type 1 receptor in tumor angiogenesis and growth, J. Clin. Invest, 112, 67, 10.1172/JCI16645
Espinosa, 2011, CSF1 expression in nongynecological leiomyosarcoma is associated with increased tumor angiogenesis, Am. J. Pathol, 179, 2100, 10.1016/j.ajpath.2011.06.021
Eubank, 2003, M-CSF induces vascular endothelial growth factor production and angiogenic activity from human monocytes, J. Immunol, 171, 2637, 10.4049/jimmunol.171.5.2637
Eubank, 2011, Opposing roles for HIF-1alpha and HIF-2alpha in the regulation of angiogenesis by mononuclear phagocytes, Blood, 117, 323, 10.1182/blood-2010-01-261792
Faibish, 2011, A YKL-40-neutralizing antibody blocks tumor angiogenesis and progression: a potential therapeutic agent in cancers, Mol. Cancer Ther, 10, 742, 10.1158/1535-7163.MCT-10-0868
Forssell, 2007, High macrophage infiltration along the tumor front correlates with improved survival in colon cancer, Clin. Cancer Res, 13, 1472, 10.1158/1078-0432.CCR-06-2073
Francescone, 2011, Role of YKL-40 in the angiogenesis, radioresistance, and progression of glioblastoma, J. Biol. Chem, 286, 15332, 10.1074/jbc.M110.212514
Francescone, 2013, Tumor-derived mural-like cells coordinate with endothelial cells: role of YKL-40 in mural cell-mediated angiogenesis, Oncogene, 10.1038/onc.2013.160
Galarneau, 2007, Increased glioma growth in mice depleted of macrophages, Cancer Res, 67, 8874, 10.1158/0008-5472.CAN-07-0177
Giraudo, 2004, An amino-bisphosphonate targets MMP-9-expressing macrophages and angiogenesis to impair cervical carcinogenesis, J. Clin. Invest, 114, 623, 10.1172/JCI200422087
Gomes, 2013, Tumor angiogenesis and lymphangiogenesis: tumor/endothelial crosstalk and cellular/microenvironmental signaling mechanisms, Life Sci, 92, 101, 10.1016/j.lfs.2012.10.008
Gordon, 2010, Macrophages define dermal lymphatic vessel calibre during development by regulating lymphatic endothelial cell proliferation, Development, 137, 3899, 10.1242/dev.050021
Gratchev, 2006, Mphi1 and Mphi2 can be re-polarized by Th2 or Th1 cytokines, respectively, and respond to exogenous danger signals, Immunobiology, 211, 473, 10.1016/j.imbio.2006.05.017
Gratchev, 2008, Expression of osteoarthritis marker YKL-39 is stimulated by transforming growth factor beta (TGF-beta) and IL-4 in differentiating macrophages, Biomark. Insights, 3, 39, 10.1177/117727190800300003
Halin, 2009, Extratumoral macrophages promote tumor and vascular growth in an orthotopic rat prostate tumor model, Neoplasia, 11, 177, 10.1593/neo.81338
Harbeck, 2002, Clinical utility of urokinase-type plasminogen activator and plasminogen activator inhibitor-1 determination in primary breast cancer tissue for individualized therapy concepts, Clin. Breast Cancer, 3, 196, 10.3816/CBC.2002.n.023
Harutyunyan, 2012, The inflammatory biomarker YKL-40 as a new prognostic marker for all-cause mortality in patients with heart failure, Immunobiology, 217, 652, 10.1016/j.imbio.2011.11.003
Harutyunyan, 2013, Serum YKL-40 predicts long-term mortality in patients with stable coronary disease: a prognostic study within the CLARICOR trial, Immunobiology, 218, 945, 10.1016/j.imbio.2012.10.015
He, 2012, Endothelial cells provide an instructive niche for the differentiation and functional polarization of M2-like macrophages, Blood, 120, 3152, 10.1182/blood-2012-04-422758
Heindl, 2010, Intraocular tumor-associated lymphangiogenesis a novel prognostic factor for ciliary body melanomas with extraocular extension?, Ophthalmology, 117, 334, 10.1016/j.ophtha.2009.06.057
Hildenbrand, 1995, Urokinase and macrophages in tumour angiogenesis, Br. J. Cancer, 72, 818, 10.1038/bjc.1995.419
Hirakawa, 2005, VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis, J. Exp. Med, 201, 1089, 10.1084/jem.20041896
Hong, 2009, Induced interleukin-8 expression in gliomas by tumor-associated macrophages, J. Neurooncol, 93, 289, 10.1007/s11060-008-9786-z
Hong, 2004, VEGF-A promotes tissue repair-associated lymphatic vessel formation via VEGFR-2 and the alpha1beta1 and alpha2beta1 integrins, FASEB J, 18, 1111, 10.1096/fj.03-1179fje
Hotchkiss, 2003, Thymidine phosphorylase and 2-deoxyribose stimulate human endothelial cell migration by specific activation of the integrins alpha 5 beta 1 and alpha V beta 3, J. Biol. Chem, 278, 19272, 10.1074/jbc.M212670200
Huang, 2011, Specifically targeting angiopoietin-2 inhibits angiogenesis, Tie2-expressing monocyte infiltration, and tumor growth, Clin. Cancer Res, 17, 1001, 10.1158/1078-0432.CCR-10-2317
Huang, 2002, Contributions of stromal metalloproteinase-9 to angiogenesis and growth of human ovarian carcinoma in mice, J. Natl. Cancer Inst, 94, 1134, 10.1093/jnci/94.15.1134
Imtiyaz, 2010, Hypoxia-inducible factor 2alpha regulates macrophage function in mouse models of acute and tumor inflammation, J. Clin. Invest, 120, 2699, 10.1172/JCI39506
Ito, 2011, Lymphangiogenesis and axillary lymph node metastases correlated with VEGF-C expression in two immunocompetent mouse mammary carcinoma models, Int. J. Breast Cancer, 2011, 867152, 10.4061/2011/867152
Jensen, 2003, High levels of serum HER-2/neu and YKL-40 independently reflect aggressiveness of metastatic breast cancer, Clin. Cancer Res, 9, 4423
Jensen, 2013, Plasma YKL-40: a potential biomarker for psoriatic arthritis?, J. Eur. Acad. Dermatol. Venereol, 27, 815, 10.1111/j.1468-3083.2012.04570.x
Jeon, 2008, Profound but dysfunctional lymphangiogenesis via vascular endothelial growth factor ligands from CD11b+ macrophages in advanced ovarian cancer, Cancer Res, 68, 1100, 10.1158/0008-5472.CAN-07-2572
Jeon, 2007, Mechanisms underlying TGF-beta1-induced expression of VEGF and Flk-1 in mouse macrophages and their implications for angiogenesis, J. Leukoc. Biol, 81, 557, 10.1189/jlb.0806517
Johansen, 2003, High serum YKL-40 levels in patients with primary breast cancer is related to short recurrence free survival, Breast Cancer Res. Treat, 80, 15, 10.1023/A:1024431000710
Johansen, 2009, Plasma YKL-40: a potential new cancer biomarker?, Future Oncol, 5, 1065, 10.2217/fon.09.66
Joukov, 1997, Proteolytic processing regulates receptor specificity and activity of VEGF-C, EMBO J, 16, 3898, 10.1093/emboj/16.13.3898
Jung, 2003, IL-1beta-mediated up-regulation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis, FASEB J, 17, 2115, 10.1096/fj.03-0329fje
Karikoski, 2009, Clever-1/Stabilin-1 regulates lymphocyte migration within lymphatics and leukocyte entrance to sites of inflammation, Eur. J. Immunol, 39, 3477, 10.1002/eji.200939896
Kastrup, 2011, Can YKL-40 be a new inflammatory biomarker in cardiovascular disease?, Immunobiology, 217, 483, 10.1016/j.imbio.2011.04.007
Kawahara, 2010, Infiltration of thymidine phosphorylase-positive macrophages is closely associated with tumor angiogenesis and survival in intestinal type gastric cancer, Oncol. Rep, 24, 405, 10.3892/or_00000873
Kerjaschki, 2005, The crucial role of macrophages in lymphangiogenesis, J. Clin. Invest, 115, 2316, 10.1172/JCI26354
Kim, 2007, Prognostic implications of immunohistochemically detected YKL-40 expression in breast cancer, World J. Surg. Oncol, 5, 17, 10.1186/1477-7819-5-17
Kioi, 2010, Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice, J. Clin. Invest, 120, 694, 10.1172/JCI40283
Klug, 2013, Low-dose irradiation programs macrophage differentiation to an iNOS(+)/M1 phenotype that orchestrates effective T Cell immunotherapy, Cancer Cell, 24, 589, 10.1016/j.ccr.2013.09.014
Konradsen, 2013, The chitinase-like protein YKL-40: A possible biomarker of inflammation and airway remodeling in severe pediatric asthma, J. Allergy. Clin. Immunol, 132, 328, 10.1016/j.jaci.2013.03.003
Kozin, 2010, Recruitment of myeloid but not endothelial precursor cells facilitates tumor regrowth after local irradiation, Cancer Res, 70, 5679, 10.1158/0008-5472.CAN-09-4446
Kurahara, 2011, Significance of M2-polarized tumor-associated macrophage in pancreatic cancer, J. Surg. Res, 167, e211, 10.1016/j.jss.2009.05.026
Kurahara, 2013, M2-polarized tumor-associated macrophage infiltration of regional lymph nodes is associated with nodal lymphangiogenesis and occult nodal involvement in pN0 pancreatic cancer, Pancreas, 42, 155, 10.1097/MPA.0b013e318254f2d1
Kwon, 2013, Mechanism of pro-tumorigenic effect of BMP-6: neovascularization involving tumor-associated macrophages and IL-1alpha, Prostate, 74, 121, 10.1002/pros.22734
Kzhyshkowska, 2010, Multifunctional receptor stabilin-1 in homeostasis and disease, ScientificWorldJournal, 10, 2039, 10.1100/tsw.2010.189
Kzhyshkowska, 2006b, Stabilin-1, a homeostatic scavenger receptor with multiple functions, J. Cell. Mol. Med, 10, 635, 10.1111/j.1582-4934.2006.tb00425.x
Kzhyshkowska, 2009, Cross-talk between endocytic clearance and secretion in macrophages, Immunobiology, 214, 576, 10.1016/j.imbio.2009.03.007
Kzhyshkowska, 2007, Human chitinases and chitinase-like proteins as indicators for inflammation and cancer, Biomark. Insights, 2, 128, 10.1177/117727190700200023
Kzhyshkowska, 2006c, Novel stabilin-1 interacting chitinase-like protein (SI-CLP) is up-regulated in alternatively activated macrophages and secreted via lysosomal pathway, Blood, 107, 3221, 10.1182/blood-2005-07-2843
Kzhyshkowska, 2006a, Novel function of alternatively activated macrophages: stabilin-1-mediated clearance of, SPARC, J. Immunol, 176, 5825, 10.4049/jimmunol.176.10.5825
Lambaerts, 2009, The signaling mechanisms of syndecan heparan sulfate proteoglycans, Curr. Opin. Cell Biol, 21, 662, 10.1016/j.ceb.2009.05.002
Laoui, 2013, Tumor hypoxia does not drive differentiation of tumor-associated macrophages but rather fine-tunes the M2-like macrophage population, Cancer Res, 74, 24, 10.1158/0008-5472.CAN-13-1196
Lee, 2005, Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors, J. Cell Biol, 169, 681, 10.1083/jcb.200409115
Leek, 1998, Association of tumour necrosis factor alpha and its receptors with thymidine phosphorylase expression in invasive breast carcinoma, Br. J. Cancer, 77, 2246, 10.1038/bjc.1998.373
Leek, 1996, Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma, Cancer Res, 56, 4625
Lewis, 2007, Tie2-expressing monocytes and tumor angiogenesis: regulation by hypoxia and angiopoietin-2, Cancer Res, 67, 8429, 10.1158/0008-5472.CAN-07-1684
Lewis, 2000, Expression of vascular endothelial growth factor by macrophages is up- regulated in poorly vascularized areas of breast carcinomas, J. Pathol, 192, 150, 10.1002/1096-9896(2000)9999:9999%3C::AID-PATH687%3E3.0.CO;2-G
Lin, 2006, Macrophages regulate the angiogenic switch in a mouse model of breast cancer, Cancer Res, 66, 11238, 10.1158/0008-5472.CAN-06-1278
Lohela, 2009, VEGFs and receptors involved in angiogenesis versus lymphangiogenesis, Curr. Opin. Cell Biol, 21, 154, 10.1016/j.ceb.2008.12.012
Ly, 2010, In aged mice, outgrowth of intraocular melanoma depends on proangiogenic M2-type macrophages, J. Immunol, 185, 3481, 10.4049/jimmunol.0903479
Mantovani, 1992, The origin and function of tumor-associated macrophages, Immunol. Today, 13, 265, 10.1016/0167-5699(92)90008-U
Mantovani, 2007, Inflammation and cancer: breast cancer as a prototype, Breast, 16, S27, 10.1016/j.breast.2007.07.013
Martens, 2006, Differential expression of a gene signature for scavenger/lectin receptors by endothelial cells and macrophages in human lymph node sinuses, the primary sites of regional metastasis, J. Pathol, 208, 574, 10.1002/path.1921
Matsubara, 2013, TIE2-expressing monocytes as a diagnostic marker for hepatocellular carcinoma correlates with angiogenesis, Hepatology, 57, 1416, 10.1002/hep.25965
Mazzieri, 2011, Targeting the ANG2/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells, Cancer Cell, 19, 512, 10.1016/j.ccr.2011.02.005
McColl, 2003, Plasmin activates the lymphangiogenic growth factors VEGF-C and VEGF-D, J. Exp. Med, 198, 863, 10.1084/jem.20030361
Medina, 2011, Myeloid angiogenic cells act as alternative M2 macrophages and modulate angiogenesis through interleukin-8, Mol. Med, 17, 1045, 10.2119/molmed.2011.00129
Mistrangelo, 2013, A novel biomarker-based analysis reliably predicts nodal metastases in anal carcinoma: preliminary evidence of therapeutic impact, Colorectal Dis, 15, 1382, 10.1111/codi.12289
Moussai, 2011, The human cutaneous squamous cell carcinoma microenvironment is characterized by increased lymphatic density and enhanced expression of macrophage-derived VEGF-C, J. Invest. Dermatol, 131, 229, 10.1038/jid.2010.266
Nakamura, 2004, Inhibition of lymphangiogenesis-related properties of murine lymphatic endothelial cells and lymph node metastasis of lung cancer by the matrix metalloproteinase inhibitor MMI270, Cancer Sci, 95, 25, 10.1111/j.1349-7006.2004.tb03166.x
Nishie, 1999, Macrophage infiltration and heme oxygenase-1 expression correlate with angiogenesis in human gliomas, Clin. Cancer Res, 5, 1107
Nishikawa, 2003, gp38k (CHI3L1) is a novel adhesion and migration factor for vascular cells, Exp. Cell Res, 287, 79, 10.1016/S0014-4827(03)00069-7
Ohta, 2002, Monocyte chemoattractant protein-1 expression correlates with macrophage infiltration and tumor vascularity in human esophageal squamous cell carcinomas, Int. J. Cancer, 102, 220, 10.1002/ijc.10705
Ong, 2012, Macrophages in human colorectal cancer are pro-inflammatory and prime T cells towards an anti-tumour type-1 inflammatory response, Eur. J. Immunol, 42, 89, 10.1002/eji.201141825
Piao, 2005, Involvement of urokinase-type plasminogen activator in sphingosylphosphorylcholine-induced angiogenesis, Exp. Dermatol, 14, 356, 10.1111/j.0906-6705.2005.00272.x
Pucci, 2009, A distinguishing gene signature shared by tumor-infiltrating Tie2-expressing monocytes, blood “resident†monocytes, and embryonic macrophages suggests common functions and developmental relationships, Blood, 114, 901, 10.1182/blood-2009-01-200931
Qian, 2010, Macrophage diversity enhances tumor progression and metastasis, Cell, 141, 39, 10.1016/j.cell.2010.03.014
Ran, 2012, Macrophage-Mediated Lymphangiogenesis: the emerging role of macrophages as lymphatic endothelial progenitors, Cancers (Basel), 4, 618, 10.3390/cancers4030618
Rego, 2013, Breast tumor cell TACE-shed MCSF promotes pro-angiogenic macrophages through NF-kappaB signaling, Angiogenesis, 10.1007/s10456-013-9405-2
Roberts, 2006, Inhibition of VEGFR-3 activation with the antagonistic antibody more potently suppresses lymph node and distant metastases than inactivation of VEGFR-2, Cancer Res, 66, 2650, 10.1158/0008-5472.CAN-05-1843
Roda, 2012, Stabilization of HIF-2alpha induces sVEGFR-1 production from tumor-associated macrophages and decreases tumor growth in a murine melanoma model, J. Immunol, 189, 3168, 10.4049/jimmunol.1103817
Rolny, 2011, HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF, Cancer Cell, 19, 31, 10.1016/j.ccr.2010.11.009
Roslind, 2008, YKL-40 protein expression is not a prognostic marker in patients with primary breast cancer, Breast Cancer Res. Treat, 112, 275, 10.1007/s10549-007-9870-7
Scavelli, 2004, Crosstalk between angiogenesis and lymphangiogenesis in tumor progression, Leukemia, 18, 1054, 10.1038/sj.leu.2403355
Schledzewski, 2006, Lymphatic endothelium-specific hyaluronan receptor LYVE-1 is expressed by stabilin-1(+), F4/80(+), CD11b(+) macrophages in malignant tumours and wound healing tissue in vivo and in bone marrow cultures in vitro: implications for the assessment of lymphangiogenesis, J. Pathol, 209, 67, 10.1002/path.1942
Schoppmann, 2002, Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis, Am. J. Pathol, 161, 947, 10.1016/S0002-9440(10)64255-1
Schoppmann, 2006, VEGF-C expressing tumor-associated macrophages in lymph node positive breast cancer: impact on lymphangiogenesis and survival, Surgery, 139, 839, 10.1016/j.surg.2005.12.008
Shao, 2013, YKL-40 acts as an angiogenic factor to promote tumor angiogenesis, Front. Physiol, 4, 10.3389/fphys.2013.00122
Shao, 2011, Breast cancer expression of YKL-40 correlates with tumour grade, poor differentiation, and other cancer markers, Br. J. Cancer, 105, 1203, 10.1038/bjc.2011.347
Shao, 2009, YKL-40, a secreted glycoprotein, promotes tumor angiogenesis, Oncogene, 28, 4456, 10.1038/onc.2009.292
Shieh, 2009, Tumor-associated macrophage correlated with angiogenesis and progression of mucoepidermoid carcinoma of salivary glands, Ann. Surg. Oncol, 16, 751, 10.1245/s10434-008-0259-6
Sica, 2012, Macrophage plasticity and polarization: in vivo veritas, J. Clin. Invest, 122, 787, 10.1172/JCI59643
Sierra, 2008, Tumor angiogenesis and progression are enhanced by Sema4D produced by tumor-associated macrophages, J. Exp. Med, 205, 1673, 10.1084/jem.20072602
Skobe, 2001b, Concurrent induction of lymphangiogenesis, angiogenesis, and macrophage recruitment by vascular endothelial growth factor-C in melanoma, Am. J. Pathol, 159, 893, 10.1016/S0002-9440(10)61765-8
Skobe, 2001a, Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis, Nat. Med, 7, 192, 10.1038/84643
Song, 2013, Lenalidomide inhibits lymphangiogenesis in preclinical models of mantle cell lymphoma, Cancer Res, 73, 7254, 10.1158/0008-5472.CAN-13-0750
Stacker, 1999, Biosynthesis of vascular endothelial growth factor-D involves proteolytic processing which generates non-covalent homodimers, J. Biol. Chem, 274, 32127, 10.1074/jbc.274.45.32127
Staples, 2011, Monocyte-derived macrophages matured under prolonged hypoxia transcriptionally up-regulate HIF-1alpha mRNA, Immunobiology, 216, 832, 10.1016/j.imbio.2010.12.005
Storr, 2012, Objective assessment of blood and lymphatic vessel invasion and association with macrophage infiltration in cutaneous melanoma, Mod. Pathol, 25, 493, 10.1038/modpathol.2011.182
Stout, 2004, Functional plasticity of macrophages: reversible adaptation to changing microenvironments, J. Leukoc. Biol, 76, 509, 10.1189/jlb.0504272
Stout, 2009, Functional plasticity of macrophages: in situ reprogramming of tumor-associated macrophages, J. Leukoc. Biol, 86, 1105, 10.1189/jlb.0209073
Takanami, 1999, Tumor-associated macrophage infiltration in pulmonary adenocarcinoma: association with angiogenesis and poor prognosis, Oncology, 57, 138, 10.1159/000012021
Takao, 1998, Expression of thymidine phosphorylase is associated with a poor prognosis in patients with ductal adenocarcinoma of the pancreas, Clin. Cancer Res, 4, 1619
Tammela, 2008, Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation, Nature, 454, 656, 10.1038/nature07083
Tjiu, 2009, Tumor-associated macrophage-induced invasion and angiogenesis of human basal cell carcinoma cells by cyclooxygenase-2 induction, J. Invest. Dermatol, 129, 1016, 10.1038/jid.2008.310
Toi, 1999, Significance of thymidine phosphorylase as a marker of protumor monocytes in breast cancer, Clin. Cancer Res, 5, 1131
Torisu, 2000, Macrophage infiltration correlates with tumor stage and angiogenesis in human malignant melanoma: possible involvement of TNFalpha and IL-1alpha, Int. J. Cancer, 85, 182, 10.1002/(SICI)1097-0215(20000115)85:2%3C182::AID-IJC6%3E3.3.CO;2-D
Vacca, 1999, Angiogenesis extent and macrophage density increase simultaneously with pathological progression in B-cell non-Hodgkin's lymphomas, Br. J. Cancer, 79, 965, 10.1038/sj.bjc.6690154
Valkovic, 2002, Correlation between vascular endothelial growth factor, angiogenesis, and tumor-associated macrophages in invasive ductal breast carcinoma, Virchows Arch, 440, 583, 10.1007/s004280100458
Wang, 2008, YKL-40 a new biomarker in patients with acute coronary syndrome or stable coronary artery disease, Scand. Cardiovasc. J, 42, 295, 10.1080/14017430802220567
Welford, 2011, TIE2-expressing macrophages limit the therapeutic efficacy of the vascular-disrupting agent combretastatin A4 phosphate in mice, J. Clin. Invest, 121, 1969, 10.1172/JCI44562
Werchau, 2012, Merkel cell carcinoma induces lymphatic microvessel formation, J. Am. Acad. Dermatol, 67, 215, 10.1016/j.jaad.2011.09.002
Werno, 2010, Knockout of HIF-1alpha in tumor-associated macrophages enhances M2 polarization and attenuates their pro-angiogenic responses, Carcinogenesis, 31, 1863, 10.1093/carcin/bgq088
Whitehurst, 2007, Anti-VEGF-A therapy reduces lymphatic vessel density and expression of VEGFR-3 in an orthotopic breast tumor model, Int. J. Cancer, 121, 2181, 10.1002/ijc.22937
Wu, 2012, Tumor-associated macrophages promote angiogenesis and lymphangiogenesis of gastric cancer, J. Surg. Oncol, 106, 462, 10.1002/jso.23110
Wyckoff, 2004, A paracrine loop between tumor cells and macrophages is required for tumor cell migration in mammary tumors, Cancer Res, 64, 7022, 10.1158/0008-5472.CAN-04-1449
Xu, 2013, CSF1R signaling blockade stanches tumor-infiltrating myeloid cells and improves the efficacy of radiotherapy in prostate cancer, Cancer Res, 73, 2782, 10.1158/0008-5472.CAN-12-3981
Yamac, 2008, Serum YKL-40 levels as a prognostic factor in patients with locally advanced breast cancer, Adv. Ther, 25, 801, 10.1007/s12325-008-0082-2
Yang, 2011, Soluble vascular endothelial growth factor receptor-3 suppresses lymphangiogenesis and lymphatic metastasis in bladder cancer, Mol. Cancer, 10, 36, 10.1186/1476-4598-10-36
Yao, 2005, Autocrine and paracrine regulation of interleukin-8 expression in lung cancer cells, Am. J. Respir. Cell Mol. Biol, 32, 540, 10.1165/rcmb.2004-0223OC
Yao, 2001, Macrophage infiltration-associated thymidine phosphorylase expression correlates with increased microvessel density and poor prognosis in astrocytic tumors, Clin. Cancer Res, 7, 4021
Zhang, 2011b, M2-polarized tumor-associated macrophages are associated with poor prognoses resulting from accelerated lymphangiogenesis in lung adenocarcinoma, Clinics (Sao. Paulo), 66, 1879, 10.1590/S1807-59322011001100006
Zhang, 2012b, M2-polarized macrophages promote metastatic behavior of Lewis lung carcinoma cells by inducing vascular endothelial growth factor-C expression, Clinics (Sao. Paulo), 67, 901, 10.6061/clinics/2012(08)08
Zhang, 2012a, Secreted protein acidic and rich in cysteine (SPARC) suppresses angiogenesis by down-regulating the expression of VEGF and MMP-7 in gastric cancer, PLoS ONE, 7, e44618, 10.1371/journal.pone.0044618
Zhang, 2011a, Survey of risk factors contributed to lymphatic metastasis in patients with oral tongue cancer by immunohistochemistry, J. Oral Pathol. Med, 40, 127, 10.1111/j.1600-0714.2010.00953.x