Role of the LKB1/AMPK pathway in tumor invasion and metastasis of cancer cells (Review)
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Resta, 2013, Cancer risk associated with STK11/LKB1 germline mutations in Peutz-Jeghers syndrome patients: Results of an Italian multi-center study, Dig Liver Dis, 45, 606, 10.1016/j.dld.2012.12.018
Chen, 2012, Mutation screening of LKB1 gene in familial Peutz-Jeghers syndrome patients, Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 29, 121
Fang, 2014, Integrative genomic analysis reveals a high frequency of LKB1 genetic alteration in Chinese lung adenocarcinomas, J Thorac Oncol, 9, 254, 10.1097/JTO.0000000000000056
Loi, 2013, Somatic mutation profiling and associations with prognosis and trastuzumab benefit in early breast cancer, J Natl Cancer Inst, 105, 960, 10.1093/jnci/djt121
Avizienyte, 1998, Somatic mutations in LKB1 are rare in sporadic colorectal and testicular tumors, Cancer Res, 58, 2087
Veleva-Rotse, 2014, STRAD pseudokinases regulate axogenesis and LKB1 stability, Neural Dev, 9, 5, 10.1186/1749-8104-9-5
Zeqiraj, 2009, Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation, Science, 326, 1707, 10.1126/science.1178377
Mirouse, 2013, LKB1 and AMPK maintain epithelial cell polarity under energetic stress, J Cell Biol, 203, 373, 10.1083/jcb.20070205310112013r
Dahmani, 2015, A novel LKB1 isoform enhances AMPK metabolic activity and displays oncogenic properties, Oncogene, 34, 2337, 10.1038/onc.2014.182
Partanen, 2013, Breaking the epithelial polarity barrier in cancer: The strange case of LKB1/PAR-4, Philos Trans R Soc Lond B Biol Sci, 368, 20130111, 10.1098/rstb.2013.0111
Li, 2014, Loss of LKB1 disrupts breast epithelial cell polarity and promotes breast cancer metastasis and invasion, J Exp Clin Cancer Res, 33, 70, 10.1186/s13046-014-0070-0
Liang, 2014, Exogenous activation of LKB1/AMPK signaling induces G1 arrest in cells with endogenous LKB1 expression, Mol Med Rep, 9, 1019, 10.3892/mmr.2014.1916
Luo, 2013, ATM and LKB1 dependent activation of AMPK sensitizes cancer cells to etoposide-induced apoptosis, Cancer Lett, 328, 114, 10.1016/j.canlet.2012.08.034
Hardie, 2013, LKB1 and AMPK and the cancer-metabolism link - ten years after, BMC Biol, 11, 36, 10.1186/1741-7007-11-36
Gormand, 2011, Regulation of AMP-activated protein kinase by LKB1 and CaMKK in adipocytes, J Cell Biochem, 112, 1364, 10.1002/jcb.23053
Hardie, 2013, The LKB1-AMPK pathway-friend or foe in cancer?, Cancer Cell, 23, 131, 10.1016/j.ccr.2013.01.009
Hardie, 2012, AMP-activated protein kinase: A target for drugs both ancient and modern, Chem Biol, 19, 1222, 10.1016/j.chembiol.2012.08.019
Rena, 2013, Molecular mechanism of action of metformin: Old or new insights?, Diabetologia, 56, 1898, 10.1007/s00125-013-2991-0
Mihaylova, 2011, The AMPK signalling pathway coordinates cell growth, autophagy and metabolism, Nat Cell Biol, 13, 1016, 10.1038/ncb2329
Carling, 2011, AMP-activated protein kinase: Nature's energy sensor, Nat Chem Biol, 7, 512, 10.1038/nchembio.610
Lu, 2015, The Warburg effect in tumor progression: Mitochondrial oxidative metabolism as an anti-metastasis mechanism, Cancer Lett, 356, 156, 10.1016/j.canlet.2014.04.001
Faubert, 2013, AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo, Cell Metab, 17, 113, 10.1016/j.cmet.2012.12.001
Teng, 2013, AMP kinase activation improves angiogenesis in pulmonary artery endothelial cells with in utero pulmonary hypertension, Am J Physiol Lung Cell Mol Physiol, 304, L29, 10.1152/ajplung.00200.2012
Rattan, 2005, 5-Aminoimida-zole-4-carboxamide-1-beta-D-ribofuranoside inhibits cancer cell proliferation in vitro and in vivo via AMP-activated protein kinase, J Biol Chem, 280, 39582, 10.1074/jbc.M507443200
van Veelen, 2011, The long and winding road to rational treatment of cancer associated with LKB1/AMPK/TSC/mTORC1 signaling, Oncogene, 30, 2289, 10.1038/onc.2010.630
Dunlop, 2014, mTOR and autophagy: A dynamic relationship governed by nutrients and energy, Semin Cell Dev Biol, 36, 121, 10.1016/j.semcdb.2014.08.006
Shang, 2011, AMPK and mTOR coordinate the regulation of Ulk1 and mammalian autophagy initiation, Autophagy, 7, 924, 10.4161/auto.7.8.15860
Mack, 2012, AMPK-dependent phosphorylation of ULK1 regulates ATG9 localization, Autophagy, 8, 1197, 10.4161/auto.20586
Fenouille, 2012, The epithelial-mesenchymal transition (EMT) regulatory factor SLUG (SNAI2) is a downstream target of SPARC and AKT in promoting melanoma cell invasion, PLoS One, 7, e40378, 10.1371/journal.pone.0040378
Wong, 2013, Matricellular proteins: Priming the tumour microenvironment for cancer development and metastasis, Br J Cancer, 108, 755, 10.1038/bjc.2012.592
Xiang, 2015, Hepatocyte nuclear factor 4 alpha promotes the invasion, metastasis and angiogenesis of neuroblastoma cells via targeting matrix metalloproteinase 14, Cancer Lett, 359, 187, 10.1016/j.canlet.2015.01.008
Magee, 2014, Daidzein, R-(+)equol and S-(−)equol inhibit the invasion of MDA-MB-231 breast cancer cells potentially via the down-regulation of matrix metalloproteinase-2, Eur J Nutr, 53, 345, 10.1007/s00394-013-0520-z
Merdad, 2014, Expression of matrix metalloproteinases (MMPs) in primary human breast cancer: MMP-9 as a potential biomarker for cancer invasion and metastasis, Anticancer Res, 34, 1355
Jiang, 2014, Blocking PI3K/Akt signaling attenuates metastasis of nasopharyngeal carcinoma cells through induction of mesenchymal-epithelial reverting transition, Oncol Rep, 32, 559, 10.3892/or.2014.3220
Son, 2010, Epithelial-mesenchymal transition and cell invasion, Toxicol Res, 26, 245, 10.5487/TR.2010.26.4.245
Wang, 2011, Epithelial-mesenchymal transition in breast cancer progression and metastasis, Chin J Cancer, 30, 603, 10.5732/cjc.011.10226
May, 2011, Epithelial-mesenchymal transition and cancer stem cells: A dangerously dynamic duo in breast cancer progression, Breast Cancer Res, 13, 202, 10.1186/bcr2789
Xu, 2009, TGF-beta-induced epithelial to mesenchymal transition, Cell Res, 19, 156, 10.1038/cr.2009.5
Weiss, 2013, The TGFbeta superfamily signaling pathway, Wiley Interdiscip Rev Dev Biol, 2, 47, 10.1002/wdev.86
Katsuno, 2013, TGF-β signaling and epithelial-mesenchymal transition in cancer progression, Curr Opin Oncol, 25, 76, 10.1097/CCO.0b013e32835b6371
Porsch, 2013, Efficient TGFβ-induced epithelial-mesenchymal transition depends on hyaluronan synthase HAS2, Oncogene, 32, 4355, 10.1038/onc.2012.475
Wiercinska, 2011, The TGF-β/Smad pathway induces breast cancer cell invasion through the up-regulation of matrix metal-loproteinase 2 and 9 in a spheroid invasion model system, Breast Cancer Res Treat, 128, 657, 10.1007/s10549-010-1147-x
Lamouille, 2007, Cell size and invasion in TGF-beta-induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway, J Cell Biol, 178, 437, 10.1083/jcb.200611146
Lamouille, 2012, TGF-β-induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion, J Cell Sci, 125, 1259, 10.1242/jcs.095299
Thakur, 2014, TGFβ-induced invasion of prostate cancer cells is promoted by c-Jun-dependent transcriptional activation of Snail1, Cell Cycle, 13, 2400, 10.4161/cc.29339
Saini, 2013, Targeting the PI3K/AKT/mTOR and Raf/MEK/ERK pathways in the treatment of breast cancer, Cancer Treat Rev, 39, 935, 10.1016/j.ctrv.2013.03.009
Yeh, 2012, Antimetastatic effects of norcantharidin on hepatocellular carcinoma by transcriptional inhibition of MMP-9 through modulation of NF-κB activity, PLoS One, 7, e31055, 10.1371/journal.pone.0031055
Zhang, 2014, S100A4 promotes squamous cell laryngeal cancer Hep-2 cell invasion via NF-κB/MMP-9 signal, Eur Rev Med Pharmacol Sci, 18, 1361
Lu, 2012, Hedgehog signaling pathway mediates invasion and metastasis of hepatocellular carcinoma via ERK pathway, Acta Pharmacol Sin, 33, 691, 10.1038/aps.2012.24
Setia, 2014, Upregulation of MAPK/Erk and PI3K/Akt pathways in ulcerative colitis-associated colon cancer, Biomed Pharmacother, 68, 1023, 10.1016/j.biopha.2014.09.006
Arechederra, 2015, p38 MAPK down-regulates fibulin 3 expression through methylation of gene regulatory sequences: Role in migration and invasion, J Biol Chem, 290, 4383, 10.1074/jbc.M114.582239
Chen, 2014, Fibulin-3 suppresses Wnt/β-catenin signaling and lung cancer invasion, Carcinogenesis, 35, 1707, 10.1093/carcin/bgu023
Liu, 2014, KIF3a promotes proliferation and invasion via Wnt signaling in advanced prostate cancer, Mol Cancer Res, 12, 491, 10.1158/1541-7786.MCR-13-0418
Wu, 2013, Identifying the regulative role of NF-κB binding sites within promoter region of human matrix metalloproteinase 9 (mmp-9) by TNF-α induction, Appl Biochem Biotechnol, 169, 438, 10.1007/s12010-012-9958-3
Oue, 2013, Hedgehog signal inhibitors suppress the invasion of human rhabdomyosarcoma cells, Pediatr Surg Int, 29, 1153, 10.1007/s00383-013-3369-6
Goodwin, 2014, An AMPK-independent signaling pathway downstream of the LKB1 tumor suppressor controls Snail1 and metastatic potential, Mol Cell, 55, 436, 10.1016/j.molcel.2014.06.021
Roy, 2010, Involvement of LKB1 in epithelial-mesenchymal transition (EMT) of human lung cancer cells, Lung Cancer, 70, 136, 10.1016/j.lungcan.2010.02.004
Shorning, 2011, Lkb1 and Pten synergise to suppress mTOR-mediated tumorigenesis and epithelial-mesenchymal transition in the mouse bladder, PLoS One, 6, e16209, 10.1371/journal.pone.0016209
Kim, 2011, Activation of AMP-activated protein kinase is essential for lysophosphatidic acid-induced cell migration in ovarian cancer cells, J Biol Chem, 286, 24036, 10.1074/jbc.M110.209908
Cerezo, 2013, Metformin blocks melanoma invasion and metastasis development in AMPK/p53-dependent manner, Mol Cancer Ther, 12, 1605, 10.1158/1535-7163.MCT-12-1226-T
Esfahanian, 2012, Effect of metformin on the proliferation, migration, and MMP-2 and -9 expression of human umbilical vein endothelial cells, Mol Med Rep, 5, 1068, 10.3892/mmr.2012.753
Hsu, 2013, AMP-activated protein kinase activation mediates CCL3-induced cell migration and matrix metalloproteinase-2 expression in human chondrosarcoma, Cell Commun Signal, 11, 68, 10.1186/1478-811X-11-68
Kim, 2012, Berberine-induced AMPK activation inhibits the metastatic potential of melanoma cells via reduction of ERK activity and COX-2 protein expression, Biochem Pharmacol, 83, 385, 10.1016/j.bcp.2011.11.008
Chou, 2014, AMPK reverses the mesenchymal phenotype of cancer cells by targeting the Akt-MDM2-Foxo3a signaling axis, Cancer Res, 74, 4783, 10.1158/0008-5472.CAN-14-0135
Choudhury, 2014, AMP-activated protein kinase (AMPK) as a potential therapeutic target independent of PI3K/Akt signaling in prostate cancer, Oncoscience, 1, 446, 10.18632/oncoscience.49
Petursson, 2013, Linked decreases in liver kinase B1 and AMP-activated protein kinase activity modulate matrix catabolic responses to biomechanical injury in chondrocytes, Arthritis Res Ther, 15, R77, 10.1186/ar4254
Ramnanan, 2010, The regulation of AMPK signaling in a natural state of profound metabolic rate depression, Mol Cell Biochem, 335, 91, 10.1007/s11010-009-0246-7
Lee, 2013, AMP-activated protein kinase inhibits TGF-β-, angiotensin II-, aldosterone-, high glucose-, and albumin-induced epithelial-mesenchymal transition, Am J Physiol Renal Physiol, 304, F686, 10.1152/ajprenal.00148.2012
Lim, 2012, AMP-activated protein kinase inhibits TGF-β-induced fibrogenic responses of hepatic stellate cells by targeting transcriptional coactivator p300, J Cell Physiol, 227, 1081, 10.1002/jcp.22824
Goncharova, 2014, Folliculin controls lung alveolar enlargement and epithelial cell survival through E-cadherin, LKB1, and AMPK, Cell Reports, 7, 412, 10.1016/j.celrep.2014.03.025
Zhou, 2011, LITAF and TNFSF15, two downstream targets of AMPK, exert inhibitory effects on tumor growth, Oncogene, 30, 1892, 10.1038/onc.2010.575
Queiroz, 2014, Metformin induces apoptosis and cell cycle arrest mediated by oxidative stress, AMPK and FOXO3a in MCF-7 breast cancer cells, PLoS One, 9, e98207, 10.1371/journal.pone.0098207
Zhou, 2009, Inactivation of AMPK alters gene expression and promotes growth of prostate cancer cells, Oncogene, 28, 1993, 10.1038/onc.2009.63
Lee, 2014, Capsaicin suppresses the migration of cholangiocarcinoma cells by down-regulating matrix metalloproteinase-9 expression via the AMPK-NF-κB signaling pathway, Clin Exp Metastasis, 31, 897, 10.1007/s10585-014-9678-x
Wu, 2012, Acrp30 inhibits leptin-induced metastasis by downregulating the JAK/STAT3 pathway via AMPK activation in aggressive SPEC-2 endometrial cancer cells, Oncol Rep, 27, 1488
Park, 2014, The involvement of AMPK/GSK3-beta signals in the control of metastasis and proliferation in hepatocarcinoma cells treated with anthocyanins extracted from Korea wild berry Meoru, BMC Complement Altern Med, 14, 109, 10.1186/1472-6882-14-109
Suzuki, 2004, ARK5 is a tumor invasion-associated factor downstream of Akt signaling, Mol Cell Biol, 24, 3526, 10.1128/MCB.24.8.3526-3535.2004