Role of apoptosis in HIV disease pathogenesis

Springer Science and Business Media LLC - Tập 15 - Trang 217-231 - 1995
Naoki Oyaizu1, Savita Pahwa1
1The Department of Pediatrics, North Shore University Hospital-Cornell University Medical College, Manhasset, New York

Tóm tắt

After approximately one and a half decades of intensive studies, the exact mechanisms to explain HIV-mediated cytopathicity are still enigmatic and need closer scrutiny. There has been a dichotomy between virological and immunological viewpoints in understanding HIV-mediated cytopathicity, the former emphasizing a killing of infected cells by HIV-1 and the latter emphasizing indirect mechanisms wherein HIV or its soluble component(s) alter CD4 T-cell function and induce susceptibility to apoptosis. Accumulating evidence points to the notion that apoptosis might be a major contributor to the depletion of CD4 T-cells in HIV infection. This review summarizes current information about the regulatory mechanisms of T-cell apoptosis and the role of apoptosis in HIV pathogenesis with the goal of providing an integrated view of HIV cytopathicity.

Tài liệu tham khảo

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