Vai trò của VEGFs trong các rối loạn chuyển hóa

Angiogenesis - Tập 23 - Trang 119-130 - 2019
M. di Somma1, M. Vliora1,2, E. Grillo1, B. Castro3, E. Dakou4, W. Schaafsma3, J. Vanparijs4, M. Corsini1, C. Ravelli1, E. Sakellariou2, S. Mitola1
1Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy
2FAME Laboratory, Department of Exercise Science, University of Thessaly, Trikala, Greece
3Histocell, S.L.Parque Tecnológico 801A, Derio, Spain
4Laboratory of Cell Genetics, Department of Biology, Faculty of Science and Bioengineering Sciences, Vrije Universiteit Brussel, Brussels, Belgium

Tóm tắt

Béo phì và các rối loạn chuyển hóa là những vấn đề sức khỏe công cộng quan trọng. Trong bài tổng quan này, vai trò của mạng lưới mạch máu và VEGF trong việc duy trì và bổ sung mô mỡ được thảo luận. Angiogenesis là một quá trình chủ chốt liên quan đến việc điều hòa sự cân bằng của các mô. sự rối loạn trong việc hình thành mạch máu mới có thể là yếu tố quyết định và góp phần vào sự khởi phát của một số tình trạng bệnh lý, bao gồm các rối loạn liên quan đến hội chứng chuyển hóa. Sự cân bằng của mô mỡ được điều chỉnh chặt chẽ bởi mạng lưới mạch máu. Các mạch máu hỗ trợ cấu trúc của mô mỡ. Mạng lưới mạch máu điều chỉnh sự cân bằng giữa các yếu tố điều hòa tích cực và tiêu cực. Trong mô mỡ trắng, yếu tố tăng trưởng nội mô mạch máu (VEGF) điều khiển các hoạt động chuyển hóa của tế bào chất béo, thúc đẩy sự chuyển đổi từ hình thái trắng sang hình thái be. Sự chuyển đổi này dẫn đến việc tăng cường tiêu thụ năng lượng. VEGF có tác động ngược lại đối với mô mỡ nâu, nơi mà VEGF tăng cung cấp oxy và cải thiện tiêu hao năng lượng, gây ra hiện tượng nhạt màu của các tế bào mỡ.

Từ khóa

#Béo phì #rối loạn chuyển hóa #mạng lưới mạch máu #VEGF #angiogenesis #hội chứng chuyển hóa

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