Role of Serotonin<sub>2A</sub> and Serotonin<sub>2B/2C</sub> Receptor Subtypes in the Control of Accumbal and Striatal Dopamine Release Elicited In Vivo by Dorsal Raphe Nucleus Electrical Stimulation

Journal of Neurochemistry - Tập 73 Số 3 - Trang 1033-1042 - 1999
Philippe De Deurwaerdère1, Umberto Spampinato1
1Laboratoire de Neuropsychobiologie des Désadaptations, UMR CNRS 5541-Université Victor Segalen Bordeaux 2, Bordeaux, France

Tóm tắt

Abstract : This study investigates, using in vivo microdialysis, the role of serotonin2A (5‐HT2A) and 5‐HT2B/2C receptors in the effect of dorsal raphe nucleus (DRN) electrical stimulation on dopamine (DA), 3,4‐dihydroxyphenylacetic acid (DOPAC), and 5‐hydroxyindoleacetic acid (5‐HIAA) extracellular levels monitored in the nucleus accumbens (NAC) and the striatum of halothane‐anesthetized rats. Following DRN stimulation (300 μA, 1 ms, 20 Hz, 15 min) DA release was enhanced in the NAC and reduced in the striatum. The 5‐HT2A antagonist SR 46349B (0.5 mg/kg) and the mixed 5‐HT2A/2B/2C antagonist ritanserin (0.63 mg/kg) significantly reduced the effect of DRN stimulation on DA release in the NAC but not in the striatum. DA responses to DRN stimulation were not affected by the 5‐HT2B/2C antagonist SB 206553 (5 mg/kg) in either region. None of these compounds was able to modify the enhancement of DOPAC and 5‐HIAA outflow induced by DRN stimulation in either the NAC or the striatum. Finally, in both brain regions basal DA release was significantly increased only by SB 206553. These results indicate that 5‐HT2A but not 5‐HT2B/2C receptors participate in the facilitatory control exerted by endogenous 5‐HT on accumbal DA release. Conversely, 5‐HT2B/2C receptors tonically inhibit basal DA release in both brain regions.

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Tài liệu tham khảo

10.1016/0028-3908(95)00138-7

Ashby C.H.J, 1996, Differential effect of the 5‐HT2B/2C receptor antagonist SB 200646 and the selective 5‐HT2A antagonist MDL 100907 on midbrain dopamine (DA) neurons in rats : an electrophysiological study., Soc. Neurosci. Abstr., 22, 1323

10.1002/ddr.430150107

10.1002/cne.901790311

10.1016/S0165-6147(00)88991-9

10.1016/0028-3908(94)00145-I

10.1002/(SICI)1098-2396(199607)23:3<125::AID-SYN1>3.3.CO;2-P

De Deurwaerdère P., 1998, Opposite change of in vivo dopamine release in the rat nucleus accumbens and striatum that follows electrical stimulation of dorsal raphe nucleus : role of 5‐HT3 receptors., J. Neurosci., 18, 6528, 10.1523/JNEUROSCI.18-16-06528.1998

10.1016/0006-8993(87)90683-4

Deutch A.Y., 1991, Mechanisms of action of atypical antipsychotic drugs. Implication for novel therapeutic strategies for schizophrenia., Schizophr. Res., 4, 21, 10.1016/0920-9964(91)90030-U

Dewey S.T., 1995, Serotonergic modulation of striatal dopamine measured with positron emission tomography (PET) and in vivo microdialysis., J. Neurosci., 15, 821, 10.1523/JNEUROSCI.15-01-00821.1995

Di Giovanni G., 1997, Selective blockade of serotonin2c receptors enhances mesostriatal and mesolimbic dopaminergic function. (Abstr.), Trends Neurosci., 20, 9

10.1016/S0028-3908(98)00014-8

Duxon M.S., 1995, Expression of 5‐HT2B receptor protein in the rat., Br. J. Pharmacol., 115, 105P

10.1002/(SICI)1096-9861(19970728)384:2<233::AID-CNE5>3.0.CO;2-2

10.1016/0306-4522(77)90120-8

10.1111/j.1476-5381.1995.tb13236.x

10.1016/0024-3205(94)00876-0

10.1016/0014-2999(94)90669-6

10.1111/j.1471-4159.1992.tb10975.x

10.1111/j.2042-7158.1980.tb12889.x

10.1176/ajp.153.4.466

10.1016/S0893-133X(98)00072-4

Kelland M.D., 1990, Serotonergic afferent regulation of the basic physiology and pharmacological responsiveness of nigrostriatal dopamine neurons., J. Pharmacol. Exp. Ther., 253, 803

10.1016/0361-9230(93)90121-Q

10.1111/j.1476-5381.1996.tb15208.x

10.1016/S0006-8993(98)00338-2

Lejeune F., 1997, Serotonin (5‐HT2C) receptors inhibit the activity of mesocortical and mesolimbic dopaminergic pathways : a combined dialysis and electrophysiological analysis., Soc. Neurosci. Abstr., 23, 975

Leysen J.E., 1985, Receptor‐binding properties in vitro and in vivo of ritanserin, a very potent and long acting serotonin S2 antagonist., Mol. Pharmacol., 27, 600

10.1007/BF02245006

10.1007/BF01277672

Meltzer H.Y., 1991, Effects of antipsychotic drugs on serotonin receptors., Pharmacol. Rev., 43, 587

10.1016/0306-4522(90)90330-7

10.1016/0306-4522(93)90241-7

10.1016/S0306-4522(96)00452-6

10.1016/0024-3205(90)90484-9

10.1113/jphysiol.1989.sp017786

OffordS.J.(1998)M100907 a highly selective 5‐HT2Aantagonist for treatment of schizophrenia : early indication of safety and clinical activity in schizophrenic patients (Abstr.) inXXIst Collegium Internationale Neuro‐Psychopharmacologicum Congress Glasgow PT10052. Cambridge University Press.

10.1007/BF02246453

PaxinosG.&WatsonC.(1986)The Rat Brain in Stereotaxic Coordinates 2nd edit. Academic Press Orlando.

10.1016/0006-8993(85)90857-1

10.1016/0024-3205(92)90423-M

10.1016/0006-8993(94)90495-2

10.1016/0169-328X(94)90223-2

10.1111/j.1476-5381.1995.tb16684.x

Prisco S., 1994, Serotonin‐dopamine interaction in the rat ventral tegmental area : an electrophysiological study in vivo., J. Pharmacol. Exp. Ther., 271, 83

10.1007/s002130050454

Rinaldi‐Carmona M., 1992, Biochemical and pharmacological properties of SR 46349B, a new potent and selective 5‐hydroxytryptamine2 receptor antagonist., J. Pharmacol. Exp. Ther., 262, 759

Schmidt C.J., 1996, Regional effects of MK‐801 on dopamine release : effects of competitive NMDA or 5‐HT2A antagonists receptor blockade., J. Pharmacol. Exp. Ther., 277, 1541

10.1016/0014-2999(92)90819-P

10.1016/0024-3205(95)00210-W

Schreiber R., 1995, 1‐(2,5‐Dimethoxy‐4‐iodophenyl)‐2‐aminopropane)‐induced head‐twitches in the rat are mediated by 5‐hydroxytryptamine (5‐HT)2A receptors : modulation by novel 5‐HT2A/C antagonists, D1 antagonists and 5‐HT1A agonists., J. Pharmacol. Exp. Ther., 273, 101

10.1111/j.1471-4159.1989.tb07319.x

Shi W., 1995, Ritanserin, a 5‐HT2A/2C antagonist, reverses direct dopamine agonist‐induced inhibition of midbrain dopamine neurons., J. Pharmacol. Exp. Ther., 274, 735

10.1016/0006-8993(89)90486-1

Sorensen S.M., 1993, Characterization of the 5‐HT2 receptor antagonist MDL 100,907 as a putative atypical antipsychotic : behavioral, electrophysiological and neurochemical studies., J. Pharmacol. Exp. Ther., 266, 684

10.1111/j.1471-4159.1985.tb04092.x

10.1002/cne.903340408

10.1016/0006-8993(94)91330-7

10.1016/S0006-8993(97)01267-5

10.1016/0014-2999(88)90110-0