Role of Prophylactic Antibiotics in Transperineal Prostate Biopsy: A Systematic Review and Meta-analysis

Johansen, 2020, Antibiotic resistance, hospitalizations, and mortality related to prostate biopsy: first report from the Norwegian Patient Registry, World J Urol, 38, 17, 10.1007/s00345-019-02837-0 Borghesi, 2017, Complications after systematic, random, and image-guided prostate biopsy, Eur Urol, 71, 353, 10.1016/j.eururo.2016.08.004 Liss, 2017, An update of the American Urological Association white paper on the prevention and treatment of the more common complications related to prostate biopsy, J Urol, 198, 329, 10.1016/j.juro.2017.01.103 Pradere, 2021, Nonantibiotic strategies for the prevention of infectious complications following prostate biopsy: a systematic review and meta-analysis, J Urol, 205, 653, 10.1097/JU.0000000000001399 Bennett, 2016, The global burden of major infectious complications following prostate biopsy, Epidemiol Infect, 144, 1784, 10.1017/S0950268815002885 Pilatz, 2021, European Association of Urology position paper on the prevention of infectious complications following prostate biopsy, Eur Urol, 79, 11, 10.1016/j.eururo.2020.10.019 Mottet, 2021, EAU-EANM-ESTRO-ESUR-SIOG guidelines on prostate cancer—2020 update. Part 1: screening, diagnosis, and local treatment with curative intent, Eur Urol, 79, 243, 10.1016/j.eururo.2020.09.042 Grummet, 2020, “TREXIT 2020”: why the time to abandon transrectal prostate biopsy starts now, Prostate Cancer Prostatic Dis, 23, 62, 10.1038/s41391-020-0204-8 Grummet, 2021, TREXIT is now: should we abandon the transrectal route for prostate biopsy?, Yes. Eur Urol Open Sci, 31, 14, 10.1016/j.euros.2021.06.009 Dimmen, 2012, Transperineal prostate biopsy detects significant cancer in patients with elevated prostate-specific antigen (PSA) levels and previous negative transrectal biopsies, BJU Int, 110, E69, 10.1111/j.1464-410X.2011.10759.x Gorin, 2020, Transperineal prostate biopsy with cognitive magnetic resonance imaging/biplanar ultrasound fusion: description of technique and early results, World J Urol, 38, 1943, 10.1007/s00345-019-02992-4 Jacewicz, 2021, Multicenter transperineal MRI-TRUS fusion guided outpatient clinic prostate biopsies under local anesthesia, Urol Oncol, 39, 10.1016/j.urolonc.2020.11.009 John JB, MacCormick A, MacDonagh R, Speakman MJ, Vennam R, Burns-Cox N. Complications following local anaesthetic transperineal prostate biopsies without antibiotic prophylaxis: an institution’s experience. J Clin Urol. In press. https://doi.org/10.1177/2051415820987661. Lopez, 2021, Local anaesthetic transperineal (LATP) prostate biopsy using a probe-mounted transperineal access system: a multicentre prospective outcome analysis, BJU Int, 128, 311, 10.1111/bju.15337 Liberati, 2009, The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration, BMJ, 339, 10.1136/bmj.b2700 AHRQ. Methods guide for effectiveness and comparative effectiveness reviews. AHRQ Publication No. 10(14)-EHC063-EF. Rockville, MD: Agency for Healthcare Research and Quality; 2014. Gunzel, 2021, Infection rate and complications after 621 transperineal MRI-TRUS fusion biopsies in local anesthesia without standard antibiotic prophylaxis, World J Urol, 39, 3861, 10.1007/s00345-021-03699-1 Patel, 2020, Testis-sparing surgery and scrotal violation for testicular masses suspicious for malignancy: a systematic review and meta-analysis, Urol Oncol, 38, 344, 10.1016/j.urolonc.2020.02.023 Asano, 2015, Continued administration of antithrombotic agents during transperineal prostate biopsy, Int Braz J Urol, 41, 116, 10.1590/S1677-5538.IBJU.2015.01.16 Baba, 2018, Assessment of antimicrobial prophylaxis in transperineal prostate biopsy: a single-center retrospective study of 485 cases, J Infect Chemother, 24, 637, 10.1016/j.jiac.2018.03.014 Babaei Jandaghi, 2016, Transperineal prostate core needle biopsy: a comparison of coaxial versus noncoaxial method in a randomised trial, Cardiovasc Intervent Radiol, 39, 1736, 10.1007/s00270-016-1437-8 Bass, 2017, Magnetic resonance imaging targeted transperineal prostate biopsy: a local anaesthetic approach, Prostate Cancer Prostatic Dis, 20, 311, 10.1038/pcan.2017.13 Bhatt, 2018, Patient experience after transperineal template prostate biopsy compared to prior transrectal ultrasound guided prostate biopsy, Cent European J Urol, 71, 43 Bigliocchi, 2007, Prostate cancer detection rate of transrectal ultrasonography, digital rectal examination, and prostate-specific antigen: results of a five-year study of 6- versus 12-core transperineal prostate biopsy, Minerva Urol Nefrol, 59 Bittner, 2015, Diagnostic performance of initial transperineal template-guided mapping biopsy of the prostate gland, Am J Clin Oncol, 38, 300, 10.1097/COC.0b013e31829a2954 Bittner, 2013, Incidence and pathological features of prostate cancer detected on transperineal template guided mapping biopsy after negative transrectal ultrasound guided biopsy, J Urol, 190, 509, 10.1016/j.juro.2013.02.021 Bott, 2006, Extensive transperineal template biopsies of prostate: modified technique and results, Urology, 68, 1037, 10.1016/j.urology.2006.05.033 Cerruto, 2014, Transrectal versus transperineal 14-core prostate biopsy in detection of prostate cancer: a comparative evaluation at the same institution, Arch Ital Urol Androl, 86, 284, 10.4081/aiua.2014.4.284 Chiu, 2021, Sectoral cancer detection and tolerability of freehand transperineal prostate biopsy under local anaesthesia, Prostate Cancer Prostatic Dis, 24, 431, 10.1038/s41391-020-00293-1 Cronin, 2017, Complications of transperineal template-guided prostate biopsy: a single centre experience in 109 cases, Surg Pract, 21, 103, 10.1111/1744-1633.12254 Danforth, 2012, Low incidence of prostate cancer identified in the transition and anterior zones with transperineal biopsy, Res Rep Urol, 4, 71 Demura, 2005, Differences in tumor core distribution between palpable and nonpalpable prostate tumors in patients diagnosed using extensive transperineal ultrasound-guided template prostate biopsy, Cancer, 103, 1826, 10.1002/cncr.21020 DiBianco, 2016, Ultrasound guided, freehand transperineal prostate biopsy: an alternative to the transrectal approach, Urol Pract, 3, 134, 10.1016/j.urpr.2015.05.007 Ding, 2021, Risk factors for infection complications after transrectal ultrasound-guided transperineal prostate biopsy, World J Urol, 39, 2463, 10.1007/s00345-020-03454-y Ekwueme, 2013, Transperineal template-guided saturation biopsy using a modified technique: outcome of 270 cases requiring repeat prostate biopsy, BJU Int, 111, E365, 10.1111/bju.12134 Eldred-Evans, 2016, The use of transperineal sector biopsy as a first-line biopsy strategy: a multi-institutional analysis of clinical outcomes and complications, Urol J, 13, 2849 Emiliozzi, 2001, The value of a single biopsy with 12 transperineal cores for detecting prostate cancer in patients with elevated prostate specific antigen, J Urol, 166, 845, 10.1016/S0022-5347(05)65849-1 Emiliozzi, 2004, The incidence of prostate cancer in men with prostate specific antigen greater than 4.0 ng/ml: a randomized study of 6 versus 12 core transperineal prostate biopsy, J Urol, 171, 197, 10.1097/01.ju.0000099824.73886.f3 Furuno, 2004, Difference of cancer core distribution between first and repeat biopsy: In patients diagnosed by extensive transperineal ultrasound guided template prostate biopsy, Prostate, 58, 76, 10.1002/pros.10298 Garcia Bennett, 2017, Evaluation of MR imaging-targeted biopsies of the prostate in biopsy-naive patients. A single centre study, Diagn Interv Imaging, 98, 677, 10.1016/j.diii.2017.06.010 Gershman, 2013, Transperineal template-guided prostate biopsy for patients with persistently elevated PSA and multiple prior negative biopsies, Urol Oncol, 31, 1093, 10.1016/j.urolonc.2012.01.001 Guo, 2017, TRUS-guided transperineal prostate 12+X core biopsy with template for the diagnosis of prostate cancer, Oncol Lett, 13, 4863, 10.3892/ol.2017.6051 Guo, 2015, Comparison between ultrasound guided transperineal and transrectal prostate biopsy: a prospective, randomized, and controlled trial, Sci Rep, 5, 16089, 10.1038/srep16089 Hadaschik, 2011, A novel stereotactic prostate biopsy system integrating pre-interventional magnetic resonance imaging and live ultrasound fusion, J Urol, 186, 2214, 10.1016/j.juro.2011.07.102 Hara, 2008, Optimal approach for prostate cancer detection as initial biopsy: prospective randomized study comparing transperineal versus transrectal systematic 12-core biopsy, Urology, 71, 191, 10.1016/j.urology.2007.09.029 Huang, 2019, Comparisons of cancer detection rate and complications between transrectal and transperineal prostate biopsy approaches—a single center preliminary study, BMC Urol, 19, 101, 10.1186/s12894-019-0539-4 Huang, 2016, Comparison of the complications of traditional 12 cores transrectal prostate biopsy with image fusion guided transperineal prostate biopsy, BMC Urol, 16, 68, 10.1186/s12894-016-0185-z Huang, 2015, Significant impact of transperineal template biopsy of the prostate at a single tertiary institution, Urol Ann, 7, 428, 10.4103/0974-7796.152052 Igel, 2001, Systematic transperineal ultrasound guided template biopsy of the prostate in patients at high risk, J Urol, 165, 1575, 10.1016/S0022-5347(05)66351-3 Iremashvili, 2010, Periprostatic local anesthesia with pudendal block for transperineal ultrasound-guided prostate biopsy: a randomized trial, Urology, 75, 1023, 10.1016/j.urology.2009.09.083 Klatte, 2013, Transperineal template-guided biopsy for diagnosis of prostate cancer in patients with at least two prior negative biopsies, Wien Klin Wochenschr, 125, 669, 10.1007/s00508-013-0421-4 Kum, 2020, Initial outcomes of local anaesthetic freehand transperineal prostate biopsies in the outpatient setting, BJU Int, 125, 244, 10.1111/bju.14620 Kum, 2019, Factors influencing urinary retention after transperineal template biopsy of the prostate: outcomes from a regional cancer centre, World J Urol, 37, 337, 10.1007/s00345-018-2390-8 Kuru, 2013, Critical evaluation of magnetic resonance imaging targeted, transrectal ultrasound guided transperineal fusion biopsy for detection of prostate cancer, J Urol, 190, 1380, 10.1016/j.juro.2013.04.043 Li, 2007, Transperineal ultrasound-guided saturation biopsies using 11-region template of prostate: report of 303 cases, Urology, 70, 1157, 10.1016/j.urology.2007.07.072 Lo, 2019, Outcomes of transperineal and transrectal ultrasound-guided prostate biopsy, Hong Kong Med J, 25, 209 Losa, 2013, Complications and quality of life after template-assisted transperineal prostate biopsy in patients eligible for focal therapy, Urology, 81, 1291, 10.1016/j.urology.2012.11.078 Mabjeesh, 2012, High detection rate of significant prostate tumours in anterior zones using transperineal ultrasound-guided template saturation biopsy, BJU Int, 110, 993, 10.1111/j.1464-410X.2012.10972.x Mai, 2016, Transperineal template-guided prostate biopsy: 10 years of experience, BJU Int, 117, 424, 10.1111/bju.13024 Marra, 2021, Transperineal freehand multiparametric MRI fusion targeted biopsies under local anaesthesia for prostate cancer diagnosis: a multicentre prospective study of 1014 cases, BJU Int, 127, 122, 10.1111/bju.15121 Martorana, 2015, Advantages of single-puncture transperineal saturation biopsy of prostate: analysis of outcomes in 125 patients using our scheme, Int Urol Nephrol, 47, 735, 10.1007/s11255-015-0967-3 Mehmood, 2017, Transperineal template-guided prostate saturation biopsies in men with suspicion of prostate cancer: a pilot study from Pakistan, Malays J Pathol, 39, 285 Merrick, 2017, Incidence, grade and distribution of prostate cancer following transperineal template-guided mapping biopsy in patients with atypical small acinar proliferation, World J Urol, 35, 1009, 10.1007/s00345-016-1976-2 Merrick, 2016, Pathology and quality of life outcomes following office-based transperineal prostate biopsy, Urology, 94, 24, 10.1016/j.urology.2016.04.020 Merrick, 2020, Active surveillance outcomes in prostate cancer patients: the use of transperineal template-guided mapping biopsy for patient selection, World J Urol, 38, 361, 10.1007/s00345-019-02695-w Meyer, 2018, Initial experience performing in-office ultrasound-guided transperineal prostate biopsy under local anesthesia using the PrecisionPoint transperineal access system, Urology, 115, 8, 10.1016/j.urology.2018.01.021 Miah, 2018, Patient reported outcome measures for transperineal template prostate mapping biopsies in the PICTURE study, J Urol, 200, 1235, 10.1016/j.juro.2018.06.033 Miah, 2020, A prospective analysis of robotic targeted MRI-US fusion prostate biopsy using the centroid targeting approach, J Robot Surg, 14, 69, 10.1007/s11701-019-00929-y Miller, 2005, Complications of transrectal versus transperineal prostate biopsy, ANZ J Surg, 75, 48, 10.1111/j.1445-2197.2005.03284.x Mischinger, 2018, Targeted vs systematic robot-assisted transperineal magnetic resonance imaging-transrectal ultrasonography fusion prostate biopsy, BJU Int, 121, 791, 10.1111/bju.14089 Muthuveloe, 2016, The detection and upgrade rates of prostate adenocarcinoma following transperineal template-guided prostate biopsy—a tertiary referral centre experience, Cent European J Urol, 69, 42 Nakai, 2017, Transperineal template-guided saturation biopsy aimed at sampling one core for each milliliter of prostate volume: 103 cases requiring repeat prostate biopsy, BMC Urol, 17, 28, 10.1186/s12894-017-0219-1 Namekawa, 2015, Prospective evaluation of the safety of transrectal ultrasound-guided transperineal prostate biopsy based on adverse events, Int J Clin Oncol, 20, 1185, 10.1007/s10147-015-0831-6 Novella, 2003, Pain assessment after original transperineal prostate biopsy using a coaxial needle, Urology, 62, 689, 10.1016/S0090-4295(03)00483-7 Pal, 2012, The role of a standardized 36 core template-assisted transperineal prostate biopsy technique in patients with previously negative transrectal ultrasonography-guided prostate biopsies, BJU Int, 109, 367, 10.1111/j.1464-410X.2011.10355.x Patel, 2020, Robotic-assisted magnetic resonance imaging ultrasound fusion results in higher significant cancer detection compared to cognitive prostate targeting in biopsy naive men, Transl Androl Urol, 9, 601, 10.21037/tau.2020.01.33 Pepdjonovic, 2017, Zero hospital admissions for infection after 577 transperineal prostate biopsies using single-dose cephazolin prophylaxis, World J Urol, 35, 1199, 10.1007/s00345-016-1985-1 Pepe, 2014, Prostate biopsy: results and advantages of the transperineal approach—twenty-year experience of a single center, World J Urol, 32, 373, 10.1007/s00345-013-1108-1 Pepe, 2016, Detection rate for significant cancer at confirmatory biopsy in men enrolled in Active Surveillance protocol: 20 cores vs 30 cores vs MRI/TRUS fusion prostate biopsy, Arch Ital Urol Androl, 88, 300, 10.4081/aiua.2016.4.300 Pepe, 2017, Confirmatory biopsy of men under active surveillance: extended versus saturation versus multiparametric magnetic resonance imaging/transrectal ultrasound fusion prostate biopsy, Scand J Urol, 51, 260, 10.1080/21681805.2017.1313310 Pepe, 2018, Is it time to perform only magnetic resonance imaging targeted cores? Our experience with 1,032 men who underwent prostate biopsy, J Urol, 200, 774, 10.1016/j.juro.2018.04.061 Pepe, 2017, Multiparametric MRI/TRUS fusion prostate biopsy: advantages of a transperineal approach, Anticancer Res, 37, 3291 Pepe, 2016, Erectile dysfunction in 1050 men following extended (18 cores) vs saturation (28 cores) vs saturation plus MRI-targeted prostate biopsy (32 cores), Int J Impot Res, 28, 1, 10.1038/ijir.2015.18 Pepe, 2015, Anterior prostate biopsy at initial and repeat evaluation: is it useful to detect significant prostate cancer?, Int Braz J Urol, 41, 844, 10.1590/S1677-5538.IBJU.2014.0234 Pepe, 2020, How many cores should be obtained during saturation biopsy in the era of multiparametric magnetic resonance? Experience in 875 patients submitted to repeat prostate biopsy, Urology, 137, 133, 10.1016/j.urology.2019.11.016 Pinkstaff, 2005, Systematic transperineal ultrasound-guided template biopsy of the prostate: three-year experience, Urology, 65, 735, 10.1016/j.urology.2004.10.067 Ristau, 2018, Free-hand transperineal prostate biopsy provides acceptable cancer detection and minimizes risk of infection: evolving experience with a 10-sector template, Urol Oncol, 36, 10.1016/j.urolonc.2018.09.013 Roberts, 2021, Transrectal versus transperineal prostate biopsy under intravenous anaesthesia: a clinical, microbiological and cost analysis of 2048 cases over 11 years at a tertiary institution, Prostate Cancer Prostatic Dis, 24, 169, 10.1038/s41391-020-0263-x Saito, 2017, Transperineal ultrasound-guided prostate biopsy is safe even when patients are on combination antiplatelet and/or anticoagulation therapy, BMC Urol, 17, 53, 10.1186/s12894-017-0245-z Salagierski, 2019, The role of a template-assisted cognitive transperineal prostate biopsy technique in patients with benign transrectal prostate biopsies: a preliminary experience, Cent European J Urol, 72, 15 Sigle, 2021, Safety and side effects of transperineal prostate biopsy without antibiotic prophylaxis, Urol Oncol, 39, 10.1016/j.urolonc.2021.02.016 Simmons, 2019, Prostate Imaging Compared to Transperineal Ultrasound-guided biopsy for significant prostate cancer Risk Evaluation (PICTURE): a prospective cohort validating study assessing Prostate HistoScanning, Prostate Cancer Prostatic Dis, 22, 261, 10.1038/s41391-018-0094-1 Singh, 2014, Prostate cancer tumour features on template prostate-mapping biopsies: implications for focal therapy, Eur Urol, 66, 12, 10.1016/j.eururo.2013.09.045 Sivaraman, 2015, Clinical utility of transperineal template-guided mapping biopsy of the prostate after negative magnetic resonance imaging-guided transrectal biopsy, Urol Oncol, 33, 10.1016/j.urolonc.2015.04.005 Smith, 2014, Transperineal sector prostate biopsies: a local anesthetic outpatient technique, Urology, 83, 1344, 10.1016/j.urology.2014.02.008 Song, 2019, The clinical utility of transperineal template-guided saturation prostate biopsy for risk stratification after transrectal ultrasound-guided biopsy, Investig Clin Urol, 60, 454, 10.4111/icu.2019.60.6.454 Stefanova, 2019, Transperineal prostate biopsies using local anesthesia: experience with 1,287 patients. prostate cancer detection rate, complications and patient tolerability, J Urol, 201, 1121, 10.1097/JU.0000000000000156 Suzuki, 2009, Safety of transperineal 14-core systematic prostate biopsy in diabetic men, Int J Urol, 16, 930, 10.1111/j.1442-2042.2009.02386.x Symons, 2013, Outcomes of transperineal template-guided prostate biopsy in 409 patients, BJU Int, 112, 585, 10.1111/j.1464-410X.2012.11657.x Szabo, 2021, Free-hand transperineal prostate biopsy under local anesthesia in the office without antibiotic prophylaxis: experience with 304 cases, J Endourol, 35, 518, 10.1089/end.2020.1086 Taira, 2013, Transperineal template-guided mapping biopsy as a staging procedure to select patients best suited for active surveillance, Am J Clin Oncol, 36, 116, 10.1097/COC.0b013e31823fe639 Taira, 2010, Performance of transperineal template-guided mapping biopsy in detecting prostate cancer in the initial and repeat biopsy setting, Prostate Cancer Prostatic Dis, 13, 71, 10.1038/pcan.2009.42 Takenaka, 2008, A prospective randomized comparison of diagnostic efficacy between transperineal and transrectal 12-core prostate biopsy, Prostate Cancer Prostatic Dis, 11, 134, 10.1038/sj.pcan.4500985 Thurtle, 2018, Improving the safety and tolerability of local anaesthetic outpatient transperineal prostate biopsies: a pilot study of the CAMbridge PROstate Biopsy (CAMPROBE) method, J Clin Urol, 11, 192, 10.1177/2051415818762683 Togo, 2014, Occurrence of infection following prostate biopsy procedures in Japan: Japanese Research Group for Urinary Tract Infection (JRGU)—a multi-center retrospective study, J Infect Chemother, 20, 232, 10.1016/j.jiac.2013.10.003 Tsivian, 2013, Short-term functional outcomes and complications associated with transperineal template prostate mapping biopsy, Urology, 82, 166, 10.1016/j.urology.2013.01.071 Voss, 2018, Utility of early transperineal template-guided prostate biopsy for risk stratification in men undergoing active surveillance for prostate cancer, BJU Int, 121, 863, 10.1111/bju.14100 Vyas, 2014, Indications, results and safety profile of transperineal sector biopsies (TPSB) of the prostate: a single centre experience of 634 cases, BJU Int, 114, 32, 10.1111/bju.12282 Wadhwa, 2017, Transperineal prostate biopsies for diagnosis of prostate cancer are well tolerated: a prospective study using patient-reported outcome measures, Asian J Androl, 19, 62, 10.4103/1008-682X.173453 Wajswol, 2020, A cohort of transperineal electromagnetically tracked magnetic resonance imaging/ultrasonography fusion-guided biopsy: assessing the impact of inter-reader variability on cancer detection, BJU Int, 125, 531, 10.1111/bju.14957 Wang, 2019, Surface-projection-based transperineal cognitive fusion targeted biopsy of the prostate: an original technique with a good cancer detection rate, BMC Urol, 19, 107, 10.1186/s12894-019-0535-8 Wegelin, 2019, Complications and adverse events of three magnetic resonance imaging-based target biopsy techniques in the diagnosis of prostate cancer among men with prior negative biopsies: results from the FUTURE trial, a multicentre randomised controlled trial, Eur Urol Oncol, 2, 617, 10.1016/j.euo.2019.08.007 Wetterauer, 2020, Feasibility of freehand MRI/US cognitive fusion transperineal biopsy of the prostate in local anaesthesia as in-office procedure-experience with 400 patients, Prostate Cancer Prostatic Dis, 23, 429, 10.1038/s41391-019-0201-y Yamamoto, 2005, Transperineal ultrasound-guided 12-core systematic biopsy of the prostate for patients with a prostate-specific antigen level of 2.5-20 ng/ml in Japan, Int J Clin Oncol, 10, 117, 10.1007/s10147-004-0464-7 Yang, 2020, Stereotactic robot-assisted transperineal prostate biopsy under local anaesthesia and sedation: moving robotic biopsy from operating theatre to clinic, J Robot Surg, 14, 767, 10.1007/s11701-020-01052-z Yazici, 2016, Predictors of prostate cancer in ultrasound-guided transperineal saturation biopsy in Turkish men with multiple prior negative biopsies, Urologia, 83, 71, 10.5301/uro.5000159 Young, 2019, A retrospective comparison of transrectal and transperineal prostate biopsies: experience of a single surgeon, J Endourol, 33, 498, 10.1089/end.2019.0170 Zhang, 2019, Evaluation of 24-core coaxial needle saturation biopsy of the prostate by the transperineal approach in detecting prostate cancer in patients without previous biopsy history: a single-center report, J Cancer Res Ther, 15, 380, 10.4103/jcrt.JCRT_384_18 Cohen, 2015, Fluoroquinolone resistance in the rectal carriage of men in an active surveillance cohort: longitudinal analysis, J Urol, 193, 552, 10.1016/j.juro.2014.08.008 Cook, 2015, Rectal swab testing before prostate biopsy: experience in a VA Medical Center urology practice, Prostate Cancer Prostatic Dis, 18, 365, 10.1038/pcan.2015.38 Adibi, 2012, Cost-effectiveness of standard vs intensive antibiotic regimens for transrectal ultrasonography (TRUS)-guided prostate biopsy prophylaxis, BJU Int, 110, E86, 10.1111/j.1464-410X.2011.10768.x Kuula, 2019, Fluoroquinolone-related adverse events resulting in health service use and costs: a systematic review, PLoS One, 14, 10.1371/journal.pone.0216029 Block M, Blanchard DL. Aminoglycosides. In: StatPearls [Internet]. Treasure Island, FL: StatPearls Publishing; 2021. https://www.ncbi.nlm.nih.gov/books/NBK541105/ Berger, 2004, Complication rate of transrectal ultrasound guided prostate biopsy: a comparison among 3 protocols with 6, 10 and 15 cores, J Urol, 171, 10.1097/01.ju.0000116449.01186.f7 Wagenlehner, 2013, Infective complications after prostate biopsy: outcome of the Global Prevalence Study of Infections in Urology (GPIU) 2010 and 2011, a prospective multinational multicentre prostate biopsy study, Eur Urol, 63, 521, 10.1016/j.eururo.2012.06.003 Roberts, 2017, Prostate biopsy-related infection: a systematic review of risk factors, prevention strategies, and management approaches, Urology, 104, 11, 10.1016/j.urology.2016.12.011 Carignan, 2012, Increasing risk of infectious complications after transrectal ultrasound-guided prostate biopsies: time to reassess antimicrobial prophylaxis?, Eur Urol, 62, 453, 10.1016/j.eururo.2012.04.044