Role of Neuroimmune Interactions in COVID-19-related Cardiovascular Damage

Springer Science and Business Media LLC - Tập 42 - Trang 555-560 - 2022
Xing Chen1, Wei-hua Qiao1, Hong Cao1, Jia-wei Shi1, Xin-ling Du1, Nian-guo Dong1
1Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Tóm tắt

Coronavirus disease 2019 (COVID-19) has caused a global pandemic impacting over 200 countries/regions and more than 200 million patients worldwide. Among the infected patients, there is a high prevalence of COVID-19-related cardiovascular injuries. However, the specific mechanisms linking cardiovascular damage and COVID-19 remain unclear. The COVID-19 pandemic also has exacerbated the mental health burden of humans. Considering the close association between neuroimmune interactions and cardiovascular disease, this review assessed the complex pathophysiological mechanisms connecting neuroimmune interactions and cardiovascular disease. It was revealed that the mental health burden might be a pivotal accomplice causing COVID-19-associated cardiovascular damage. Specifically, the proinflammatory status of patients with a terrible mood state is closely related to overdrive of the hypothalamus-pituitary-adrenal (HPA) axis, sympathovagal imbalance, and endothelial dysfunction, which lead to an increased risk of developing cardiovascular injury during COVID-19. Therefore, during the prevention and treatment of cardiovascular complications in COVID-19 patients, particular attention should be given to relieve the mental health burden of these patients.

Tài liệu tham khảo

Li YC, Bai WZ, Hashikawa T. The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients. J Med Virol, 2020,92(6):552–555 Liu Y, Yang Y, Zhang C, et al. Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury. Sci China Life Sci, 2020,63(3):364–674 Wang L, He W, Yu X, et al. Coronavirus disease 2019 in elderly patients: Characteristics and prognostic factors based on 4-week follow-up. J Infect, 2020,80(6):639–645 Cao Y, Li L, Feng Z, et al. Comparative genetic analysis of the novel coronavirus (2019-nCoV/SARS-CoV-2) receptor ACE2 in different populations. Cell Disc, 2020,6(1):11 Kumar S, Maurya VK, Prasad AK, et al. Structural, glycosylation and antigenic variation between 2019 novel coronavirus (2019-nCoV) and SARS coronavirus (SARS-CoV). Virusdisease, 2020,31(1):13–21 Xu H, Zhong L, Deng J, et al. High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa. Int J Oral Sci, 2020,12(1):8 South AM, Diz DI, Chappell MC. COVID-19, ACE2, and the cardiovascular consequences. Am J Physiol Heart Circ Physiol, 2020,318(5):H1084–H1090 Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet, 2020,395(10223):497–506 Liu B, Li M, Zhou Z, et al. Can we use interleukin-6 (IL-6) blockade for coronavirus disease 2019 (COVID-19)-induced cytokine release syndrome (CRS)? J Autoimmun, 2020,111:102452 Rizzo P, Vieceli Dalla Sega F, Fortini F, et al. COVID-19 in the heart and the lungs: could we “Notch” the inflammatory storm? Basic Res Cardiol, 2020,115(3):31 Tan W, Aboulhosn J. The cardiovascular burden of coronavirus disease 2019 (COVID-19) with a focus on congenital heart disease. Int J Cardiol, 2020,309:70–77 Santos CF. Reflections about the impact of the SARS-COV-2/COVID-19 pandemic on mental health. Braz J Psychiatry, 2020,42(3):329 Liang L, Ren H, Cao R, et al. The Effect of COVID-19 on Youth Mental Health. Psychiatr Quarterly, 2020,91 (3):841–852 Halaris A. Inflammation-Associated Co-morbidity Between Depression and Cardiovascular Disease. In: Dantzer R, Capuron L, eds. Inflammation-Associated Depression: Evidence, Mechanisms and Implications. Cham: Springer International Publishing, 2017:45–70. Kadoya M, Koyama H. Sleep, Autonomic Nervous Function and Atherosclerosis. Int J Mol Sci, 2019,20(4):794 Carter P, Reynolds J, Carter A, et al. The impact of psychiatric comorbidities on the length of hospital stay in patients with heart failure. Int J Cardiol, 2016,207:292–296 Wang D, Hu B, Hu C, et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus—Infected Pneumonia in Wuhan, China. JAMA, 2020,323(11):1061–1069 Shi S, Qin M, Shen B, et al. Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan, China. JAMA Cardiol, 2020,5(7):802–810 Bhatraju PK, Ghassemieh BJ, Nichols M, et al. Covid-19 in Critically Ill Patients in the Seattle Region—Case Series. New Engl J Med, 2020,382(21):2012–2022 Guo T, Fan Y, Chen M, et al. Cardiovascular Implications of Fatal Outcomes of Patients With Coronavirus Disease 2019 (COVID-19). JAMA Cardiol, 2020,5(7):811–818 Zheng YY, Ma YT, Zhang JY, et al. COVID-19 and the cardiovascular system. Nat Rev Cardiol, 2020,17(5):259–260 Clerkin KJ, Fried JA, Raikhelkar J, et al. COVID-19 and Cardiovascular Disease. Circulation, 2020,141(20):1648–1655 Zhai Y, Du X. Addressing collegiate mental health amid COVID-19 pandemic. Psychiatry Res, 2020,288:113003 Huang Y, Zhao N. Generalized anxiety disorder, depressive symptoms and sleep quality during COVID-19 outbreak in China: a web-based cross-sectional survey. Psychiatry Res, 2020,288:112954 Moccia L, Janiri D, Pepe M, et al. Affective temperament, attachment style, and the psychological impact of the COVID-19 outbreak: an early report on the Italian general population. Brain Behav Immun, 2020,87:75–79 Kang L, Li Y, Hu S, et al. The mental health of medical workers in Wuhan, China dealing with the 2019 novel coronavirus. Lancet Psychiatry, 2020,7(3):e14 Mo Y, Deng L, Zhang L, et al. Work stress among Chinese nurses to support Wuhan in fighting against COVID-19 epidemic. J Nurs Manag, 2020;28(5):1002–1009 Maben J, Bridges J. Covid-19: Supporting nurses’ psychological and mental health. J Clin Nurs, 2020,29 (15–16):2742–2750 Chavan SS, Pavlov VA, Tracey KJ. Mechanisms and therapeutic relevance of neuro-immune communication. Immunity, 2017,46(6):927–942 Yoo BB, Mazmanian SK. The Enteric Network: Interactions between the Immune and Nervous Systems of the Gut. Immunity, 2017,46(6):910–926 Lai NY, Mills K, Chiu IM. Sensory neuron regulation of gastrointestinal inflammation and bacterial host defence. J Intern Med, 2017,282(1):5–23 Borovikova LV, Ivanova S, Zhang M, et al. Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature, 2000,405(6785):458–462 Hu H, Ma F, Wei X, et al. Coronavirus fulminant myocarditis treated with glucocorticoid and human immunoglobulin. Eur Heart J, 2020,42(2):206 Zeng JH, Liu YX, Yuan J, et al. First case of COVID-19 complicated with fulminant myocarditis: a case report and insights. Infection, 2020,48(5):773–777 Zhu H, Rhee JW, Cheng P, et al. Cardiovascular Complications in Patients with COVID-19: Consequences of Viral Toxicities and Host Immune Response. Curr Cardiol Rep, 2020,22(5):32 Mehta P, McAuley DF, Brown M, et al. COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet, 2020,395(10229):1033–1034 Femenía T, Giménez-Cassina A, Codeluppi S, et al. Disrupted Neuroglial Metabolic Coupling after Peripheral Surgery. J Neurosci, 2018,38(2):452–464 Walker KA, Gross AL, Moghekar AR, et al. Association of peripheral inflammatory markers with connectivity in large-scale functional brain networks of non-demented older adults. Brain Behav Immun, 2020,87:388–396 Lopez RB, Brown RL, Wu ELL, et al. Emotion Regulation and Immune Functioning During Grief: Testing the Role of Expressive Suppression and Cognitive Reappraisal in Inflammation Among Recently Bereaved Spouses. Psychosom Med, 2020,82(1):2–9 Maes M, Yirmyia R, Noraberg J, et al. The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression. Metab Brain Dis, 2009,24(1):27–53 Li D, Wang Y, Jin X, et al. NK cell-derived exosomes carry miR-207 and alleviate depression-like symptoms in mice. J Neuroinflammation, 2020,17(1):126 Petralia MC, Mazzon E, Fagone P, et al. The cytokine network in the pathogenesis of major depressive disorder. Close to translation? Autoimmun Rev, 2020,19(5):102504 Zhang J, Lin W, Tang M, et al. Inhibition of JNK ameliorates depressive-like behaviors and reduces the activation of pro-inflammatory cytokines and the phosphorylation of glucocorticoid receptors at serine 246 induced by neuroinflammation. Psychoneuroendocrinology, 2020, 113:104580 Roman M, Irwin MR. Novel neuroimmunologic therapeutics in depression: A clinical perspective on what we know so far. Brain Behav Immun, 2020,83:7–21 Slavich GM, Irwin MR. From stress to inflammation and major depressive disorder: a social signal transduction theory of depression. Psychol Bull, 2014,140(3):774–815 McAlpine CS, Kiss MG, Rattik S, et al. Sleep modulates haematopoiesis and protects against atherosclerosis. Nature, 2019,566(7744):383–387 Johnson JD, Barnard DF, Kulp AC, et al. Neuroendocrine Regulation of Brain Cytokines After Psychological Stress. J Endocr Soc, 2019,3(7):1302–1320 Hao G, Youssef NA, Davis CL, et al. The role of DNA methylation in the association between childhood adversity and cardiometabolic disease. Int J Cardiol, 2018,255:168–174 Peters EM, Liezmann C, Klapp BF, et al. The neuroimmune connection interferes with tissue regeneration and chronic inflammatory disease in the skin. Ann N Y Acad Sci, 2012,1262:118–126 Tonhajzerova I, Sekaninova N, Bona Olexova L, et al. Novel Insight into Neuroimmune Regulatory Mechanisms and Biomarkers Linking Major Depression and Vascular Diseases: The Dilemma Continues. Int J Mol Sci, 2020,21(7):2317 Ortega E, Gálvez I, Martín-Cordero L. Adrenergic Regulation of Macrophage-Mediated Innate/Inflammatory Responses in Obesity and Exercise in this Condition: Role of β2 Adrenergic Receptors. Endoc Metab Immune Disord Drug Targets, 2019,19(8):1089–1099 Agac D, Estrada LD, Maples R, et al. The beta2-adrenergic receptor controls inflammation by driving rapid IL-10 secretion. Brain Behav Immun, 2018,74:176–185 Tracey KJ. The inflammatory reflex. Nature, 2002,420(6917):853–859 Shi S, Liang J, Liu T, et al. Depression increases sympathetic activity and exacerbates myocardial remodeling after myocardial infarction: evidence from an animal experiment. PloS One, 2014,9(7):e101734 Dorey TW, Moghtadaei M, Rose RA. Altered heart rate variability in angiotensin II—mediated hypertension is associated with impaired autonomic nervous system signaling and intrinsic sinoatrial node dysfunction. Heart Rhythm, 2020,17(8):1360–1370 Okada H, Yoshida S, Hara A, et al. Vascular endothelial injury exacerbates coronavirus disease 2019: The role of endothelial glycocalyx protection. Microcirculation, 2021,28(3):e12654 Balint B, Jaremek V, Thorburn V, et al. Left atrial microvascular endothelial dysfunction, myocardial inflammation and fibrosis after selective insular cortex ischemic stroke. Int J Cardiol, 2019,292:148–155 Toya T, Sara JD, Ahmad A, et al. Incremental Prognostic Impact of Peripheral Microvascular Endothelial Dysfunction on the Development of Ischemic Stroke. J Am Heart Assoc, 2020,9(9):e015703 Antonino T, Mario D, Antonio P. Endothelial Dysfunction and Inflammation in Ischemic Stroke Pathogenesis. Curr Pharm Des, 2020,26(34):4209–4219 Kuang Y, Li X, Liu X, et al. Vascular endothelial S1pr1 ameliorates adverse cardiac remodelling via stimulating reparative macrophage proliferation after myocardial infarction. Cardiovasc Res, 2021,117(2):585–299 Schmitz SL, Abosi OJ, Persons JE, et al. Impact of Mood on Endothelial Function and Arterial Stiffness in Bipolar Disorder. Heart Mind (Mumbai), 2018,2(3):78–84 Sauvet F, Arnal PJ, Tardo-Dino PE, et al. Protective effects of exercise training on endothelial dysfunction induced by total sleep deprivation in healthy subjects. Int J Cardiol, 2017,232:76–85 Jin X, Jin C, Nakamura K, et al. Increased dipeptidyl peptidase-4 accelerates chronic stress-related thrombosis in a mouse carotid artery model. J Hypertens, 2020,38(8):1504–1513 Sawicki CM, McKim DB, Wohleb ES, et al. Social defeat promotes a reactive endothelium in a brain region-dependent manner with increased expression of key adhesion molecules, selectins and chemokines associated with the recruitment of myeloid cells to the brain. Neuroscience, 2015,302:151–164 Fiedorowicz JG, Coryell WH, Rice JP, et al. Vasculopathy Related to Manic/Hypomanic Symptom Burden and First-Generation Antipsychotics in a Sub-Sample from the Collaborative Depression Study. Psychother Psychosom, 2012,81(4):235–243 Gupta AK, Jneid H, Addison D, et al. Current Perspectives on Coronavirus Disease 2019 and Cardiovascular Disease: A White Paper by the JAHA Editors. J Am Heart Assoc, 2020,9(12):e017013 Guan WJ, Liang WH, He JX, et al. Cardiovascular comorbidity and its impact on patients with COVID-19. Eur Respir J, 2020,55(6):2001227