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Vai trò của Matrix Metalloproteinases và lợi ích điều trị của việc ức chế chúng trong chấn thương tủy sống
Tóm tắt
Bài tổng quan này sẽ tập trung vào matrix metalloproteinases (MMPs) và các chất ức chế của chúng trong bối cảnh chấn thương tủy sống (SCI). MMPs có mẫu hình biểu hiện tế bào và thời gian cụ thể trong tủy sống bị thương. Chúng tôi sẽ xem xét các chức năng đa dạng của chúng trong tủy sống bị tổn thương cấp tính và trong quá trình chữa lành vết thương. Hoạt động quá mức của MMPs, đặc biệt là gelatinase B (MMP-9), trong tủy sống bị tổn thương cấp tính góp phần vào sự phá vỡ hàng rào máu-tủy sống, sự xâm nhập của bạch cầu vào tủy sống bị tổn thương, cũng như quá trình apoptosis. MMP-9 và MMP-2 điều chỉnh viêm và đau thần kinh sau chấn thương dây thần kinh ngoại vi và có thể góp phần vào cơn đau do SCI gây ra. Việc ức chế dược lý sớm các MMPs hoặc các gelatinase (MMP-2 và MMP-9) dẫn đến sự cải thiện trong quá trình hồi phục thần kinh lâu dài và có liên quan đến việc giảm sẹo thần kinh và đau thần kinh. Trong quá trình chữa lành vết thương, gelatinase A (MMP-2) đóng một vai trò quan trọng trong việc hạn chế sự hình thành của sẹo thần kinh ức chế, và chuột thiếu gen này cho thấy quá trình hồi phục bị suy giảm. Những phát hiện này cho thấy vai trò phức tạp và khác biệt về thời gian của MMPs trong SCI. Vì hoạt động gelatinase sớm là có hại, đang nổi lên sự quan tâm trong việc phát triển các liệu pháp nhắm vào gelatinase mà sẽ được điều chỉnh đặc biệt cho tủy sống bị tổn thương cấp tính. Do đó, chúng tôi tập trung vào việc phát triển các chất ức chế gelatinase chọn lọc.
Từ khóa
#MMPs #chấn thương tủy sống #gelatinase #ức chế dược lý #phục hồi thần kinhTài liệu tham khảo
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