Role of B cell antigen receptor in regulation of V(D)J recombination and cell survival

Springer Science and Business Media LLC - Tập 21 Số 2 - Trang 259-263 - 2000
Nemazee, David1
1Department of Immunology, IMM-29, The Scripps Research Institute, La Jolla

Tóm tắt

B lymphocytes learn through the interaction of the B cell receptor with antigens in the context of B cell developmental stage and environmental cues. B cells can respond by proliferation and antibody secretion, programmed cell death, or modification of the antibody genes themselves through secondary immunoglobulin gene rearrangements or somatic point mutation. Acritical learning process is that of self/nonself-discrimination. We have shown that one potent mechanism for immune self-tolerance in B cells is ongoing antibody light chain gene rearrangements, which can result in “receptor editing” that gene rearrangements, which can result in “receptor editing” that changes antigen receptor specificity. This process appears to be developmentally regulated, because it is confined to cells at an immature stage of development. Cells at later stages of development can be tolerized by apoptosis, but probably not by receptor editing.

Tài liệu tham khảo

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