Role and Mechanism of Gut Microbiota in Human Disease
Tóm tắt
The human gut microbiome is a huge microbial community that plays an irreplaceable role in human life. With the further development of research, the influence of intestinal flora on human diseases has been gradually excavated. Gut microbiota (GM) dysbiosis has adverse health effects on the human body that will lead to a variety of chronic diseases. The underlying mechanisms of GM on human diseases are incredibly complicated. This review focuses on the regulation and mechanism of GM on neurodegenerative diseases, cardiovascular diseases, metabolic diseases and gastrointestinal diseases, thus providing a potential target for the prevention and treatment of disease.
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Abbasalizad Farhangi, 2020, Gut microbiota-associated trimethylamine N-oxideand increased cardiometabolic risk in adults: a systematic review and dose-responsemeta-analysis, Nutr. Rev, 1, 10.1093/nutrit/nuaa111
Abbott, 2020, Are infections seeding some cases of Alzheimer’s disease, Nature, 587, 22, 10.1038/d41586-020-03084-9
Almeida, 2020, A unified catalog of 204,938 reference genomesfrom the human gut microbiome, Nat. Biotechnol., 39, 105, 10.1038/s41587-020-0603-3
Aoki, 2017, A proliferative probiotic Bifidobacterium strain in the gut ameliorates progression of metabolic disorders via microbiota modulation and acetate elevation, Sci. Rep., 7, 10.1038/srep43522
Bakay, 2019, The Genetic Contribution to Type 1 Diabetes, Curr. Diabetes Rep., 19, 116, 10.1007/s11892-019-1235-1
Bedarf, 2017, Functional implications of microbial and viral gut metagenome changes in early stage L-DOPA-naïve Parkinson’s disease patients, Genome Med., 9, 39, 10.1186/s13073-017-0428-y
Beyer, 2009, Molecular pathology of Lewy body diseases, Int. J. Mol. Sci., 10, 724, 10.3390/ijms10030724
Bharwani, 2017, Oral treatment with Lactobacillus rhamnosus attenuates behavioural deficits and immune changes in chronic social stress, BMC Med., 15, 7, 10.1186/s12916-016-0771-7
Brown, 2016, Prolonged antibiotic treatment induces a diabetogenic intestinal microbiome that accelerates diabetes in NOD mice, ISME J., 10, 321, 10.1038/ismej.2015.114
Canfora, 2019, Gut microbial metabolites in obesity, NAFLD and T2DM, Nat. Rev. Endocrinol., 15, 261, 10.1038/s41574-019-0156-z
Caruso, 2020, Host–microbiota interactions in inflammatory bowel disease, Nat. Rev. Immunol., 20, 411, 10.1038/s41577-019-0268-7
Chen, 2020, Gut dysbiosis contributes to amyloid pathology, associated with C/EBPβ/AEP signaling activation in Alzheimer’s disease mouse model, Sci. Adv., 6, 10.1126/sciadv.aba0466
Chou, 2019, Trimethylamine N-Oxide, Circulating EndothelialProgenitor Cells, and Endothelial Function in Patients with Stable Angina, Sci. Rep., 9, 4249, 10.1038/s41598-019-40638-y
Chu, 2019, Small metabolites, possible big changes: a microbiota-centered view of non-alcoholic fatty liver disease, Gut, 68, 359, 10.1136/gutjnl-2018-316307
Collaboration, 2017, Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19.1 million participants, Lancet, 389, 37, 10.1016/S0140-6736(16)31919-5
Collins, 2012, The interplay between the intestinal microbiota and the brain, Nat. Rev. Microbiol., 10, 735, 10.1038/nrmicro2876
Crusell, 2018, Gestational diabetes is associated with change in the gut microbiota composition in third trimester of pregnancy and postpartum, Microbiome, 6, 89, 10.1186/s40168-018-0472-x
Da Silva, 2018, Nonalcoholic fatty liver disease is associated with dysbiosis independent of body mass index and insulin resistance, Sci. Rep., 8, 1466, 10.1038/s41598-018-19753-9
De La Cuesta-Zuluaga, 2018, Gut microbiota is associated with obesity and cardiometabolic disease in a population in the midst of Westernization, Sci. Rep., 8, 11356, 10.1038/s41598-018-29687-x
De Munck, 2020, Intestinal permeability in human nonalcoholic fatty liver disease: A systematic review and meta-analysis, Liver Int., 40, 2906, 10.1111/liv.14696
De Palma, 2015, Microbiota and host determinants of behavioural phenotype in maternally separated mice, Nat. Commun., 6, 7735, 10.1038/ncomms8735
De Vadder, 2016, Microbiota-Produced Succinate Improves Glucose Homeostasis via Intestinal Gluconeogenesis, Cell Metab., 24, 151, 10.1016/j.cmet.2016.06.013
Del Bo, 2020, A polyphenol-rich dietary pattern improvesintestinal permeability, evaluated as serum zonulin levels, in older subjects: The MaPLE randomisedcontrolled trial, Clin. Nutr., S0261-5614(20)30689-0
Ding, 2019, Revisit gut microbiota and its impact on human health and disease, J. Food Drug Anal., 27, 623, 10.1016/j.jfda.2018.12.012
Donertas Ayaz, 2020, Gut microbiota and neuroinflammation in pathogenesis of hypertension: A potential role for hydrogen sulfide, Pharmacol. Res., 153, 10.1016/j.phrs.2020.104677
Durgan, 2017, Obstructive Sleep Apnea-Induced Hypertension: Role of the Gut Microbiota, Curr. Hypertens. Rep., 19, 35, 10.1007/s11906-017-0732-3
Ebrahimzadeh Leylabadlo, 2020, From role of gut microbiota to microbial-based therapies in type 2-diabetes, Infect. Genet. Evol., 81, 10.1016/j.meegid.2020.104268
Eftychi, 2019, Temporally distinct functions of the cytokines IL-12 and IL-23 drive chronic colon inflammation in response to intestinal barrier impairment, Immunity, 51, 367, 10.1016/j.immuni.2019.06.008
Elfil, 2020, Implications of the Gut Microbiome in Parkinson’s Disease, Mov Disord., 35, 921, 10.1002/mds.28004
Fan, 2021, Gut microbiota in human metabolic health and disease, Nat. Rev. Microbiol., 19, 55, 10.1038/s41579-020-0433-9
Fluckiger, 2020, Cross-reactivity between tumor MHC class I-restricted antigens and an enterococcal bacteriophage, Science, 369, 936, 10.1126/science.aax0701
Gerhardt, 2018, Changes of Colonic Bacterial Composition in Parkinson’s Disease and Other Neurodegenerative Diseases, Nutrients, 10, 708, 10.3390/nu10060708
Haghikia, 2018, Gut microbiota-dependent TMAO and risk of cardiovascular events in patients with stroke: relation to pro-inflammatory monocytes, Eur. Heart J., 39, 475, 10.1093/eurheartj/ehy565.P2467
Harach, 2017, Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota, Sci. Rep., 7, 10.1038/srep41802
Hasain, 2020, Gut Microbiota and Gestational Diabetes Mellitus: A Review of Host-Gut Microbiota Interactions and Their Therapeutic Potential, Front. Cell Infect. Microbiol., 10, 10.3389/fcimb.2020.00188
Heintz-Buschart, 2018, The nasal and gut microbiome in Parkinson’s disease and idiopathic rapid eye movement sleep behavior disorder, Movement Disord., 33, 88, 10.1002/mds.27105
Hill-Burns, 2017, Parkinson’s disease and Parkinson’s disease medications have distinct signatures of the gut microbiome, Mov Disord., 32, 739, 10.1002/mds.26942
Homayouni, 2020, Prevention of Gestational Diabetes Mellitus (GDM) and Probiotics: Mechanism of Action: A Review, Curr. Diabetes Rev., 16, 538, 10.2174/1573399815666190712193828
Hopfner, 2017, Gut microbiota in Parkinson disease in a northern German cohort, Brain Res., 1667, 41, 10.1016/j.brainres.2017.04.019
Hoyles, 2018, Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women, Nat. Med., 24, 1070, 10.1038/s41591-018-0061-3
Iruzubieta, 2020, A Role for Gut Microbiome Fermentative Pathways in Fatty Liver Disease Progression, J. Clin. Med., 9, 1369, 10.3390/jcm9051369
Jahansouz, 2016, Bile Acids Increase Independently From Hypocaloric Restriction After Bariatric Surgery, Ann. Surg., 264, 1022, 10.1097/sla.0000000000001552
Jensen, 2018, Increase in clinically recorded type 2 diabetesafter colectomy, Elife, 7, 10.7554/eLife.37420
Jiang, 2015, Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease, J. Clin. Invest., 125, 386, 10.1172/jci76738
Jie, 2017, The gut microbiome in atherosclerotic cardiovascular disease, Nat. Commun., 8, 845, 10.1038/s41467-017-00900-1
Jonsson, 2017, Role of gut microbiota in atherosclerosis, Nat. Rev. Cardiol., 14, 79, 10.1038/nrcardio.2016.183
Kadosh, 2020, The gut microbiome switches mutant p53 fromtumour-suppressive to oncogenic, Nature, 586, 133, 10.1038/s41586-020-2541-0
Karbach, 2016, Gut Microbiota Promote Angiotensin II-Induced Arterial Hypertension and Vascular Dysfunction, J. Am. Heart Assoc., 5, 10.1161/JAHA.116.003698
Kelly, 2015, Crosstalk between Microbiota-Derived Short-Chain Fatty Acids and Intestinal Epithelial HIF Augments Tissue Barrier Function, Cell Host Microbe, 17, 662, 10.1016/j.chom.2015.03.005
Kim, 2020, Transfer of a healthy microbiota reduces amyloid and tau pathology in an Alzheimer’s disease animal model, Gut, 69, 283, 10.1136/gutjnl-2018-317431
Kim, 2020, Intestinal FGF15/19 physiologically repress hepatic lipogenesis in the late fed-state by activating SHP and DNMT3A, Nat. Commun., 11, 5969, 10.1038/s41467-020-19803-9
Kobayashi, 2017, Therapeutic potential of Bifidobacterium breve strain A1 for preventing cognitive impairment in Alzheimer’s disease, Sci. Rep., 7, 13510, 10.1038/s41598-017-13368-2
Koeth, 2013, Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis, Nat. Med., 19, 576, 10.1038/nm.3145
Kozarov, 2005, Human atherosclerotic plaque contains viable invasive Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis, Arterioscler. Thromb. Vasc. Biol., 25, e17, 10.1161/01.ATV.0000155018.67835.1a
Kuang, 2017, Connections between the human gut microbiome and gestational diabetes mellitus, GigaScience, 6, 1, 10.1093/gigascience/gix058
Larraufie, 2018, SCFAs strongly stimulate PYY production in human enteroendocrine cells, Sci. Rep., 8, 74, 10.1038/s41598-017-18259-0
Lavelle, 2020, Gut microbiota-derived metabolites as key actorsin inflammatory bowel disease, Nat. Rev. Gastroenterol. Hepatol., 17, 223, 10.1038/s41575-019-0258-z
Li, 2019, Mild cognitive impairment has similar alterations as Alzheimer’s disease in gut microbiota, Alzheimers Dement., 15, 1357, 10.1016/j.jalz.2019.07.002
Li, 2019, Gut Microbiota Differs Between Parkinson’s Disease Patients and Healthy Controls in Northeast China, Front. Mol. Neurosci., 12, 10.3389/fnmol.2019.00171
Li, 2014, Dysbiosis of gut fungal microbiota is associated with mucosal inflammation in Crohn’s disease, J. Clin. Gastroenterol., 48, 513, 10.1097/mcg.0000000000000035
Li, 2016, Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe-/- Mice, Circulation, 133, 2434, 10.1161/circulationaha.115.019645
Li, 2020, Implication of the gut microbiome composition of type 2 diabetic patients from northern China, Sci. Rep., 10, 5450, 10.1038/s41598-020-62224-3
Li, 2017, Gut microbiota dysbiosis contributes to the development of hypertension, Microbiome, 5, 14, 10.1186/s40168-016-0222-x
Li, 2017, Gut microbiota-dependent trimethylamine N-oxide in acute coronary syndromes: a prognostic marker for incident cardiovascular events beyond traditional risk factors, Eur. Heart J., 38, 814, 10.1093/eurheartj/ehw582
Lin, 2018, Gut microbiota in patients with Parkinson’s disease in southern China, Parkinsonism Relat. Disord., 53, 82, 10.1016/j.parkreldis.2018.05.007
Liu, 2017, Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention, Nat. Med., 23, 859, 10.1038/nm.4358
Long, 2019, Peptostreptococcus anaerobius promotes colorectal carcinogenesis and modulates tumour immunity, Nat. Microbiol., 4, 1, 10.1038/s41564-019-0541-3
Macia, 2015, Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome, Nat. Commun., 6, 6734, 10.1038/ncomms7734
Mancuso, 2017, Alzheimer’s disease and gut microbiota modifications: The long way between preclinical studies and clinical evidence, Pharmacol. Res., 129, 329, 10.1016/j.phrs.2017.12.009
Maria, 2010, The H1 haplotype of the tau gene (MAPT) is associated with mild cognitive impairment, J. Alzheimer’s Dis., 19, 909, 10.3233/JAD-2010-1285
Meng, 2015, Emerging role of hydrogen sulfide in hypertension and related cardiovascular diseases, Br. J. Pharmacol., 172, 5501, 10.1111/bph.12900
Miao, 2020, Erythrocyte n-6 Polyunsaturated Fatty Acids, Gut Microbiota and Incident Type 2 Diabetes: A Prospective Cohort Study, Curr. Develop. Nutr., 4, 1452, 10.1093/cdn/nzaa061_080
Minter, 2017, Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APP(SWE)/PS1(ΔE9) murine model of Alzheimer’s disease, Sci. Rep., 7, 10411, 10.1038/s41598-017-11047-w
Mitra, 2015, In silico analyses of metagenomes from human atherosclerotic plaque samples, Microbiome, 3, 38, 10.1186/s40168-015-0100-y
Mollica, 2017, Butyrate Regulates Liver Mitochondrial Function, Efficiency, and Dynamics in Insulin-Resistant Obese Mice, Diabetes, 66, 1405, 10.2337/db16-0924
Morais, 2020, The gut microbiota-brain axis in behaviour and brain disorders, Nat. Rev. Microbiol., 10.1038/s41579-020-00460-0
Muller, 2020, Microbiota-modulated CART(+) enteric neuronsautonomously regulate blood glucose, Science, 370, 314, 10.1126/science.abd6176
Murray, 2015, Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countrie, Lancet, 386, 2145, 10.1016/S0140-6736(15)61340-X
Nagpure, 2016, Interaction of Hydrogen Sulfide with Nitric Oxide in the Cardiovascular System, Oxid. Med. Cell. Longevity, 2016, 6904327, 10.1155/2016/6904327
Nemet, 2020, A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors, Cell, 180, e822, 10.1016/j.cell.2020.02.016
Nie, 2018, Serum Trimethylamine N-Oxide Concentration Is Positively Associated With First Stroke in Hypertensive Patients, Stroke, 49, 2021, 10.1161/strokeaha.118.021997
Pan, 2018, miR-192 is upregulated in T1DM, regulates pancreatic β-cell development and inhibits insulin secretion through suppressing GLP-1 expression, Exp. Ther. Med., 16, 2717, 10.3892/etm.2018.6453
Peng, 2018, Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies, Nature, 557, 558, 10.1038/s41586-018-0104-4
Qian, 2018, Alteration of the fecal microbiota in Chinese patients with Parkinson’s disease, Brain Behav. Immun., 70, 194, 10.1016/j.bbi.2018.02.016
Raman, 2013, Fecal microbiome and volatile organic compound metabolome in obese humans with nonalcoholic fatty liver disease, Clin. Gastroenterol. Hepatol., 11, 868, 10.1016/j.cgh.2013.02.015
Robles-Vera, 2017, Antihypertensive Effects of Probiotics, Curr. Hypertens. Rep., 19, 26, 10.1007/s11906-017-0723-4
Rom, 2020, Glycine-based treatment ameliorates NAFLD bymodulating fatty acid oxidation, glutathione synthesis, and the gut microbiome, Sci. Transl. Med., 12, 10.1126/scitranslmed.aaz2841
Sampson, 2016, Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease, Cell, 167, 1469, 10.1016/j.cell.2016.11.018
Sanchez-Rodriguez, 2020, The Gut Microbiota and Its Implication in the Development of Atherosclerosis and Related Cardiovascular Diseases, Nutrients, 12, 605, 10.3390/nu12030605
Schaubeck, 2016, Dysbiotic gut microbiota causes transmissible Crohn’s disease-like ileitis independent of failure in antimicrobial defence, Gut, 65, 225, 10.1136/gutjnl-2015-309333
Scheperjans, 2015, Gut microbiota are related to Parkinson’s disease and clinical phenotype, Mov Disord., 30, 350, 10.1002/mds.26069
Shikata, 2019, Potential Influences of Gut Microbiota on the Formation of Intracranial Aneurysm, Hypertension (Dallas Tex. 1979), 73, 491, 10.1161/HYPERTENSIONAHA.118.11804
Si, 2020, Colorectal cancer occurrence and treatment basedon changes in intestinal flora, Semin. Cancer Biol., S1044-579X(20)30100-0
Sittipo, 2019, Microbial Metabolites Determine Host Health andthe Status of Some Diseases, Int. J. Mol. Sci., 20, 5296, 10.3390/ijms20215296
Skye, 2018, Microbial Transplantation with Human Gut Commensals Containing CutC Is Sufficient to Transmit Enhanced Platelet Reactivity and Thrombosis Potential, Circ. Res., 123, 1164, 10.1161/CIRCRESAHA.118.313142
Thaiss, 2016, Persistent microbiome alterations modulate the rate of post-dieting weight regain, Nature, 540, 544, 10.1038/nature20796
Tischmann, 2019, Effects of a High-Protein/Moderate-CarbohydrateDiet on Appetite, Gut Peptides, and Endocannabinoids-A Preview Study, Nutrients, 11, 2269, 10.3390/nu11102269
Toral, 2019, Critical Role of the Interaction Gut Microbiota - Sympathetic Nervous System in the Regulation of Blood Pressure, Front. Physiol., 10, 10.3389/fphys.2019.00231
Tsoi, 2017, Peptostreptococcus anaerobius Induces Intracellular Cholesterol Biosynthesis in Colon Cells to Induce Proliferation and Causes Dysplasia in Mice, Gastroenterology, 152, 1419, 10.1053/j.gastro.2017.01.009
Turnbaugh, 2006, An obesity-associated gut microbiome with increased capacity for energy harvest, Nature, 444, 1027, 10.1038/nature05414
Turnbaugh, 2009, The Effect of Diet on the Human Gut Microbiome:A Metagenomic Analysis in Humanized Gnotobiotic Mice, Sci. Trans.Med., 1, 6ra14, 10.1126/scitranslmed.3000322
Vallianou, 2019, Understanding the Role of the Gut Microbiome and Microbial Metabolites in Obesity and Obesity-Associated Metabolic Disorders: Current Evidence and Perspectives, Curr. Obes. Rep., 8, 317, 10.1007/s13679-019-00352-2
Veiga-Fernandes, 2016, Neuro-Immune Interactions at Barrier Surfaces, Cell, 165, 801, 10.1016/j.cell.2016.04.041
Wang, 2011, Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease, Nature, 472, 57, 10.1038/nature09922
Wang, 2018, [Efficacy of probiotics on the treatment of non-alcoholic fatty liver disease], Zhonghua Nei Ke Za Zhi, 57, 101, 10.3760/cma.j.issn.0578-1426.2018.02.004
Wang, 2019, Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer’s disease progression, Cell Res., 29, 787, 10.1038/s41422-019-0216-x
Wong, 2017, Gavage of Fecal Samples From Patients With Colorectal Cancer Promotes Intestinal Carcinogenesis in Germ-Free and Conventional Mice, Gastroenterology, 153, 1621, 10.1053/j.gastro.2017.08.022
World Obesity FederationObesity and overweight.2020
Wu, 2020, The Gut Microbiota in Prediabetes and Diabetes: A Population-Based Cross-Sectional Study, Cell Metab., 32, 379, 10.1016/j.cmet.2020.06.011
Wu, 2020, Microbiota-derived metabolite promotes HDAC3activity in the gut, Nature, 586, 108, 10.1038/s41586-020-2604-2
Xu, 2011, Synergistic steatohepatitis by moderate obesity and alcohol in mice despite increased adiponectin and p-AMPK, J. Hepatol., 55, 673, 10.1016/j.jhep.2010.12.034
Yan, 2017, Alterations of the Gut Microbiome in Hypertension, Front. Cell Infect. Microbiol., 7, 10.3389/fcimb.2017.00381
Yang, 2015, Gut dysbiosis is linked to hypertension, Hypertension (Dallas Tex. 1979), 65, 1331, 10.1161/HYPERTENSIONAHA.115.05315
Yano, 2015, Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis, Cell, 161, 264, 10.1016/j.cell.2015.02.047
Zeng, 2020, Citrus polymethoxyflavones attenuate metabolic syndrome by regulating gut microbiome and amino acid metabolism, Sci. Adv., 6, 10.1126/sciadv.aax6208
Zeng, 2020, Gut Microbiota and Heart, Vascular Injury, Gut Microbiota and Pathogenesis of Organ Injury., 107, 10.1007/978-981-15-2385-4_8
Zhang, 2018, Time for food: The impact of diet on gut microbiota and human health, Nutrition, 51
Zhang, 2020, Intestinal fatty acid-binding protein mediates atherosclerotic progress through increasing intestinal inflammation and permeability, J. Cell. Mol. Med., 24, 5205, 10.1111/jcmm.15173
Zheng, 2020, Hyocholic acid species improve glucose homeostasis through a distinct TGR5 and FXR signaling mechanism, Cell Metab., 10.2139/ssrn.3528695
Zhou, 2020, Evaluating the Causal Role of Gut Microbiota in Type 1 Diabetes and Its Possible Pathogenic Mechanisms, Front. Endocrinol., 11, 10.3389/fendo.2020.00125
Zhou, 2020, Gut Microbiota Profile in Patients with Type 1 Diabetes Based on 16S rRNA Gene Sequencing: A Systematic Review, Dis. Markers, 2020, 10.1155/2020/3936247
Zhu, 2016, Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk, Cell, 165, 111, 10.1016/j.cell.2016.02.011
Zhu, 2020, Gut microbiota in atherosclerosis: focus on trimethylamine N-oxide, APMIS Acta Pathol. Microbiol. Immunol. Scand., 128, 353, 10.1111/apm.13038