Robust generation of new hair cells in the mature mammalian inner ear by adenoviral expression of Hath1

Ben-Arie, 1997, Math1 is essential for genesis of cerebellar granule neurons, Nature, 390, 169, 10.1038/36579 Ben-Arie, 2000, Functional conservation of atonal and Math1 in the CNS and PNS, Development, 127, 1039, 10.1242/dev.127.5.1039 Bermingham, 1999, Math1, Science, 284, 1837, 10.1126/science.284.5421.1837 Chen, 2002, The role of Math1 in inner ear development, Development, 129, 2495, 10.1242/dev.129.10.2495 Cho, 2000, Gene therapy could aid hearing, ScienceNOW, 518, 1 Corwin, 1988, Regeneration of sensory hair cells after acoustic trauma, Science, 240, 1772, 10.1126/science.3381100 Dazert, 2001, In vivo adenoviral transduction of the neonatal rat cochlea and middle ear, Hear Res., 151, 30, 10.1016/S0378-5955(00)00189-1 Fekete, 2000, Making sense of making hair cells, Trends Neurosci., 23, 386, 10.1016/S0166-2236(00)01668-4 Fekete, 1998, Hair cells and supporting cells share a common progenitor in the avian inner ear, J. Neurosci., 18, 7811, 10.1523/JNEUROSCI.18-19-07811.1998 Forge, 1993, Ultrastructural evidence for hair cell regeneration in the mammalian inner ear, Science, 259, 1616, 10.1126/science.8456284 Forge, 1998, Hair cell recovery in the vestibular sensory epithelia of mature guinea pigs, J. Comp. Neurol., 397, 69, 10.1002/(SICI)1096-9861(19980720)397:1<69::AID-CNE6>3.0.CO;2-G Gale, 2002, Survival of bundleless hair cells and subsequent bundle replacement in the bullfrog’s saccule, J. Neurobiol., 50, 81, 10.1002/neu.10002 Gu, 1997, Age-related decreases in proliferation within isolated mammalian vestibular epithelia cultured in control and glial growth factor2 media, Assoc. Res. Otolaryngol. Abstr., 20, 98 Hasson, 1995, Expression in cochlea and retina of myosin VIIa, the gene product defective in Usher syndrome type 1B, Proc. Natl. Acad. Sci. USA, 92, 9815, 10.1073/pnas.92.21.9815 Helms, 1998, Progenitors of dorsal commissural interneurons are defined by MATH1 expression, Development, 125, 919, 10.1242/dev.125.5.919 Holt, 1999, Functional expression of exogenous proteins in mammalian sensory hair cells infected with adenoviral vectors, J. Neurophysiol., 81, 1881, 10.1152/jn.1999.81.4.1881 Inoue, 2001, Math6, a bHLH gene expressed in the developing nervous system, regulates neuronal versus glial differentiation, Genes Cells, 6, 977, 10.1046/j.1365-2443.2001.00476.x Jarman, 1993, Atonal is a proneural gene that directs chordotonal organ formation in the Drosophila peripheral nervous system, Cell, 73, 1307, 10.1016/0092-8674(93)90358-W Jero, 2001, Cochlear gene delivery through an intact round window membrane in mouse, Hum. Gene Ther., 12, 539, 10.1089/104303401300042465 Jones, 1996, Regeneration of sensory cells after laser ablation in the lateral line system, J. Neurosci., 16, 649, 10.1523/JNEUROSCI.16-02-00649.1996 Kanekar, 1997, Xath5 participates in a network of bHLH genes in the developing Xenopus retina, Neuron, 19, 981, 10.1016/S0896-6273(00)80391-8 Kay, J., Finger-Baier, K., Roeser, T., Staub, W., H.B., 2001. Retinal ganglion cell genesis requires lakritz, a zebrafish atonal Homolog. Neuron 30, 725–736 Lanford, 2000, Expression of Math1 and HES5 in the cochleae of wildtype and Jag2 mutant mice, J. Assoc. Res. Otolaryngol., 1, 161, 10.1007/s101620010023 Larkin, 2000, Can lost hearing be restored?, Lancet, 356, 744, 10.1016/S0140-6736(05)73651-5 Lim, 1992, Structural Development of the Cochlea, 33 Luebke, 2001, Cochlear function and transgene expression in the guinea pig cochlea, using adenovirus- and adeno-associated virus-directed gene transfer, Hum. Gene Ther., 12, 773, 10.1089/104303401750148702 Rubel, 1995, Mammalian vestibular hair cell regeneration, Science, 267, 701, 10.1126/science.7839150 Rusch, 1998, Postnatal development of type I and type II hair cells in the mouse utricle, J. Neurosci., 18, 7487, 10.1523/JNEUROSCI.18-18-07487.1998 Ryals, 1988, Hair cell regeneration after acoustic trauma in adult Coturnix quail, Science, 240, 1774, 10.1126/science.3381101 Sandler, 1985, DNA repair synthesis in the pancreatic islets of streptozotocin-treated mice, Diabet. Res., 2, 255 Seppa, 2000, New inner ear hair cells grow in rat tissue, Science News, 157, 342, 10.2307/4012334 Shailam, 1999, Expression of proneural and neurogenic genes in the embryonic mammalian vestibular system, J. Neurocytol., 28, 809, 10.1023/A:1007009803095 Shou, 1999, BMPs inhibit neurogenesis by a mechanism involving degradation of a transcription factor, Nat. Neurosci., 2, 339, 10.1038/7251 Tomita, 2000, Mammalian achaete-scute and atonal homologs regulate neuronal versus glial fate determination in the central nervous system, EMBO J., 19, 5460, 10.1093/emboj/19.20.5460 Walsh, 1992, Functional Development of the Cochlea and the Cochlear Nerve, 161 Warchol, 1993, Regenerative proliferation in inner ear sensory epithelia from adult guinea pigs and humans, Science, 259, 1619, 10.1126/science.8456285 Warchol, 1995, Response to, Science, 267, 704, 10.1126/science.267.5198.704 Xiang, 1998, Requirement for Brn-3c in maturation and survival, but not in fate determination of inner ear hair cells, Development, 125, 3935, 10.1242/dev.125.20.3935 Yagi, 1999, Hair cell protection from aminoglycoside ototoxicity by adenovirus-mediated overexpression of glial cell line-derived neurotrophic fac, Hum. Gene Ther., 10, 813, 10.1089/10430349950018562 Yang, 2001, Requirement of Math1 for secretory cell lineage commitment in the mouse intestine, Science, 294, 2155, 10.1126/science.1065718 Zheng, 1997, Analysis of rat vestibular hair cell development and regeneration using calretinin as an early marker, J. Neurosci., 17, 8270, 10.1523/JNEUROSCI.17-21-08270.1997 Zheng, 2000, Overexpression of Math1 induces robust production of extra hair cells in postnatal rat inner ears, Nat. Neurosci., 3, 580, 10.1038/75753 Zheng, 1999, Immunocytochemical and morphological evidence for intracellular self-repair as an important contributor to mammalian hair cell recovery, J. Neurosci., 19, 2161, 10.1523/JNEUROSCI.19-06-02161.1999 Zheng, 2000, Hes1 is a negative regulator of inner ear hair cell differentiation, Development, 127, 4551, 10.1242/dev.127.21.4551 Zine, 2001, Hes1 and Hes5 activities are required for the normal development of the hair cells in the mammalian inner ear, J. Neurosci., 21, 4712, 10.1523/JNEUROSCI.21-13-04712.2001