Robust axonal growth and a blunted macrophage response are associated with impaired functional recovery after spinal cord injury in the MRL/MpJ mouse

Baker, 2006, Neuroblast protuberances in the subventricular zone of the regenerative MRL/MpJ mouse, J Comp Neurol, 498, 747, 10.1002/cne.21090 Basso, 1995, A sensitive and reliable locomotor rating scale for open field testing in rats, J Neurotrauma, 12, 1, 10.1089/neu.1995.12.1 Basso, 1996, Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection, Exp Neurol, 139, 244, 10.1006/exnr.1996.0098 Basso, 2006, Basso mouse scale for locomotion detects differences in recovery after spinal cord injury in five common mouse strains, J Neurotrauma, 23, 635, 10.1089/neu.2006.23.635 Beare, 2006, Location of injury influences the mechanisms of both regeneration and repair within the MRL/MpJ mouse, J Anat, 209, 547, 10.1111/j.1469-7580.2006.00641.x Beattie, 1990, Metamorphosis alters the response to spinal cord transection in Xenopus laevis frogs, J Neurobiol, 21, 1108, 10.1002/neu.480210714 Behrmann, 1992, Spinal cord injury produced by consistent mechanical displacement of the cord in rats: behavioral and histologic analysis, J Neurotrauma, 9, 197, 10.1089/neu.1992.9.197 Benowitz, 2007, Combinatorial treatments for promoting axon regeneration in the CNS: strategies for overcoming inhibitory signals and activating neurons' intrinsic growth state, Dev Neurobiol, 67, 1148, 10.1002/dneu.20515 Bresnahan, 1987, A behavioral and anatomical analysis of spinal cord injury produced by a feedback-controlled impaction device, Exp Neurol, 95, 548, 10.1016/0014-4886(87)90299-8 Chernoff, 2000, Matrix metalloproteinase production in regenerating axolotl spinal cord, Wound Repair Regen, 8, 282, 10.1046/j.1524-475x.2000.00282.x Chernoff, 2002, Spinal cord regeneration: intrinsic properties and emerging mechanisms, Semin Cell Dev Biol, 13, 361, 10.1016/S1084952102000927 Chernoff, 2003, Urodele spinal cord regeneration and related processes, Dev Dyn, 226, 295, 10.1002/dvdy.10240 Church, 1968, Wound healing in the web membrane of the fruit bat, Br J Surg, 55, 26, 10.1002/bjs.1800550108 Clark, 1998, A new murine model for mammalian wound repair and regeneration, Clin Immunol Immunopathol, 88, 35, 10.1006/clin.1998.4519 Clarke, 1988, Regeneration of descending axons in the spinal cord of the axolotl, Neurosci Lett, 89, 1, 10.1016/0304-3940(88)90471-5 Colwell, 2006, Skin wounds in the MRL/MPJ mouse heal with scar, Wound Repair Regen, 14, 81, 10.1111/j.1524-475X.2005.00092.x Condic, 2002, Extracellular matrix in spinal cord regeneration: getting beyond attraction and inhibition, Neuroreport, 13, A37, 10.1097/00001756-200203040-00002 Davies, 1997, Regeneration of adult axons in white matter tracts of the central nervous system, Nature, 390, 680, 10.1038/37776 Davies, 1999, Robust regeneration of adult sensory axons in degenerating white matter of the adult rat spinal cord, J Neurosci, 19, 5810, 10.1523/JNEUROSCI.19-14-05810.1999 Faulkner, 2004, Reactive astrocytes protect tissue and preserve function after spinal cord injury, J Neurosci, 24, 2143, 10.1523/JNEUROSCI.3547-03.2004 Ferretti, 2003, Changes in spinal cord regenerative ability through phylogenesis and development: lessons to be learnt, Dev Dyn, 226, 245, 10.1002/dvdy.10226 Fitch, 1999, Cellular and molecular mechanisms of glial scarring and progressive cavitation: in vivo and in vitro analysis of inflammation-induced secondary injury after CNS trauma, J Neurosci, 19, 8182, 10.1523/JNEUROSCI.19-19-08182.1999 Fitch, 2008, CNS injury, glial scars, and inflammation: Inhibitory extracellular matrices and regeneration failure, Exp Neurol, 209, 294, 10.1016/j.expneurol.2007.05.014 Fleming, 2006, The cellular inflammatory response in human spinal cords after injury, Brain, 129, 3249, 10.1093/brain/awl296 Fry, 2003, Regeneration of supraspinal axons after complete transection of the thoracic spinal cord in neonatal opossums (Monodelphis domestica), J Comp Neurol, 466, 422, 10.1002/cne.10904 Goss, 1975, Epidermal downgrowths in regenerating rabbit ear holes, J Morphol, 146, 533, 10.1002/jmor.1051460408 Gourevitch, 2003, Matrix metalloproteinase activity correlates with blastema formation in the regenerating MRL mouse ear hole model, Dev Dyn, 226, 377, 10.1002/dvdy.10243 Goussev, 2003, Differential temporal expression of matrix metalloproteinases after spinal cord injury: relationship to revascularization and wound healing, J Neurosurg, 99, 188 Hampton, 2004, Altered CNS response to injury in the MRL/MpJ mouse, Neuroscience, 127, 821, 10.1016/j.neuroscience.2004.05.057 Herrmann, 2008, STAT3 is a critical regulator of astrogliosis and scar formation after spinal cord injury, J Neurosci, 28, 7231, 10.1523/JNEUROSCI.1709-08.2008 Inman, 2003, Ascending sensory, but not other long-tract axons, regenerate into the connective tissue matrix that forms at the site of a spinal cord injury in mice, J Comp Neurol, 462, 431, 10.1002/cne.10768 Jakeman, 2000, Traumatic spinal cord injury produced by controlled contusion in mouse, J Neurotrauma, 17, 299, 10.1089/neu.2000.17.299 Jones, 2005, Inflammatory-mediated injury and repair in the traumatically injured spinal cord, Curr Pharm Des, 11, 1223, 10.2174/1381612053507468 Kigerl, 2007, Toll-like receptor (TLR)-2 and TLR-4 regulate inflammation, gliosis, and myelin sparing after spinal cord injury, J Neurochem, 102, 37, 10.1111/j.1471-4159.2007.04524.x Kigerl, 2006, Comparative analysis of lesion development and intraspinal inflammation in four strains of mice following spinal contusion injury, J Comp Neurol, 494, 578, 10.1002/cne.20827 Kwiecien, 2008, Long-distance axonal regeneration in the filum terminale of adult rats is regulated by ependymal cells, J Neurotrauma, 25, 196, 10.1089/neu.2007.0454 Lane, 2007, Age-related differences in the local cellular and molecular responses to injury in developing spinal cord of the opossum, Monodelphis domestica, Eur J Neurosci, 25, 1725, 10.1111/j.1460-9568.2007.05439.x Lazarov-Spiegler, 1996, Transplantation of activated macrophages overcomes central nervous system regrowth failure, FASEB J, 10, 1296, 10.1096/fasebj.10.11.8836043 Leferovich, 2001, Heart regeneration in adult MRL mice, Proc Natl Acad Sci U S A, 98, 9830, 10.1073/pnas.181329398 Li, 2001, Genetic control of the rate of wound healing in mice, Heredity, 86, 668, 10.1046/j.1365-2540.2001.00879.x Li, 2001, Analysis of gene expression in the wound repair/regeneration process, Mamm Genome, 12, 52, 10.1007/s003350010230 Lu, 2008, Growth factors and combinatorial therapies for CNS regeneration, Exp Neurol, 209, 313, 10.1016/j.expneurol.2007.08.004 Ma, 2001, Behavioral and histological outcome following graded contusion injury in C57Bl/6 mice, Exp Neurol, 169, 239, 10.1006/exnr.2001.7679 Ma, 2004, Enhanced axonal growth into a spinal cord contusion injury site in a strain of mouse (129X1/SvJ) with a diminished inflammatory response, J Comp Neurol, 474, 469, 10.1002/cne.20149 McBrearty, 1998, Genetic analysis of a mammalian wound-healing trait, Proc Natl Acad Sci U S A, 95, 11792, 10.1073/pnas.95.20.11792 McKeon, 1995, Injury-induced proteoglycans inhibit the potential for laminin-mediated axon growth on astrocytic scars, Exp Neurol, 136, 32, 10.1006/exnr.1995.1081 Monaghan, 2007, Early gene expression during natural spinal cord regeneration in the salamander Ambystoma mexicanum, J Neurochem, 101, 27, 10.1111/j.1471-4159.2006.04344.x Noble, 2002, Matrix metalloproteinases limit functional recovery after spinal cord injury by modulation of early vascular events, J Neurosci, 22, 7526, 10.1523/JNEUROSCI.22-17-07526.2002 Noble, 1989, Correlative analyses of lesion development and functional status after graded spinal cord contusive injuries in the rat, Exp Neurol, 103, 34, 10.1016/0014-4886(89)90182-9 Okada, 2006, Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury, Nat Med, 12, 829, 10.1038/nm1425 Popovich, 1999, Depletion of hematogenous macrophages promotes partial hindlimb recovery and neuroanatomical repair after experimental spinal cord injury, Exp Neurol, 158, 351, 10.1006/exnr.1999.7118 Popovich, 2008, Can the immune system be harnessed to repair the CNS?, Nat Rev Neurosci, 9, 481, 10.1038/nrn2398 Popovich, 1997, The cellular inflammatory response after spinal cord injury in Sprague-Dawley and Lewis rats, J Comp Neurol, 377, 443, 10.1002/(SICI)1096-9861(19970120)377:3<443::AID-CNE10>3.0.CO;2-S Reddien, 2004, Fundamentals of planarian regeneration, Annu Rev Cell Dev Biol, 20, 725, 10.1146/annurev.cellbio.20.010403.095114 Scheff, 2002, A statistical method for analyzing rating scale data: the BBB locomotor score, J Neurotrauma, 19, 1251, 10.1089/08977150260338038 Schnell, 1999, Acute inflammatory responses to mechanical lesions in the CNS: differences between brain and spinal cord, Eur J Neurosci, 11, 3648, 10.1046/j.1460-9568.1999.00792.x Slack, 2004, Cellular and molecular mechanisms of regeneration in Xenopus, Philos Trans R Soc Lond B Biol Sci, 359, 745, 10.1098/rstb.2004.1463 Snow, 2002, Binding characteristics of chondroitin sulfate proteoglycans and laminin-1, and correlative neurite outgrowth behaviors in a standard tissue culture choice assay, J Neurobiol, 51, 285, 10.1002/neu.10060 Sroga, 2003, Rats and mice exhibit distinct inflammatory reactions after spinal cord injury, J Comp Neurol, 462, 223, 10.1002/cne.10736 Steinmetz, 2005, Chronic enhancement of the intrinsic growth capacity of sensory neurons combined with the degradation of inhibitory proteoglycans allows functional regeneration of sensory axons through the dorsal root entry zone in the mammalian spinal cord, J Neurosci, 25, 8066, 10.1523/JNEUROSCI.2111-05.2005 Steward, 2003, False resurrections: distinguishing regenerated from spared axons in the injured central nervous system, J Comp Neurol, 459, 1, 10.1002/cne.10593 Tucker, 2008, Elevated MMP Expression in the MRL mouse retina creates a permissive environment for retinal regeneration, Invest Ophthalmol Vis Sci, 49, 1686, 10.1167/iovs.07-1058 Ueno, 2005, Accelerated wound healing of alkali-burned corneas in MRL mice is associated with a reduced inflammatory signature, Invest Ophthalmol Vis Sci, 46, 4097, 10.1167/iovs.05-0548 Wang, 1996, Evidence for growth of supraspinal axons through the lesion after transection of the thoracic spinal cord in the developing opossum Didelphis virginiana, J Comp Neurol, 371, 104, 10.1002/(SICI)1096-9861(19960715)371:1<104::AID-CNE6>3.0.CO;2-7 Werner, 2007, Keratinocyte-fibroblast interactions in wound healing, J Invest Dermatol, 127, 998, 10.1038/sj.jid.5700786 Yin, 2006, Oncomodulin is a macrophage-derived signal for axon regeneration in retinal ganglion cells, Nat Neurosci, 9, 843, 10.1038/nn1701 Zhang, 1996, Genetic influences on cellular reactions to spinal cord injury: a wound-healing response present in normal mice is impaired in mice carrying a mutation (WldS) that causes delayed Wallerian degeneration, J Comp Neurol, 371, 485, 10.1002/(SICI)1096-9861(19960729)371:3<485::AID-CNE10>3.0.CO;2-I