Rituximab in refractory sarcoidosis: a single centre experience
Tóm tắt
Sarcoidosis is a granulomatous disease whose outcome varies from spontaneous remission to chronic refractory disease. Provided that steroids represent the gold standard as a first line treatment, many immune suppressants drugs are currently used in the disease management. However, refractory disease is still a great challenge. Rituximab is an anti-CD20 chimeric monoclonal antibody, currently used for the treatment of B cell malignancies and systemic autoimmune diseases. There are few case reports describing the successful use of Rituximab in refractory sarcoidosis with lung, eye, lymph nodes and skin involvement. In this paper we described three different case reports in which Rituximab has been used to treat refractory sarcoidosis and we reviewed the existing literature.
Tài liệu tham khảo
Hunninghake GW, Costabel U, Ando M, Baughman R, Cordier JF, du Bois R et al (1999) ATS/ERS/WASOG statement on sarcoidosis. American Thoracic Society/European Respiratory Society/World Association of Sarcoidosis and other Granulomatous Disorders. Sarcoidosis Vasc Diffuse Lung Dis 16:149–173
Crommelin HA, Vorselaars AD, van Moorsel CH, Korenromp IH, Deneer VH, Grutters JC (2014) Anti-TNF therapeutics for the treatment of sarcoidosis. Immunotherapy 6:1127–1143
Facco M, Cabrelle A, Teramo A, Olivieri V, Gnoato M, Teolato S et al (2011) Sarcoidosis is a Th1/Th17 multisystem disorder. Thorax 66:144–150
Lee NS, Barber L, Akula SM, Sigounas G, Kataria YP, Arce S (2011) Disturbed homeostasis and multiple signaling defects in the peripheral blood B-cell compartment of patients with severe chronic sarcoidosis. Clin Vaccine Immunol 18:1306–1316
Geetha D, Hruskova Z, Segelmark M, Hogan J, Morgan MD, Cavero T et al (2015) Rituximab for treatment of severe renal disease in ANCA associated vasculitis. J Nephrol. doi:10.1007/s40620-015-0208-y
Munoz SA, Gandino IJ, Orden AO, Allievi A (2015) Rituximab in the treatment of eosinophilic granulomatosis with polyangiitis. Reumatol Clin 11:165–169
Reff ME, Carner K, Chambers KS, Chinn PC, Leonard JE, Raab R et al (1994) Depletion of B cells in vivo by a chimeric mouse human monoclonal antibody to CD20. Blood 83:435–445
Puechal X, Gottenberg JE, Berthelot JM, Gossec L, Meyer O, Morel J et al (2012) Rituximab therapy for systemic vasculitis associated with rheumatoid arthritis: Results from the AutoImmunity and Rituximab Registry. Arthritis Care Res Hoboken 64:331–339
Alberici F, Jayne DR (2014) Impact of rituximab trials on the treatment of ANCA-associated vasculitis. Nephrol Dial Transplant 29:1151–1159
Alberici F, Smith RM, Jones RB, Roberts DM, Willcocks LC, Chaudhry A et al (2015) Long-term follow-up of patients who received repeat-dose rituximab as maintenance therapy for ANCA-associated vasculitis. Rheumatology 54(7):1153–1160. doi:10.1093/rheumatology/keu452
Bomprezzi R, Pati S, Chansakul C, Vollmer T (2010) A case of neurosarcoidosis successfully treated with rituximab. Neurology 75:568–570
Sawaya R, Radwan W (2013) Sarcoidosis associated with neuromyelitis optica. J Clin Neurosci 20:1156–1158
Dasilva V, Breuil V, Chevallier P, Euller-Ziegler L (2010) Relapse of severe sarcoidosis with an uncommon peritoneal location after TNFalpha blockade. Efficacy of rituximab, report of a single case. Joint Bone Spine 77:82–83
Lower EE, Baughman RP, Kaufman AH (2012) Rituximab for refractory granulomatous eye disease. Clin Ophthalmol 6:1613–1618
Belkhou A, Younsi R, El Bouchti I, El Hassani S (2008) Rituximab as a treatment alternative in sarcoidosis. Joint Bone Spine 75:511–512
Sweiss NJ, Lower EE, Mirsaeidi M, Dudek S, Garcia JG, Perkins D et al (2014) Rituximab in the treatment of refractory pulmonary sarcoidosis. Eur Respir J 43:1525–1528
Gottenberg JE, Guillevin L, Lambotte O, Combe B, Allanore Y, Cantagrel A et al (2005) Tolerance and short term efficacy of rituximab in 43 patients with systemic autoimmune diseases. Ann Rheum Dis 64:913–920