Risks and benefits of β-receptor blockers for pregnancy hypertension: overview of the randomized trials

Laura A. Magee1, Einat Elran1, Shelley B. Bull2, Alexander Logan2, Gideon Koren1
1Motherisk Program, Division of Clinical Pharmacology/Toxicology, The Hospital for Sick Children, Toronto, Ont., Canada
2Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ont., Canada

Tài liệu tham khảo

1990, Report on high blood pressure in pregnancy, Am J Obstet Gynecol, 163, 1691, 10.1016/0002-9378(90)90653-O 1994 Sulyok, 1989, Endocrine factors in the neonatal adaptation, Acta Physiol Hung, 74, 329 Sibai, 1996, Treatment of hypertension in pregnant women, New Engl J Med, 335, 267, 10.1056/NEJM199607253350407 Collins R, Duley L. Beta-blockers in the treatment of pre-eclampsia. In: Enkin MW, Keirse MJNC, Renfrew MJ, Neilson JP, editors. Pregnancy and childbirth module. ‘Cochrane Database of Systematic Reviews’: Review No. 03998, 20 April 1993. Published through ‘Cochrane Updates on Disk’. Oxford: Update Software, 1993, Disk Issue 2. Collins R, Duley L. Beta-blockers vs. methyldopa in the treatment of pre-eclampsia. In: Enkin MW, Keirse MJNC, Renfrew MJ, Neilson JP, editors. Pregnancy and childbirth module. ‘Cochrane Database of Systematic Reviews’: Review No. 03999, 20 April 1993. Published through ‘Cochrane Updates on Disk’. Oxford: Update Software, 1993, Disk Issue 2. Collins R, Duley L. Labetalol vs hydralazine in severe pregnancy-induced hypertension. In: Enkin MW, Keirse MJNC, Renfrew MJ, Neilson JP, editors. Pregnancy and childbirth module. ‘Cochrane Database of Systematic Reviews’: Review No. 04392, 7 May 1992. Published through ‘Cochrane Updates on Disk’. Oxford: Update Software, 1993, Disk Issue 2. Collins R, Duley L. Intravenous labetalol vs. i.v. diazoxide in severe preeclampsia. In: Enkin MW, Keirse MJNC, Renfrew MJ, Neilson JP, editors. Pregnancy and childbirth module. ‘Cochrane Database of Systematic Reviews’: Review No. 04400, 20 April 1993,. Published through ‘Cochrane Updates on Disk’. Oxford: Update Software, 1994, Disk Issue 1. Sharp, 1996, The relation between treatment benefit and underlying risk in meta-analysis, Br Med J, 313, 735, 10.1136/bmj.313.7059.735 Thompson, 1994, Why sources of heterogeneity in meta-analysis should be investigated, Br Med J, 309, 1351, 10.1136/bmj.309.6965.1351 StatXact 3 for Windows; statistical software for exact nonparametric inference. CYTEL Software Corporation, Cambridge, USA, 1995. Sackett, 1996, Down with odds ratios!, Evidence-Based Med, 1, 164 Fleiss, 1993, The statistical basis of meta-analysis, Stat Methods Med Res, 2, 121, 10.1177/096228029300200202 Robins, 1986, Estimators of the Mantel–Haenszel variance consistent in both sparse data and large strata limiting models, Biometrics, 42, 311, 10.2307/2531052 Orwin, 1983, A fail-safe N for effect size in meta-analysis, J Educ Stat, 8, 157, 10.2307/1164923 Begg, 1985, A measure to aid in the interpretation of published clinical trials, Stat Med, 4, 1, 10.1002/sim.4780040103 Demets, 1987, Methods for combining randomized clinical trials: Strengths and limitations, Stat Med, 6, 341, 10.1002/sim.4780060325 Cruikshank, 1992, Intra-uterine growth retardation and maternal labetalol treatment in a random allocation controlled study, J Obstet Gynaecol, 12, 223, 10.3109/01443619209004032 Cruikshank, 1991, Maternal obstetric outcome measured in a randomised controlled study of labetalol in the treatment of hypertension in pregnancy, Clin Exp Hypertens Pregnancy, B10, 333, 10.3109/10641959109012919 Cruickshank, 1992, Does labetalol influence the development of proteinuria in pregnancy hypertension? A randomised controlled study, Eur J Obstet Gynecol Reprod Biol, 45, 47, 10.1016/0028-2243(92)90192-2 Bott-Kanner, 1992, Antihypertensive therapy in the management of hypertension in pregnancy-A clinical double-blind study of pindolol, Clin Exp Hypertens Pregnancy, B11, 207, 10.3109/10641959209031044 Plouin, 1990, A randomized comparison of early with conservative use of antihypertensive drugs in the management of pregnancy-induced hypertension, Br J Obstet Gynaecol, 97, 134, 10.1111/j.1471-0528.1990.tb01738.x Butters, 1990, Atenolol in essential hypertension during pregnancy, Br Med J, 301, 587, 10.1136/bmj.301.6752.587 Pickles, 1989, The fetal outcome in a randomized double-blind controlled trial of labetalol versus placebo in pregnancy-induced hypertension, Br J Obstet Gynaecol, 96, 38, 10.1111/j.1471-0528.1989.tb01574.x Pickles, 1992, A randomised placebo controlled trial of labetalol in the treatment of mild to moderate pregnancy induced hypertension, Br J Obstet Gynaecol, 99, 964, 10.1111/j.1471-0528.1992.tb13698.x Sibai, 1987, A comparison of labetalol plus hospitalization versus hospitalization alone in the management of preeclampsia remote from term, Obstet Gynecol, 70, 323 Hogstedt, 1985, A prospective controlled trial of metoprolol-hydralazine treatment in the hypertension during pregnancy, Acta Obstet Gynecol Scand, 64, 505, 10.3109/00016348509156729 Hogstedt, 1984, Effect of metoprolol on fetal heart rate patterns during pregnancy and delivery, Clin Exp Hypertens Pregnancy, B3, 152 Wichman, 1984, A placebo controlled trial of metoprolol in the treatment of hypertension in pregnancy, Scand J Clin Lab Invest, 169, 90, 10.3109/00365518409085385 Wichman, 1985, Metoprolol in the treatment of mild to moderate hypertension in pregnancy-effects on the mother, Clin Exp Hypertens Pregnancy, B4, 141, 10.3109/10641958509020966 Wichman, 1984, Metoprolol in the treatment of hypertension in pregnancy: effects on the newborn baby, Clin Exp Hypertens Pregnancy, B3, 153 Rubin, 1984, Obstetric aspects of the use in pregnancy-associated hypertension of the β-adrenoreceptor antagonist atenolol, Am J Obstet Gynecol, 150, 389, 10.1016/S0002-9378(84)80145-3 Rubin, 1983, Placebo-controlled trial of atenolol in treatment of pregnancy-associated hypertension, Lancet, 1, 431 Rubin, 1984, Atenolol in the management of pregnancy associated hypertension: Obstetric and paediatric aspects, Clin Exp Hypertens Pregnancy, B3, 154 Hjertberg, 1993, Neonatal adaptation in hypertensive pregnancy: a study of labetalol vs hydralazine treatment, J Perinat Med, 21, 69, 10.1515/jpme.1993.21.1.69 Oumachigui, 1992, A comparative evaluation of metoprolol and methyldopa in the management of pregnancy-induced hypertension, Indian Heart J, 44, 39 Sibai, 1990, A comparison of no medication versus methyldopa or labetalol in chronic hypertension during pregnancy, Am J Obstet Gynecol, 162, 960, 10.1016/0002-9378(90)91297-P Plouin, 1988, Comparison of antihypertensive efficacy and perinatal safety of labetalol and methyldopa in the treatment of hypertension in pregnancy: a randomized controlled trial, Br J Obstet Gynaecol, 95, 868, 10.1111/j.1471-0528.1988.tb06571.x Lardoux, 1988, Essai ouvert, comparatif, avec tirage au sort pour le traitement de l’HTA gravidique moderee: methyldopa, acebutolol, labetalol, Arch Mal Coeur, 81, 137 Rosenfeld, 1986, Treatment of hypertension during pregnancy with hydralazine monotherapy or with combined therapy with hydralazine and pindolol, Eur J Obstet Gynecol Reprod Biol, 22, 197, 10.1016/0028-2243(86)90066-3 Ellenbogen, 1986, Management of pregnancy-induced hypertension with pindolol-comparative study with methyldopa, Int J Gynaecol Obstet, 24, 3, 10.1016/0020-7292(86)90015-9 Gallery, 1985, Antihypertensive treatment in pregnancy: analysis of different responses to oxprenolol and methyldopa, Br Med J, 291, 563, 10.1136/bmj.291.6495.563 Livingstone, 1983, Propranolol in pregnancy; three year prospective study, Clin Exp Hypertens Pregnancy, B2, 341, 10.3109/10641958309006092 Fidler, 1983, Randomised controlled comparative study of methyldopa and oxprenolol in treatment of hypertension in pregnancy, Br Med J, 286, 1927, 10.1136/bmj.286.6382.1927 Lamming, 1980, Comparison of the alpha and beta blocking drug, labetalol, and methyldopa in the treatment of moderate and severe pregnancy-induced hypertension, Clin Exp Hypertens Pregnancy, A2, 865, 10.3109/10641968009037147 Redman, 1978, A controlled trial of the treatment of hypertension in pregnancy: labetalol compared with methyldopa, vol. 591, 101 Jannet, 1994, Nicardipine versus metoprolol in the treatment of hypertension during pregnancy: a randomized comparative trial, Obstet Gynecol, 84, 354 Paran, 1995, β-adrenergic blocking agents in the treatment of pregnancy-induced hypertension, Int J Clin Pharmacol Ther, 33, 119 Bhorat, 1993, Malignant ventricular arrhythmias in eclampsia: a comparison of labetalol with dihydralazine, Am J Obstet Gynecol, 168, 1292, 10.1016/0002-9378(93)90383-T Mabie, 1987, A comparative trial of labetalol and hydralazine in the acute management of severe hypertension complicating pregnancy, Obstet Gynecol, 70, 328 Mabie, 1987, A comparative trial of labetalol and hydralazine for acute management of severe hypertension complicating pregnancy, Clin Exp Hypertens Pregnancy, B6, 91 Ashe, 1987, Comparison of labetalol and dihydralazine in hypertensive emergencies of pregnancy, SAMJ, 71, 354 Michael, 1986, Intravenous labetalol and intravenous diazoxide in severe hypertension complicating pregnancy, Aust NZ J Obstet Gynaecol, 26, 26, 10.1111/j.1479-828X.1986.tb01523.x Garden, 1982, Intravenous labetalol and intravenous dihydralazine in severe hypertension in pregnancy, Clin Exp Hypertens Pregnancy, B1, 371, 10.3109/10641958209139860 Ramanathan, 1988, The use of labetalol for attenuation of the hypertensive response to endotracheal intubation in preeclampsia, Am J Obstet Gynecol, 159, 650, 10.1016/S0002-9378(88)80027-9 Tunstall, 1969, The effect of propranolol on the onset of breathing at birth, Br J Anaesth, 41, 792 Ross, 1983, Intravenous terbutaline and simultaneous β1-blockade for advanced premature labor, Am J Obstet Gynecol, 147, 897, 10.1016/0002-9378(83)90242-9 Sanchez-Ramos, 1996, Randomized trial of oxytocin alone and with propranolol in the management of dysfunctional labor, Obstet Gynecol, 88, 517, 10.1016/0029-7844(96)00223-2 Li, 1990, The effect of labetalol on mild pre-eclampsia, 191 Hjertberg, 1990, Neonatal outcome in infants <1500 g; a randomized study of labetalol- vs. dihydralazine-treated hypertensive pregnant women, 191 Thorley, 1984, Randomised trial of atenolol and methyldopa in pregnancy related hypertension, Clin Exp Hypertens Pregnancy, B3, 168 Walker, 1984, The effect of maternal labetalol on the neonate, Clin Exp Hypertens, B3, 150 Marlettini, 1990, Randomized comparison of calcium antagonists and beta-blockers in the treatment of pregnancy-induced hypertension, Curr Ther Res, 48, 684 El-Qarmalawi, 1995, Labetalol vs. methyldopa in the treatment of pregnancy-induced hypertension, Int J Gynecol Obstet, 49, 125, 10.1016/0020-7292(95)02351-C Hjertberg, 1993, Comparison of outcome of labetalol or hydralazine therapy during hypertension in pregnancy in very low birth weight infants, Acta Obstet Gynecol Scand, 72, 611, 10.3109/00016349309021152 Walker, 1982, Labetalol in pregnancy-induced hypertension: fetal and maternal effects, vol. 591, 148 Walker, 1983, Treatment of acute pregnancy-related hypertension; labetalol and hydralazine compared, Postgrad Med J, 59, 168 Harper, 1991, Maternal and fetal haemodynamics in hypertensive pregnancies during maternal treatment with intravenous hydralazine or labetalol, Br J Obstet Gynaecol, 98, 453, 10.1111/j.1471-0528.1991.tb10339.x Kyle, 1992, Comparative risk-benefit assessment of drugs used in the management of hypertension in pregnancy, Drug Safety, 7, 233, 10.2165/00002018-199207030-00007 Borzak, 1995, Discordance between meta-analyses and large-scale randomized, controlled trials, Ann Intern Med, 123, 873, 10.7326/0003-4819-123-11-199512010-00010 van den Anker, 1995, Assessment of glomerular filtration rate in preterm infants by serum creatinine: comparison with inulin clearance, Pediatrics, 96, 1156, 10.1542/peds.96.6.1156