Risk of asthma and allergic outcomes in the offspring in relation to maternal food consumption during pregnancy: A Finnish birth cohort study

Pediatric Allergy and Immunology - Tập 23 Số 2 - Trang 186-194 - 2012
Maijaliisa Erkkola1, Bright I. Nwaru2, Minna Kaila3, Carina Kronberg‐Kippilä4, Jorma Ilonen5,6, Olli Simell7, Riitta Veijola8, Mikael Knip3,9,10, Suvi Μ. Virtanen4,11,2
1Division of Nutrition, Department of Food and Environmental Sciences, University of Helsinki, Helsinki, Finland
2Tampere School of Health Sciences, University of Tampere, Finland
3Department of Pediatrics, Tampere University Hospital, Tampere, Finland
4Nutrition Unit, Department of Lifestyle and Participation, National Institute of Health and Welfare, Helsinki, Finland
5Department of Clinical Microbiology, University of Eastern Finland, Kuopio, Finland
6Immunogenetics Laboratory, 20014 University of Turku, Turku, Finland
7Department of Pediatrics, University of Turku, Turku, Finland
8Department of Pediatrics, University of Oulu, Oulu, Finland
9Folkhälsan Research Institute, Helsinki, Finland
10Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
11Science Center of Pirkanmaa Hospital District, Tampere, Finland

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To cite this article: Erkkola M, Nwaru BI, Kaila M, Kronberg‐Kippilä C, Ilonen J, Simell O, Veijola R, Knip M, Virtanen SM. Risk of asthma and allergic outcomes in the offspring in relation to maternal food consumption during pregnancy: A Finnish birth cohort study. Pediatr Allergy Immunol 2012: 23: 186–194.AbstractBackground:  Epidemiological and immunological studies suggest that maternal diet during pregnancy might affect the development of allergic diseases in the offspring. The authors set out to study the effect of maternal food consumption during pregnancy on the emergence of the International Study of Asthma and Allergies in Childhood (ISAAC)‐based allergic outcomes: asthma, allergic rhinitis, and wheeze by the 5 yr of age.Methods:  Data from 2441 children at 5 yr of age were analyzed within the Finnish Type 1 Diabetes Prediction and Prevention (DIPP) Nutrition Study, a population‐based birth cohort study. Maternal diet was assessed with a validated food frequency questionnaire.Results:  In multiple regression models adjusted for known confounders, low maternal consumption of leafy vegetables (adjusted odds ratio [aOR]: 1.55; 95% CI: 1.21, 1.98), malaceous fruits (aOR: 1.45; 95% CI: 1.15, 1.84), and chocolate (aOR: 1.36; 95% CI: 1.09, 1.70) were positively associated with the risk of wheeze in children. High maternal consumption of fruit and berry juices was positively associated with the risk of allergic rhinitis (aOR: 1.40; 95% CI: 1.03, 1.90) in children. No associations were observed between maternal food consumption and asthma.Conclusions:  Development of allergic diseases in preschool children may be influenced by intrauterine exposure to maternal diet.

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Pediatric Allergy and Immunology

Tập 23 Số 2

186-194

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