Rủi ro ung thư vú xâm lấn ở phụ nữ dân tộc Hán mang alen C TGFB1 rs1982073 và alen G FGFR2 rs1219648 tại Bắc Trung Quốc

Springer Science and Business Media LLC - Tập 125 - Trang 575-582 - 2010
Xiao-Hui Chen1, Xiao-Qing Li1,2, Ying Chen3, Yu-Mei Feng1,2
1Department of Biochemistry and Molecular Biology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
2Key Laboratory of Breast Cancer Prevention and Treatment of the Ministry of Education, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
3Clinical Laboratory, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

Tóm tắt

Tỷ lệ mắc bệnh cao và hành vi xâm lấn mạnh mẽ của ung thư vú có liên quan đến những biến thể di truyền. Các polymorphism nucleotide đơn (SNPs) ở nhiều gen đã được chứng minh là yếu tố nguy cơ cho ung thư vú. Trong nghiên cứu này, chúng tôi đã đánh giá mối liên hệ của SNP rs1982073 (Leu10Pro) trong gen yếu tố tăng trưởng beta 1 (TGFB1) và SNP rs1219648 trong gen thụ thể yếu tố tăng trưởng sợi 2 (FGFR2) với nguy cơ và độ xâm lấn của ung thư vú ở phụ nữ dân tộc Hán tại Bắc Trung Quốc. Phương pháp phân loại allele TaqMan đã được thực hiện để xác định kiểu gen rs1982073 và rs1219648 trên 447 trường hợp ung thư vú và 406 đối chứng khỏe mạnh tuổi tương đương. Kết quả cho thấy tần suất kiểu gen của rs1982073 và rs1219648 không khác biệt đáng kể giữa bệnh nhân ung thư vú và đối chứng khỏe mạnh. Tuy nhiên, đối với SNP TGFB1 rs1982073, những người mang alen C (kiểu gen T/C+C/C) có khả năng cao hơn trong việc mang các khối u có độ xâm lấn lớn (bậc mô học III) so với những người mang kiểu gen T/T (bậc I–II) (OR = 3.45, 95% CI: 1.48–8.00, P = 0.004). Đối với SNP FGFR2 rs1219648, những người mang alen G (kiểu gen A/G+G/G) có liên quan một cách đáng kể hơn với các khối u có di căn hạch bạch huyết so với những người mang kiểu gen A/A (không di căn hạch) (OR = 1.69, 95% CI: 1.11–2.58, P = 0.016). Do đó, các SNP của TGFB1 rs1982073 và FGFR2 rs1219648 có thể đóng góp vào việc xác định các bệnh nhân bị ung thư vú xâm lấn hơn ở phụ nữ Hán tại Bắc Trung Quốc.

Từ khóa

#ung thư vú #SNP #TGFB1 #FGFR2 #dân tộc Hán

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