Risk factors, complications and outcome of cholelithiasis in children: A retrospective, single‐centre review

Journal of Paediatrics and Child Health - Tập 52 Số 10 - Trang 944-949 - 2016
Ceyda Tuna Kırşaçlıoğlu1, Bekir Çakır2, Gülşah Bayram3, Fatih Akbıyık4, Pamir Işık5, Bahattin Tunç5
1Department of Pediatric Gastroenterology, Ankara Child Health and Diseases Hematology-Oncology Research and Training Hospital, Ankara, Turkey
2Well Child Clinic, Ankara Child Health and Diseases Hematology-Oncology Research and Training Hospital, Ankara, Turkey
3Department of Radiology, Ankara Child Health and Diseases Hematology-Oncology Research and Training Hospital, Ankara, Turkey
4Department of Pediatric Surgery, Ankara Child Health and Diseases Hematology-Oncology Research and Training Hospital, Ankara, Turkey
5Department of Pediatric Hematology, Ankara Child Health and Diseases Hematology-Oncology Research and Training Hospital, Ankara, Turkey

Tóm tắt

AimThe aim of this study was to evaluate the clinical presentation, risk factors, complications, treatment and outcomes of cholelithiasis in children.MethodsChildren with cholelithiasis were reviewed for demographic information, predisposing factors, presenting symptoms, laboratory findings, complications, treatment and outcome, retrospectively.ResultsA total of 254 children with cholelithiasis (mean age: 8.9 ± 5.2 years) were recruited to the study. Girls (52.8%) were significantly older than boys (P < 0.001). Symptomatic patients (59%) were significantly older than asymptomatic patients (P = 0.002). Abdominal pain was the most frequent symptom. No risk factors were identified in 56.6% of the patients. Ceftriaxone (20%) was the most commonly associated risk factor. At presentation, at least one of the following complications was seen in 14.1% of patients: cholecystitis (10.9%), obstructive jaundice (2.7%), pancreatitis (1.96%) and cholangitis (1.2%). There was no relationship between gallstone size and symptoms, aetiological factors and complications. The cholelithiasis dissolution rate was higher in younger children (P = 0.032), in those with biliary sludge (P < 0.0001) and ceftriaxone‐related cholelithiasis (P < 0.001). Haemolytic anaemia (P = 0.001) and older age (P = 0.002) were associated with stable stones. Ursodeoxycholic acid was administered to 94.4% of patients at presentation. Twenty‐nine patients underwent cholecystectomy, and seven patients underwent endoscopic retrograde cholangiopancreotography. Patients who were symptomatic at presentation had significantly more frequent symptoms at follow‐up (P < 0.001)ConclusionsDissolution rate of cholelithiasis was higher in younger children, biliary sludge formation and ceftriaxone‐related cholelithiasis but lower in older children and haemolytic anaemia‐related cholelithiasis.

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Journal of Paediatrics and Child Health

Tập 52 Số 10

944-949

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